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INDONESIAN JOURNAL OF PHARMACY

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Published by Universitas Gadjah Mada

ISSN : 23389427 EISSN : 23389486 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.

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Articles 706 Documents

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Purification and characterization of anti-multidrug resistances bacteria from actinomycetes associated sponge Herlina Rante; Wahyono .; Yosi B. Murti; Gemini Alam
Indonesian Journal of Pharmacy Vol 21 No 3, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Actinomycetes are one kind of the microorganisms that very important producer of secondary metabolites for drugs.Active substances of microbial origin have been searched through a series of screening methos to obtain novel compounds and strains. The purpose of this research was to characterize the antibacterial coumpound from actinomycetes associated sponge and identification of actinomycetes base on morfology and fisiology characteristic. Isolation of actinomycetes from sponge were done bypour and spreap plate. A total of actinomycetes strain were isolated from sponges collected at Barrang Lompo island, Makassar, South Sulawesi, Indonesia. One of them showed strong activity against antibiotic resistant bacteria with concentration 0.0195µg. Characterisation of antimicrobial coumpound base on IR spectrum determined derivate of carboxylic acid. The result obtained from the morphological and physiological characterisation, determined the strain a Streptomyces spKey words: sponges, actinomycetes, secondary metabolic, bacteria resistan

LACTAGOGUE EFFECT OF UYUP-UYUP (TRADITIONAL MEDICINE) AND Sauropus androgynus Merr EXTRACT ON PIGEON INGLUVIES GLANDS Ika Puspita Sari
Indonesian Journal of Pharmacy Vol 14 No 1, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Sauropus androgynus Merr. and uyup-uyup have been used as lactagogue traditional medicine since long time ago, but the pharmacological mechanism was unclear. This research has been done to determine prolactin induction of S. androgynus Merr and uyup-uyup as lactagogue agents. S. androgynus Merr leaf extract and uyup-uyup were given to the pigeon for 7 and 14 consecutive days, the epithelium tunica mucous of ingluvies glands induced by prolactin was then determine. The result showed that S. androgynus Merr. leaf extract and uyup-uyup have lactagogue effect as determined by prolactin induction. The induction of prolactin after S. androgynus Merr leaf extract administration (dose 54 mg/kg Body Weight (BW) for 14 days comparable to that of moloco B12 (dose 189 mg/kg BW) after 7 days administration (p<0.05).Key words : lactagogue, prolactin, tunica mucous

Influence of drying methods to quality of meniran herb (Phyllanthus niruri LINN.) Rivai, Harrizul; Nurdin, Hazli; Suyani, Hamzar; Bakhtiar, Amri
Indonesian Journal of Pharmacy Vol 22 No 1, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Effects of drying methods in obtaining the extractive, phenolic content and antioxidant activity in Phyllanthus niruri Linn. herbs have been investigated. The drying methods tested were air-drying at ambient temperature, oven-drying at 40 °C, oven-drying at 60 °C, and fresh samples as control. Results revealed that drying of the fresh plant caused the decrease of extractive obtainability, phenolic content and antioxidant activity. There were significant differences among drying methods (p < 0.05). Among the drying methods tested, the best result was by oven-drying at 40 °CKey words: Antioxidant, Phyllanthus niruri Linn., drying methods, phenolic compounds

Antibiotic usage in pediatric respiratory tract infection NM Yasin; MB Bahari; HIM Ismail
Indonesian Journal of Pharmacy Vol 16 No 1, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Respiratory tract infections are the worldwide main cause of death in children aging less than 5 years. In developed countries; respiratory tract infections are the leading cause of morbidity, accounted for 20% of medical consultation, 30% of work absenteeism and 75 % of all antibiotic prescription. Upper respiratory tract infections in children, which often associated with viral infection, and in average about 40 – 60 % of children with upper respiratory tract infections were prescribed with antibiotics. The type of antibiotics also varies from hospital to another.The objectives of this study are to describe the pattern, outcome, and cost of antibiotic usage in pediatric respiratory tract infections. A prospective study of pediatrics admitted to Pediatric Ward, Penang Hospital for respiratory tract infections was carried out. Appropriate descriptive analysiswas used. The results showed that penicillin, erythromycin; amoxicillinclavulanate were the most commonly prescribed antibiotics for respiratory tract infections. The average duration of antibiotic therapy 3.0 ± 3.2 days, fever clearance time 2.2 ± 2.4 days, improvement of sign and symptoms 3.7 ± 2.5 days and mean length of stay in the ward was 4.9 ± 2.8 days. The average cost of antibiotics was RM 14.83 ± 83.13, and total cost of respiratory tract infections treatment was RM 98.88 ± 65.87.Key words: antibiotic, respiratory tract infection, pediatric, hospital

