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Jurnal Kimia (Journal of Chemistry)

jchem
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Published by Universitas Udayana

ISSN : 19079850 EISSN : 25992740 DOI : 10.24843/JCHEM

Core Subject : Science,

Chemistry

Jurnal Kimia (Journal of Chemistry) publishes papers on all aspects of fundamental and applied chemistry. The journal is naturally broad in scope, welcomes submissions from across a range of disciplines, and reports both theoretical and experimental studies.

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 518 Documents

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ISOLASI DAN IDENTIFIKASI SENYAWA AKTIF ANTIJAMUR DARI DAUN MIMBA (Azadiractha indica A. Juss.) SEBAGAI PENGENDALI JAMUR Fusarium sp. PADA TANAMAN BUAH NAGA (Hylocereus sp.) Sri Wahjuni; Ni Made Puspawati; Ni Putu Rusma Eva Arista
Jurnal Kimia (Journal of Chemistry) Vol. 10, No. 2 Juli 2016
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Pada penelitian ini dilakukan isolasi, identifikasi dan uji aktivitas antijamur dari ekstrak daun mimba (AzadirachtaIndica) terhadap jamur Fusarium sp. Tujuan penelitian ini adalah untuk mengetahui konsentrasi minimum ekstrak mimba yang dapat menghambat pertumbuhan jamur Fusarium sp. dan mengidentifikasi golongan senyawa aktifnya. Serbuk daun mimba sebanyak 1000 gram diekstraksi menggunakan etanol 70%. Kemudian ekstrak pekat etanol dipartisi dengan menggunakan n-heksana, kloroform dan etil asetat. Hasil skrining awal uji aktivitas antijamur yang dilakukan pengamatan selama tiga hari menunjukkan ekstrak kloroform memiliki aktivitas antijamur dengan daya hambat sebesar 1 mm. Ekstrak kloroform selanjutnya diuji aktivitas antijamur dengan varian konsentrasi. Pada konsentrasi 10 ppm dan 30 ppm tidak menunjukkan adanya daya hambat, sedangkan pada konsentrasi 50; 70; dan 100 ppm menunjukkan daya hambat berturut-turut yaitu 9,5; 9,75; dan 18,3 mm yang termasuk kategori sedang sampai kuat. Ekstrak kloroform selanjutnya dipisahkan dengan kromatografi kolom menggunakan silika gel sebagai fase diam dan n-heksana : etil asetat : kloroform (1:1:1) sebagai fase gerak dan diperoleh 3 fraksi. Hasil uji kemurnian menunjukkan fraksi 3 dikatakan relatif murni secara KLT. Selanjutnya fraksi 3 diuji fitokimia dan diidentifikasi menggunakan spektrofotometer UV-Vis dan Inframerah. Hasil uji fitokimia menunjukkan fraksi 3 merupakan senyawa terpenoid. Hasil analisis UV-Vis fraksi 3 memberikan serapan maksimum pada panjang gelombang 410,80 nm, 325,60 nm, dan 269,40 nm yang diduga adanya transisi elektron dari n-?* , n-?*, dan ?-?*. Berdasarkan hasil spektra inframerah dan fitokimia fraksi 3 menunjukkan puncak yang sesuai dengan gugus fungsi karakteristik terpenoid yaitu O-H, C-H alifatik, C=O karbonil, dan C=C alifatik.

MOLECULAR DOCKING LIKOPEN SEBAGAI ANTIOSTEOPOROSIS SECARA IN SILICO N. M.P. Susanti; D. P.D. Saputra; P. L. Hendrayati; I. P.D.N. I. P. D. N. Parahyangan; G. A.K. Amarawati
Jurnal Kimia (Journal of Chemistry) Vol.13 No.1 Januari 2019
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Osteoporosis is a degenerative disease due to the reduction of mass or bone tissue so that the bones become brittle. One of the causes of the fragility of bone is the formation of free radicals due to oxidative stress by reactive oxygen species (ROS). ROS can stimulate bone resorption. Lycopene is a compound contained in tomatoes found in large quantities. Lycopene is known to have strong antioxidant activity. The purpose of this research is to know the activity of lycopene as antiosteopotosis from tomato fruit through antioxidant mechanism using molecular docking method in silico. The stages of this research are preparation of 3D lycopene structure database and SOD and GPx protein, protein preparation using Chimera 1.10.1 application, optimization of lycopene 3D structure using HyperChem 8 application, and validation of molecular docking and lycopene docking methods on the proteins using Autodock application 4.2. The results showed that lycopene was able to interact with SOD and GPx proteins shown by negative bond energy, ie -0.75 and -1,61 kcal mol respectively. These interactions show that lycopene can neutralize free radicals by inducing SOD and GPx proteins so that oxidative stress triggering the bone resorption which as one of the causes of osteoporosis can be prevented

