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Majalah Obat Tradisional

TradMedJ
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Published by Universitas Gadjah Mada

ISSN : 14105918 EISSN : 24069086 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.

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Articles 10 Documents

Search results for , issue "Vol 24, No 1 (2019)" : 10 Documents clear

The Influence of Menthol in Ethanol Extract of Meniran Gel (Phyllanthus niruri L.) as a Hair Growth Promoter in Male Wistar Rats Sri Luliana; Rise Desnita; Utia Mufliha
Majalah Obat Tradisional Vol 24, No 1 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Phyllanthus niruri L. is known to promote hair growth. Menthol is one of the enhancers which promotes drug penetration into the skin. The aim of this research is to determine the potential of menthol in P. niruri Ethanol Extracts gel preparation as a hair growth promoter. The test animals were randomized into 4 groups: normal group, negative control (gel without extract and menthol), E1 group (Ethanol Extracts of P. niruri 5% gel without menthol) and E2 group (Ethanol Extracts of P. niruri 5% gel with menthol). Hair growth activity test was conducted by applying the gel on the rats’ back, and hair length was measured on the 7th, 14th and 21st days, while the hair was weighed on the 21st day. The results showed that the E2 group had an average hair length and hair weight of 12.45±3.457 mm and hair weight of 28.53±7.681 mg, greater than the E1 group of 10.67±2.455 mm and 19.87±9.552 mg respectively. Based on these results, it can be concluded that adding menthol in P. niruri Ethanol Extract gel preparation can influence hair growth and thickness.

The Development of Creambath Preparation with Combination of Garlic Extract (Allium sativum L.) and Custard Apple Seeds Extract (Annona squamosa L.) as Anti-Dandruff and Anti Head Lice (Pediculus humanus capitis) Mudita Mudita; Swasono R Tamat; Agung Eru Wibowo
Majalah Obat Tradisional Vol 24, No 1 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Allicin and ajoene are active compounds in garlic which have proven to be of benefit as antifungal. Meanwhile, the content of oleic acid and triglycerides from the custard apple seeds extract showed anti-fungal activity in vitro. This study aimed to obtain a preparation of creambath combination of garlic extract and custard apple seeds extract which have anti-dandruff and anti head lice activity. Garlic extract was obtained by adding phosphate buffer with freeze-dry method, while custard apple seeds extract was obtained from maceration using petroleum ether. Garlic extract provides an anti-dandruff effect with a minimum inhibitory concentration (MIC) of 6.25 mg/mL and the smallest custard apple seeds extract (LD 100%, 3 hours) which is 3.13 mg/mL can provide anti head lice effect. Variations in the concentration of the combination of garlic extract and custard apple seeds extract used in creambath preparations were (6.25 mg/mL and 3.13 mg/mL), (12.5 mg/mL and 6.25 mg/mL) and (25 mg/mL and 12.5 mg/mL). The resulting creambath preparations have characteristics that are light green, green tea flavored, homogeneous, semisolid form, o/w cream type, pH 5.85-6.25, viscosity 34,000-72,000 cps with thixotropic pseudoplastic flow properties, average size particle 34.31-57.66 μm, anti-dandruff activity with diameters of inhibitory 9, 12, and 16 mm in 72 hours incubation time and LD 100% hair lice activity in 157, 133 and 105 minutes.

Physical Characteristic and Antibacterial Activity of Silver Nanoparticles from Green Synthesis Using Ethanol Extracts of Phaleria macrocarpa (Scheff.) Boerl Leaves Tri Puji Lestari; Fitia Abbas Tahlib; Johan Sukweenadhi; Kartini kartini; Christina Avanti
Majalah Obat Tradisional Vol 24, No 1 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

