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MNJ (Malang Neurology Journal)

MNJ
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Published by Universitas Brawijaya

ISSN : 24076724 EISSN : 24425001 DOI : -

Core Subject : Science,

Neuroscience

Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.

Arjuna Subject : -

Articles 7 Documents

Search results for , issue "Vol 3, No 1 (2017): January" : 7 Documents clear

EFFECT OF ALPHA LIPOIC ACID ON MDA LEVELS AND HISTOLOGY OF BRAIN IN TYPE 1 DM Mahfud, Rania Arif; Lyrawati, Diana; Sarwono, Imam
Malang Neurology Journal Vol 3, No 1 (2017): January
Publisher : Malang Neurology Journal

Background. Diabetic neuropaty is a condition that can affect pyramidal cells and neuronal cells in theÂ hippocampus. Alpha lipoic acid is effective in pathological conditions where ROS (Reactive Oxygen Species)Â have been implicated, include in brain.Objective. To investigate effects of ALA on oxidative stress in diabetic brain of male Wistar rats.Methods. True experimental design and Posttest Only Control Group are used in this study. Thirty male rats were randomly divided into 5 groups: normal rats without ALA (NTA), diabetic rats without ALA (DTA), diabetic rats with ALA 80 mg, ALA dose 200 mg, and ALA dose 500 mg/kg/day. ALA therapy in mice conducted orally once a day. Diabetes was induced in rats by single intraperitonial injection of streptozotocin (STZ) at 60 mg/kg body weight. The content of malondialdehyde (MDA) in the brain was measured by spectrophotometeric assays. Brain structure (pyramidal cell in hippocampus) was assessed by staining with hematoxylin and eosin.Results. MDA levels in the DTA, DA80 and DA200 is greater than the levels of MDA in the NTA group, but not statistically significant at the MDA values (p = 0,260). Test-Product Moment Pearson correlation showed a weak positive relationship and not significant (r = 0,327) between the groups of NTA, DA80 and DA200 with MDA. No differences pyramidal cell structure between NTA and DTA.Conclusion. The treatment for 4 weeks with ALA had not reduced oxidative stress in diabetic brain.

BETA AMYLOID POLYCLONAL ANTIBODY IMMUNOGENICITY AS EARLY DEVELOPMENT STUDY OF EARLY DIAGNOSIS FOR ALZHEIMERâ€™S DISEASE Indra, Muhamad Rasjad; Marhaendraputro, Eko Arisetijono; Hidayat, Rudi Rakhmad
Malang Neurology Journal Vol 3, No 1 (2017): January
Publisher : Malang Neurology Journal

Background. Alzheimer's disease is a progressive neurologic disease of the brain that triggers irreversibleÂ neuronal cell loss, which can interfere with social and occupational functioning. The theory of ACHÂ (Amyloid Cascade Hypothesis) states there are deposits and misfolding of beta amyloid protein thus leadÂ to the formation of plaques and tangles in neurons cells.Objective. To identify the immunogenicity of beta amyloid polyclonal antibodies that can be developed as a first step early diagnosis of Alzheimer's disease.Methods. Rrandomized group post test only design conducted on rabbits. Blood samples were taken from rabbits that had been injected antigen once a week for 5 weeks. Variables were found in this study is the formation of beta amyloid polyclonal antibody with detection levels using dot blot and ELISA methods.Results. It has been reproduced specific polyclonal antibody beta amyloid which has been evidenced by the bond between the antigen with the antibody in a dot blot.Conclusion. The beta amyloid antibodies can be produced through production techniques with a polyclonal antibody against beta amyloid antigen induced rabbit.

DIAGNOSIS AND MANAGEMENT OF NONCONVULSIVE STATUS EPILEPTICUS (NCSE) Pramesti, Fathia Annis; Husna, Machlusil; Kurniawan, Shahdevi Nandar; Rahayu, Masruroh
Malang Neurology Journal Vol 3, No 1 (2017): January
Publisher : Malang Neurology Journal

Status epilepticus is an emergency condition in the field of neurology are often undiagnosed and are associated with high mortality and long-term disability. One type of status epilepticus is nonconvulsive status epilepticus (NCSE) in which the diagnosis of NCSE is very difficult because the clinical manifestations appear is agitation or confusion, nystagmus or bizarre behavior such as lip smacking or take goods in the air.The diagnosis was based on clinical features, especially the mental status or the disrupted of consciousness and the changes in the EEG. Diagnosis of NCSE is an important first step, which can avoid the delay in therapy in order to prevent irreversible brain damage. Treatment is by administering benzodiazepines and antiepileptic drugs, while the prognosis is determined by the etiology and associated with brain damage there.

