Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

All

INDONESIAN JOURNAL OF PHARMACY

3
Website

Published by Universitas Gadjah Mada

ISSN : 23389427 EISSN : 23389486 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.

Arjuna Subject : -

Articles 706 Documents

58 59 60 61 62

Isolation of bacterial pathogen Escherichia coli o157:h7 in seafood samples and detection of flich7 gene by using PCR Marlina Marlina
Indonesian Journal of Pharmacy Vol 20 No 2, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm0iss0pp73-76

Escherichia coli O157:H7 is an important human pathogen causing haemorrhagic colitis, haemolytic-uraemic syndrom and thrombotic thrombocytopenic purpura.In this study, P. pelagicus dan P. merguensis samples were collected from markets in Padang from Sept 2007 until Feb 2008. For isolation of the bacteria, samples were firstly enriched in mEC media, followed by plating onto CHROMAgar 0157 for E.coli O157:H7. Consequently, the suspected colonies were confirmed by polymerase chain reaction (PCR) assay using primers specific for O157:H7 to detect a fliCH7 gene. Only 15 of them confirmed as E. coliO157:H7 in PCR assay.Key words: Escherichia coli O157:H7, CHROMAgar 0157, fliCH7 gene, PCR.

The influence of mfp-implant on tissue pertinent changes of wistar rattus-rattus Widjijono Widjijono
Indonesian Journal of Pharmacy Vol 21 No 1, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Fluoride for caries prevention if consumes for a long period, it is sometimes made bored. Normally, fluoride intake is uncontrolled and cause fluorosis. Alternatively, implant fluor becomes the controlled method. Te study was aimed to determine the influence of MFP-implant on tissue pertinent changes of Wistar Rattus-rattus. The research subjects were Rattus-rattus mother of 20 rats (2 days pregnant). Twenty rats were divided into 4 groups, namely control (K), implant P1, implant P2 and implant P3. Subcutaneous implantation was done on rat back. On the 8th day, euthanasia was done. Excission was done surround the implant tissue, then blocked and fixed by formalin buffer. The specimen was cut along the implant tissue were examined by light microscope. The data were analyzed by descriptive statistic. The result showed that the incision was cured on the 5th – 7th day. Tissue pertinent changes determination showed that there was lipid cell infiltration and relatively thicker of tissue on implant P3 and. there was not any inflammation cell infiltrated and fibrous tissue. In conclusion, the infiltration of lipid cell on implant P3. The implant P2 was fulfilled the requirement of implant devices.Key words : MFP-implant, pertinent changes, rat

Teratogenicity study of combination of ginger rhizome extract and noni fruit extract in Wistar rat Elin Sukandar
Indonesian Journal of Pharmacy Vol 20 No 1, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm0iss0pp48-54

Ginger (Zingiber officinale Roscoe var. sunti Val.) extract in combination with noni (Morinda citrifolia Linn.) extract has been proven to be effective in tuberculosis patients. To examine its safety in pregnancy condition, the influence of combination of ethanol extract of ginger and ethanol extract of noni fruit had been studied in pregnant Wistar rat. The ginger and noni extract were administered orally at dose level combination of 50 and 50 mg/kg BW , 500 and 500 mg/kg BW , 1000 and 1000 mg/kg BW on day sixth to fifteenth of gestation. The mother was sacrified on day nineteenth of gestation to observe life fetus, resorption, and growfail fetus. One third of the fetuses eviscerated for skeletal staining with alizarin red and two third of the fetuses were hardened with Bouin’s fixation solution. No malformation were found in the eviscerated group. The combination at all doses did not cause any fetus resorption, growth failure and did not cause malformation in organ and skeleton. The combination dose of 500 and 500 as well as 1000 and 1000 mg/kg BW caused dark red to black color in the liver of rat fetuses of 7.3 and 8.3 % respectively.Key words: teratogenicity study, Zingiber officinale Roscoe var. sunti Val, Morinda citrifolia Linn.

