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Dental Journal (Majalah Kedokteran Gigi)
Published by Universitas Airlangga
ISSN : 19783728     EISSN : 24429740     DOI : -
Core Subject : Health,
Dentistry
The Dental Journal (Majalah Kedokteran Gigi) (e-ISSN:2442-9740; p-ISSN:1978-3728) is published by the Faculty of Dental Medicine, Universitas Airlangga. Its diciplinary focus is dental science and dental hygiene. The Dental Journal (Majalah Kedokteran Gigi) is published in English on a quarterly basis with each 50-60 page edition containing between nine and eleven scientific articles on research, study literature and case studies. Contributors to the Dental Journal (Majalah Kedokteran Gigi) included: dental researchers, dental practitioners, lecturers, and students drawn from Indonesia and a wide range of other countries.
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Articles 950 Documents
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A dilution method to increase the yield of engineered basic fibroblast growth factor Widyantoro, Indira; Hirata, Isao; Kato, Koichi
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 3 (2025): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i3.p219-223

Abstract

Background: Genetically engineered chimeric proteins have potential applications as components of dental materials and can be synthesized recombinantly in various cells, including bacteria, yeast, insects and mammals. However, increasing the yields of functionally active products remains a challenge. Purpose: This study focused on basic fibroblast growth factor fused with pentadeca (GGGGS)3 peptide as a linker and hexahistidine as an affinity tag (bFGF-PH). The objective was to enhance the yield of bFGF-PH expressed in bacteria by employing a dilution method. Methods: Escherichia coli was used to express bFGF-PH in a soluble form, which was then purified using metal chelate affinity chromatography. The protein solution was diluted 100-fold with a buffer solution to promote spontaneous refolding. Subsequently, the protein solution was concentrated using metal chelate affinity chromatography. Circular dichroism (CD) spectroscopy was used to analyze the protein’s structure, assessing its correct folding by comparing it to a reference spectrum obtained through computer-based simulation. Results: The dilution method prevented bFGF-PH aggregation, and CD spectroscopy suggested that the protein was correctly folded. As a result, a total of 3.0 mg of bFGF-PH was obtained per liter of lysogeny broth medium, which was higher than the yield achieved using the conventional method. Conclusion: The dilution method examined in this study increased the yield of correctly folded bFGF-PH.
Influence of anxiety and vital signs before dental treatment Pilco-Chicaiza, Joselyn G.; Tubon, Irvin; Salinas-Goodier, Carmen; Dalgo-Flores, Violeta; Vaca-Altamirano, Gabriela L.
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 3 (2025): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i3.p237-241

Abstract

Background: In the dental field, the anxiety that patients experience before attending a dental appointment is a factor that has increased the rates of oral diseases. This could be because patients visit the dentist less frequently and, in many cases, when they already require specialized treatment. Purpose: The purpose of this research was to determine the levels of anxiety and how they influence the vital signs of patients. Methods: The population consisted of 217 patients who received dental care at a health center and accepted the informed consent provided. The Modified Corah Dental Anxiety Scale (MDAS) was used to determine the level of anxiety. Statistical tests, such as the chi-square test, logistic regression, and odds ratio, were used to determine whether anxiety influences vital signs and dental treatment success. Results: All patients showed anxiety, which was distributed as mild (24.9%), moderate (26.7%), high (7.4%), and severe or phobic (41%). Regarding vital signs, 61.8% of patients presented some alteration in blood pressure, 56.7% had alterations in heart rate, 12.4% showed low oxygen saturation levels, and 24% presented alterations in respiratory rate. Despite these factors, 98.6% of the treatments the patients underwent were successful, and only 1.4% were affected by the influence of anxiety. Conclusion: It was found that the patients presented anxiety at different levels, which affected the typical values of vital signs. However, this situation did not affect the success of the dental treatment.
Oral health promotion on social media: Perceptions of Malaysian young adults Zaberi, Zarikh Hafizah Saqina; Mohd Nor, Nor Azlida; Kamarudin, Yasmin; Kherul Anuwar, Ainol Haniza; Hariyani, Ninuk
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 3 (2025): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i3.p224-230

