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INDONESIAN JOURNAL OF PHARMACY

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Published by Universitas Gadjah Mada

ISSN : 23389427 EISSN : 23389486 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.

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Articles 706 Documents

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PRODUCTION OF QUININE ALKALOID BY SOME ENDOPHYTIC MICROBES WITH ADDITION OF INDUCER SUBSTANCES (Studies on Endophytic Microbes of Cinchona sp. plants (2)) Simanjuntak, Partomuan; Parwati, Titi; ., Bustanussalam; Prana, Titik K.; Shibuya, Hirotaka
Indonesian Journal of Pharmacy Vol 13 No 1, 2002
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Endophytic microbes have been known to be potential as the sources of active compound for medicines. Optimization of medium, including of inducer addition, is necessary to obtain optimum products. This study, therefore, was aimed to investigate the effect of Cinchona succirubra bark powder addition in the production of quinine compound by endophytic microbe growing in two different liquid media. Endophytic microbe isolated from Cinchona sp. were shaker incubated in Potato Dextrose Broth (PDB) and Phoma media with the addition of bark powder of C. succirubra for 3 days. Quinine production was analyzed with High Performance Liquid Chromatography (HPLC). The result showed an increasing of quinine production for each microbes. Highest increasing of quinine production (2.2 folds) was yielded by mold culture (J3P1) grown in PDB medium.Keywords: inducer, quinine, endophytic microbe, Cinchona succirubra

The formation of inclusion complex of phenobarbital with hydroxypropyl-Î²-cyclodextrine Isadiartuti, Dewi; ., Suwaldi
INDONESIAN JOURNAL OF PHARMACY Vol 16 No 1, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Phenobarbital, a hypnotic and sedative agent, was found to form inclusion complex with hydroxypropyl-Î²-cyclodextrine at 1:1 molar ratio. The formation of inclusion complex in the solution was detected due to the increased solubility of phenobarbital and in the solid was confirmed by differential scanning calorimetry, X-Ray diffractometry, and infrared spectroscopy.In the solid, inclusion complex was prepared by freezed drying method. The inclusion complex formed was characterized, compared with phenobarbital, hydroxypropyl-Î²-cyclodextrine, and the physical mixture of phenobarbital and hydroxypropyl-Î²-cyclodextrine.Analyses using DSC and X-ray diffractometry showed that phenobarbital formed inclusion complex with hydroxypropyl-Î²-cyclodextrine.Key words : phenobarbital, hydroxypropyl-Î²-cyclodextrine, inclusion complex

Synthesis of Tetrahydro Pentagavunon-0 Ritmaleni, Ritmaleni; Simbara, Ari
Indonesian Journal of Pharmacy Vol 21 No 2, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Curcumin, tetrahydrocurcumin, and monoketone curcumin analogue, pentagamavunone-0 (PGV-0), have been investigated as antioxidant, antiinflammatory and anticancer. This research was aimed to synthesise the Tetrahydropentagamavunone-0 (THPGV-0) compound which assumed as an active metabolite of PGV-0. The hydrogenation reaction was applied to the synthesis of THPGV-0 from PGV-0 using Pd/C 10 % as catalyst at room temperature. The structure elucidation was analysed by using spectroscophy method. The synthetic result showed that THPGV-0 asa white crystalline powder in 25 % with melting point about 122-123 oC.Key words: pentagamavunone-0, Tetrahydropentagamavunone-0, hydrogenation

CHEMICAL CONSTITUENT DETECTION AND OXYTOXIC EFFECT OF INSOLUBLE ETHANOLIC FRACTION OF INFUSION OF Kaempferia angustifolia Roscue LEAVES ON ISOLATED UTERUS OF GUINEA PIGS Pramono S.; Sumastuti R.
Indonesian Journal of Pharmacy Vol 14 No 3, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

To establish the scientific base on the use of Kaempferia angustifolia leaves as Indonesian post partus traditional drug, an experiment was done on isolated uterus guinea pigs. The infusion of Kaempferia angustifolia leaves was evaporated and the residu was then extracted with ethanol. The ethanolic fraction and the insoluble fraction were tested on isolated uterus guinea pig after addition of 1 ml of 10 IU/ml oxytocin. The active fraction was then dissolved in distlled water in order temterature. The chemical constituents of the active fraction were detected by thin layer chromatographic method. The results showed that the insoluble ethanolic fraction of the infusion increased significantly the contraction of uterus after the addition of oxytocin (p<00.5). Further more, the water soluble fraction and the residue of the active fraction had also similar activities.Keywords : Kaempferia angustifolia, oxytoxic effect, flavonoids, tanin, pectin

A retrospective study on drug interactions in Dr. Sardjito Hospital Yogyakarta Fita Rahmawati; Rini Handayani; Vivi Gosal
Indonesian Journal of Pharmacy Vol 17 No 4, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The increasing number of drugs available and the increasing use of multidrug regimens which enhance the possibility for drug interactions. The aim of the study was to determine the frequency of drug-drug interaction and drug-food interaction both in outpatients and hospitalized patients. The research was also to determine the pattern of drug interaction mechanism and drugs which often show interaction.The Research type was descriptive. The data were conducted by retrospective, simple random sampling, taken from 90 samples of geriatrics patient hospitalized medical record in Interne medicine during June- September 2003, 120 samples of outpatient prescription took care from Haspita Farma Pharmacies during July-December 2003. Evaluation of the data was carried out descriptively.The result of the study showed that drug interaction occurred in 59% cases of hospitalized patient and 69% cases of outpatient. It was identified the existence of 125 drug interaction in hospitalized patient consists of 48 drug-drug interaction and 77 drug-food interaction. The pattern of drug interaction mechanism was pharmacokinetics pattern of drug interaction mechanism 36%, pharmacodinamic 16 % and unknown 48 %. The drug which often have interaction were furosemid, captopril, aspirin, and ceftriakson. In outpatient, It was identified 128 drug interactions consist of 47 drug-drug interactions case and 81 drug-food interaction. The mechanism pattern was pharmacokinetic 72%, pharmacodinamic 19% and unknown 11 %.The drug which often had interaction was phenitoin, phenobarbital, isoniasid, and rifampicin.Key words : drug interaction, Dr. Sardjito Hospital, Geriatric

Biochemical research of phenyclidine reseptor : Interaction to specific bonding to the lower affinity receptor Gusdinar, Tutus; Chicheportiche, Robert
Indonesian Journal of Pharmacy Vol 18 No 4, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Fixed concentration of MK-801 molecule had been used as a specific ligand for differenciating two kinds of phencyclidine (PCP) and thienylphencyclidine (TCP) receptors. By using several drug molecules which have different pharmacological action, as well as such molecular affinity (IC50) to the rat brain, it was obtained that both of these interacting receptors had equal character for its higher or lower affinity sites. The MK-801 molecule inhibited much strongly (IC50 is about 10 nM) fixation of 3HTCP to its higher affinity receptor and much weakly (IC50 is about 10 μM) fixation of 3H-PCP to its lower affinity receptor. The MK-801 molecule could be used as well for differenciating two 3H-TCP receptors, the higher and the lower affinity.Key words : phencyclidine – thienylphencyclidine – MK-801 – higher affinity receptor– lower affinity receptor.

