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INDONESIAN JOURNAL OF PHARMACY

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Published by Universitas Gadjah Mada

ISSN : 23389427 EISSN : 23389486 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.

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Articles 706 Documents

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ANTICANCER ACTIVITY OF MANGOSTEEN PERICARP DRY EXTRACT AGAINST MCF-7 BREAST CANCER CELL LINE THROUGH ESTROGEN RECEPTOR -α Setiawati, Agustina
Indonesian Journal of Pharmacy Vol 25 No 3, 2014
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Breast cancer has very complex morphological and molecular characteristic. Estrogen receptor is one of biomarker in breast cancer progression, more than 60% breast cancer overexpress estrogen receptor α (ERα). Xanthone in Garcinia mangostana was investigated whether to have anticancer activity on colorectal, prostate, lung, blood and breast cancer. This research was focused on molecular mechanism of anticancer activity of mangosteen pericarp extract (MPE) on ER-α. This study used MCF-7 cells as a model of ER-α overexpressed breast cancer cells. Cytotoxic study towards MCF-7 cells was designed by using MTT test, further apoptotic induction assay was determined by double staining method using acridine orange and ethidium bromide. Extract molecular mechanism against breast cancer was assayed by immunocytochemistry. The MTT data was analyze using probit analysis to get IC50 then apoptosis and immunocytochemistry data were analysis qualitative analysis. MPE had strong cytotoxic activity on MCF-7 cells with IC50 of 45μg/mL and morphological changes passed through apoptosis induction. The expression of ER-α in MPE treated cells was same as untreated cells. MPE did not suppress ER-α in both nucleus and cytoplasm. Anticancer activity of MPE misht be mediated by other gene involved in ER-α signaling pathway in breast cancer cells.

Ibuprofen salt production and its application in tablet dosage form Hadisoewignyo, Lannie; Fudholi, Achmad; Muchalal, M.
Indonesian Journal of Pharmacy Vol 20 No 3, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Ibuprofen is an anti-inflammatory drug and is practically insoluble in water. The low melting point and the poor flowability of ibuprofen can lead to process difficulty in tablets production. The purpose of this research was to make the sodium salt form of ibuprofen which has better solubility in water.Sodium ibuprofen salt was prepared by reacting the ibuprofen and sodium hydroxide, then characterized using TG/DTA, DSC, spectrophotometer UV-VIS, spectrophotometer IR, X-ray diffraction, and SEM. Tablets were prepared by wet granulation method.The characterization result showed that sodium ibuprofen result of the synthesis was dehydrate form with melting point of 199.9 °C. Granules of sodium ibuprofen result of the synthesis had better flowability and bigger density than ibuprofen granules. The physical characterization of the tablet showed that the formula of sodium ibuprofen resulted from the. Sodium ibuprofen showed the higher release rate than ibuprofen so can give quicker onset of action.Key words: sodium ibuprofen, ibuprofen, dissolution.

Radiation exposure of radiation workers from 1997 – 2006 based on the criteria and working period toto Trikasjono; Zainul kamal
Indonesian Journal of Pharmacy Vol 21 No 2, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The external acceptance dose of radiation worker inYogyakarta have been studied. This research was done in this three specific areas A,B,C, because of worker in this trihedral have hit high probability radiation exposure. Radiation exposure worker were taken from each worker who wears Thermoluminescent Dosimeteron period 1997-2006. Exposure result of radiation is done every year in Laboratory Safety, Health and Environment, Centre of Research and Development Safety Radiation, National Nuclear Energy Agency. This research aim is to know how much exposure dose of radiation accepted by worker radiation weather have been fulfilled or not the system limitation of dose which have been specified by International Commission on Radiological Protection (ICRP) and or Nuclear Energy Regulation Agency and also determine furthermore step to guarantee health and safety worker radiation worker. Radiation worker that chosen as sample of research are 45 workers that are radiation worker. Data collection which is used in this research using personnel radiation monitors. The result of this analysis indicate that distribution acceptance of annual dose personal of group interval 0-2 mSv, and acceptance of highest dose 6.09 mSv in the year 1998 from section A. Whole acceptance of dose of external personal at worker from third monitored area, still below the dose of limitation Nuclear Energy Regulation Agency which is recommended is 50 mSv/year and ICRP 1990 is 20 mSv/year.Key words: personal radiation exposure, radiation worker, radiation

