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INDONESIA
Indonesia Chimica Acta
Published by Universitas Hasanuddin
ISSN : 2085014X     EISSN : 26556049     DOI : -
Core Subject : Engineering,
Chemical Engineering, Chemistry & Bioengineering
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) is a peer-reviewed research journal that is devoted to the dissemination of new and original knowledge in all branches of chemistry. The result of research and development in the fields of chemistry in both experimental and theory/ computation, chemical-based technological innovations, and chemical applications in industrial fields. The journal publishes original research articles or review articles in organic chemistry, inorganic chemistry, analytical chemistry, physical chemistry, biochemistry, and environmental chemistry.
Arjuna Subject : -
Articles 142 Documents
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The Analysis of Total Phenolic Content of Siam Weed Leaf Extract (Chromolaena Odorata L.) and Antibacterial Activity Test Against Escherichia coli and Staphylococcus aureus yusriadi tamuddin; Mega Fia Lestari; Hasri Hasri; Maryono Maryono; Netti Herawati
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 15, No 1: June 2022
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v15i1.21074

Abstract

This study aims to determine the total phenolic content of extracts of water, methanol, and ethyl acetate of Siamese weed leaves and to test their bioactivity against Escherichia coli and Staphylococcus aureus. This research includes testing of active compound groups and determination of total phenolic and bioactivity tests. The total phenolic content was determined by the Folin-Ciocalteu method using a UV-Vis spectrophotometer. The results of the analysis showed that the extracts of water, methanol, and ethyl acetate were 54.0647; 44.9289; and 9.2005 mg GAE/g extract. The results of the bioactivity test of aqueous extracts were greater than that of methanol and ethyl acetate extracts where the minimum inhibitory concentration (MIC) of aqueous extracts against E. coli bacteria was at a concentration of 0.1%, while against S. aureus bacteria the bioactivity of methanol extracts was greater than that of aqueous extracts and ethyl acetate concentrations. minimum inhibitory (MIC) 0.5%. Keywords: Antibacterial, Siamese weed leaves, total phenolic.
Molecular Docking Analysis and ADMET Properties of Isoquinoline Derivatives as Potential Acetylcholinesterase Inhibitors Herlina Rasyid; Mardiyanti Riska
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 15, No 2: December 2022
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v15i2.21572

Abstract

Alzheimer’s disease (AD) are the progressive necrosis of central cholinergic neurons, followed by intra and hippocampal acetylcholine (ACh) levels. Acetylcholinesterase Enzyme (AChE) is an enzyme that is responsible for the metabolic breakdown of acetylcholine (ACh). The hydrolysis of ACh by excess amount of AChE decreases the amount of ACh in the brain, thus interfering with the normal brain functions. Modelling of seven isoquinoline derivative compounds is done by using Computer-Assisted Drug Design (CADD) such as molecular docking and ADMET properties calculation. The results obtained show that compound 13, 14, 16, and 17 have a lower binding energy about -9 kcal/mol. It can be caused due to the more electron donating groups in these compounds. ADMET properties calculation is attempted to evaluate the interaction between the four compounds (13, 14, 16, and 17) when entering the body systems. ADMET calculation result is showing that compounds 13 and 14 fulfill the parameter in adsorption properties while the others are not. Indicating that compounds 13 and 14 are potential to be Alzheimer’s drug. This result is in line with experimental study.
Development of Antioxidant Edible Films Based on Chitosan Enriched with Dragon Fruit (Polyrhizus hyloroceus) Peel Extract Abdur Rahman Arif; Fitriani B; Hasnah Natsir
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 15, No 1: June 2022
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v15i1.22004

Abstract

Formulation and characterization of chitosan-based edible film with fortification of dragon fruit peel extract (DFPE) were investigated. The effect of the addition of DFPE on the characteristics of edible films was observed through the parameters of antioxidant activity, thickness, water vapor transmission rate, mechanical properties, FTIR and biodegradation. The antioxidant activity of edible films was tested by the DPPH radical inhibition method. The results showed that increasing the concentration of DFPE increased the value, the rate of water vapor transmission, antioxidant activity and the rate of biodegradation but decreased the tensile strength. The elongation of the DFPE edible film has a better value (maximum 22,385 ± 7,196%) compared to the control edible film (14,545 ± 1,208). This study shows that the addition of DFPE into chitosan-based edible films can be developed as active packaging.
Quality Test of Corn Flour from Pulut Corn Cob Waste ( Zea mays ceratina. L) by Fermentation mirnawati mirna
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 15, No 2: December 2022
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v15i2.18405

