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Majalah Obat Tradisional
Published by Universitas Gadjah Mada
ISSN : 14105918     EISSN : 24069086     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.
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Articles 12 Documents
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Search results for , issue "Vol 29, No 3 (2024)" : 12 Documents clear
Characterization and Antioxidant Potential of Acacia nilotica Synthesized Callus and Seed Nanoparticles Ibe, Ifeanyi Jude; Zailani, Hauwa Ahmed; Dahiru, Mubarak Muhammad; Gali, Ishaku Adamu
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.94215

Abstract

This research aimed to explore the callogenesis, characterization, and antioxidant potential of Acacia nilotica callus and seed silver nanoparticles. The callus induction was accomplished using plant growth hormones. The silver nanoparticles (AgNPs) were synthesized from the seed and callus extracts and characterized using Gas chromatography-mass spectroscopy (GC-MS), X-ray diffraction (XRD), and Scanning electron microscopy (SEM). The antioxidant activities were evaluated by 1, 1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP) assays, molecular docking, and molecular dynamics simulations. The callus formation ranged from 77% to 100%. The AgNPs exhibited a face-centered cubic structure with the size predicted to be 25 nm while the SEM images showed the AgNPs had clustered topography and variable surface morphology. Exactly 33 and 26 compounds were respectively identified in the callus and seed with 8-Hexadecenal 14-methyl- (Z)- (7.71%) and linoleic acid (15.77%) being the most abundant, respectively. A significantly (p < 0.05) higher DPPH and FRAP activities were demonstrated by the callus at the highest dose (1 mg/ml). Moreover, 22-Stigmasten-3-one and 3-(azepan-1-yl)-1,2-benzothiazole 1,1-dioxide, respectively from the callus and seed exhibited the most favorable docking interactions with xanthine oxidase, cytochrome P450 21A2, and myeloperoxidase with a possible activity disruption. Conclusively, the callogenesis technique might be regarded as a reliable alternative to produce pharmacologically active secondary metabolites and nanoparticles against oxidative stress-linked ailments. Moreover, 22-Stigmasten-3-one and 3-(azepan-1-yl)-1,2-benzothiazole 1,1-dioxide might be good starting materials for novel therapeutics synthesis against oxidative stress.
In vivo Wound Healing Activity of Tamanu Oil (Calophyllum inophyllum l.) Extracted by Cold-Pressed and Hot-Pressed Methods and Their Fatty Acids Composition Rakhmawati, Rita; Wahyuni, Dinar Sari Cahyaningrum; Ainurofiq, Ahmad; Hadi, Saptono; Choiri, Syaiful; Retnaningtyas, Estu; Pratama, Tiara Dewi Salindri
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.97146

Abstract

Tamanu oil is a promising natural wound healer due to its chemical compounds, particularly fatty acids. Cold-pressed or hot-pressed methods are commonly used to obtain this oil from Calophyllum seed. However, there needs to be research documenting the impact of these two extraction methods on the fatty acid profile and wound healing activity. Therefore, the study aims to characterize the fatty acid profiles of cold-pressed and hot-pressed tamanu oils using Gas Chromatography and evaluate their wound healing activity in vivo. The fatty acid profiles were analyzed using GC, and the wound healing tests were conducted on animal subjects divided into four groups: negative control, positive control (Bioplacenton®), cold-pressed tamanu oil, and hot-pressed tamanu oil. Cold-pressed tamanu oil showed superior fatty acid characteristics with an acid value of 38,71 Mg KOH/g fat and a peroxide value of 3,0095 mEq O2/kg, indicating that oil is stable against oxidation.  The length of the wound was observed daily for up to 8 days to assess its effect. The parameters observed were the percentage of wound healing and the total AUC based on the average length of the wound. Cold-pressed tamanu oil demonstrated the highest wound healing efficacy compared to both the positive control and hot-pressed tamanu oils. Both cold (11,67± 0,78) and hot-pressed tamanu oil (11,87 ± 0,61) exhibited significant differences in AUC value compared to the negative control group (13,07 ± 0,38), highlighting the potential of tamanu oil as a wound healing agent.

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