IDENTIFICATION OF Klebsiella pneumoniae RESISTANT MUTANTS AGAINST BRL 41897A ANTIBIOTIC USING SOUTHERN BLOT ANALYSIS. M. Kuswandi
Indonesian Journal of Pharmacy Vol 13 No 4, 2002
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Isolation of Klebsiella pneumoniae resistant mutants against BRL 41897A antibiotics using TnphoA has yielded 30 mutants which have been characterized. In order to identify whether the mutants are as a result of the insertion (transposition) of TnphoA, and to count how many copies of TnphoA are inserted in the each mutant chromosome, several chromosomal DNA of the mutants have been cut with restriction enzymes and analised using Southern blot method and DIG conjugation. The results showed that at least one mutant (KSL19) carried one copy of transposon, whereas at least 2 mutants (KSL38 and KSL52, ) have 2 copies. It is obvious that TnphoA mutagenesis provides an efficient method of selecting mutants which are defective in genes controlling expression of the outer membrane and the periplasmic membrane proteins.Key words: Resistant K. pneumoniae mutants- TnphoA mutagenesis – BRL 41897A- Southern Blot.

The bioavailability of furosemide-polyethylene glycol (PEG 4000) solid dispersion in male rabbits Ellies Tianti
Indonesian Journal of Pharmacy Vol 16 No 2, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Furosemide is a potential diuretic drug usually used for the secondary treatment of hypertension. Unfortunately this agent is very slightly soluble in water, so it has poor bioavailability. The oral administration of drug shows that only 60 % of the dose can be absorbed.The aim of the present study is to increase the bioavailability of furosemide by mixing the furosemide-PEG 4000 solid dispersion (1 : 1) in capsule dosage forms (formula A). The powder of LasixR tablet in capsules was used as a standard reference (formula B), and the original powder of furosemide in capsules was used as control (formula C). All of the formulas contained 40 mg of furosemide.The bioavailability of these formulas was evaluated following oral administration in male rabbits using The Latin Square Cross Over Design, then the plasma furosemide concentrations were analyzed spectrofluorometrically. The results indicated that the bioavailability of furosemide in the formula A was equal to that of the formula B (P > 0,05) or both formulas were bioequivalent. But the Cpmax value of the formula C was significantly lower in comparison with the formulas A and B.Key words: furosemide, solid dispersion, bioavailability.

Activity of ethanol extracts of seledri (Apium graveolens) herbs and urang aring (Eclipta prostata (L.)L.) leaves against Pityrosporum ovale Elin Yulinah Sukandar; Suwendar .; Ernita Ekawati
Indonesian Journal of Pharmacy Vol 17 No 1, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Seledri (Apium graveolens) and urang aring (Eclipta prostata (L.)L.) have been used traditionally for hair grow. In this study, we want to test wether the both substances have an activity against Pityrosporum ovale as fungi causing dandruff. Anti Pityrosporum ovale activity of ethanol extracts of seledri (Apium graveolens) herbs and urang aring (Eclipta prostata (L.)L.) leaves had been studied using agar diffusion and dilution methods. Anti Pityrosporum ovale activity was shown by both of the two extracts, but seledri herbs extract showed stronger effect with inhibition diameter of as large as 16.33 ± 2.08 at the concentration of 5% w/v whereas that of urang aring leaves showed the inhibition diameter of 12.67 ±1.15 at the same concentration using agar difusion method. With agar dilution method, both of the two extracts still showed the inhibitory effects at the concentration of as low as 0.11 mg/mL.Key words : antifungi, Pityrosporum ovale, seledri, urang aring

The effect of combination of Carbopol 934P and 940P with Metolose 90SH-4000, 90SH-15.000 and 90SH-100.000 to the adhesive strength of mucoadhesive granules on stomach and intestine Teti Indrawati; Goeswin Agoes; Elin Yulinah; Yeyet Cahyati
Indonesian Journal of Pharmacy Vol 15 No 3, 2004
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Sustein release dosage form with mukoadhesive system in stomach is a drugs delivery system that can increase bioavailability. The study was conducted the effect of polimers combination to mucoadhesive strength. Granules prepared by dry and wet granulation using the combination of Carbopol 934P and Carbopol 940P with Metolose 90SH-4000, Metolose 90SH- 15.000 and Metolose 90SH-100.000. Granules adhesive strength on stomach and intestinal mouse was investigated by mucoadhesive and wash off test. The results indicated that all of the mucoadhesive granules that prepared by wet and dry granulations could completely adhere on stomach and intestine in 5 minutes. Mucoadhesive strength on stomach and intestine of a single polymer was better than that of combinations of polymers. The strongest adhesion on stomach showed by Carbopol 940P and Metolose 90SH-15.000 combination (40 : 20).Key word : Adhesive, mucoadhesive granules.

Antiplasmodial activity of two fractions obtained from n-hexane extract of Garcinia parvifolia Miq stem bark Syamsudin .; Soesanto Tjokrosonto; Subagus Wahyuono; Mustofa .
Indonesian Journal of Pharmacy Vol 18 No 4, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Antiplasmodial activity of fractions A and B obtained from n-hexane extract of stem bark of Garcinia parvifolia have been evaluated. The in vitro antiplasmodial activity was investigated on two strains of Plasmodium falciparum, FCR-3 a chloroquine resistant and D10, a chloroquine sensitive strains and their antiplasmodial activity was expressed by the concentration inhibiting 50.% of the parasite growth (IC50). The results showed that the fractions A and B were active against P. falciparum with the IC50 values of 2,79 ± 0,10 μg/mL and 12,30 ± 1,21.μg/mL on FCR-3 strain and 1,52 ± 0,24.μg/mL and 4,66 ± 1,24 μg/mL on D10 strain. Identification of active constituents in the both fractions showed the existence of triterpenoide, steroide and flavonoide compounds.Key words: Antiplasmodial activity , Garcinia parvifolia, active constituents.

PHARMACEUTICAL EXCIPIENTS: GLOBAL REGULATORYISSUES Dureja, Harish; Kumar, Dinesh
INDONESIAN JOURNAL OF PHARMACY Vol 24 No 4, 2013
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

An excipient may be defined as an ingredient that is intentionally added to a drug for purposes other than the therapeutic or diagnostic effect at the intended dosage. Excipients have functional roles in pharmaceutical dosage forms which include the suitable form of consistency, modulating solubility and bioavailability of active ingredients, enhancing stability of the active ingredients in finished dosage form and many others. In most of the developed countries, the excipients are regulated as an active pharmaceutical ingredient. In Europe, it is assumed that novel excipients need to be evaluated as new chemical entities. In United State, the Food and Drug Administration assesses and permits use excipients as part of new drug application. The lack of harmonized international regulatory guidelines leads to the formation of the International Pharmaceutical Excipients Council (IPEC) in 1991. The IPEC was found to calibrate with different countries like Japan, Europe and China to address prevalent industry concerns related to the international harmonization of excipients standards, the introduction of useful new excipients to market place, and development of safety evaluation guidelines for the excipients. In the present study, an attempt has been made to investigate global issues governing regulations of pharmaceutical excipients.Key words: pharmaceutical excipient, regulatory guidelines, IPEC

ANTHELMINTIC ACTIVITY OF Cuminum cyminum, FOENICULUM VULGARE AND Eugenia caryophyllusAGAINST Pheritima posthuma Satish Kumar; Kamal Kumar Goyal; Syed Bilal
Indonesian Journal of Pharmacy Vol 23 No 4, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Ethanol extract of fruit of Cuminum cyminum (EECC), aqueous extract of fruit of Cuminum cyminum (AECC), Ethanol extract of fruit of Foeniculum vulgare (EEFV), aqueous extract of fruit of Foeniculum vulgare (AEFV) and Ethanol extract of flowering bud of Eugenia caryophyllus( EEEC), aqueous extract of flowering bud of Eugenia caryophyllus( AEEC) were taken up for in vitro studies on the Anthelmintic activity against Pheritima posthuma. Different concentrations (25, 50, 100, 200mg/mL) were used for the activity is compared with the reference standard Albendazole at concentration 20mg/mL and normal saline( 0.9% NaCl) was used in control treatment. The results were expressed in terms of time in minutes to report the time of paralysis and time of death of the earth worms. The results obtained from study indicate towards anthelmintic activity, supporting folk used of all three plants compared with reference standard. The result established that EEEC and AEEC is more potent as compared with EECC, AECC and EEFV, AEFV.Key words: Anthelmintic activity, Cuminum cyminum, Eugenia caryophyllus, Foeniculum vulgare, Pheritima posthuma.

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