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All Journal Majalah Obat Tradisional ALCHEMY Jurnal Penelitian Kimia BERDIKARI : Jurnal Inovasi dan Penerapan Ipteks
Dinar Sari Cahyaningrum Wahyuni
Active Pharmaceutical Discovery And Development, Program Studi S1 Farmasi, Universitas Sebelas Maret
Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Energy Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Metabolomic Study of Three Species in Zingiberaceae Family based on 1H-NMR Dinar Sari Cahyaningrum Wahyuni; Magdalena Kristanti; Soerya Dewi Marliyana; Yudi Rinanto
Majalah Obat Tradisional Vol 24, No 1 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (309.811 KB) | DOI: 10.22146/mot.41071

Abstract

Zingiberaceae is an economical plant and widely used as traditional medicines. Its rhizomes have been reported to have biological effects due to their metabolites content. However, metabolites profiling in Zingiberaceae has been little reported comprehensively. Therefore, this study aimed to profile primary and secondary metabolite of three species Zingiberaceae rhizomes (Zingiber amaricans BI, Zingiber officinale Roscoe, and Alpinia purpurata (Vieill.) K.Schum using 1H-NMR-based metabolomic approach. All samples were collected from local farmer located in Nguter, Sukoharjo, Central Java. Multivariate statistical analysis and ANOVA applied to measure the differences. It resulted that metabolite profiling discriminated between Zingiber and Alpinia samples. Fructose, α-glucose, β-glucose, sucrose, malic acid, alanine, valine, and shogaol contributed in discrimination between Z. amaricans BI, Z. officinale Roscoe, and A. purpurata (Vieill.) K.Schum. Sugar (α-glucose, β-glucose, fructose, and sucrose) and malic acid were significantly higher in Alpinia than in Zingiber samples. Relative concentration of amino acids (alanine and valine) and shogaol were significantly higher in Z. officinale. This result might be useful for databases and supplementary informations in Z. amaricans, Z. officinale, and A. purpurata taxonomy classifications.
Metabolite Profiling of Three Curcuma Species (Zingiberaceae) Based on H-NMR Spectroscopy Dinar Sari Cahyaningrum Wahyuni; Mutya Puti Wardianti; Yudi Rinanto; Soerya Dewi Marliyana
ALCHEMY Jurnal Penelitian Kimia Vol 15, No 1 (2019): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.15.1.23914.79-88

Abstract

Genus Curcuma, Zingiberaceae, is a typical medicinal plant in tropical region especially in Indonesia. It has been studied to have antioxidant, antimicrobial, antitumor, anti-inflammatory and anticancer activities. However, little knowledge of the metabolic profile both primary and secondary metabolites have been reported. Thus, this study aims to investigate metabolic profiling both primary and secondary metabolites simultaneously in the Curcuma species based on proton nuclear magnetic resonance (1H-NMR) spectroscopy. The present work applied metabolomic study which measured the qualitative and quantitative characteristic metabolites. The Curcuma species, Curcuma aeruginosa Roxb., Curcuma xanthorrhiza Roxb., and Curcuma longa L., collected from Nguter, Sukoharjo, Indonesia. Two-dimensional (2D)-NMR techniques were applied to further identify a number of different types of compounds. Multivariate data analysis such as Principal Component Analysis (PCA) applied to reveal differences among species. A clear difference occurred among 3 Curcuma species. Primary metabolites responsible for the discrimination are alanine (C. xanthorrhiza Roxb. was 3.78 times higher than in C. longa L), sugars (C. xanthorrhiza Roxb. were 6.03 and 3.81 times higher in C. aeruginosa Roxb. and C. longa L. respectively). Besides, secondary metabolites which differed among 3 species are curcumin (C. xanthorrhiza Roxb. were 38.25 and 25 times higher than in C. aeruginosa Roxb.) and xanthorrhizol (C. longa L. were 62 and 44.4 times higher than in C aeruginosa Roxb.).
Implementasi Teknik Granulasi Serbuk Jamu untuk Optimalisasi Proses Produksi Pabrik Jamu Suti Sejati Ahmad Ainurofiq; Syaiful Choiri; Dinar Sari Cahyaningrum Wahyuni; Saptono Hadi; Rita Rakhmawati; Nestri Handayani; Estu Retnaningtyas Nugraheni; Muhammad Adam Firdausi
Berdikari: Jurnal Inovasi dan Penerapan Ipteks Vol 10, No 2 (2022): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/berdikari.v10i2.13262