Abstract

Background: Over the years, social media (SM) has become a powerful tool for communication and health promotion, enabling health professionals to connect with wider audiences in real time. However, there is a lack of qualitative data to understand end users’ perspectives on what is effective and what may require improvement. Purpose: This study aimed to explore preferences, reactions, and perceived impacts of oral health (OH) promotion on SM among Malaysian young adults. Methods: This qualitative study involved in-depth interviews with young adults aged 20–35 years. Purposive sampling was used to ensure diverse representation across several states in Malaysia. Twenty interviews were recorded and transcribed verbatim. Data were coded and analyzed thematically using Atlas.ti software. Three main themes—preferences, reactions, and perceived impacts—and seven sub-themes emerged from the analysis. Results: The young adults expressed positive views regarding OH promotion activities on SM. Most participants preferred visually appealing OH content, such as short videos and infographics, delivered in simple terms in the national language, and presented by health professionals. Although some participants identified as silent readers who did not actively engage with OH-related content, most believed that SM interventions had positively influenced their OH knowledge, attitudes, and behaviors. Conclusion: Most participants had positive perceptions of OH promotion through SM interventions, with some expressing clear content preferences. These findings may support the development of more effective OH promotion strategies in Malaysia that better align with user expectations.
Effect of tooth graft particle size on the healing process of femur defects in Wistar rat (Rattus norvegicus) Fauzia, Malianawati; Kumala, Ega Lucida Chandra; Brilliando, Okky Satria; Ayu, Devi Amelia; Napitu, Theresia Agata Winnitya
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p388-394

Abstract

Background: Teeth have potential as bone graft materials because of their organic and inorganic components that can stimulate osteoinduction, osteoconduction, and osteogenesis. An important success indicator of treatment using this graft material is the formation of osteoblast and new blood vessels in the applied area. Purpose: To investigate the number of osteoblast, osteoclast, and new blood vessels in bone healing after the implantation of tooth-derived bone graft materials measuring 20, 40, and 60 mesh. Methods: Thirty-six Wistar rats with a 2 mm defect on the right femoral dextra condile were divided into four groups. P0 (n=9) was the control group, where the defect was not filled by any material. In the other groups, the defects were filled by 20-mesh (P1; n=9), 40-mesh (P2; n=9), and 60-mesh (P3; n=9) tooth graft material. The Wistar rats were sacrificed after 2 weeks, and then the preparations were hematoxylin eosin staining. The data were analyzed using one-way analysis of variance and Tukey’s post hoc test. Results: The highest number of osteoblast was in the P3 group with a mean of 49.67, highest number of new blood vessels in the P2 group with a mean of 39.89, and highest number of osteoclast in the P1 group with a mean of 20.44. Statistical analysis showed a significant difference in the number of new blood vessels, osteoclast, and osteoblast in each group (p=0.000; p<0.05). Conclusion: Particle size differences in tooth graft material affect osteogenesis and angiogenesis in the bone healing process.
Salivary glucose levels and estimation of food intake in type 2 diabetes mellitus patients Tjahajawati, Sri; Chandra, Angievel; Rafisa, Anggun
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p336-341

Abstract

Background: Saliva, an easily collectible organic fluid, offers a noninvasive means for multiple samplings to determine salivary glucose levels, comparable to blood and potentially helpful in diagnosing and monitoring type 2 diabetes mellitus. Purpose: This research was carried out to determine the value of salivary glucose levels and food intake in patients with type 2 diabetes mellitus. Methods: This research utilized a descriptive quantitative method with a cross-sectional approach. The study population comprised type 2 diabetes mellitus patients in Bandung and Jatinangor. The samples, consisting of 27 individuals from each group—type 2 diabetes mellitus patients and healthy participants—were collected through purposive sampling. Saliva was collected using the spitting method and measured to determine salivary glucose levels (mg/dL). Food intake per day (in grams) was assessed using a semi-quantitative food frequency questionnaire and converted using NutriSurvey 2007. Results: Among the 27 participants with type 2 diabetes mellitus, salivary glucose levels were found to be ≥2 mg/dL (mean 23.47 mg/dL), whereas in the healthy group, 5 participants (18.5%) exhibited salivary glucose levels <2 mg/dL (mean 8.29 mg/dL). Most type 2 diabetes mellitus patients and healthy participants reported food intake below the Indonesian dietary recommendations. Conclusion: In our limited sample, salivary glucose levels in type 2 diabetes mellitus patients were higher compared to healthy participants. Energy intake in both groups showed similar results. Salivary glucose levels and BMI exhibited a correlation, though notably weak in this study.
Early intervention of anterior crossbite and unfavorable tongue posture with a prefabricated myofunctional appliance: A case report Asturini, Putri Ganesha; Wahono, Nieka Adhara
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p415-420

