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INDONESIAN JOURNAL OF PHARMACY

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Published by Universitas Gadjah Mada

ISSN : 23389427 EISSN : 23389486 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.

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Articles 10 Documents

Search results for , issue "Vol 16 No 3, 2005" : 10 Documents clear

The impact of hot melt granulation method on propranolol hydrochloride physicochemical properties Ilma Nugrahani; Hasan Rahmat; Joshita Djajadisastra
Indonesian Journal of Pharmacy Vol 16 No 3, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Hot melt granulation is based on agglomeration by use of thermoplastic binder material that is solid at room temperature and softens and melts at higher temperature. By selecting a binder that is insoluble in water, melt granulation is a way of producing modified release granules, i.e. lipids/waxes to exhange the release of soluble drugs. The critical problem of this method is drugs instability because of heating. It has been studied the impact of hot melt granulation method on propranolol hydrochloride physicochemical properties. Physicochemical properties were evaluated including : water content titration – Karl Fischer, chemical structure analysis by Fourier Transforms Infrared Spectrophotometry (FTIR), and thermodynamic analysis by Differential Scanning Calorimetry (DSC). The results showed that hot melt granulation did not change the propranolol hydrochloride physicochemical structure but it changed anhydrate ß lactose to anhydrate a lactose. Key words : carnauba wax ; hot melt granulation; propranolol hydrochloride; physicochemical properties.

Synthesis of Phenethyl-aza-ß-Lactam (1,2-Dimethyl4(R,S)-Phenethyl-[1,2]Diazetidin-3-One) Ritmaleni Ritmaleni; Varinder K Anggarwal
Indonesian Journal of Pharmacy Vol 16 No 3, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Racemic spiro-epoxide, (7RS, 1RS, 3RS)-phenethyl-10-oxa-1,3-dithiaspiro[6,7]octane 1,3-dioxide 12, can be synthesised in four step reactions, sequences starting from the commercially available 1,3-dithiane 8. The synthesis of aza ß-lactam, 1,2-dimethyl-4(R,S)-phenethyl-[1,2]diazetidin-3one 13, was successfully carried out by opening the epoxide by 1,2-dimethyl hydrazine salt in moderate yield. Keywords : epoxide, aza-ß-lactam

Synthesis of thiazol derivative compounds from Î±-bromo asil bromida and thiourea ., Tjiptasurasa
Indonesian Journal of Pharmacy Vol 16 No 3, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Thiazol compounds are mostly used as therapeutics in varies effects. These compounds could be synthesized from starting materials that had been produced by local agrochemical industries i.e. alcohol (from the alcohol factories) and urea (from the fertilizer factory). Yielded bromacylbromide could be used to acylate urea derivatives to form aliphatic bromacylurea. When thiourea was used the cyclization product happened i.e. occurred thiazolon derivatives (without bromine). The lost of bromine could be detected by losing of cluster peak of bromine isotope on MS-spectra. The products of these processes were pure, there were 2-aminothiazol- 4-one 2-amino-5-methyl-thiazol-4-one and 2-amino-5-ethyl-thiazol-4-one. Key word : alcohol, thiourea, aminothiazol-4-one.

Phytochemical compounds and the effect of ‘bangunbangun’ leaves (Coleus amboinicus, L.) water extract on phagocytosis activity of neutrophil cell rat (Rattus norvegicus) Christin Marganingsih Santosa; Triana Hertiani
Indonesian Journal of Pharmacy Vol 16 No 3, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Traditional medicine has been recognized and widely used in Indonesia for healthy care or alternative medication in certain diseases. However, without scientific evidence, traditional medicine of empirical evidence cannot be used for modern health medication. This research was designed to find out the mains compound despite of Bangun-bangun aqueous extract from Kaliurang district using phytochemistry analysis such as Thin Layer Chromatography method and determine the effect on neutrophil cell activities by observing their phagocytosis. The result showed that the main compounds of Bangun-bangun leaves from Kaliurang district are polyphenol, saponin, flavonol glycoside and essential oil. Administration of the extract with the doses of Bangun-bangun leaves treatment 19,0 g/kg bw/oral/day (group A) and 31,5 g/kg bw/oral/day (group B) increased neutrophil cell phagocytosis up to 50% and 60 %, respectively, compared to those of controls which is 10% during 30 days treatment. Neutrophil cell phagocytosis in group B and C capability increase up to 80% (p