SENYAWA AKTIF ANTIMAKANDARI UMBI GADUNG (Dioscorea hispida Dennst) Sri Rahayu Santi
Jurnal Kimia (Journal of Chemistry) Vol. 4, No. 1 Januari 2010
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (185.68 KB)

Isolation and identification of active antifeedant compounds from gadung tuber (Dioscorea hispida Dennst)has been carried out. As much as 12.03 g of concentrated methanol extract was resulted from 5.0 kg dry gadung tuberthat was macerated using methanol. Further, this extract was partitioned with n-hexane to obtain 2 concentratedextracts in n-hexane and methanol. The result of antifeedant test showed that the methanol extract was more activethan the n-hexane extract.Separations of the methanol extract using column chromatography (stationary phase : silica gel 60, mobilephase : methanol-chloroform 6:5) resulted four fractions. The most active fraction, FA , showed 2 spots on the TLC,so it was separated using preparative TLC which resulted in 2 fractions (FA.1 and FA.2). The antifeedant activity ofFA.1 fraction was higher than FA.2 fraction and it gave only 1 spot on the TLCThe result of identification using phytochemical test and spectrophotometer analysis suggested that FA.1fraction was alkaloid compound whose maximum wave length was 277.1 nm and it contained N-H (3425.3 cm-1), CHaliphatic (2927.7 and 2854.5 cm-1), C=O (1735.8 cm-1), C-N (1110.9 cm-1) and N-C=O (621.9 cm-1).

SEQUENTIAL EXTRACTION UNTUK PENENTUAN BIOAVAILABILITAS LOGAM Co DAN Ni DALAM SEDIMEN DI KAWASAN PERAIRAN PELABUHAN BENOA DENPASAR BALI Yulius Leo Adeputra; Emmy Sahara; A. A. I. A. M. Laksmiwati
Jurnal Kimia (Journal of Chemistry) Vol. 9, No. 2 Juli 2015
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

This research was aimed to establish the total concentrations of Ni and Co and then to determine the fractions of various species of the two metals in the sediments. The bioavailability of Co and Ni was determined using sequential extraction technique. The total concentrations of Co and Ni obtained in the sediment were 27.2484 mg/Kg and 41.9458 mg/Kg, respectively. The speciation of Co and Ni found the sediment were 29.83% and 55.86 % in the EFLE fraction; 4.04% and 6.40% in the fraction of Fe / Mn oxides; 13.72 % Co and Ni not detectable in the organic-sulfide fractions; 46.15% and 38.14% in the resistant fraction. Therefore the bioavailability of Co and Ni obtained in the Benoa Port sediment were of 12.9653mg/Kg and 23.3565 mg/Kg respectively.

EFEKTIFITAS PENGOLAHAN AIR EFFLUENT MENJADI AIR REKLAMASI DI INSTALASI PENGOLAHAN AIR LIMBAH SUWUNG DENPASAR DITINJAU DARI KANDUNGAN KEKERUHAN, TOTAL ZAT TERLARUT (TDS), DAN TOTAL ZAT TERSUSPENSI (TSS) Luh Putu Widya Kalfika Devi; K. G. Dharma Putra; A. A. Bawa Putra
Jurnal Kimia (Journal of Chemistry) Vol. 7, No. 1 Januari 2013
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

The application of water reclamation system has been researched for the concentrations of Total Suspended Solid (TSS), Total Dissolved Solid (TDS), and turbidity in the effluent of waste water treatment in Suwung Denpasar. The aims of the research are to determine the effect of each stage of water reclamation, to determine the effectiveness water reclamation system and to know the quality reclaimed water. The results showed that each stage of water reclamation system can decrease the concentrations of TSS, TDS, and turbidity from effluent. The percentage of reduction of TSS, TDS, and turbidity in biological filtration system were 85.60 %, 63.75 %, and 62.78 % respectively. The pre-ozonation system were 63.82 %, 64.93 %, and 73.78 % respectively and the coagulation and membrane systems were 60.58 %, 92.48 %, dan 74.58 % respectively. The overall rate of effectivenes of waste water reclamation system was 97.94% for TSS, 99.04% for TDS and 97.52% for turbidity.