Abstract

Background: Anterior crossbite in the primary dentition may be an early indicator of a developing Class III malocclusion. Clinical findings, hereditary factors, and environmental influences, such as breathing problems and tongue posture, should be considered for early intervention. Purpose: This case report describes the early diagnosis and intervention of anterior crossbite and unfavorable tongue posture as potential risk factors contributing to a Class III growth pattern. Case: An 8-year-old girl with a history of preterm birth and a familial history of Class III malocclusion presented with the chief complaint: lower teeth in front of upper teeth. Clinical findings included anterior crossbite in the primary canines, mild lower incisor crowding, and mesiocclusion in both second primary molars. The cephalogram revealed bimaxillary retrusion (SNA = 79°, SNB = 74°), a skeletal Class I (ANB = 4°, Wits = –2 mm), and a forward tongue posture. Case Management: An ENT specialist diagnosed the patient with allergic rhinitis, without any airway obstruction. A prefabricated myofunctional appliance was prescribed to guide the eruption of permanent teeth into their ideal positions, eliminate maxillary growth restriction, and retrain tongue posture. The anterior crossbite of the primary teeth and the crowding were corrected within 9 months. Use of the appliance is ongoing until all permanent incisors have fully erupted and ideal occlusion is achieved. Conclusion: Myofunctional therapy during early mixed dentition may serve as a beneficial interceptive treatment to retrain orofacial muscles and guide the eruption of permanent teeth into an ideal occlusion.
Effect of freeze-dried platelet-rich plasma on FGF-2 and type I collagen expression in traumatic ulcers of diabetes mellitus: An in vivo study Riskayanti, Ni Putu; Radithia, Desiana; Maharani, Annissaqiella; Hendarti, Hening Tuti; Rahayu, Retno Pudji; Surboyo, Meircurius Dwi Condro; Ernawati, Diah Savitri
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p361-366

Abstract

Background: Diabetes mellitus is a chronic disease characterized by the pancreas’s inadequate production of insulin or the body’s impaired utilization of insulin, resulting in dysregulation of blood sugar levels. Diabetes mellitus causes prolonged wound healing due to decreased growth factors, including fibroblast growth factor 2 (FGF-2) and type I collagen. Purpose: This research analyzes the effect of topical administration of freeze-dried platelet-rich plasma (FD-PRP) on the healing process of traumatic ulcers in diabetic Wistar rats by increasing FGF-2 and type I collagen expression. Methods: Allogenic FD-PRP was obtained from the blood of 35 Wistar rats and 2% carboxymethyl cellulose (CMC) was added to make a gel formulation. Diabetes was induced in 30 Wistar rats using streptozotocin, followed by the creation of traumatic ulcers on the lower labial mucosa using a hot burnisher. The traumatic ulcers were then topically treated with FD-PRP gel in the treatment group and 2% CMC gel in the control group. Analysis of FGF-2 and type I collagen expression was performed through indirect immunohistochemical methods following treatment for 3, 5, and 7 days. Results: The expression of FGF-2 and type I collagen in the FD-PRP was higher than in the control group (p < 0.05). Conclusion: Topical application of FD-PRP plays an important role, especially in increasing the FGF-2 and type 1 collagen expression, in the healing process of traumatic ulcers in diabetic Wistar rats.
Difference of mandibular trabecular bone fractal dimension values on panoramic radiographs of vegetarians and nonvegetarians in Medan City Kartika, Dewi; Manja, Cek Dara; Wulandari, Pitu; Salamatusshodri; Sidabutar, Herlina
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p347-354