Abstract

Pulut type corn or waxy corn has been developed in several areas in South Sulawesi. From year to year, the productivity of corn pulut has increased, this also shows that agricultural waste production has also increased. The agricultural waste produced by corn cobs. The purpose of this study was to determine the processing of corncob waste into cornflour and to determine the characterization of the quality of cornflour, especially microbial contamination based on SNI standards. Methods: water content using a gravimetric method, ash content using a gravimetric method, microbial contamination test using ALT method of 25-250 colonies/gram counted, and analysis of mold and E. coli bacteria. The results showed that the ash content was 0.0766%, 17.49 % moisture content, 17.49% protein content, ALT 1.9 x 106, mold analysis of 10,4 x 102 colonies/gram, and analysis of E. coli bacteria amounting to 8,1 APM / g and Bacillus cereus with a resistance value of <1.0 x 102coloni/g (negative value) indicates that it does not meet the SNI standard.
Optimization of FeSO4 Molarity for Synthesis of Prussian Blue Pigment from Iron Sand from Sunur Beach Estuary, Pariaman Nafis Sudirman
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 15, No 2: December 2022
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v15i2.20087

Abstract

The objective of this research was to see how the molarity of Iron(II) sulfate (FeSO4) solution affected the coloring of the Prussian blue pigment produced, to find the best synthesis conditions. The coprecipitation methods were used to synthesize Prussian blue from FeSO4 and K3[Fe(CN)6] solutions. The molarity of iron(II) sulfate (FeSO4) was varied to 0.005 M, 0.0025 M, and 0.00125 M in this research, with the resulting products referred to as K1, K2, and K3. The UV-Visible spectrophotometer was used to analyze the produced pigment. The molarity of Iron(II) sulfate (FeSO4) impacts the final Prussian blue pigment, as observed in the experiment with variations in the molarity of FeSO4. The optimum color of Prussian blue, with a peak near-standard UV-Visible spectra at 686 nm, was produced at 11.85 mM FeSO4 molarity, which was very much by the standard absorbance wavelength Prussian blue pigment.
The Effect of Titanium Dioxide Nanoparticle Composites as an Antibacterial in Synthesizing Polyurethane Biopolymers andibudirohmi andi rahmi
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 15, No 2: December 2022
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v15i2.24324

Abstract

Abstract. In the health sector, the use of polyurethane (PU) as a basic material for the manufacture of medical devices also creates problems related to local and systemic infections. One of the most appropriate ways to overcome this problem is to add titanium dioxide (TiO2) nanoparticles to the urethane polymer to produce a biodegradable polymer and bacterial decontamination. In synthesizing decontaminating polyurethane bacteria, several characterization techniques were carried out, including polymer test, namely strain and stress, functional group analysis using Fourier Transform Infra-Red (FTIR), and antibacterial test. Based on the results of the FTIR test analysis, shows a change in the functional group. At wave number 1724.36 cm-1, the N-H functional group appears, this absorption is the absorption of the urethane group and TiO2 is in the range of 513.07 cm-1. Mechanical properties test showed strain (28.92 - 21.88% GL) and young modulus at intervals (5,484-3,268 MPa). and the antibacterial test showed that the inhibitory power of test samples A1 and A4 with resistance diameters of 8mm and 8mm proved to be very effective in killing E.Coli bacteria while A1¹, A2¹, A3¹, and A4 killed could not kill S. Aureus bacteria inhibitors. The characterization results show that the polyurethane biopolymer can be used as a medical device with bacterial decontamination properties.
Synthesis Optimation and Characterization of κ-Carrageenans from Eucheuma cottonii Nurlaida Nurlaida; Husna Saadatul; Aswar Aswar
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 16, No 1: June 2023
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v16i1.25487

Abstract

The objectives of the study are to determine the best condition for Eucheuma cottonii, obtained from Bantaeng regency, to produce κ-Carrageenan and to determine the characteristics of the carrageenan. Concentration of NaOH and KCl that are used to extract carrageenan, extraction time, and precipitation time are some variables that are measured for carrageenan extraction. After the best extraction condition is found, then the next step is characterization of the produced carrageenan. The best combination found to extract the highest amount of carrageenan are NaOH 4%, extraction time of 1 hour, KCl 6%, and precipitation time of 1 hour as well. For the characterization of ash, fiber, sulfate content, and viscosity are 2.24%; 0.65%; 0.35%; and 5 cP respectively.
A Phytochemical Profile and Acute Toxicity of Meistera aculeata (Roxb). Skornick. & M.F. Newman Fruits (Zingiberaceae) Hendrisno Hendrisno; Megawati Megawati; Agusriyadin Agusriyadin; Sabandar Carla Wulandari
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 16, No 1: June 2023
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v16i1.26638