FOTODEGRADASI FENOL MENGGUNAKAN KOMPOSIT Ag/ZnO YANG DISINTESIS DENGAN METODE KOPRESIPITASI Ni Putu Diantariani; Ida Ayu Gede Widihati
Jurnal Kimia (Journal of Chemistry) Vol. 11. No.2 Juli 2017
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Penelitian ini mengenai fotodegradasi fenol dengan menggunakan komposit Ag/ZnO yang disintesis dengan metode kopresipitasi. Penelitian yang dilakukan meliputi sintesis komposit Ag/ZnO, penentuan kondisi optimum fotodegradasi, penentuan efektivitas dan laju fotodegradasi fenol dengan menggunakan fotokatalis komposit Ag/ZnO. Hasil penelitian menunjukkan bahwa metode kopresipitasi dapat menghasilkan komposit Ag/ZnO dengan persentase Ag dalam komposit sebesar 3,4%. Komposit Ag/ZnO yang dihasilkan mempunyai aktivitas fotokatalitik yang tinggi. Kondisi optimum proses fotodegradasi fenol dengan komposit Ag/ZnO yaitu menggunakan komposit Ag/ZnO sebanyak 50 mg, pH larutan fenol 7 dan diradiasi dengan sinar UV selama 8 jam. Efektivitas fotodegradasi fenol rata-rata dengan fotokatalis komposit Ag/ZnO pada kondisi optimum sebesar (82,88±0,41)%.

PROFIL BIOAUTOGRAFI DAN UJI PENANGKAP RADIKAL 2,2-DIFENIL-1-PIKRIHIDRAZIL OLEH EKSTRAK ETANOL DAUN BINAHONG (Anredera scandens (L.) Moq.) DAN FRAKSI-FRAKSINYA P. O. Samirana; D. A. Swastini; A. A. G. R. Y. Putra; I P. W. Kusuma; N. P. A. Y. Pratiwi; V. A. Setiawan
Jurnal Kimia (Journal of Chemistry) Vol.14 No.1 Januari 2020
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Free radicals are atoms or molecules that have one or more unpaired electrons and are highly reactive. Antioxidants can inhibit the excessive oxidation reaction. The leaves of binahong (Anredera scandens (L.) Moq.) are one part of plants which contain flavonoid compounds and tannins that have scientific activity as antioxidants.This study aims to determine the bioautographic profile and to test the antioxidant activity of the ethanol extract of the leaves of Anredera scandens (L.) Moq. useing 2.2-diphenyl-1-pikrilhidrazil radical capture method. The extraction process produced 19.22% yield, 14.68% (14.684 grams) chloroform fraction, 11.22% (11.224 grams) n-hexane fraction, 3.09% (3.094 grams) ethyl acetate fraction, and 23.90% (23.904 grams) n-butanol fraction. The results of bioautographic profile test using KLT densitometry method proved that ethanol extract, chloroform fraction and ethyl acetate fraction have DPPH radical capture activities. The determination of total flavonoid content found that ethyl acetate fraction contained higher total flavonoids than other fractions. In the ethyl acetate fraction, high total flavonoid level and low IC50 values were obtained, while the n-hexane fraction had low flavonoid level and high IC50 values. Keywords: antioxidants, binahong leaves, free radicals, flavonoids, IC50.

UJI AKTIVITAS ANTIBAKTERI FRAKSI KULIT BATANG NANGKA I Made Dira Swantara; Ida Bagus Gede Darmayasa; Ni Komang Ayu Kumala Dewi
Jurnal Kimia (Journal of Chemistry) Vol. 5, No. 1 Januari 2011
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (118.415 KB)

This research aims to isolate and identify antibacterial compounds in jackfruit bar husk (Artocarpus heterophyllus, Lam.). 735.55 gramc of jackfruit bar husk yielded 500,25 grams of crude methanol.extract. The methanol extract was fractionated using petroleum ether, ethyl acetate and of n-butanol and then evaporated to yield crude extract of ethyl acetate 4.11 grams of petroleum ether (yellowish), 2.11 grams of ethyl acetate extract (brownish), and 1.17 grams of n-butanol (dark green).Bioactivitigs tests to Staphylococcus aureus and Eschericia coli showed that ethyl acetate extract had the largest inhibition zone. The purification of ethyl acetate extract with column chromatography resulted a faction which was antibacterial active (faction C).Identification of faction C using Gas Chromatography Mass Spectroscopy showed 3 compounds namely methyl hexadecanoate, dioctyl hexadioate, and dioctyl-1,2-benzene dicarboxylate.