Methyleugenol, a major metabolite on culture of endophytic fungi isolated from pandan wangi plant Yuliasri Jamal
Indonesian Journal of Pharmacy Vol 20 No 4, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Two kinds of endophytic fungi i.e. Colletotricum sp. PWD2 and Coelomycetes PWA1 isolated from pandan wangi (Pandanus amarylifolius) have been cultivated in a liquid medium, GYP for 3 weeks at room temperature without agitation. The ethyl acetate extracts derived from liquid cultures showed antifungal activity against Saccharomyces cerevisiae. The GC-MS analysis results showed methyleugenol as main metabolite in the ethyl acetate extract of both fungi cultures.Key words: pandan wangi, Pandanus amarylifolius, endophytic fungi, antifungal, methyleugenol

Population-Based Approach to Analyze Sparse Sampling Data in Biopharmaceutics and Pharmacokinetics using Monolix and NONMEM Akhmad Kharis Nugroho; Arief Rahman Hakim; Lukman Hakim
Indonesian Journal of Pharmacy Vol 28 No 4, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Although it has been developed since 1972, the implementation of a population-based modeling approach in Indonesia, particularly to analyze biopharmaceutics and pharmacokinetics data is still very limited. This study was aimed to evaluate the performance of Monolix and NONMEM, two of the popular software packages in a population-based modeling approach, to analyze the limited data (sparse sampling data) of the time profiles of the simulated plasma drug concentration of a theoretical compound. and NONMEM were used to model the limited data (40 data points) as a results of the random selection from the 180 point data of simulated plasma drug concentration (Cp) on 20 subjects at 0.25; 0.5; 0.75; 1; 1.5; 3; 6; 12 and 18 hours after per-oral administration of a 100mg of a theoretical compound. Population values of the absorption rate constant (Ka), the elimination rate constant (Kel) and volume of distribution (Vd) were compared to the average Ka, Kel and Vd obtained by the conventional method (two stage approach) using PKSolver on the Cp data of all subjects. The calculation system of a nonlinear mixed effect model in Monolix and NONMEM, successfully describes the sparse data, based on the visual evaluation of the goodness of fit. Comparison of parameter estimates of population values in Monolix and NONMEM are in the range of 94 to 108% of the real values of the rich data analysed by PKSolver. A population-based modeling can adequately analyze limited or sparse data, demonstrating its capability as an important tool in clinical studies, involving patients.

Review of Insulin Therapy In Type 2 Diabetes Mellitus Ambulatory Patients Budi Suprapti; Nia Widyasari; Mahardian Rahmadi; Cahyo Wibisono
Indonesian Journal of Pharmacy Vol 28 No 4, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The purposes of this study were to review utilization of insulin therapy in type 2 diabetes mellitus out patients and identify its drug related problems. The data were collected cross-sectionally with purposive sampling method in the period March 2016 until May 2016 in Outpatient Clinic Universitas Airlangga Teaching Hospital Surabaya. The results of 240 patients showed that insulin was used as monotherapy insulin in 2,9% patients; combination 1 insulin & 1-4 OAD in 31,3%; basal bolus therapy 27,9%; combination basal−bolus therapy & 1-3 OAD 43,9%. Based on blood glucose target achievement, only 20,8% of patients achieve the target, 75,1% failed to achieve the target and 4,1% suffered from hypoglycemia. Drug related problems identified adverse drug reaction of antidiabetic therapy such as hypoglycemia (6.7%), nausea (3.8%), bloating (1.3%), increase of flatulency (2.9%) and inappropriate combination (0,4%). In conclusion insulin therapy was complicated and individually, most of the patients still did not reach the target and there was potential drug related problem in this patients group. So that caring from solid inter-professional health collaboration is needed

The effect of mengkudu fruit methanolic extract and methanolic residual fraction on GLUT-4 protein elevation Aguslina Kirtishanti
Indonesian Journal of Pharmacy Vol 20 No 4, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Investigating in the Diabetes Mellitus drug which one having good activity and tolerance to patients are still in researchers’ concern. One of the main topics now days is the use of mengkudu plants as a traditional medicine of Diabetes Mellitus. This research was aimed to determine the increase of GLUT-4 protein in type 2 Diabetes Mellitus rats after given methanolic extract and methanolic residual of mengkudu fruit. The male rats were diabetic induced with exogenous i.p. insulin for 10 days. After showing hyperglycemic effect, the rats were given orally methanolic extract and methanolic residual fraction of mengkudu fruit for 4 days. On the fifth day, fasting blood glucose was measured and the rats were sacrificed to take the thigh muscle tissue for immunohistochemical calculation.The result showed that methanolic extract and methanolic residual of mengkudu fruit increase the amount of GLUT-4 protein, but can not reduce fasting blood glucose levels of male white rats.Key words : mengkudu fruit (Morinda citrifolia L.), methanolic extract and methanolic residual, type 2 Diabetes Mellitus, GLUT-4 protein

