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INDONESIAN JOURNAL OF PHARMACY

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Published by Universitas Gadjah Mada

ISSN : 23389427 EISSN : 23389486 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.

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Articles 706 Documents

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Inhibitory potency of some methoxyphenyl derivatives compounds on class mu GST activity in vitro Sudibyo Martono
Indonesian Journal of Pharmacy Vol 16 No 1, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Methoxy phenyl derivative’s compounds i.e. curcumin, ferulic acid, and indomethacin have been reported to have inhibitory effects on rat’s liver glutathione S-transferases (GST) activity. Vaniline and ferulic acid have been known as degradation products of curcumin, and still have methoxy phenyl groups on the structures. Until the recent years, there is no information concerning the influences of methoxy phenyl derivative’s compounds i.e. vaniline, dimethylcurcumin and ethyl-p-methoxycinnamate on GST-activity. The aim of this research is to study the correlation of the inhibitory activity of class mu GST isolated from uninduced and phenobarbital-induced rat liver cytosol by curcumin, dimethylcurcumin, vaniline, indomethacin, ethyl pmethoxycinnamate, and ferulic acid. GST activity was measured spectrophotometrically on the conjugation of DCNB and GSH. The results showed that the inhibitory activity of mu class GST in uninduced or phenobarbital-induced rat liver GST were decreasing as follow : curcumin, dimethylcurcumin, vaniline, indomethacin, ethyl p-methoxycinnamate, and ferulic acid.Key words: methoxyphenyl derivative’s compounds, glutathione S-transferases activity.

Drug Related Problem (DRP) of Dengue Hemorragic Fever (DHF) medication in pediatric patient` Yasin, Nanang Munif; Sunowo, Joko; Supriyanti, Eri
INDONESIAN JOURNAL OF PHARMACY Vol 20 No 1, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Every year, Dengue Hemorrhagic Fever (DHF) is the big problem Indonesianâs government with high incidency and high mortality. It would increased length of stay and high cost. The objectives of this study are to identify drug-related problems in DHF patient include need for additional drug therapy, unnecessary drug therapy, wrong drug, drug interaction, dosage to high, and dosage too low.A prospective study of pediatrics admitted to Pediatric Ward, X Private Hospital Yogyakarta for DHF infections was carried out since February-April 2006. Appropriate descriptive analysis was used.The results showed that unnecessary drug therapy the most drugrelated problems in 22 patient from 65 pediatic patient.The other DRP were dosage too low in 14 patient, dosage too high in 10 patient, wrong drug in 4 patient, and need for additional drug therapy in 2 patient, rescpectively. Antibiotics were the most cause of drug-related problems in DHF patient.Key words : Dengue Hemorrhagic Fever (DHF), Drug-Related Problem (DRP), Antibiotic , Hospital.

Dead time determination and its influence to retention index in GC system using polar capillary column Idroes, Rinaldi; Oesman, Frida
Indonesian Journal of Pharmacy Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

In this research for the determination of dead timeused a method that is mathematically calculated as iteration and linearization of the polar capillarry column in Gas Chromatography (GC) type DN-Wax, by injecting the homologous series of n-alkanes (n-pentane up to n-decane) on GC system. The dead time values obtained are then used to determine the Kovats Retention Index (Retention Index, RI). The results indicated that the retention index had values of systematic error those are more accurate than the retention time (tR), corrected retention time (tR') and retention factor(k'), but the retention index shows the value of random error slightly larger than with other retention parameters. In this study the average values obtained by the iteration method, the dead time was 3.52 minutes with a correlation coefficient of 0.9998.Retention index values obtained are at the confidence level 92.11%-97.06% with the systematic errors 2.04%-7.89%, while the linearization method showed the average value of the dead time 3.3 minutes witha correlation coefficient of 0.9992, but the value of retention index values obtained show that the systematic error is very large.Key words:Dead time, Retention Index, Homologous Series, GC

Antibacterial and antioxidative activity tests on extract of siuri (Koordersiodendron pinnatum (Blanco) Merr.) cortex Praptiwi .; Mindarti Harapini
Indonesian Journal of Pharmacy Vol 15 No 3, 2004
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The aim of the study was to determine the in-vitro antibacterial and antioxidative activities of siuri (Koordersiodendron pinnatum) bark extract. Ethanolic, hexane, chloroform and ethyl acetate extracts were tested for antibacterial activity against 7 bacteria isolates which were 4 Gram Positive bacteria (Staphylococcus aureus, S. epidermidis, Streptococcus agalactiae, Corynebacterium sp.) and 3 Gram Negative bacteria (Salmonella enteritidis, Eschericia coli, Pseudomonas aeruginosa). Extract concentrations used were : 50, 25, 12.5 and 6.75%. The experiments were conducted in triplicate in Mueller Hinton Agar (MHA). Antioxidative test was performed at the concentration of 1, 5 and 10% with aquadest as a negative control and α-tocopherol as positive control. The results showed that the ethyl acetate extract inhibited the growth of 7 bacteria tested, and the growth inhibition area on Gram negative bacteria was wider than that of 10 units of penicillin. Peroxide value of ethanol extract (111.29) was lower than that of α-tocopherol. Increasing extract concentration reduced the absorbance value.Key words : Koordersiodendron pinnatum, antibacteria, antioxidant.

Isolation of bacterial pathogen Escherichia coli o157:h7 in seafood samples and detection of flich7 gene by using PCR Marlina .; Elidahanum Husni; Fitri Amalinda; Son Radu; Mitsuaki Nishibuchi
Indonesian Journal of Pharmacy Vol 20 No 2, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Escherichia coli O157:H7 is an important human pathogen causing haemorrhagic colitis, haemolytic uraemic syndrom and thrombotic thrombocytopenic purpura.In this study, P. pelagicus dan P. merguensis samples were collected from markets in Padang from Sept 2007 until Feb 2008. For isolation of the bacteria, samples were firstly enriched in mEC media, followed by plating onto CHROMAgar 0157 for E.coli O157:H7. Consequently, the suspected colonies were confirmed by polymerase chain reaction (PCR) assay using primers specific for O157:H7 to detect a fliCH7 gene. Only 15 of them confirmed as E. coli O157:H7 in PCR assay.Key words: Escherichia coli O157:H7, CHROMAgar 0157, fliCH7 gene, PCR

BIOTRANSFORMATION OF CINCHONA ALKALOID COMPOUNDS BY MOLD Xylaria sp.TO CINCHONA N-OXIDE ALKALOIDS [Studies on Endophytic Microbes of Cinchona spp. plants (5)] Partomuan Simanjuntak; Bustanussalam .; Titik K. Prana; K. Ohashi; Hirotaka Shibuya
Indonesian Journal of Pharmacy Vol 13 No 2, 2002
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

A biotransformation study on alkaloid chinchona compounds (quinine, quinidine, cinchonidine, cinhonine) by endophytic microbe from Cinchona succirubra have been done. The biotransformation for 2 days after preculture yielded cinchona N-oxide compounds (quinine N-oxide, quinidine N-oxide, cinchonidine N-oxide, cinchonine N-oxide) alkaloids and the bioassay of the compounds also showed effectiveness as antimalaria. Purification the biotransfomed compound was conducted by a high performance liquid chromatograph (HPLC) and determination of chemical structure was done based on carbon nuclear magnetic resonance (NMR).Key words : Biotransformation, endophyte microbe, Xylaria sp., Cinchona succirubra Pav., cinchona alkaloid, quinine, quinine N-oxide

ACUTE TOXICITY OF NEW COMPOUNDS 12,13-DIHIDRO--AMYRIN-20,30-en-3-ACETAT ; 12-13-DIHIDRO--AMYRIN-20,30-en-3-ol AND -SITOSTAN-20,30-en-3-ol TO Artemia – Salina Leach Sri Mulyani M.
Indonesian Journal of Pharmacy Vol 12 No 4, 2001
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Acute toxicity assay of new compound from nature resources is very important to be carried out. This research was to perform an acute toxicity assays of new compound from Eupatorium inulifolium H.B.K. Acute toxicity assays was carried out using Brine Shrimp Bioassay method. The result showed that two compounds, 12,13-dihydro--amyrin-20,30-en-3-ol and -sitostan-20,21-en-3-ol displayed toxicity (LC50 < 1000 g/ml), and LC50 of 12,13-dihydro--amyrin-20,30-en-3-acetate was exceeding 1000 g/ml.Key words: 12,13-dihydro--amyrin-20,30-en-3-ol, 12,13-dihydro--amyrin-20,30-en-3-acetate, -sitostan-20,21-en-3-ol, toxicity assay, Artemia salina Leach.

Pivotal role reelin signaling pathway in the development of tolerance to morphine-induced antinociception Bambang Subakti Zulkarnanin; Junaidi Khotib
Indonesian Journal of Pharmacy Vol 19 No 3, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The huge endogenous macromolecule protein responsible for controlling migration and dendritic growth of developing neurons, reelin, has recently been proposed that its signaling pathway modulates synaptic plasticity in the adult rodent brain. This study was carried out to investigate the pivotal role of the reelin signaling pathway in the development of tolerance to morphine induced antinociception. There was evidence that repeated intracerebroventricular administration of reelin’s monoclonal antibody, the competitive inhibitor to reelin – apolipoprotein receptor E2 recombinant, and disabled1 (Dab1) protein inhibitor – MG132, resulted in the inhibition to the development of antinociception tolerance to morphine administration. Furthermore, chronic in vivo administration with morphine caused significance increase of the immunoreactivity (IR) for phosphorylated-Dab1 in the thalamus. These data suggested that persistent activation of reelin signaling pathway due to chronic administration of morphine may be responsible for the development of tolerance to morphine-induced antinociception.Key words: Morphine tolerance, Neuronal plasticity, Opioid receptor, Reelin signalling pathway

Characterization and dissolution studies of Furosemide solid dispersions using polyethylene glycol (PEG), talc and PEG-talc as dispersion carriers Yandi Syukri; Diny Rizayulianty; Yuni Darty
Indonesian Journal of Pharmacy Vol 15 No 1, 2004
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Solid dispersions of furosemide were prepared by melting and solvent methods using polyethylene glycol (PEG) 6000, talc and PEG – talc as dispersion carrier in order to improve furosemide dissolution. The increase of dissolution and physical properties of its powder was evaluated. Only furosemide solid dispersions with combination of PEG – talc 1 : 3 showed a good physical properties. The assay of the effect of PEG – talc ratio on furosemide dissolution showed that the increase of ratio of PEG – talc increased significantly dissolution rate.Key Word : furosemide, solid dispersion, dissolution

Studi on the in vitro release of ibuprofen from xanthan gum matrix combined with a crosslinking agent Hadisoewignyo, Lannie; Fudholi, Achmad
Indonesian Journal of Pharmacy Vol 18 No 3, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Ibuprofen is non-steroidal anti-inflammatory drugs that is often used so frequently in a day that is can cause the patient to forget to take it. Besides it may cause gastro intestinal disturbances, which increase with the frequent of use. Many studies have been undertaken to obtain ibuprofen controlled release systems. Based on this, this study is done to find out the in vitro release kinetic of ibuprofen from xanthan gum matrix combined with a crosslinking agent, that is locust bean gum or calcium sulphate.In this research there were six formulas sustained release ibuprofen tablet that was made by the same compression pressure. Formula I, II and III used matrix combination of xanthan gum and locust bean gum (1:½, 1:1, 1:1½), while formula IV, V and VI used matrix combination of xanthan gum and calcium sulphate (1:½, 1:1, 1:1½). Afterward, the physical and release characteristics of the tablet were examined.The results showed that the compactibility of matrix combination of xanthan gum and locust bean gum was different from the matrix combination of xanthan gum and calcium sulphate. Combination of xanthan gum and locust bean gum and also calcium sulphate as crosslinking agent can influence the physical properties and the release profile of tablet.Key words: ibuprofen, xanthan gum, locust bean gum, calcium sulphate, dissolution, sustained release tablet.

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