Abstract

Meistera aculeata (Roxb). Skornick. & M.F. Newman belongs to the ginger family (Zingiberaceae) and locally known as ‘Susube’ by natives of Konawe district of Southeast Sulawesi. M. aculeata is an endemic plant and its fruit has been consumed by the locals. Until today, study on chemistry and biological activity aspects of M. aculeata has yet investigated. Hence, this research aimed to identify phytochemical contents and acute toxicity of M. aculeata fruits extracted using ethanol as the solvent. Phytochemical screening showed the accumulation of alkaloids, tannins, flavonoids, terpenoids, and saponins in the ethanol extract of M. aculeata fruits. Meanwhile, the Brine Shrimp Lethality Test (BSLT) revealed that ethanol extract of M. aculeata fruits has a weak acute toxicity (LC50 683,9 ppm) when compared with potassium dichromate as the positive control of the assay (LC50 8,3 ppm). The study concluded that M. aculeata fruits could be used in the development of drugs from natural sources.
Antiseptic Liquid Soap from Corn Oil (Zea mays L) and Aloe Vera Extract with The Variation of SLS (Sodium Lauryl Sulfate) Neny M Aras; Santi Santi; Nur Riska Amaliah; Isma Isma; Yusriadi Yusriadi
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 16, No 1: June 2023
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v16i1.26653

Abstract

Liquid soap is a cleaning agent made from a chemical reaction between potassium hydroxide and fatty acids from vegetable oils and animal fats. This study aims to determine the quality and formulation used in making antiseptic liquid soap from aloe vera with the variation of Sodium Lauryl Sulfate (SLS). Previous research on making liquid soap from aloe vera produced soap with free alkaline levels and a high pH and still lacking foam. In this study, liquid soap was made by adding variation of SLS (Sodium Lauryl Sulfate), as a foam booster and citric acid as a substance that can control the pH of the soap. The resulting liquid soap product was analyzed for pH value, foam stability, free alkali content/FFA, viscosity, density, ALT and bacterial test. The results showed that each soap formula produced match with the requirements of SNI 2588-2017 and the best formulation is the F2.
Synthesis of 3-(3,4-diacetoxyphenyl)acrylic acid and 4-(oxo-3-(piperidin-1-yl)pro-1-en-1-yl)-1,2-phenylendiacetate from 3-(3,4-dihydroxyphenyl)acrylic acid and their toxicity test by Brine Shrimp Lethality Test method Musrifah Tahar; Nunuk Hariani Soekamto
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 16, No 1: June 2023
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v16i1.26898

Abstract

Derivatization 3-(3,4-dihydroxyphenyl)acrylic acid to 3-(3,4-diacetoxyphenyl)acrylic acid (1) and 4-(oxo-3-(piperidin-1-yl)pro-1-en-1-yl)-1,2-phenylendiacetate (3) and its toxicity test has been successfully carried out. Derivatization was carried out through acetylation, chlorination, and amidation reactions. The acetylation reaction was carried out using acetic anhydride in pyridine solvent at room temperature for 4 hours to produce compound 1 as a white amorphous solid with m.p. 181-183oC and yield of 85.68%. The chlorination reaction was carried out using thionyl chloride in toluene solvent at the reflux temperature of 79°C for 4 hours and continued with in situ amidation using piperidine in dichloromethane solvent at room temperature to produce compound 3 as a white crystal with m.p. 139-141oC and yield of 39.45%. The toxicity test of the two compounds against Artemia salina Leach shrimp larvae using probit analysis showed that compounds 1 and 3 were toxic with LC50 values ​​of 8.919 μg/mL and 84.511 μg/mL, respectively. This data shows that the acetylation of 3-(3,4-dihydroxyphenyl)acrylic acid compound (LC50 = 46.50 μg/mL) increases the toxicity to larvae of Artemia salina Leach shrimp. Keywords: 3-(3,4-dihydroxyphenyl)acrylic acid, 3-(3,4-diacetoxyphenyl)acrylic acid, 4-(oxo-3-(piperidin-1-yl)pro-1-en-1-yl)-1,2-phenylendiacetate, Artemia salina Leach.

Page 12 of 15 | Total Record : 142

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