Evaluation on Management of Pesticide Poisoning of Hospitalized Patients in Hospital A Yogyakarta during thePeriod of January 2001 until December 2002 Nurlaila .; Imono Argo Donatus; Meiyanto Edy
Indonesian Journal of Pharmacy Vol 16 No 3, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The study on pesticide poisoning management was performed in Hospital A, Yogyakarta during the period of January 2001 until December 2002. This is designed to investigate wether the implementation of the poison management has already been conducted properly and to assess the percentage of the succesful therapy in the hospital. The present study was conducted using a descriptive observational design which include the case series reports by a retrospective method. The subject were 34 pesticide poisoning-hospitalized patients. Data were collected based on patient medical records such as the number of poisoning cases including the cause, initial treatments, characteristic of the clinical sign, the laboratory assessment, advanced treatments, healing or recovery, and death. The results were descriptively analyzed by examining the raw data. The data were calculated as the percentage of the groups towards the total subjects. The results showed that the pestiside poisoning management in the Hospital A was adequately performed. The number of the patients that was recovered from poisoning was 34 patients (100%). However, from the viewpoints of initial treatment, laboratory assessment, and poisoning therapy, the poisoning management still needs to be improved.

Antiurolitihatic potency of Ketimun juice (Cucumis sativus L.) on white male rats using Kalkuli method Sumi WIjaya; Farida L Darsono
Indonesian Journal of Pharmacy Vol 16 No 3, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The aim of this research was to know the antiurolitihatic activities of Ketimun juice (Cucumis sativus L.) on white male rats which have been induced with hydroxyproline 30 % with a dose of 2,5 g/Kg BW. The 20% Ketimun juice (1.5 ml/100 g BW) and distilled water 1.5 ml/100 g BW were given the test animals orally. The parameter tests were characteristics of the kidney : the colour, shape, size and ratio of kidney weight /200 g BW and 24 hour urine on the first and the third days which included pH, 24 hour urine volumes and the calcium content in the urine. The data were analyzed using one sampel t-test. There were significant differences (p

The influence of ethanol fractions of infusa of Plantago major L. leaves in effectivity of octyl methoxycinnamate as active ingredient of sunscreen Nining Sugihartini; Marchaban .; Suwidjiyo Pramono.
Indonesian Journal of Pharmacy Vol 16 No 3, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Octyl methoxycinnamate is an active ingredient of that is degraded by solar irradiation resulting it usage as sunscreen becomes less effective. An antioxidant has capability as a photo-protector. Flavonoid in the ethanolic fraction of Plantago major, L. leaves is reported to have an antioxidant. This research was aimed to examine the influence of the addition of the ethanolic fraction of Plantago major, L. leaves to the effectiveness of octyl methoxycinnamate as a sunscreen. In this research, two formulas were prepared. Formula I contained octyl methoxycinnamate per se and formula II contained a mixture (1:1) of octyl methoxycinnamate and ethanolic fraction of Plantago major, L. leaves. Both formulas were exposed to the sun light for 5 hours (09.00-14.00 WIB) in which samples were taken every hour. The effectiveness of octyl methoxycinnamate was calculated based on the percentage of erythema transmission and the percentage of pigmentation transmission, prior and after the irradiation by the sun light for 5 hours. The statistical data analysis was performed based on the Student t test with a confidence level of 95%. The addition of the ethanol fraction of Plantago major, L. leaves significantly reduced the percentage of the erythema transmission after solar irradiation (p

