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All Journal Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Jurnal Sains dan Teknologi Farmasi INDONESIAN JOURNAL OF PHARMACY Jurnal Kesehatan Medika Saintika JOPS (Journal Of Pharmacy and Science) JSFK (Jurnal Sains Farmasi & Klinis) SCIENTIA JOURNAL Buletin Ilmiah Nagari Membangun JFIOnline Majalah Kedokteran Andalas YARSI Medical Journal JURNAL FARMASIMED (JFM) Menara Ilmu Indonesian Journal of Global Health research Jurnal Ilmu Keperawatan dan Kebidanan Pharmaceutical Sciences and Research (PSR)
Almahdy A
Fakultas Farmasi Universitas Andalas
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Effect of gambir extract Uncaria gambierRoxb. on fetal of pregnant mice induced by alcohol A, Almahdy
INDONESIAN JOURNAL OF PHARMACY Vol 21 No 2, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (249.198 KB) | DOI: 10.14499/indonesianjpharm0iss0pp115-120

Abstract

Anomaly  in  the  fetus  of  mice  may  induced  by  the  present  of  oxidative stress on the dam during gestation. Alcohol is a potential substance that able to generate the oxidative stress. Antioxidant theoretically should reduce the above process.  Gambir  extract  is  a  notorious  non  toxic  herbal  which  rich  of antioxidants.  This  study  aims  to  see  whether  the  oxidative  stress  in pregnant mice  induced  by  alcohol  could  be  suppressed  with  gambir  extracts.  The results showed that administration of gambir extract to thepregnant dam of mice after been induced by alcohol during gestation, reduced the presence of a thrombus on the pup.Key words: Gambir extract, ethanol, teratogen, mice
Uji Praklinis Efek Anti Inflamasi dan Toksisitas Fraksi Aktif Spilanthes Paniculata Wall & Dc Djamain, Armi; Almahdy, Almahdy; Adnan, Adek Zamrud
Jurnal Sains dan Teknologi Farmasi Vol 17 No 1 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

The aim of this study was to evaluate an antiinflamation effect of S.paniculata and Siabadicencis extracts at the dose of 300 mg/200 g BW by induction of rats paw edema. Edema condition was induced by administration of 0,2 ml aqueous solution of 0,1 % carrageenan. This was followed by the assay of antiinflamatory effect of fractionated S. paniculata extract with hexane, DCM, ethyl acetate and butanol respectively. A decrease in rats paw edema volume was measured after treatments. Results showed that percent inhibition of inflammation after administration of Siabadicencis, S. paniculata extracts and positive control were 35;48 and 63 % respectively, while that of the hexane, DCM, ethyl acetate and butanol fraction was 69, 27, 53, and 43 % respectively. The antiinflamation effect of the hexane fraction was then determined at various doses (10 ; 20 and 30 mg/20 g BW with positive control acetosal 1,3 mg/20 g BW, by induction of rat back edema. The edema was induced by administration of 1 % carrageen in sessame oil at day 0 (0,1 ml) and day 1 st (0,5 ml) respectively. Parameters such as edema volume, haemoglobin and haematocrit were observed. Results indicated that percent inhibition of inflammation diameter after administration of the fraction at doses  10, 20, 30 mg/20 g BW and acetosal 1,3 mg/20 g BW on day 5th was 11 ; 15 ; 17 ; and 20 % respectively. While percent inhibition of inflammation volume of those groups were 19, 38, 62 and 63 % respectively the haemoglobine (Hb) of dose group 10, 20, 30 mg/20 g BW and negative control was 14.808 ; 15.117 and 12.944 g/dL respectively and 45,25 that of control positive 44,2 respectively. The mean value of necrosis hepatocyte at 3 sites of dose group 30 mg/20 g BW, positive and negative control groups was 6,38 ; 13,82 and 3,55 respectively.
Uji Fetotoksisitas Ekstrak Daun Kemangi (Ocimum Sanctum L.) pada Mencit Putih A, Almahdy; Yandri, Marina
Jurnal Sains dan Teknologi Farmasi Vol 15 No 1 (2010)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

The fetotoxicity effect of  methanolic extract  of the leaf of  kemangi (Ocimum Sanctum L.) on mice had been studied. The extract was given orally at various doses of 50, 100, and 200 mg/kg BW at 6th ­ until 15th day of pregnancy. On the 18th day of  pregnancy laparactomy was perpormed on half number of fetuses from each litter. Mice on  doses of 500 mg/kg BW showed abortion. Macroscopic observation on the fetuses showed some anomalis of body weight compared to control but there was no malformation occured at all doses.
Uji Toksisitas Perkembangan Siprofloksasin dan Studi Histologi Terhadap Mencit Putih Zakiah, Noni; Almahdy, Almahdy; Muchtar, M. Husni
Jurnal Sains dan Teknologi Farmasi Vol 17 No 1 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

A study was conducted to determine the “development toxicity” of ciprofloxacin and litters kidney. The aim of this study was to observe teratogenic effect of ciprofloxacin, and observing its effect on behaviour development and litters kidney. Twenty four pregnant mice were divided into 4 groups : control, and treatments with oral dose of ciprofloxacin of 14,3 mg, 28,5 mg, and 57,1 mg/kg body weight/day for 10 days, coincided with sixth day until fifteenth day of pregnancy for prenatal and posnatal test. Half of the animals were killed on day 18 of gestation and the others half were allowed to deliver. Fetuses were removed by caesarean section. For postnatal test, ciprofloxacin exposed at first day of lactation until weaning. Behaviour toxicity was conducted by Behavioral Test Battery, and observing its effect on litters kidney by paraffin method. Quantitative data were analyzed with Anova and Duncan’s Multiple Range Test. Results showed that teratogenic effects of ciprofloxacin were fetuses death, resorption and hemorrhage. For behaviour toxicity, delayed ability was noticed at 28,5 mg/kg BW obviously, histologically there were disturbances of kidney, which were the thickening of bowman’s capsule, constriction of glomerular capillaries and necrosis.
Perbandingan Sosiodemografi End Stage Renal Failure Yang Disebabkan oleh Diabetes Mellitus dan Hipertensi Fitria, Najmiatul; A, Almahdy; Gillani, Syed Wasif
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Our study aimed at evaluating sociodemographic value between diabetes mellitus and hypertension as the main cause of end-stage renal failure. Retrospective cross-sectional study was used as the research method. Two hundred end-stage renal failure patient records at 2010 were used to evaluate this study. Statistical analysis was done using statistical package of social sciences (SPSS 17®). Ethical clearance was issued by respective clinical research committee. Sociodemographic factors included gender, age, race, education and lifestyle. Results showed that from 200 end-stage renal failure patients there were 1% secondary to diabetes mellitus, 26.5% secondary to hypertension and 44% secondary to diabetes mellitus and hypertension. Case of end-stage renal failure in male secondary to diabetes mellitus (39%) was higher than hypertension (23.5%). End-stage renal failure secondary to diabetes mellitus was higher than hypertension (14%) in female. 33.5% patients were smokers, 22% were end-stage renal failure secondary to diabetes mellitus and the rest were secondary to hypertension. Statistical analysis showed no significant correlation (sig.>0.05) between lifestyle and end-stage renal failure secondary to diabetes mellitus and hypertension.
ANALISIS CEMARAN TIMBAL [Pb(II)] PADA TANAMAN SAWI HIJAU (Brassica rapa var. ParachinensisL) YANG DITANAM DI PINGGIR JALAN PASAR TALANG BANJAR – DUSUN KUBANG GAJAH SECARA SPEKTROFOTOMETRI SERAPAN ATOM Nurhasanah, Nurhasanah; A, Almahdy; Raihana, Nadia
SCIENTIA JOURNAL Vol 6 No 1 (2017): SCIENTIA JOURNAL
Publisher : SCIENTIA JOURNAL

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Abstract

Telah dilakukan penelitian terhadap kadar cemaran timbal pada tanaman sawi hijau (Brassica rapavar. parachinensisL) yang ditanam dipinggir jalan Pasar Talang Banjar – Dusun Kubang Gajah. Padapenelitian ini pengambilan sampel dilakukan pada tiga daerah, yaitu, Dusun Kubang Gajah Kab.MuaraJambi, Talang Banjar Tanjung Nangka Kota Jambi dan Pal Merah Jeramba Bolong Kota Jambi.Masing-masing sampel yang telah dikeringkan kemudian di serbuk,dan didestruksi basah denganpelarut asam nitrat dan hidrogen peroksida. Serapan larutan diukur dengan menggunakanSpektrofotometri Serapan Atom pada panjang gelombang217,0 nm.Kadar cemaran timbal pada sayuran sawi hijau yang diperoleh pada masing-masing daerahpengambilan sampel adalah, Dusun Kubang Gajah Kab.Muara Jambi0,00 ppm,Talang Banjar TanjungNangka Kota Jambi 0,00 ppm, dan Pal Merah Jeramba Bolong Kota Jambi0,2 ppm. Kadar cemarantimbal yang didapatkan pada penelitian ini ternyata belum melewati batas ambang yang telah ditetapkan oleh Standar Nasional Indonesia (SNI), yaitu 0,5 ppm  
ISOLASI SENYAWA SITOTOKSIK TERHADAP SEL KANKER PAYUDARA DARI KULIT BATANG Garcinia griffithii T. Anders Wahyuni, Fatma Sri; Lusianti, Mittha; Almahdy, .; Dachriyanus, .
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 4, No 4 (2009)
Publisher : Indonesian Research Gateway

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Abstract

A cytotoxic compound was isolated from n-hexane the stem bark of Garcinia griffithii T. Anders. (Guttiferae) as colourless needles from which melted at 242-243oC. Based on spectroscopies data of this compound was identified as isoxanthocymol. Cytotoxic assay using Microculture Tetrazolium (MTT) assay showed that isoxanthocymol was active against breast cancer cell line MCF-7, with IC50 value 35,46 μg/ml.   ABSTRAK Telah diisolasi senyawa sitotoksik dari kulit batang Garcinia griffithii T. Anders. (Guttiferae). Senyawa diisolasi dari fraksi n-heksana berupa amorf tidak berwarna dengan jarak leleh 242-2430C. Dari data spektroskopi massa, 1H-RMI, 13C-RMI, diketahui bahwa senyawa tersebut adalah isoxanthocymol. Pengujian aktifitas sitotoksik isoxanthocymol dilakukan dengan metode Microculture Tetrazolium (MTT) terhadap sel kanker payudara MCF-7, dan memperlihatkan aktifitas dengan nilai IC50 sebesar 35,46 μg/ml.
Evaluasi Efek Teratogen Ekstrak Terpurifikasi yang Diisolasi dari Fraksi Etil Asetat Daun Surian (Toona sureni (Blume) Merr) Suharti, Suharti; Yosmar, Rahmi; Fitriani, Ade; Almahdy, Almahdy
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 8, No 2 (2016)
Publisher : Indonesian Research Gateway

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Abstract

Evaluation of teratogenic effects of purified extract isolated fromethyl acetate fractionation of surian leaves (Toona sureni (Blume) Merr.) onwhite female fetus mice has been carried out. The extract was given to miceorally in solution at doses of 5, 10, and 20 mg/kg BW on 6th until 15th day ofpregnancy. On 18th day of pregnancy, laparatomy was performed, then two– third of fetuses were immersed in alizarin red solution and the remainingin Bouin’s solution. The analyzed parameters were the weight of pregnantmice, the number of fetuses, the weight of fetuses, skeletal malformation andmorphology. The result showed that malformations were not shown in dose of 5mg/kg BW, but in dose of 10 mg/kg BW from one mice found one fetus causedlate growth and death. While on dose 20 mg/kg BW, one mice was not death.
Uji Efek Sitotoksik Ekstrak Etanol Daun Asam Kandis pada Mencit Putih Betina dengan Metode Penetapan Mironukleus Wahyuni, Fatma Sri; Afrina, Uci; A, Almahdy
Jurnal Farmasi Indonesia Vol 6, No 2 (2012)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (486.973 KB) | DOI: 10.35617/jfi.v6i2.126

Abstract

The cytotoxic effect of ethanolic extract of the leaf of Garcinia cowa Roxb had been studied b bone marrow micronucleus test. Fourty five female mice were clasified into five groups: negative control, positive control, 30 mg/kgBW extract, 100 mg/kgBW extract, and 300 mg/kgBW extract. Each group was divided into three groups based on the duration of treatment. The mice were induced with 50 mg/kgBW cyclophosphamide intraperitoneally. After 30 hours, the extract were administered orally into the treatment groups for the duration of 3,7, and 15 days. After treatment, the mice were sacrified to obtain their femur marrow. The parameter investigated was the number of micronucleus. It was shown that the extract at does of 30, 100 and 300 mg/kgBW decreased the percentage of micronucleus cells significantly compared with positive control (p<0,05). The highest decrease of micronuclei cells was showed by the dose of 100 mg/kgBW.Keywords : cytotoxic effect, Garcinia cowa Roxb, bone marrow micronucleus test.AbstrakTelah dilakukan penelitian tentang efek sitotoksik dari ekstrak etanol daun asam kandis (Garcinia cowa Roxb) dengan Metoda Penetapan Mikrinukleus. Sebanyak 45 ekor mencit putih betina, dibagi menjadi lima kelompok yaitu kontrol negatif, kontrol positif, 30 mg/kgBB), 100mg/kgBB, dan 300 mg/kgBB. Tiap-tiap kelompok dibagi lagi menjadi tiga kelompok berdasarkan lama pemberian sediaan uji. Mencit diinduksi dengan siklofosfamida 50 mg/kgBB secara intraperitoneal. Setelah 30 jam, kelompok uji diberikan ekstrak uji secara oral selama 3,7 dan 15 hari. Setalah perlakuan, mencit dikorbankan dan diambil sumsum tulang femurnya. Parameter yang diamati adalah persentase jumlah sel mikronuklei. Hasil penelitian menunjukkan sediaan uji pada dosis 30, 100 dan 300 mg/kkBB mampu menurunkan persentase jumlah sel mikronuklei secara signifikan dibandingkan kontrol positif (P<0,05). Penurunan persentase sel mikronuklei paling besar diberikan oleh sediaan uji dosis 100 mg/kgBB.Kata kunci : Efek sitotoksik, Garcinia cowa Roxb, metode penetapan mikronukleus.
Evaluasi Efek Teratogen Ekstrak Terpurifikasi yang Diisolasi dari Fraksi Etil Asetat Daun Surian (Toona sureni (Blume) Merr) Suharti, Suharti; Yosmar, Rahmi; Fitriani, Ade; Almahdy, Almahdy
Jurnal Farmasi Indonesia Vol 8, No 2 (2016)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (840.123 KB) | DOI: 10.35617/jfi.v8i2.511

Abstract

Evaluation of teratogenic effects of purified extract isolated fromethyl acetate fractionation of surian leaves (Toona sureni (Blume) Merr.) onwhite female fetus mice has been carried out. The extract was given to miceorally in solution at doses of 5, 10, and 20 mg/kg BW on 6th until 15th day ofpregnancy. On 18th day of pregnancy, laparatomy was performed, then twoâ?? third of fetuses were immersed in alizarin red solution and the remainingin Bouinâ??s solution. The analyzed parameters were the weight of pregnantmice, the number of fetuses, the weight of fetuses, skeletal malformation andmorphology. The result showed that malformations were not shown in dose of 5mg/kg BW, but in dose of 10 mg/kg BW from one mice found one fetus causedlate growth and death. While on dose 20 mg/kg BW, one mice was not death.
Co-Authors Ade Fitriani, Ade Adek Zamrud Adnan Afrina, Uci Ahsol Hasyim Al-Khansaa, Syawwal Andini, Airiza Fitri Andre, Boy Armenia, Armenia Armenia, Armenia Armi Djamain Biomechy Oktomalioputri, Biomechy Boy Andre Dachriyanus Dafiriani, Putri Dafriani, Putri Deddi Prima Putra Desmini, Yuliya Dini Qurrata Ayuni Dwisari Dillasamola eliza arman, eliza Elvionita, Cindy Esi Afriyanti Fatma Sri Wahyuni Hansen Nasif Jayawarsa, A.A. Ketut Kurniasi, Fitra Lailaturrahmi Lailaturrahmi Lailaturrahmi, Lailaturrahmi Lusianti, Mittha Mardinus, Mardinus Marina Yandri Muchtar, M. Husni Najmiatul Fitria Noni Zakiah Noverial, Noverial Nurhasanah Nurhasanah Prabandasari, Gustia Indah Prima Putra, Deddi Primadhini, Tessa Amanda Putri, Biomechy Oktomalio Rahmi Yosmar Raihana, Nadia Sahputra, Roni Eka Sari, Azzahra Ayu Sari, Novita Purnama Sari, Yelly Oktavia Skunda Diliarosta Syed Wasif Gillani Varizal, Hagi Verawati Verawati Yohannes Alen