The Green Synthesis method is widely developed due to its environmentally friendly, cost-effective, and easy application for nanoparticle-scale synthesis. Among all metal nanoparticles, silver nanoparticles are the most utilized products in the field of nanotechnology. Biomolecules contained in plant extracts can reduce the size of silver particles to nano size. This study aims to determine the antibacterial properties and activity of silver nanoparticles synthesized with the ethanol extract of mahkota dewa leaves. The formation of silver nanoparticles is monitored with UV-Vis absorption and its change in color. Parameters evaluated are shape, size, particle size distribution, composition, metal residue, and a functional group of nanoparticles, using Scanning Electron Microscopy (SEM), Particle Size Analyzer (PSA), X-Ray Diffraction (XRD), and Fourier Transform InfraRed (FTIR) instrument. The research on UV-Vis color and absorption show black silver color with the wavelength of 450-465nm. The characterization result shows spherical-shaped silver nanoparticle. Furthermore, PDI best value on concentration of 0.125% is 0,221±0,0482 with average particle size of 130,300±12,6858 nm. The diffraction pattern of silver nanoparticle with XRD test indicates that the nanoparticles contain the silver component. Antibacterial activity test shows that silver nanoparticles have a greater inhibition zone than AgNO3, and 0.125% ethanol extract of mahkota dewa leaves against Escherichia coli and Staphylococcus aureus. From the results of the study, it can be concluded that the ethanol extract from mahkota dewa leaves can be used as a bioreductor agent to produce silver nanoparticles which have greater antimicrobial activity compared to Ag and ethanol extract from mahkota dewa leaves.

The Effect of Papaya Seed Ethanol Extract in Vivo on The Number of Osteoblasts Cells of Periodontitis-Induced Rats Ratih Pusporini; Ahmad Basori; Agung Krismariono
Majalah Obat Tradisional Vol 24, No 1 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

The papaya seed ethanol extract is rich in antioxidant ingredients, such as flavonoids and phenolic acids. One of the main factors causing chronic inflammatory in periodontitis is oxidative stress. Administration of papaya seed extract is assumed to increase the number of rat osteoblast cells induced periodontitis. This research was conducted to analyze the effect of papaya seed extract on osteoblasts cells of rat induced periodontitis. This research represented an experimental laboratory-based investigation involving 35 rats of the Rattus norvegicus strain divided into 5 treatment groups (K, P1, P2, P3, P4). Control group (K) was not induced by periodontitis and was not given an extract, while group P induced periodontitis using LPS Phorphyromonas gingivalis (P.gingivalis) for 7 days and continued wire mesh installation around the mandibular incisors in the form of number “8” for 7 days. P1 group was given feed only without extract, while the rest were given extract of 200 mg/kgBB, 300mg/kgBB, and 400mg/kgBB. The data obtained were analyzed with a one-way ANOVA test. The results showed that the average number of osteoblasts varied significantly between the groups. There was an increase in the average number of osteoblast cells in rat induced periodontitis after given papaya seed extract.

The Antimalarial Activity of the Water Extract of Simpur (Dillenia Indica L) Leaves against Plasmodium Berghei in Mice Hafrizal Riza; Andhi Fahrurroji; Supriyanto Supriyanto; Arif Wicaksono
Majalah Obat Tradisional Vol 24, No 1 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Malaria, caused by the climate of the subtropical area and the forest with many rivers and immovable water, is a contagious disease that still becomes a health problem in West Kalimantan. Simpur is a plant that is used by the locals to cure malaria. Therefore, this research aims to study the antimalarial activity in vivo and the 50% inhibitory concentration (IC50) of the water extract of Simpur leaves (Dillenia indica L) against Plasmodium berghei. This research used Peter Test method that used 7 test groups based on the test solution namely positive control group that was given dihydroartemisinin+piperaquine (DHP), negative control that was given aquabidestilata and the test group that was given the water extract of Simpur leaves with various doses of 20, 40, 60, 80 and 100 mg/Kg BB of mice, which each group was given the test solution for 3 days. The result shows that the water extract of Simpur leaves could lower the parasitemia count with IC50 19,22 mg/kg BB.