Abstract

The process of making herbal powder needs to be optimized because it is not efficient, and the filling process is still manually into teabags. The purpose of empowerment is to increase the effectiveness and efficiency of the herbal medicine-making process through a pharmaceutical approach with granulation techniques. This service is based on data obtained quantitatively in the laboratory, including the characteristics of the size distribution of Simplicia powder and granules and the flowability of herbal medicine powders. The data obtained were analyzed statistically with a 95% confidence level (p=0.05). The results showed that the granulation technique increased the flowability of the herbal powder with a flowability of 0 to 11.94±0.54 g/second. The granulation technique is able to improve the process of extracting herbs during brewing. The success of this activity is measured through the technique of increasing the flowability of herbal powders and the use of automatic teabag fillers. The results of the program showed that the granulation technique was able to increase the efficiency of the herbal powder manufacturing process at the Suti Sehati Herbal Medicine Factory, Sukoharjo.
Penggunaan Pewarna Alami dan Pengisi Jamu Instan Bagi UKM Obat Tradisional Syaiful Choiri; Estu Retnaningtyas Nugraheni; Rita Rakhmawati; Ahmad Ainurofiq; Saptono Hadi; Dinar Sari Cahyaningrum Wahyuni
Berdikari: Jurnal Inovasi dan Penerapan Ipteks Vol 11, No 1 (2023): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/berdikari.v11i1.12975

Abstract

The demand for traditional medicine increased during the pandemic, including instant herbal medicine for children. Children who consume herbal medicine are more interested in colorful products according to the advertised taste, while adult consumers are more interested in herbal compositions that are slightly sweeter (less sugar). This service aims to provide alternative natural dyes and non-sugar fillers for instant herbal products. Accordingly, the service was carried out in two stages. The service program was carried out using the tutorial method and focus group discussions (FGD). Tutorials were carried out online with natural materials as a source of alternative natural dyes and innovations in the use of non-sugar fillers. Group discussions focused on innovations in using non-sugar fillers with low production costs. The results showed that Rosella flowers (Hibiscus sabdariffa L.) are recommended as natural dyes for instant herbal medicine for children for red, yellow, and purple colors, while Suji leaves (Dracaena Angustifolia) for green colors. Additionally, Maltodextrin Fluidized Bed Dryer (FBD) ) is recommended as a non-sugar filler.
In vivo Wound Healing Activity of Tamanu Oil (Calophyllum inophyllum l.) Extracted by Cold-Pressed and Hot-Pressed Methods and Their Fatty Acids Composition Rakhmawati, Rita; Wahyuni, Dinar Sari Cahyaningrum; Ainurofiq, Ahmad; Hadi, Saptono; Choiri, Syaiful; Retnaningtyas, Estu; Pratama, Tiara Dewi Salindri
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.97146

Abstract

Tamanu oil is a promising natural wound healer due to its chemical compounds, particularly fatty acids. Cold-pressed or hot-pressed methods are commonly used to obtain this oil from Calophyllum seed. However, there needs to be research documenting the impact of these two extraction methods on the fatty acid profile and wound healing activity. Therefore, the study aims to characterize the fatty acid profiles of cold-pressed and hot-pressed tamanu oils using Gas Chromatography and evaluate their wound healing activity in vivo. The fatty acid profiles were analyzed using GC, and the wound healing tests were conducted on animal subjects divided into four groups: negative control, positive control (Bioplacenton®), cold-pressed tamanu oil, and hot-pressed tamanu oil. Cold-pressed tamanu oil showed superior fatty acid characteristics with an acid value of 38,71 Mg KOH/g fat and a peroxide value of 3,0095 mEq O2/kg, indicating that oil is stable against oxidation.  The length of the wound was observed daily for up to 8 days to assess its effect. The parameters observed were the percentage of wound healing and the total AUC based on the average length of the wound. Cold-pressed tamanu oil demonstrated the highest wound healing efficacy compared to both the positive control and hot-pressed tamanu oils. Both cold (11,67± 0,78) and hot-pressed tamanu oil (11,87 ± 0,61) exhibited significant differences in AUC value compared to the negative control group (13,07 ± 0,38), highlighting the potential of tamanu oil as a wound healing agent.
Co-Authors Ahmad Ainurofiq Ahmad Ainurofiq Ahmad Ainurofiq, Ahmad ESTU RETNANINGTYAS N Magdalena Kristanti Muhammad Adam Firdausi Mutya Puti Wardianti Nestri Handayani Nita Etikawati Pratama, Tiara Dewi Salindri Rita Rakhmawati Rita Rakhmawati, Rita Saptono Hadi Saptono Hadi Saptono Hadi, Saptono Soerya Dewi Marliyana Soerya Dewi Marliyana Syaiful Choiri Yudi Rinanto Yudi Rinanto