KEMAMPUAN TANAH HUTAN MANGROVE SEBAGAI SUMBER ENZIM DALAM HIDROLISIS ENZIMATIK SUBSTRAT SEKAM PADI Ni Luh Md. Widayantini; I Nengah Wirajana; Putu Suarya
Jurnal Kimia (Journal of Chemistry) Vol. 8, No. 1 Januari 2014
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Cellulase activity of mangrove forest soil from Suwung Kauh Beach in Bali has been reported in previous study. An enzymatic hydrolysis of rice husk with this mangrove forest soil as a source of enzymes was conducted. The aim of this study was to determine the ability of this mangrove forest soil as a source enzymes in hydrolyzing rice husk with and without delignification incubated in varied durations. The rice husk with and without delignification were mixed with mangrove forest soil and incubated at pH 7 and 29oC with a various incubation times of 0, 1, 2 , 3, and 4 weeks. Reducing sugar content of the results of incubation was measured by spectrophotometry using the Nelson-Somogyi method. The results of this study showed that the mangrove forest soil can hydrolyse the delignification rice husk, but could not degrade the rice husk without delignification. The highest reducing sugar content of 0,892 mg/100mL was resulted from hydrolysis of the delignification rice husk during one week. This result indicated that the mangrove forest soil as a source of cellulase had an ability in hydrolyzing the delignificated rice husk in pH 7 and 29oC incubated in one week.

¬¬¬¬¬¬¬¬¬UJI AKTIVITAS ANTIOKSIDAN EKSTRAK DAN FRAKSI KULIT BUAH MANGGIS (Garcinia mangostana L.) MENGGUNAKAN METODE DPPH N. P. A. D. Wijayanti; A. A. G. R. Y. Putra; I. A. P. Suryantari; G. A. D. Dwiantari
Jurnal Kimia (Journal of Chemistry) Vol. 12 No.1 Januari 2018
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Penelitian mengenai uji aktivitas antioksidan ekstrak dan fraksi kulit buah manggis menggunakan metode DPPH ini bertujuan untuk untuk memperoleh perbandingan nilai IC 50 antara ekstrak dan fraksi sehingga diperoleh aktivitas antioksidan yang optimum serta mengetahui golongan senyawa dari fraksi aktif. Metode yang digunakan untuk fraksinasi adalah kolom kromatografi dengan adalah pelarut bergradien n-hexana: etil asetat (9:1, 8:2, 7:3, 6:4, 5:5, 4:6, 3:7, 2:8, 1:9, 0:10). Uji pendahuluan KLT dilakukan untuk melihat kromatogram yang sama, dengan menggunakan fase gerak kloroform P:metanol (9,5:0,5) v/v sehingga diperoleh fraksi gabungan A(4 dan 5), B(6-14), C(15-22), D(23-36). Profil KLT–bioautografi aktivitas antioksidan digambarkan dengan semua spot berwarna kuning dengan latar belakang ungu dan terdapat 3 spot pada ekstrak dan fraksi A, B, dan C sedangkan 2 spot pada fraksi D. Kemudian masing-masing fraksi aktif dan ekstrak ditentukan nilai IC50 menggunakan metode DPPH. Hasil analisa data menujukkan ekstrak dan fraksi A, B, C, D menunjukkan aktivitas antioksidan dengan nilai IC50 berturut-turut adalah 27,51 µg/mL, 22,46 µg/mL, 22,72/mL, 10,71 µg/mL, 15,71µg/mL. Fraksi C merupakan fraksi yang memiliki aktivitas lebih kuat jika dibandingkan dengan ekstrak dan fraksi lainnya dengan kandungan kimia flavonoid dan polifenol yang mampu meredam radikal bebas DPPH.

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Ni Putu Diantariani

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Home Page

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Editorial Address Program Studi Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Udayana Kampus Bukit Jimbaran, Jimbaran, Bali, Indonesia

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Contact Name
Ni Putu Diantariani

Contact Email
jurnalkimia@unud.ac.id

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+628123640424

Journal Mail Official
jurnalkimia@unud.ac.id

Editorial Address
Program Studi Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Udayana Kampus Bukit Jimbaran, Jimbaran, Bali, Indonesia

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Kota denpasar,

Bali

INDONESIA