Cost analysis of Diabetes mellitus therapy in Dr. Sardjito Hospital Yogyakarta Aisyah, Tri Murti
INDONESIAN JOURNAL OF PHARMACY Vol 17 No 3, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Diabetes mellitus is a chronic disorder that has been recognized by Indonesian government as a major public health problem with far reaching consequences not just for its adverse impact on the health of Indonesian, but also for the economic burden it places on the health care systems. The objective of this study was to describe the therapeutic cost of outpatient diabetes mellitus type 2.A descriptive study was performed on patient who were admitted to the Department of Endocrinology of the Sardjito Hospital between July and August 2005. Patient were included if they were ambulatory during the time of the study. Exclusion criteria were patients with any other diseases. Only direct medical cost was considered (perspective from hospital). Direct costs to this analysis were cost of drugs, visit to the physician, laboratory examinations, and cost of diabetes-related complications and concomitant therapies.From the 100 examined patients, 44 percent were females and 56 percent were males. The average age of the patients was 60.75 ranging from 41 to 85 years of age. The average total costs per patient per month was Rp 208,500 with a maximum to be Rp 754,500. The largest cost was drug acquisition costs (59.5%), followed by cost of diabetes-related complications (31%). The control of blood glucose using combination therapy was more frequently attained in patients taking sulfonylurea and biguanid (44.62%). The combination of biguanid, Î±-glucosidase inhibitor, and insulin had the greatest expense, equal to Rp.571,000. Hypertension, neuropathy, and hyperlipidemia were the most frequently mentioned complications diseases. The cost for diabetes-related complication included hypertension and retinopathy had the greatest expense, equals to Rp 754,500.Key words: cost-identification, diabetes mellitus, Dr. Sardjito hospital

Satyrium nepalense: A RARE MEDICINAL ORCHID OF WESTERN HIMALAYA (INDIA); PHYTOCHEMICAL SCREENING, ANTIMICROBIAL EVALUATION AND CONSERVATION STUDIES Mishra, Abhay Prakash; Saklani, Sarla
Indonesian Journal of Pharmacy Vol 23 No 3, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Satyrium nepalense is an endangered medicinal herb found at the higher altitude of 2400-5000m. Local inhabitant used tubers of Satyrium nepalense as an energetic tonic and as an important medicine to cure different type of fever in traditional health care system of Uttarakhand (INDIA). Present study was carried out to evaluate the phytochemical, antibacterial screening against four (Streptococcus mutans, Pseudomonas aeruginosa, Staphylococcus aureus and Klebsiella pneumoniae) microorganisms in methanolic extracts and habitat studies for conservation of S. nepalense. Tubers of Satyrium nepalense were extracted separately with methanol by hot extraction process using soxhlet apparatus. The extracts were subjected to Lyophilization to get dry extract and preserved in aseptic condition. The different group reagents used for phytochemical screening as dragendorffs’s for alkaloid, molisch’s test for carbohydrates, shinoda test for flavonoids etc. Antibacterial study was carried out by disc diffusion method. The highest zone of inhibition was recorded as 15.0±0.00 mm against Klebsiella pneumonia and 15.0±0.82 mm against Staphylococcus aureus. Phytochemical screening shows the presence of alkaloids, carbohydrates/glycosides, flavonoids and unsaturated sterols/triterpenes in Satyrium nepalense. The result indicates that methanolic extract of Satyrium nepalense shows potent antibacterial activity against all four bacterial strains.Key words: Uttarakhand, Satyrium nepalense, medicinal orchid, antibacterial, phytochemicals