THE DISSOLUTION AND DIFFUSION OF FUROSEMIDE ON SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) iis - wahyuningsih; Sugiyanto Sugiyanto; Ag. Yuswanto; Ronny Martien
Indonesian Journal of Pharmacy Vol 28 No 2, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Furosemide a diuretic exhibits low solubility in water and low bioavailability. The purpose of this study was to determine the effect SNEDDS formation to dissolution and diffusion of furosemide. SNEDDS was made with a mixture of 66% tween 80, 26% propylene glycol, 8% oleic acid and furosemide 40mg/mL. Test for SNEDDS dissolution of the capsules was developed using USP dissolution apparatus I and compared to market products, furosemide suspenssion and furosemide powder. The medium consists of 900mL of Artificial Gastric Fluid (AGF) , phosphate buffer pH 5.8 at 37±0.5°C and stirred with a speed of 100rpm. Diffusion test of SNEDDS furosemide was conducted by using reversed rat intestinal bowel and compared to furosemide suspension and furosemide solution. The SNEDDS formulation could enhance the dissolution and diffusion of furosemide compared to the non-SNEDDS formulation

Apoptotic induction of ribosome-inactivating proteins (RIPs) isolated from Carica papaya L. leaves on cancer cell-lines Sismindari, Sismindari
Indonesian Journal of Pharmacy Vol 20 No 1, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm0iss0pp9-16

Carica papaya L. leaves are potential for cancer treatment, this is due to the presence of Ribosome-inactivating proteins (RIPs), which demonstrated a cytotoxic effect on cancer cell lines. Therefore, this research was done to find out the effect of protein fraction containing RIPs isolated from C. papaya in the induction of apoptosis on cancer cell-lines (Raji and myeloma cell-lines).The protein fraction was isolated from Carica papaya L. leaves using ammonium sulphate precipitation and analyzed the activity on supercoiled double stranded DNA cleavage, in order to identify the presence of RIP. The active fraction called â€˜CP proteinâ€™, was then analyzed on the induction of apoptosis by double staining method using acrydin orange-ethidium bromide, followed by analyzing the expressions of p53 and bcl2 using immunocytochemistry.The results demonstrated that the CP protein possessed cytotoxic activities on myeloma and Raji cell-lines with the IC50 of 1.80 mg/mL and 2.49 mg/mL respectively. Late apoptosis was detected on myeloma but not on Raji cell lines which was incubated with 0.9 mg/mL and 0.6 mg/mL of CP proteins respectively. In addition, the protein was able to increase the expression of apoptotic regulatory protein, p53, on myeloma cell-line and almost undetected on Raji cell-line.Key Words : Ribosome-inactivating proteins (RIPs), Carica papaya L. , expression of p53 and Bcl-2, myeloma cell-line, Raji cell-line

BIOACTIVE TERPENOID FROM THE BALINESE NUDIBRANCH Hypselodoris infucata Mudianta, I Wayan; Martiningsih, Ni Wayan; Prasetia, I Nyoman Dodik; Nursid, Muhammad
Indonesian Journal of Pharmacy Vol 27 No 2, 2016
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Marine organisms, in particular nudibranchs (Mollusca: nudibranchia), are known as a rich source of chemically diverse secondary metabolites exhibiting potential as antimalarial, anti-inflammatory, antiviral and anticancer activity. We presented the chemical investigation of an extract of nudibranch Hypselodoris infucata collected from Bali, an unexplored water but rich in nudibranch diversity. The extract contained the known (â€“)-furodysinin (1), a furanosesquiterpene that for the first time isolated from this species. Metabolite 1 was purified by chromatography and the structure was characterised by comparison of 1H NMR data with that of the reported data. The absolute configuration was determined by comparing the optical rotation values with the known enantiomer. In vitro cytotoxic activity of compound 1 against HeLa cell line displayed an IC50 at 102.7Âµg/mL. We also report for the first time the development of a method to assay nudibranch extracts for their feeding deterrence activity against local shrimps Penaeus vannamei. The extract show food rejection with highly significant difference in respect to the control (P = 0.0061) at natural concentration of 3.0mg/mL.Keywords: nudibranch, natural product, feeding deterrence, Hypselodoris