GRAPEâ€™S LEATHER AND SEED EXTRACT (VITIS VINIFERA) IMPROVING THE FUNCTION OF WISTAR RATSâ€™ MOTOR (RATTUS NORVEGICUS) ISCHEMIC STROKE MODEL Indra, Muhamad Rasjad; Lie, Zanella Yolanda
Malang Neurology Journal Vol 3, No 1 (2017): January
Publisher : Malang Neurology Journal

Background. Grape peel and seed extract (Vitis vinifera), that has resveratrol, is one of many antioxidantsÂ that can pass through blood brain barrier and can induce release neurotrophic factor that contribute inÂ ERK 1/2 pathway mechanism in post stroke.Objective. To prove that grape peel and seed extract can regenerate neuron in brain functional.Methods. True experimental design with five groups in this research. The five groups are negative control, positive control, grape peel and seed extract 50mg/KgBW, 100mg/KgBW, and 200mg/KgBW. rats are given grape peel and seed extract in variable dose to know how extractâ€™s effect in neuron repairment. The repairment is monitored from ladder rung walking test score.Results. Range average score ladder rung walking test post stroke dan post treatment group N, K, Ra, Rb, dan Rc, were 0 Â± 0, 0.001028933 Â± 0.011664445, 0.123214286 Â± 0.019834983, 0.064744427 Â± 0.024296721, 0.03781401 Â± 0.006888803. Statistical test used Annova significantly p;0,001.Dose 50mg/KgBW is effective in repairing neuron.Conclusion. Grapeâ€™s leather and Seed extract 50 mg/kgBW can improve neuron regeneration on animal model.

PARKINSON AND STEM CELL THERAPY Gunawan, Gerry; Dalhar, Mochamad; Kurniawan, Shahdevi Nandar
Malang Neurology Journal Vol 3, No 1 (2017): January
Publisher : Malang Neurology Journal

Parkinson's disease is a neurodegenerative disorder that is progressive about the movement or control of movement. The disease often occurs in people over the age of 60 years. The etiology of Parkinson's disease caused by a combination of genetic and environmental factors. Because overall life expectancy increases, the number of people with Parkinson's disease will increase in the future. Treatment of Parkinson's disease can be used with pharmacological therapy and nonpharmacological therapy. Pharmacological therapy can use levodopa, monoamine oxidase-B inhibitors, dopamine agonists, anticholinergics and amantadine, while nonpharmacological therapies may use the method of stem cell therapy. Stem cells are master cells that have two important characteristics that can perform self-renewing through cell division and can be induced to become cells with specific functions. The aim of Stem cell therapy in Parkinson's disease to replace the damaged dopaminergic cells.

THE EFFECT OF INFECTION OF MYCOBACTERIUM TUBERCULOSIS STRAIN H37RV TOWARDS THE EXPRESSION OF TNF- Î± IN THE BRAIN Santoso, Giovani Anggasta; Sujuti, Hidayat; Hidayati, Dwi Yuni Nur
Malang Neurology Journal Vol 3, No 1 (2017): January
Publisher : Malang Neurology Journal

Background. Tuberculosis caused by mycobacterium tuberculosis. The support of these inflamated factorsÂ contained in this focus determine the prognosis of TB towards Central Nervous System. One of theÂ inflammation factors is TNF-Î±.Objective. To find the expression of TNF-Î± on the brain which are infected by M. tuberculosis.Methods. Experimental study, Wild Mus musculus to compare the group which has got infected before. The similiar study has been conducted by Laksmi Wulandari, pulmonologist. The observation towards the expression of TNF-a into a mouseâ€™s brain was done by using the imunohistokimia method. It is marked by the brown color in the core, sitoplasma and the cell with upgrading size 100x times 20.Results. This is evident that significanly corelation (P = 0.000) between independent Mycobacterium tuberculosis infection at incubation periode 8 and 16 weeks) and dependent variabel (TNF-Î± expression on brain winstar tissue that infected by Mycobacterium tuberculosis for 8 and 16 weeks).Conclusion. Strong relationship between expression of TNF-a and the M. Tuberculosisâ€™ infection.

THE DIFFERENCE LEVEL OF NUTRITIONAL STATUS WITH CLINICAL OUTCOME IN PATIENT WITH ACUTE PHASE ISCHEMIC STROKE Junaidi, Edwina Narulita Sari Agustin; Winarsih, Sri; Nasution, Tina Handayani
Malang Neurology Journal Vol 3, No 1 (2017): January
Publisher : Malang Neurology Journal

Background. Nutritional status is predictor that can affects on clinical outcome in patient with acuteÂ phase ischemic stroke.Objective. To investigate the difference of nutritional status level with clinical outcome in patient withÂ acute phase ischemic stroke.Methods. Cohort retrospective design used medical record of all registered acute ischemic stroke patientÂ in hospital Dr. Saiful Anwar Malang. 60 sample that inquired inclusion criteria and classified into three groups (the group of patient with acute phase ischemic stroke with normal nutrition status, undernutritionÂ status, and overnutrition status). Nutritional status measured with body mass index parameter and clinical outcome measured with of NIHSS score admission and NIHSS score discharge.Results. There were 60 had good clinical outcome with undernutrition status (n=20) amount 65%, normal nutrition status (n=20) amount 70% and overnutrition status (n=20) amount 60%. The difference of nutritional status level with clininical outcome in patient with acute phase ischemic stroke showed that no significantly difference (chi square, p-value=0,803).Conclusion. There is no difference of nutritional status level with clinical outcome in patient with acute phase ischemic stroke.

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