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BALI MEDICAL JOURNAL (BMJ)
Published by Universitas Udayana
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Bali Medical Journal (BMJ), P-ISSN 2089-1180, E-ISSN 2302-2914 is an international and peer-reviewed journal published quarterly in print and online by Sanglah General Hospital in collaboration to Indonesian Physician Forum and Indonesian College of Surgeon, Bali-Indonesia which was founded in 2011. The Journal aims to bridge and integrate the intellectual, methodological, and substantive diversity of medical scholarship, and to encourage a vigorous dialogue between medical scholars and practitioners. The Journal welcomes contributions which promote the exchange of ideas and rational discourse between practicing educators and medical researchers all over the world.
Arjuna Subject : -
Articles 179 Documents
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ORAL ADMINISTRATION OF NUTMEG ON MEMORY BOOSTING AND REGAINING IN WISTAR ALBINO RATS Jissa, G.; Sai-Sailesh, K.; Mukadan, and J. K.
BALI MEDICAL JOURNAL Vol 3 No 1 (2014)
Publisher : BALI MEDICAL JOURNAL

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Abstract

Background: This study provides further evidence for improvement of memory by oral consumption of nutmeg. The present study was undertaken with an objective to study the effects of oral administration of nutmeg on memory boosting and regaining. Methods: Here we investigate the influence of oral intake of nutmeg on behavioral task performance by using T-maze and radial arm maze and physiological measures relative to a milk control group. Results: We have observed significant memory boosting and memory regaining effects of nutmeg when administered orally. This effect may be due to facilitation of acetylcholine activity by decreasing acetylcholinesterase activity of nutmeg. Hence we recommend further research in this area by investigating compound metabolism to optimize quantification of memory performance following nutmeg consumption.
Cinnamon Extract Effect on Osteoblast Activity in Diabetic Wistar Rats Andiwijaya, Fahrin Ramadan; Prihatanto, Fundhy Sinar Ikrar; Susanto, Hermawan
BALI MEDICAL JOURNAL Vol 5 No 2 (2016)
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Abstract

Background: Diabetes is clinically known to cause prolongation to bone fracture healing. This research aims to find the effect of cinnamon in the process of bone remodeling, and changes in the activity of osteoblast cells in diabetic bone after giving cinnamon as a supplement in diabetic rats. Method: The design employed was experimental with randomized post-test group design research. A total of 24 Wistar Rats was randomly divided into four groups, which consist of normal without treatment, normal with treatment, diabetic without treatment and diabetic with treatment. Treatment of 300 mg/kg cinnamon extract was given per orally. Upon euthanizing the samples, femur samples were taken and processed to histopathological slides. All slides were analyzed under light microscopes to find the osteoblast cells. The Kruskal-Wallis method was used to test the results; due to the population of sample was not normally distributed. Results: The osteoblast cells found were scored in mean ranks. The normal group mean rank 12.25, normal with treatment group 12.17, diabetic without treatment group 8.58, and diabetic with treatment group 17.00. Asymptotic significance was 0.195. Conclusion: This research concludes that there is no significant increase in osteoblast activity in diabetic Wistar rats after the administration of 300 mg/kg cinnamon extract.
PREVALENCE OF HYPERURICEMIA AT NEPALGUNJ MEDICAL COLLEGE, BANKE-NEPAL Singh, P.; Khan, S.; Mittal, R.K.
BALI MEDICAL JOURNAL Volume 1, Number 3, September-December 2012
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Abstract

Objective: The prevalence of hyperuricemia varied in different populations and it appeared to be increasing in the past decades. Recent studies suggest that hyperuricemia is an independent risk factor for cardiovascular disease. Method: One thousand eighty seven patients, attending Nepalgunj medical college and Teaching Hospital, Banke, Nepal from March 2011 to February 2012 were included in this study. The reference range was 3.5 – 7.0 mg/dL in males and 2.6 – 6.0 mg/dL in females. Hyperuricemia was de?ned as a Serum Uric Acid level of more than 7.0 mg/dL in males and of more than 6.0 mg/dL in females. The uric acid was determined by uricase /PAP method. Test was performed in the central laboratory of Biochemistry, Nepalgunj Medical College & teaching Hospital, Banke, Nepal. Results: A number of 1487 studies were selected, the statistical information of which was collected for systematic analysis. The results showed that the high prevalence of hyperuricemia found in females(22.86%) as compare to males(18.98). It was found that 21-40 age group is on high risk for hyperuricemia.Conclusion: The prevalence of hyperuricemia is different as the period of age and it increases after 21-40 years in male and in female. Serum uric acid level was high in female as compare to male.
THERAPEUTIC MILD HYPOTHERMIA TOWARDS BLOOD LACTATE LEVELS AND GLASGOW COMA SCORE IN SEVERE TRAUMATIC BRAIN INJURY Pardamean, D. T.; Prasetyo, E.; Oley, M.
BALI MEDICAL JOURNAL Vol 4 No 2 (2015)
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Abstract