Effect of the combination of C.domestica extract and essential oil of C.xanthorrhiza roxb. on leucocyte count in synovial fluid compared to that of pyroxicam Kertia, Nyoman; A.D., Imono; ., Mufrod; Catur, Eny; Rahardjo, Poerwono; Asdie, Ahmad Husain
Indonesian Journal of Pharmacy Vol 16 No 3, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Osteoarthritis (OA) is the most prevalence rheumatic disease. The non steroidal antiinflamatory drugs display some side effect especially on the gastrointestinal tract, liver, kidney and blood clotting. Kunyit (Curcuma domestica L.) and temulawak (Curcuma xanthorrhiza Roxb.) as natural herbal remedies are developed for antiinflammation, antioxidant and cholagoga. The aim of this present research was to study the effect of combination of Curcuma domestica extract and essential oil of Curcuma xanthorrhiza Roxb on the leucocyte count in the synovial fluid of patient with osteoarthritis compared to that of pyroxicam. A double blind randomized clinical trial was used and conducted at Dr. Sardjito Hospital Yogyakarta. After washed out period the knee synovial fluid was aspirated and the leucocyte count was examined. Patients were randomized for receiving piroxicam capsule 10 mg twice daily or combination of 3,66 ± 0,65 % w/w curcuminoid extract of Curcuma domestica L.and 25 ml essential oil containing curcumen, bergamoten germacren B, Curserenon, Germacron, Xanthorrizol as a major component with 27,64 ± 0,85 % relative concentration of xanthorrhizol each capsule; two times a day for two week period. At the end of this study the synovial fluid was examined. Decreasing the inflamation of synovial area was parrallel with decreasing leucocyte count by 174.56 ± 161.73 per mm3 (p

The effect of pretreatment of Broccoli (Brassica oleracea L. var. botrytis L.) to rifampicin pharmacokinetics in rats Wahyono, Djoko; Hakim, Arief Rahman
Indonesian Journal of Pharmacy Vol 16 No 3, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Consuming the meal during drug therapy could influence on pharmacokinetics profile of the drugs. The research was aimed to observe broccoli (Brassica oleracea L. var. botrytis L.) activities to rifampicin pharmacokinetics in rats. The study of interaction broccoli with rifampicin pharmacokinetics was conducted employing a completely randomaized design using female Sprague Dawley rats which were divided into 3 groups (6 rats for each group). The results have shown that the pharmacokinetics values of rifampicin in the animals prefed with broccoli 23.43 mg/kg BW 1 hours prior to single oral administration of the drug (P-II) did not change significantly (P>0.10). Prefeeding the animals with broccoli 23.43 g/kg BW once daily for 7 consecutive days (P-I) has increased the total clearance of rifampicin 46.90% (P

Antioxidant potency of ethanolic extract of Kemuning leaves (Murraya paniculata (L) Jack ) in vitro Rohman, Abdul; Riyanto, Sugeng
Indonesian Journal of Pharmacy Vol 16 No 3, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Antioxidants are the compounds capable to inhibit free radical reactions in the human body. This research was aimed to identify the antioxidant potency of ethanolic extract of kemuning leaves in vitro by using linoleic-thiocyanate and DPPH (2,2-diphenyl-1-picryl hydrazyl) methods. The ethanolic extract of kemuning leaves was diluted in various concentrations i.e. 1%,5% and 10% and determined their antioxidant potencies. By using linoleic-thiocyanate method, the result suggested, that ethanolic extract of 1%; 5 % and 10 % showed antioxidant potencies and had significant different absorbances (P < 0,05). The antioxidant potencies of ethanolic extract with different concentrations were also measured by DPPH method and the result showed that ethanolic extracts of kemuning leaves revealed the antioxidant activity with the IC50 of 126,17 µg/ml, 15 times lower than that of vitamin E (IC of 8,27 µg/ml). The antioxidant activity of kemuning leaves probably due to the flavonoid content.

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