THE APPLICATION OF HYDROTROPES AS MEDIUM IN THE EXTRACTION OF ANDROGRAPHOLIDE Hartati, Indah; Kurniasari, Laeli; Anas, Yance; Aniq, Nur
Indonesian Journal of Pharmacy Vol 25 No 4, 2014
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Hydrotrope solutions provide safe and effective media for the microwave assisted extraction of andrographolide, the major bioactive chemical constituent of plant Andrographis paniculata. Microwave assisted extraction of androgpaholide was carried out by using hydrotropes, sodium benzoate and urea. The objective of this work were to determine the Minimum Hydrotrope Concentration (MHC) and to determine the effectiveness of each hydrotrope with respect to andrographolide at different system powers. The microwave assisted extractions of andrographolide were carried out at different concentration of hydrotropes (0.2-3M) and different system powers (39.9 and 119.7 Watt). Twenty grams of Andrographis paniculata dried powder were added to 200 ml of hydrotrope solutions and extracted in a microwave extractor for 15 minutes. The research result showed that the percentage of the microwave assisted extraction of andrographolide by using sodium benzoate and urea were up to 10.9% and 1.05% respectively. The Minimum Hydrotrope Concentration and the effectiveness of hydrotropes that was measured in term of Setschenow constant (Ks) were reported for two hydrotropes used in this study.Â

Morphological studies of apoptotic HeLa cells death induced by eurycomanone Nurkhasanah .; Azimahtol Hawariah Lope Pihie; Jalifah Latip
Indonesian Journal of Pharmacy Vol 20 No 4, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Eurycomanone is a cytotoxic ingredient found in Eurycoma longifolia Jack. Previous studies have noted its activity against many epithelial cell lines. In this study, eurycomanone had obvious cytotoxic effect on HeLa cells by methylene blue staining assays. After HeLa cells were treated with eurycomanone, typical morphological changes, including cytoplasm shrinkage and decrease of cell volume were observed by light microscope. Chromatin condensation and nuclear fragmentation could be observed by fluorescence microscope after staining with Hoechst 33258 nuclear staining. DNA fragmentation and apoptotic body formation that is characteristic of apoptosis could be determined after treated cells were assayed with TUNEL (terminal deoxynucleotidyl transferase mediated d-UTP nick end labeling). The externalization of phosphatidyl serine (PS) could be determined by flow cytometry analysis using Annexin-V/PI double staining. The result suggested that eurycomanone exerted antiproliferative activity on HeLa cells by inducing apoptosis.Key words : eurycomanone, cytotoxic, apoptosis, HeLa

Geometric Isomers and Cytotoxic Effect On T47D Cells of Curcumin Analogues PGV-0 and PGV-1 Edy Meiyanto; Muhammad Da'i; Supardjan A. M.; Umar Anggara Jenie
Indonesian Journal of Pharmacy Vol 18 No 1, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Curcumin analogues 2,5-bis-(4’-hidroxy-3’-methoxy)-benzilidinecylopentanone (PGV-0) and 2,5-bis-(4’hidroxy-3’,5’-dimethyl)-benzilidinecylopentanone (PGV-1) have a potency to be developed as cytotoxic agent. The aims of this research are to elucidate the geometric isomer and to study the cytotoxic effect on T47D cells of both compounds. To establish the geometric isomer these compounds, they were elucidated by LC-MS, 1H-NMR, 13C-NMR, HMBC, HMQC, NOESY. Their cytotoxic effect were evaluated by MTT assay method on T47D cells. The results concluded that the geometric isomer of PGV-1 is zusammen-zusammen (Z-Z) and PGV-0 is entgegen-entgegen (EE). The IC50 of both compounds are 1.74 and 9.39 μM respectively.Key words: PGV-0, PGV-1, Cytotoxicity

IDENTIFICATION OF IROMP PROTEIN OF K.PNEUMONIAE RESISTANT MUTANTS AGAINST BRL41897 USING SDS –PAGE Kuswandi, M.
Indonesian Journal of Pharmacy Vol 14 No 2, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Initial characterization, the MIC, Fe uptake and detection of siderophores, of the resistance K.pneumoniae mutants against BRL41897A (KSL mutants) showed that there were differences amongs them. Therefore it was necessary to observe the OMP and IROMP proteins of the mutants especially which had different MIC’s to the WT galur (M10). Results from SDS-PAGE analysis showed that KSL19 produced 49kDa protein weakly and similar result was found in the 22 kDa protein production by KSL38, KSL52, KSL58 and KSL59. Using Fe-CAA media -media lack of Fe - showed that 3 mutants synthesized certain protein weaker than M10 galur, KSL19 in the production of the 88 kDa protein, KSL38 and KSL59 at the 80 kDa protein. We also observed that KSL19 synthesized new 88 kDa protein. This result showed that certain mutant which had decreased production of one protein could stimulate another weak protein.Key words: SDS-PAGE – IROMP – K.pneumoniae mutants – BRL 41897A.

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