Abstract

Background: Vegetarians are known to be more susceptible to experiencing bone mineral density decreases compared to nonvegetarians. The trabecular bone is sensitive to any changes that disrupt the balance of bone metabolism. On panoramic radiographs, bone density can be evaluated by analyzing the fractal dimensions (FD) of the mandibular trabecular bone. Purpose: This analytical cross-sectional study aimed to assess the mandibular trabecular bone FD values on panoramic radiographs of vegetarians and nonvegetarians in Medan City. Methods: This study used a purposive-sampling technique and obtained 30 digital panoramic radiographs of vegetarians and nonvegetarians in Medan City, aged 20 to 40 years, between January and February 2023, at the radiology installation of Dental and Oral Hospital Universitas Sumatera Utara and Laboratory Clinic Pramita Medan. Fractal analysis was performed using ImageJ 1.54c software with the box-counting method. The data distribution was assessed using the Shapiro–Wilk test. The data were analyzed using an independent samples T-test. Results: The results showed that the FD values of the mandibular trabecular bone were significantly different between the two groups (p = 0.000). Conclusion: The mean FD values on the panoramic radiographs were lower in the vegetarian mandibular trabecular bone than in the nonvegetarian mandibular trabecular bone. Considerations need to be made by dentists when performing treatments related to mandibular trabecular bone surgery in vegetarians.
Linear and three-dimensional volumetric analysis of maxillary sinus in Saudi Arabian population: A cone-beam computed tomography study Singhai, Anuroop; Gharote, Harshkant; AlAbrash, Mohamad Abdulhamid; AlRajhi, Raghad Saad; Abdullah, Ranya Qasem; AlWatban, Haya Ahmed
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p325-329

Abstract

Background: The maxillary sinus presents as an important anatomical structure and understanding its radiographic anatomy is crucial for surgical procedures such as dental implant placement and extractions. Measuring the linear and volumetric dimensions of the maxillary sinus is essential for accurate treatment planning and a favorable outcome. Forensic odontology requires population-specific data for victim identification. There is therefore some need to develop a multicentric, multiethnic data registry. Purpose: The present study evaluates and compares the dimensions of maxillary sinuses and their relationship with individual height in the Saudi Arabian population, using cone-beam computed tomography (CBCT). Methods: The study subjected CBCT scans of 30 individuals to linear and volumetric analysis. The measurements were taken by two observers and mean dimensions were used for the analysis. Linear and volumetric dimensions were measured for the total sample and male (n=11) and female (n=19) categories. Results: Differences between linear and volumetric dimensions were statistically nonsignificant for males, females, and the overall sample. Correlations between left- and right-sinus dimensions were significant within females and the overall group. There was weak association between individual height and maxillary sinus dimensions. Conclusion: There is no significant variation between right and left maxillary sinus dimensions among the Saudi Arabian population. A negative correlation was observed between overall height and left maxillary sinus volume in both genders, and with right sinus volume in females only.
Confirmation of the potential mechanism of pentagamavunon-0 against temporomandibular arthritis using bioinformatic approaches Robin, Dwi Merry Christmarini; Ardhani, Retno; Novitasari, Dhania; Kusumawardani, Banun; Aulia Rahman, Faaza; Meiyanto, Edy; Purwanti, Nunuk
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p367-375

Abstract

Background: Non-steroidal anti-inflammatory drugs (NSAID) are widely used in temporomandibular joint osteoarthritis management. However, the side effects of NSAIDs on multiple organs need to be anticipated. Curcumin is known for its anti-inflammatory and analgesic potential, comparable to that of NSAIDs. In a previous study, structurally modified curcumin increased the pharmacological effect and simultaneously reduced the toxicity and side effects of curcumin. Pentagamavunon-0 (PGV-0) is one of the active components synthesized by the structure modification of curcumin. Purpose: In this study, we identify the potential target of PGV-0 on the pathogenesis of temporomandibular arthritis characterized by inflammation. Methods: We used a bioinformatics approach to compare the PGV-0 target with curcumin and diclofenac sodium as controls. We identified overlapping gene targets of bioactive compounds (PGV-0, curcumin, or diclofenac sodium) retrieved from the SwissTargetPrediction and GeneCards platforms, specifically for temporomandibular arthritis. An interaction model among targets was developed using the STRING database and Gene Ontology Panther to expound on the bioactive compound’s function on the key signaling pathway. Finally, we formulated a molecular docking prediction between the bioactive compound and the target protein marker derived from the previous analysis using Molecular Operating Environment tools. Results: This study found that curcumin and PGV-0 targeted different molecular pathways in temporomandibular arthritis compared to diclofenac sodium. Curcumin and PGV-0 shared a similar pathway to curcumin by modulating metalloproteinases (MMPs), especially MMP-9 and MMP-13. Moreover, diclofenac sodium influenced cyclooxygenase metabolism. Conclusion: In this study, PGV-0 targeted metalloproteinase in temporomandibular arthritis pathogenesis. This finding underlines the PGV-0 advantage in preventing metalloproteinase-related tissue damage in temporomandibular arthritis.

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