Wound Healing Effects of Edible Bird’s Nests Oinment (Aerodramus fuciphagus) in Alloxan-Induced Male Rats Dita Ayulia Dwi Sandi; Yaumi Musfirah
Majalah Obat Tradisional Vol 24, No 1 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Edible bird's nest (Aedrodramus fuchipagus) contains EGF (Epidermal Growth Factor) and sialic acid which is useful in wound healing. The aim of this study was to investigate the effect of edible bird's nest on the injured Alloxan-induced rats to form optimal ointment formulation of edible bird's nest (Aedrodramus fuchipagus) which can heal wounds. The method used in this research is experimental using 25 Sprague Dawley rats divided into 5 groups in which each group consists of 5 rats; Group I was the control group (Vaseline + Betadine®), Group II, III, and IV were the group of EBN + Betadine® with concentrations of 10%, 20%, and 30%; and Group V was of the Sanoskin Meladerm® (SM) + Betadine® group. The rats were modeled for diabetes by inducing Alloxan (150mg/kgBW/i.p) and exposed with DM when the blood sugar level was > 200 mg/dL. The back skins were sliced as long as 2 cm and 2 mm depth and were given treatment according to the group, 1 x daily for 10 days. Parameters that were noticed were length wound, length of the dry wound, and the number of days of scab formation. The results obtained in the control group were 10%, 20%, and 30% on the EBN group, and the SM group on the 9th day were 1.3±0.2449, 0.34±0.427, 0.56±0.4586, 0±0, 0±0. The results of the average length of the dry wound in the control group were 10%, 20%, and 30% on the EBN group, and the SM group were 1±0.5, 2±1.5, 4±0, 8, 1±0.8, and 2±0.63. While the result of the average day of scab formation on the control group was 10%, 20%, and 30% on the EBN groups, SM Groups were 1.3±0.47, 2.2±1.6, 3.8±0.8, 1±0, and 2±0.63. Based on Kruskal Wallis test, there were significant differences in the wound length among treatment groups (sig 0.013) and significant differences in dry wounds among treatment groups (sig 0.046), but there was no difference in the time of scab formation among treatment groups (sig 0.066). In conclusion, edible bird’s nest (Aedrodramus fuchipagus) ointment concentration of 30% is the most optimal ointment to wound healing in Alloxan-induced male rats when compared to Sanoskin Melladerm.

Metabolomic Study of Three Species in Zingiberaceae Family based on 1H-NMR Dinar Sari Cahyaningrum Wahyuni; Magdalena Kristanti; Soerya Dewi Marliyana; Yudi Rinanto
Majalah Obat Tradisional Vol 24, No 1 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Zingiberaceae is an economical plant and widely used as traditional medicines. Its rhizomes have been reported to have biological effects due to their metabolites content. However, metabolites profiling in Zingiberaceae has been little reported comprehensively. Therefore, this study aimed to profile primary and secondary metabolite of three species Zingiberaceae rhizomes (Zingiber amaricans BI, Zingiber officinale Roscoe, and Alpinia purpurata (Vieill.) K.Schum using 1H-NMR-based metabolomic approach. All samples were collected from local farmer located in Nguter, Sukoharjo, Central Java. Multivariate statistical analysis and ANOVA applied to measure the differences. It resulted that metabolite profiling discriminated between Zingiber and Alpinia samples. Fructose, α-glucose, β-glucose, sucrose, malic acid, alanine, valine, and shogaol contributed in discrimination between Z. amaricans BI, Z. officinale Roscoe, and A. purpurata (Vieill.) K.Schum. Sugar (α-glucose, β-glucose, fructose, and sucrose) and malic acid were significantly higher in Alpinia than in Zingiber samples. Relative concentration of amino acids (alanine and valine) and shogaol were significantly higher in Z. officinale. This result might be useful for databases and supplementary informations in Z. amaricans, Z. officinale, and A. purpurata taxonomy classifications.

Effects of Poly-herbal Tablet as Herbal Medicine on Lipid Level Woro Rukmi Pratiwi; Eti Nurwening Sholikhah; Dwi Aris Agung Nugrahaningsih; Mia Munawaroh Yuniyanti; Mustofa Mustofa; Ngatidjan Ngatidjan
Majalah Obat Tradisional Vol 24, No 1 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Dyslipidemia is one of the high-risk factors that cause cardiovascular disease and the prevalence is increasing all the time. Garlic (Alii sativi) has been suggested to reduce serum lipid level. Poly-herbal is herbal medicine that has been widely used in Indonesia, and it contains Alii sativi, Belericae fructus, Curcumae aeroginosae, and Amomi fructus extract. This study aimed to evaluate the effects of poly-herbal tablet on lipid levels in dylipidemia subjects. The study was conducted for 6 weeks on 58 dyslipidemic subjects. The subject was divided into 2 groups. Group 1 was given Poly-herbal with the dose 2x1200 mg, and group 2 was not given anti-dyslipidemic drugs (control group). Serum lipid level (total cholesterol, LDL, HDL, and triglycerides) were checked before the treatment (H0) and after the treatment (M6). There was a significant difference on the reduction of serum lipids level between the group that given Poly-herbal vs control group, respectively total cholesterol (-12.04±3.2 vs 8.38±4.3; p=.000), LDL (-4.42±2.8 vs 6.93±4.7; p=.049) and HDL (-2.62+1.0 vs 3.31+1.4; p=.005). Triglyceride level on Poly-herbal group is not significantly decreased. In Poly-herbal group there was also a decrease in HDL levels which was not statistically significant (-2.62±1, p=.015). This is probably due to the HDL baseline in the control group included in the normal HDL category (57.38 ± 14.9) so that the HDL levels after being given treatment did not increase. This study suggests that using Poly-herbal in dyslipidemia subjects can reduce the level of total cholesterol and LDL.