Background: Raised body temperature is a common occurrence after severe traumatic brain injury (TBI). TBI is accompanied by regional alterations of brain metabolism, reduction in metabolic rates and possible energy crisis. This metabolic disturbance reflected by increase and accumulation of the brain lactate levels. The study aimed to evaluate the effect of therapeutic mild hypotermia (TMH) on lactate levels and GCS (Glasgow Coma Score) of severe TBI. Methods: Fourthy patients with TBI were randomly divided into normothermia (n=20) and mild hypothermia (n=20) group. Body temperature of hypothermia group was maintained at 35°C for 72 hours. Blood lactate level and GCS were determined before and after hypothermia therapy ( on 3th and 7th day). Results: The mean lactate {5.370 vs 4.025 mmol/L, p
Blood hsCRP And PGE2 Content With Clinical Outcome Using Modified Fenestratio-Restorative Spinoplasty Better Than Lamonectomy-Fusion In Lumbar Stenosis Mahadewa, T. B. G.; -, Sri-Maliawan; Raka-Sudewi, A. A.; Wiryana, M
BALI MEDICAL JOURNAL Volume 1, Number 2, May-August 2012
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Abstract

Objective: Modified Fenestration-Restorative Spinoplasty (MFRS) technique is an alternative to lumbar stenosis treatment, providing the equal decompression comparing with laminectomy techniques, without the implant, less expensive and complication rates. The purpose of this study was to determine which technique gives better inflammation and clinical outcome based on high sensitive C-Reactive Protein biomarker (hsCRP) and Prostaglandin E2 (PGE2), Visual Analog Scale (VAS) of the day 7th postsurgery and ODI scores 3rd month post surgery. Methods: This study design is an experimental pretest-posttest randomized control group design. Results:  This study results showed that the mean levels of hsCRP day 7th postsurgery were differ significantly between MFRS (23,09 ± 15,3 mg/L) compared to LF (39,53 ± 24,4 mg/L). Likewise for the mean levels of PGE2 day 7th postsurgery were differ significantly between MFRS (491,39 ± 528,5 pg/ml) compared to LF (1103,7 ± 1033,6 pg/ml) at the significance level of p <0.05). MFRS clinical outcomes better than LF (p <0.05), for means of VAS value day 7th postsurgery and ODI score 3rd month postsurgery. Perioperative variable analysis shows that MFRS was better than LF in: length of surgery, blood loss, postsurgery Hb and patient length of stay (p<0,05). Conclusions: MFRS technique is an alternative technique of lumbar stenosis treatment better than the LF, in terms of improved levels of hsCRP and PGE2, leading to faster clinical outcomes improvement, less complications and lower costs. MFRS technique should be used as a treatment of lumbar stenosis.
Gaharu Leaf Water Extract Reduce MDA and 8-OHdG Levels and Increase Activities SOD and Catalase in Wistar Rats Provided Maximum Physical Activity Parwata, I Made Oka Adi; Manuaba, Ida Bagus Putra; Sutirtayasa, I Wayan Putu; Wita, I Wayan
BALI MEDICAL JOURNAL Vol 5 No 3 (2016)
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Abstract

Background: Oxidative stress occurs due to an imbalance of the number of free radicals by the number of endogenous antioxidant produced by the body i.e. Superoxide Dismutase (SOD), Gluthathione Peroxidase (GPx), and Catalase. The imbalance between the number of free radicals and antioxida nts can be overcome with the end ogenous antioxidant intake that exogenous oxidative stress can be reduced. O ne of exogenous antioxidants is natural Gaharu leaf water extract. Objective: This research focus on the effect of Gaharu leaf water extract in reducing MDA and 8- OHdG and increase the activity of SOD and Catalase. Methods: This study was an experimental with post only controls group design. Experiment was divided into 5 groups of w istar rats, each consisting of 5 animals, i.e. negative control group without extract [K (-)], treatment 1 treated 50 mg/ kg BW/day of the extract (T1), treatment 2 treated 10 0 mg/ kg BW/day of the extract (T2), treatment 3 treated 200 mg/ kg BW/day of the extract (T3), and positive control group [K (+)] treated with vitamin Cat a dose 50 mg/ kg BW/day. All groups treated for 10 weeks. Every day, before treatment, each group was given a maximum swimming activity for 1.5 hours for 10 weeks. ELISA was used to measure MDA, 8-OHdG, SOD , and C atalase activities . Result: The research results showed that treatment of extract of leaves of Gaharu with an higher dose from 50 mg/kg BW up to 200 mg/ kg BW significantly decline (p
EFFECTIVENESS OF DIFFERENT DETERGENT SOLUTIONS AS LARVISIDE FOR AEDESAEGYPTI LARVAE Sudarmaja, I Made; Swastika, I Kadek
BALI MEDICAL JOURNAL Vol 4 No 1 (2015)
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Abstract