Page 60 of 71 | Total Record : 706

58 59 60 61 62

Filter by Year

2001 2020

Filter By Issues

All Issue Vol 31 No 2, 2020 Vol 31 No 1, 2020 In Press Vol 31 No 1, 2020 Vol 30 No 4, 2019 Vol 30 No 3, 2019 Vol 30 No 2, 2019 Vol 30 No 2, 2019 Vol 30 No 1, 2019 Vol 30 No 1, 2019 Vol 29 No 4, 2018 Vol 29 No 4, 2018 Vol 29 No 3, 2018 Vol 29 No 3, 2018 Vol 29 No 2, 2018 Vol 29 No 1, 2018 Vol 28 No 4, 2017 Vol 28 No 4, 2017 Vol 28 No 3, 2017 Vol 28 No 3, 2017 Vol 28 No 2, 2017 Vol 28 No 2, 2017 Vol 28 No 1, 2017 Vol 27 No 4, 2016 Vol 27 No 4, 2016 Vol 27 No 3, 2016 Vol 27 No 3, 2016 Vol 27 No 2, 2016 Vol 27 No 2, 2016 Vol 27 No 1, 2016 Vol 27 No 1, 2016 Vol 26 No 4, 2015 Vol 26 No 4, 2015 Vol 26 No 3, 2015 Vol 26 No 3, 2015 Vol 26 No 2, 2015 Vol 26 No 1, 2015 Vol 26 No 1, 2015 Vol 25 No 4, 2014 Vol 25 No 4, 2014 Vol 25 No 3, 2014 Vol 25 No 3, 2014 Vol 25 No 2, 2014 Vol 25 No 1, 2014 Vol 25 No 1, 2014 Vol 24 No 4, 2013 Vol 24 No 4, 2013 Vol 24 No 3, 2013 Vol 24 No 3, 2013 Vol 24 No 2, 2013 Vol 24 No 2, 2013 Vol 24 No 1, 2013 Vol 24 No 1, 2013 Vol 23 No 4, 2012 Vol 23 No 3, 2012 Vol 23 No 2, 2012 Vol 23 No 2, 2012 Vol 23 No 1, 2012 Vol 23 No 1, 2012 Vol 22 No 4, 2011 Vol 22 No 4, 2011 Vol 22 No 3, 2011 Vol 22 No 3, 2011 Vol 22 No 2, 2011 Vol 22 No 2, 2011 Vol 22 No 1, 2011 Vol 21 No 4, 2010 Vol 21 No 4, 2010 Vol 21 No 3, 2010 Vol 21 No 2, 2010 Vol 21 No 2, 2010 Vol 21 No 1, 2010 Vol 21 No 1, 2010 Vol 20 No 4, 2009 Vol 20 No 4, 2009 Vol 20 No 3, 2009 Vol 20 No 3, 2009 Vol 20 No 2, 2009 Vol 20 No 1, 2009 Vol 20 No 1, 2009 Vol 19 No 4, 2008 Vol 19 No 3, 2008 Vol 19 No 3, 2008 Vol 19 No 2, 2008 Vol 19 No 1, 2008 Vol 19 No 1, 2008 Vol 18 No 4, 2007 Vol 18 No 3, 2007 Vol 18 No 3, 2007 Vol 18 No 2, 2007 Vol 18 No 1, 2007 Vol 17 No 4, 2006 Vol 17 No 3, 2006 Vol 17 No 3, 2006 Vol 17 No 2, 2006 Vol 17 No 2, 2006 Vol 17 No 1, 2006 Vol 17 No 1, 2006 Vol 16 No 4, 2005 Vol 16 No 4, 2005 Vol 16 No 3, 2005 Vol 16 No 2, 2005 Vol 16 No 2, 2005 Vol 16 No 1, 2005 Vol 16 No 1, 2005 Vol 15 No 4, 2004 Vol 15 No 4, 2004 Vol 15 No 3, 2004 Vol 15 No 2, 2004 Vol 15 No 2, 2004 Vol 15 No 1, 2004 Vol 15 No 1, 2004 Vol 14 No 4, 2003 Vol 14 No 3, 2003 Vol 14 No 2, 2003 Vol 14 No 1, 2003 Vol 14 No 1, 2003 Vol 13 No 4, 2002 Vol 13 No 4, 2002 Vol 13 No 3, 2002 Vol 13 No 3, 2002 Vol 13 No 2, 2002 Vol 13 No 2, 2002 Vol 13 No 1, 2002 Vol 12 No 4, 2001 Vol 12 No 4, 2001 Vol 12 No 3, 2001 Vol 12 No 2, 2001 Vol 12 No 2, 2001 Vol 12 No 1, 2001 Vol 12 No 1, 2001 More Issue

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name -

Contact Email -

Phone -

Journal Mail Official -

Editorial Address -

Location Kab. sleman, Daerah istimewa yogyakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA