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INDONESIAN JOURNAL OF PHARMACY

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Published by Universitas Gadjah Mada

ISSN : 23389427 EISSN : 23389486 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.

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Articles 706 Documents

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ANALYSIS OF FACTORS AFFECTING PATIENT SATISFACTION IN JKN SYSTEM: PATIENT CHARACTERISTICS, JKN SERVICES, AND PHARMACY SERVICES Satibi Satibi
Indonesian Journal of Pharmacy Vol 26 No 4, 2015
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

National Health Insurance (JKN) is a health insurance system by using mechanisms of social health insurance held by BPJS. Satisfaction of participants will affect the sustainability of the system JKN. Factors affecting patient satisfaction are patient characteristics, JKN services, and pharmacy services. This study aimed to examine the influence of patient characteristics, JKN services, and pharmacy services with patient satisfaction in the primary health facilities. This research is analytic with cross sectional survey design. Data taken quantitatively by using questionnaires and equipped with qualitative data from interviews to deepen the findings in the field. The sampling technique used is random sampling for primary health facilities with a total sample of 55 health facilities and purposive sampling for a sample of patients with a total sample of 300 respondents. Data were analyzed using Chi-Square to examine relationship between patient characteristics with patient satisfaction and linear regression to examine the relationship between services in JKN system with patient satisfaction. Characteristics of patients who have a significant relationship to the patient satisfaction is education (p=0.020), employment (p = 0.001), income (p = 0.000), and membership status (p = 0.005).There is a significant relationship between services in JKN system includes JKN sevices with patient satisfaction (p = 0.000) and pharmacy service in the era of JKN with patient satisfaction (p = 0.000). The conclusion of this study is the patient characteristics include education, employment, income and membership status, and service in JKN system includes JKN services and pharmacy services in the era of JKN has a significant relationship with the satisfaction of patients at primary health facilities.Keywords: patient characteristics, JKN services, pharmacy services, patient satisfaction

Identification of physical interaction between trimethoprim and sulfamethoxazole by contact method kofler and crystallization reaction Zaini, Erizal
INDONESIAN JOURNAL OF PHARMACY Vol 21 No 1, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Identification of solid state interaction between TMP and SMZ by hot contact method Kofler and crystallization reaction had been carried out. The results of hot contact method Kofler shown formation a new crystalline habit as long and thin needle shaped on contact zone (mixing zone) between Solid TMP and SMZ. It had a different melting point in compared to its single component. Crystallization reaction between two of supersaturated solution of component TMP and SMZ in methanol solvent also indicated the growth of crystal habit as similar asÂ hot contact method Kofler. Solid state interaction between TMP and SMZ was confirmed by microscopic SEM, powder X-ray diffraction, and thermal DSC. Microscopic analysis by SEM showed significantly the change of habit and morphology ofÂ crystal as long and thin needle shaped. New powder X-ray diffraction (PXRD) interferences peaks were observed in addition to PXRD interference peaks of each component that proved formation of cocrystalline phase. Thermogram DSC indicated a newÂ endothermic peak corresponding to melting point of a new cocrystalline phase at temperature 178,82 Â°C.Key words : trimethoprim, sulfamethoxazole, physical interaction, cocrystalline phase

NATIONAL HEALTH COVERAGE SYSTEM : PHARMACISTS AND JKN PARTICIPANT SATISFACTION IN PRIMARY HEALTH FACILITIES Satibi Satibi
Indonesian Journal of Pharmacy Vol 27 No 4, 2016
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

National Health Insurance is a health protection system for participants to obtain health care benefits and protection to meet basic health needs that organized based on social insurance and equity principles. JKN in cooperation with the primary health facilities to provide comprehensive health services including pharmacy services. Pharmacist responsible for drug availability and affordability that affected by drug procurement process, drug distribution process, and drug cost claiming process.This research’s aim to determine relationship between national health insurances services to pharmacists satisfaction and to determine relationship between pharmacy services to outpatient satisfaction at primary health facilities. Data used in research are primary data that collected through questionnare and interview. The method used is purposive sampling which the data is analyzed using linear and multiple regresion and see significant value (p). The number of respondents was 40 pharmacists and 150 patients in health centers and primary clinics scattered in Sleman, Bantul, and Kota Yogyakarta. The results showed that the process of procurement and distribution of drugs have a relationship with a pharmacist satisfaction while drug costs not process claims with consecutive p 0.010, 0.002, and 0.261. Related to the satisfaction of the outpatient pharmacy services result there is a relationship of drug availability (p = 0.003), service time (p = 0.006), and get drug (p = 0.000) to the satisfaction of outpatients. The conclusion of this study is the process of procurement and distribution of drugs have a relationship with a pharmacist satisfaction. In addition, the availability of pharmacy services such as medication, a drug services, and the provision of drug information also has a significant relationship to the satisfaction of outpatients in health facilities first rate.Keywords: pharmacy services, pharmacists, patients, JKN

CYP1A1 and GST expression of hepatocytes induced by 7,12-dimethylbenz(a)anthracene and the influence of ethanolic extract of Gynura procumbens Iwan Sahrial Hamid
Indonesian Journal of Pharmacy Vol 20 No 4, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The cytochrome P-450 (CYP) and glutathione S-transferase (GST) enzyme systems may influence the biological effects of carcinogens. As such, these enzymes may predict the developmental risk of breast cancer, as well as be potential targets for chemoprevention. The purpose of this study was to compare the expression of CYP1A1 and GSTµ between treatment groups. Expression of CYP1A1 and GSTµ was quantified in liver tissue from 18 female Sprague Dawley rats aged 40 days, which randomly divided into six treatment groups. Those are base line group (without DMBA and ethanolic extract treatment), DMBA induced cancer group, the other two groups was administrated by DMBA after treated by ethanolic extract in two different doses, 300 mg /kg BW and 750 mg/kg BW. The last two groups were given two doses of extract ethanolic only, without initiated of DMBA. The ingestion of the extract was carried for three weeks and the ingestion of DMBA was performed twice in the third week. The expression CYP1A1 and GST was quantified by immunohistochemistry. CYP1A1 expression was significantly higher (P < 0.05) in cancer group (DMBA) as compared with other groups. On the other hand, GST expression was lower in cancer group (P < 0.05). Result of this study demonstrated that ethanolic extract leaves of G. procumbens in 300 mg/kg BW dose could inhibit CYP1A1 stronger than are other and induced GSTµ level. Has effect on ethanolic extract leaves of G. procumbens has ability in played role of as blocking agent in preventing initiation stage of carsinogenesis, therefore it should be taken into account for chemopreventing agent in mammary carsinogenesis.Key words : Gynura procumbens, breast cancer, hemopreventive, CYP1A1, GSTμ

Development And Validation Of Stability Indicating RP-HPLC Method For Determination Of Ceritinib Adhao, Vaibhav Suresh; Sharma, J; Thakre, M
INDONESIAN JOURNAL OF PHARMACY Vol 28 No 4, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

A new, simple, specific, accurate and precise RP-HPLC method was developed for determination of Ceritinib. In the present study, stress testing of Ceritinib was carried out according to ICH guidelines Q1A (R2). Ceritinib was subjected to stress conditions of hydrolysis, oxidation, photolysis and neutral decomposition. Extensive degradation was found to occur in acidic, condition. Mild degradation was observed in basic and at thermal conditions. Successful separation of drug from degradation products formed under stress conditions was achieved on a Hypersil BDS C18 column (250 mm Ã 4.6 mm, 5.0 Î¼ particle size) using acetonitrile: acetate buffer (pH 3.7 Â± 0.05) (50:50 v/v), at a flow rate of 1.0 mL/min and column was maintained at 40ËC. Quantification and linearity was achieved at 272 nm over the concentration range of 5 - 100 Î¼g/mL for Ceritinib. The method was validated for specificity, linearity, accuracy, precision, LOD, LOQ and robustness.

Provision of Patient Medication Counseling Service In A Tertiary-Care Eye Hospital In Bandung: A Gap Analysis of Patientâ€™s Need, Standard and Service Provider Resources Hendrayana, Tomi; Zazuli, Zulfan; Fadhila, Genialita; Cahyono, Nur Sidik
Indonesian Journal of Pharmacy Vol 28 No 4, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Many studies showed that counseling can improve patient adherence and reduce medication-related problems leading to reach an optimal outcome therapy. The aims of this study were to identify patientâ€™s need, healthcare professionalâ€™s support, pharmacistâ€™s readiness and step to be taken to meet standard for implementing patient medication counseling service. Questionnaires has been given to hospitalized-patient to identify the patientâ€™s need and to healthcare professionals in recognizing their supports, followed by survey of pharmacistâ€™s readiness. Gap analysis was then carried out to identify the additional resources to be provided for conducting the service. About 103 patients were enrolled and eager for drug counseling to be implemented with pharmacist as healthcare counselor. Approximately 46 nurses and 25 active-medical-doctors were participated and giving their support for pharmacist to provide the service; and pharmacists are ready to conduct patient medication counseling with minor adjustment. Gap analysis concluded that additional resources should be furnished, e.g. information module consist of standard information needed by the patient, standard operational procedure, and updated literatures. Due to lack of pharmacist, counseling service only be delivered to patient who has a complex antibiotic regimen therapy. Our data showed that patient medication counseling service in this center could be quickly implemented.

Biological evaluation of 99mTc-ethambutol for early detection of tuberculosis infection in animal model Rizky Juwita
Indonesian Journal of Pharmacy Vol 20 No 4, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm0iss0pp55-61

Tuberculosis (TB) is the single most infectious disease, killing millions of people globally. Conventional modalities for TB detection many times the disease is diagnosed at delayed stage and can not use for deep seated infection.Therefore, research and development of 99mTc-ethambutol to detect and locate TB at an early stage in any anatomical site have been conducted in PTNBRBATAN Bandung. The result of biological evaluation of 99mTc-ethambutol whichstudied in rat and mice are as follow, biodistribution study showed accumulation of 99mTc-ethambutol in thigh with infected TB at 4 hours post injection via vein with ratio 2.90 target/non target. Blood clearence studies exhibited 44.96 % of 99mTc-ethambutol remain in the blood within 5 minutes of 99mTc-ethambutol administration. Renal clearance study exhibited of 79.52 % 99mTc-ethambutolexcreted from the urine after 24 hours. The images were acquired with a Gamma-camera at different time intervals 1.2 3 and 4 hours showed localization of the 99mTc-ethambutol in infected TB animal model. This study showed that 99mTc-ethambutol is a promises radiopharmaceutical to detect TB infection rapidly and has accuracy with high sensitivity and specificity.Key words : radiopharmaceutical, 99mTc-ethambutol, imaging, Mycobacteriumtuberculosis.

Antiinflamatory and antidepressive activities of Extract Curcuma xanthorrhiza Roxb in Systemic Lupus Erythematosus Maria Caecilia Setiawati; Zulies Ikawati; I Nyoman Kertia
Indonesian Journal of Pharmacy Vol 28 No 3, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Systemic Lupus Erythemathosus is an autoimmune, inflammatory, chronic disorder characterized by multiorgan system involvement. Depression and anxiety are frequent complaints among patients with lupus erythematosus, so antidepressive treatment should be an important element of the therapy of patients with lupus erythematosus. Research into curcumin’s potential as a treatment for depression is still in its infancy, although several potential antidepressant mechanisms of action have been identified. 4-weeks double-blind, placebo-controlled clinical trial was conducted in 14 SLE patients (10 as treatment group and 4 as control group) The BDI (Beck Depression Inventory) score was calculated and TNF α concentration was measured in the serum subjects before and after treatment. Correlation between TNF α concentration and BDI was assessed. After 4 weeks treatment, the TNF α concentration from subjects in treatment group were significantly lower than before ( p <0.001) but the BDI score were not significantly lower than before (p = 0.059). The TNF α concentration and BDI score showed positive correlation, p = 0,024. This study demonstrate that Curcuma xanthorrhiza Roxb extract can decrease serum TNF α concentration and reduce clinically symptoms of depression in SLE patients

The Effect of Medication Reminder Chart on Level Adherence in diabetes mellitus type 2 patients at RSUD Sleman Yogyakarta Suffiana, Yunita; Rahmawati, Fita; Andayani, Tri Murti
INDONESIAN JOURNAL OF PHARMACY Vol 28 No 2, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Patient adherence is a key factor that determines the outcome of diabetes mellitus therapy. This study was conducted to determine the effect of a medication reminder chart on level adherence and clinical outcome in patients with Type 2 diabetes mellitus. The experimental study used pretest-posttest design with control group was conducted during February until April of 2016 at Sleman Hospital in Yogyakarta. Patients were categorized into two groups of different subjects, who received of medication reminder chart tools were 40 patients (Code A) and the other 40 patients were assigned to control group (Code B). Morisky Medication Adherence Scale of 8-item (MMAS-8) was used to measure adherence. Clinical outcome were measured based on FBG decrease (mg/dl). Two independent sample t-test was using to determine the mean differences of the average score of the adherence level before and after using the medication reminder chart.Â The results of this study showed that Medication Reminder Chart compared control groups improved adherence (p=0.000) but did not improve clinical outcome (p=0.411). The pharmacist might use The Medication Reminder Chart to improve medication adherence for chronic disease.

Drug Related Problem (DRP) of Dengue Hemorragic Fever (DHF) medication in pediatric patient Nanang Yasin
Indonesian Journal of Pharmacy Vol 20 No 1, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm0iss0pp27-34

Every year, Dengue Hemorrhagic Fever (DHF) is the big problem Indonesian’s government with high incidency and high mortality. It would increased length of stay and high cost. The objectives of this study are to identify drug-related problems in DHF patient include need for additional drug therapy, unnecessary drug therapy, wrong drug, drug interaction, dosage to high, and dosage too low.A prospective study of pediatrics admitted to Pediatric Ward, X Private Hospital Yogyakarta for DHF infections was carried out since February-April 2006. Appropriate descriptive analysis was used.The results showed that unnecessary drug therapy the most drugrelated problems in 22 patient from 65 pediatic patient. The other DRP were dosage too low in 14 patient, dosage too high in 10 patient, wrong drug in 4 patient, and need for additional drug therapy in 2 patient, rescpectively. Antibiotics were the most cause of drug-related problems in DHF patient.Key words : Dengue Hemorrhagic Fever (DHF), Drug-Related Problem (DRP), Antibiotic , Hospital.

Page 53 of 71 | Total Record : 706

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