Background: Dengue hemorrhagic fever the spread of which is mediated by Aedesaegypti mosquito that becomes a health problem in Indonesia every year. Some natural and chemical substances had been experimented to combat Aedesaegypti, one of them is detergent solution. This study aims to investigate the effect of several concentrations of detergent to kill Aedesaegypti larvae, and to find out the lethal concentration (LC)50, LC90, and LC95. Method: Randomized posttest only control group design was applied to observe the percentage of Aedesaegypti larvae instar III-IV killed when they contacted to various detergent concentrations within 24 hour of observation. Results: This study result showed that detergent with the concentration of 0.12 g/l; 0.14 g/l; 0.16 g/l; 0.18 g/l; 0.20 g/l; 0.22 g/l and 0.24 g/l respectively showed the killing of Aedesaegypti larvae 37.6%, 42.4%, 74.4%, 85.6%, 89.6%, 95.2% and 100%, respectively. Probit analysis showed that LC50 = 0.14 gram/liter, LC90 = 0.20 g/l and LC95=0.22 g/l.
LIVER DYSFUNCTION IN DIABETIC PATIENTS ADMITTED IN REFERRAL HOSPITAL Takhelmayum, Roshan; Thanpari, C.; Singh, T. Paras
BALI MEDICAL JOURNAL Vol 3 No 3 (2014)
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Abstract

Background: Liver function tests (LFTs) are group of tests that help in diagnosis, monitoring therapy, and assessing prognosis of liver disease. To estimate liver function tests in diabetic patients attending OPD of Central Referral Hospital, Sikkim, India. Methods: This study was conducted in Central Referral Hospital, Gangtok, Sikkim, India between October 2007 to April 2008. A total of 150 diabetic patients and 50 controls were taken to assess the liver function tests (LFTs) by measuring Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP) & total bilirubin (TB). Results: Total Bilirubin (TB) was found to be elevated in maximum number of patients, 84 (56%) out of 150 patients and followed by both AST and ALT, 39 (26%) each out of 150 patients. Conclusion: LFTs in type-2 diabetic patients are found to be statistically significant when compared with normal healthy controls.
Management of Spinal Tuberculosis (TB) in Developing Country Mahadewa, Tjokorda G. B.
BALI MEDICAL JOURNAL Vol 5 No 2 (2016)
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Abstract

Background: Tuberculosis on the spine is involved approximately 1 % of all tuberculosis cases. It is a lethal type of TB skeletal due to highly neurologic compromised because of adjacent medullary compression and incidence kyphotic deformity. Early diagnosis and management of this disease is mandatory to prevent serious complications. Method: Serial case report was conducted in Sanglah General Hospital from January 2014 until December 2015. All patients were diagnosed based on local protocol using appropriate imaging technique. All patients were treated by anti-tuberculosis drugs for 2 weeks followed by functional assessment by MMT, ASIA, and JOA. Result: The author reported 10 patients of spinal TB whom were treated in Sanglah Hospital, Bali between January 2014-Desember 2015. Among pts 8 male and 2 female with location of spinal TB i.e 4 in thoracal, 4 in lumbal and 2 in cervicothoracal. Preoperative ASIA scale was an average scale C and postoperative ASIA scale was in D. The average JOA pre-surgical score was 10.5 and postsurgical was 14.5. Improvement using the formula JOA achieved with an average of 21.6 %. All patients neurologically improved, no complications and surgical implant failures in this series. Conclusions: Surgical management of spinal tuberculosis, if delivered with appropriate indication, proved to be effective in correcting spinal kyphosis. Early management is mandatory in order to ensure better prognosis.
REGULATORY INFORMATION MANAGEMENT: Novel Approaches for Health Care System Saha, D.
BALI MEDICAL JOURNAL Vol 2 No 3 (2013): Vol.2, No.3, September-December 2013
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Abstract

In managing chemistry, manufacturing and controls documents; the larger process is involved for electronic regulatory submissions to health authorities. This is a case of an entire process standard providing significant gains in efficiency. A solution is needed for this area of the biopharmaceutical industry. Within a Regulatory affiars, there are Information Management needs, particularly related to the electronic Common Technical Document (eCTD) submission process. There are a number of methods for adding efficiencies to the submission process, particularly through automation and standards. Consider the overall process of a sponsor producing an eCTD submission and within it the specific process of transferring Chemistry, Manufacturing and Controls (CMC) documents from a manufacturer to the sponsor. Keeping in mind the overall eCTD process, consider the specific CMC process to illustrate where and how inefficiencies can be changed.

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