COBALT INDUCTION ON BIOSYNTHESIS OF CYANOCOBALAMIN by Streptomyces olivaceus IFO 3409. Kasanah, Noer; Tunjung Pratiwi, Silvia Utami
Indonesian Journal of Pharmacy Vol 13 No 3, 2002
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The structure of cyanocobalamin containing an essensial cobalt is as part the compound. The aim of this study was to investigate the influence of cobalt on biosynthesis of cyanocobalamin done by Streptomyces olivaceus IFO 3409. This experiment was carried out by cultivating S. olivaceus in fermentation medium contained glucose 1,5%, pepton 1%, yeast extract 0,25%, trace mineral and each of medium was added cobalt 5, 10, 20 ppm. Cyanocobalamin synthesized by the cells was harvested on the last exponential phase. The amount of cyanocobalamin was analyzed by spectrophotometer. The results show that no cyanocobalamin was produced by S. olivaceus culture without kobalt or treated with 5 ppm cobalt on medium. However cyanocobalamin was produced if the culture medium was treated with 10 and 20 ppm cobalt respectively. It was concluded that cobalt induced on cyanocobalamin biosyntesis, therefore optimation of adding kobalt might be examined on getting maximal cyanocobalamin produced by Streptomyces olivaceus IFO 3409.Key words: cyanocobalamin, cobalt, Streptomyces olivaceus IFO 3409.

Effect of ethanol extract of Erythrina fusca Lour (cangkring) leaves on suppression of cyclooxygenase-2 expression in raji cell line Zullies Ikawati; Agung Endro Nugroho; Winda Werdhinindah
Indonesian Journal of Pharmacy Vol 17 No 2, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

COX-2. COX-2 is expressed highly in inflammation and cancer cells. The effect of ethanol extract of Erythrina fusca Lour (cangkring) toward suppression of COX-2 expression in Raji cells was studied using immunocytochemistry method. This research showed that ethanol extract of E. fusca Lour leaves on concentration of 250,0; 125,0; dan 62,50 μg/mL was able to suppress the COX-2 expression significantly in comparison to control, with the inhibition of 70,19 ± 2,14 %; 44,69 ± 1,62 %; and 23,25 ± 2,21 %.Key words: COX-2 expression, anti-inflammation, anti cancer, Raji cells, ethanol extract of E. fusca leaves, immunocytochemistry

Single dose trypanocide surveillance of diminazene aceturate on mice infected by trypanosoma Lazuardi, Mochamad
Indonesian Journal of Pharmacy Vol 16 No 4, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Diminazene aceturate is one of a limited number compounds currently market for treatment infection cases of infection blood eucaryot parasits llike a Leishmania, and Trypanosoma The research design of this research was post test only control groups design for founding single therapeutics dose of the eukariyot parasite blood. The serial range dose of this research was used at 1,5 to 4 mg/kg bw by intraperitoneal administreted to infected mice (Mus musculus albinus) of the Trypanosoma evansi Bangkalan isolates. The result of this research showed the minimum single therapeutics dose at 3,5 mg/kg bw (p

SUBSTANTIATION ON SHORT TERM EFFICACY AND SAFETY OF INSULIN ANALOGUES IN NORTH INDIAN SUPERSPECIALITY HOSPITAL Koladi, Mohammad Ali
INDONESIAN JOURNAL OF PHARMACY Vol 25 No 3, 2014
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Diabetes mellitus is associated with high morbidity and mortality among patients and its prevalence is increasing at an alarming rate worldwide. Insulin analogues are reported to have better efficacy and safety as compared to conventional insulin therapy, however, substantiation of data in different geographical areas with genomic variation is yet to be established. The study was aimed to evaluate and compare the effectiveness and clinical safety profile of insulin analogues with regular insulin. In this prospective, randomized, observational study conducted at a Superspeciality hospital in India,78 diabetic patients on insulin therapy were recruited. The efficacy and safety markers of 24 patients on biphasic insulin analogue, 33 on recombinant insulin analogue and 21 on regular insulin were observed for 13 weeks. The collected data was statistically analyzed by using Instat software.The efficacy markers such as glycosylated hemoglobin, fasting and postprandial glucose values showed superior improvement with the insulin analogues at the end of 13 weeks study. Insulin analogues produced significantly fewer incidents of minor hypoglycemia without any significant alteration in BMI and weight gain. The results of our studies suggest that insulin analogues are safer and effective with regards to glycemic control and in the event of hypoglycemia over regular insulin.

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