Potency of Black Soybean (Glycine max (L.) Merr) Extract and Daidzein as Antioxidant and Antihyaluronidase Tandiah Asan; I Nyoman Ehrich Lister; Edy Fachrial; Annisa Amalia; Wahyu Widowati; Buter Samin; Liena Liena
Majalah Obat Tradisional Vol 24, No 1 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Black soybean (Glycine max (L.) Merr.) is a plant that is widely planted and consumed in Indonesia. In addition, black soybean has unique content of isoflavones, such as daidzein, which is one of the active compounds that have the effect of fighting free radicals and can inhibit the aging process. The purpose of this study is to analyze the antioxidant potency possessed by black soybean extract (BSE) and daidzeinin inhibiting aging of the skin. The method used is a colorimetric test. The type of antioxidant test used is H2O2 scavenging and inhibiting the activity of the hyaluronidase enzyme for antiaging. BSE has better effectiveness of H2O2 scavenging (IC50: 286.24±11.16 (µg/mL)) than daidzein compound (IC50: 366.16±2.54 (µg/mL)). In the inhibition of hyaluronidase enzyme, the daidzein has more effective activities (IC50: 95.80±3.98 (µg/mL)) compared to BSE (IC50: 152.56±13.98 (µg/mL)). The antioxidant and anti-aging activities possessed by BSE make it possible to be used as a cosmetic ingredient for skin aging therapy.

Effect of Red Onion (Allium cepa var ascalonicum) Skin Ethanolic Extract on the Motility and the Adhesion Index of Pseudomonas aeruginosa and Macrophage Phagocytosis Index Irma Prasety Ayu Nugraheni; Derana Widyastika; Sofia Maulida; Heni Susilowati; Alma Linggar Jonarta
Majalah Obat Tradisional Vol 24, No 1 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Red onion skin (Allium cepa var ascalonicum) contains various ingredients that may function as antibacterial agents against microorganisms, as well as anti-inflammatory and immunomodulator agents for host cells, such as macrophages. Pseudomonas aeruginosa found in the oral cavity is commensal bacteria that may turn into opportunistic pathogen by utilizing its virulence factors such as motility and adhesion to the host cell. The purpose of this study was to investigate the effect of red-onion-skin ethanolic extract towards P. aeruginosa ATCC 9027 on the motility and adhesion ability, furthermore, to know its effect on the macrophage phagocytosis. The research was conducted into three parts of experiment using red-onion-skin ethanolic extract. Extract-induced bacterial motility test was carried out on semi-solid media, stained using 0.1% crystal violet, then the radial length of the bacterial movement was measured. The bacterial adhesion index to buccal cells was calculated after incubated for two hours and stained with Gram stain. Phagocytic activity of the host cells on P. aeruginosa was done by exposing the extract to the mouse peritoneal macrophages, then the phagocytosed bacteria were counted after Giemsa staining. Statistical test results from the three experiments showed significant differences between the test groups compared to the control groups (p <0.05). It was concluded that the red onion-skin ethanolic extract not only affects P. aeruginosa by reducing swarming motility and preventing bacterial adhesion to buccal epithelial cells, but also induces the host cells by increasing the ability of macrophage phagocytosis to these bacteria.

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Pudyastuti Kusumaningrum

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Kab. sleman,

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