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INDONESIA
Indonesia Chimica Acta
Published by Universitas Hasanuddin
ISSN : 2085014X     EISSN : 26556049     DOI : -
Core Subject : Engineering,
Chemical Engineering, Chemistry & Bioengineering
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) is a peer-reviewed research journal that is devoted to the dissemination of new and original knowledge in all branches of chemistry. The result of research and development in the fields of chemistry in both experimental and theory/ computation, chemical-based technological innovations, and chemical applications in industrial fields. The journal publishes original research articles or review articles in organic chemistry, inorganic chemistry, analytical chemistry, physical chemistry, biochemistry, and environmental chemistry.
Arjuna Subject : -
Articles 142 Documents
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Comparative Study of Synthesis and Characterisation of Complex Compounds of Co(II) and Fe(III) Metal Ions with Ligands N-Etilisopropyldithiocarbamate and Its Application as an Additive in Lubricants Dian , Ranggina; Yunus, Muhammad Arham; Afrianti S, Lamuru; Indah , Raya
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 17, No 1: June 2024
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v17i1.34606

Abstract

The aim of the synthesis and characterization of Co(II) and Fe(III) metal ions with N-Ethylisopropyldithiocarbamate ligands is to produce dithiocarbamate complex molecules that can be utilized in pharmacology, industry, agriculture, and chemistry in the future. The in situ method, which involves reacting secondary amines with carbon disulfide in ethanol solvent (dithiocarbamate ligands) and metals dissolved in ethanol solvent (metal ions), was used to synthesize complicated chemicals. Melting point, conductivity value, FT-IR, and UV-Vis analyses were used to characterize complicated compounds. The resulting Co(II)-N-Etilisopropyldithiocarbamate complex compounds are black in color and Fe(III)-N-Ethylisopropyldithiocarbamate are dark green, with a yield of 64.12% and 41.87%, respectively, with different conductivity values,≠0 (electrolyte compound). From the results of the FT-IR analysis, the presence of Co-S bonds was identified at the absorption band of 362.62 cm-1 and Fe-S at the absorption band of 354.90 cm-1. Maximum wavelength absorption UV-Vis, Co(II) (λmax = 330 nm) > Fe(III) (λmax = 310 nm). Characterization results based on the measurement of kinematic viscosity values, Fe(III)-N-ethylisopropyldithiocarbamate complex compounds are more effective as the additives in lubricants than Co(II)-N–Ethylisopropyldithiocarbamate at a temperature of 100 oC.
Synthesis of Gold (Au) Nanoparticles by using Bioreductor of Cocoa (Theobroma cacao L.) Rind Extract and It's Antibacterial Activity Test Sabir, Fabriani; Arif, Abdur Rahman; Kasim, Syahruddin
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 17, No 2: December 2024
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v17i2.33204

Abstract

Research on the Synthesis of Gold (Au) Nanoparticles by using Bioreductor of Cocoa (Theobroma cacao L.) Rind Extract and Its Antibacterial Activity Test has been done. This Green Synthesis method uses methanol as a solvent to extract organic compounds in the cocoa rind that function as bioreductants. The results of the synthesis were continued by testing its activity as an antibacterial. The form of gold nanoparticles can be confirmed after 30 minutes of stirring. The characterization of gold nanoparticles was carried out using a UV-Vis spectrophotometer, Fourier Transform Infrared (FTIR), X-Ray Diffraction (XRD), and Scanning Electron Microscopy-Energy Dispersive X-Ray (SEM-EDX). Based on the analysis of UV-Vis spectrophotometer, the maximum wavelength was at 553 nm with an absorbance value of 0.164. The FTIR results indicate the presence of a hydroxyl group that acts as a metal ion reducing agent so that it is not charged, while the results of the XRD analysis confirm that the gold nanoparticle crystals are Face Centered Cubic (FCC) and based on the Scherrer approach the particle size distribution has an average diameter of 6.303 nm. The SEM-EDX results showed that the gold nanoparticles had a spherical shape and were located in the M electron shell. The gold nanoparticles had an inhibitory zone of 8.9 mm in Pseudomonas aeruginosa and 7.6 mm in Bacillus subtilis bacteria.
In Silico Insight of Natural Compounds in Ageratum Conyzoides L as Anti Breast Cancer Candidate by Molecular Docking Against EGFR Tjitda, Putra Jiwamurwa Pama; Wahyuningsih, Tutik Dwi; Nitbani, Febri Odel
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 17, No 2: December 2024
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v17i2.35928

Abstract

The regulation of proliferation and apoptosis in cancer cells, particularly breast cancer, hinges on the control exerted by the epidermal growth factor receptor (EGFR). Naturally derived EGFR inhibitors from natural compounds show significant potential for future advancements. This study aims to assess the efficacy of active compounds found in Ageratum Conyzoides L as EGFR inhibitors. Evaluation involved molecular docking studies of flavonoid, chromene, terpene, sterol, and acid compounds against EGFR using PDB ID 1m17. Additionally, the ADMET properties and drug-like characteristics of the most promising compounds were characterized. Findings reveal that compound C2 (fisetin) exhibits the most favorable binding energy of -8.9 kcal/mol. Fisetin establishes crucial interactions, particularly with the catalytic site at Met765 of the hinge protein. Fisetin also engages in hydrophobic interactions in regions I and II, involving Val702, Leu694, and Leu820. ADMET profiling of fisetin demonstrates favorable attributes, suggesting its potential as a promising anticancer agent based on drug-likeness assessments.
The Effectiveness of Bulk Polymerization and Precipitation Polymerization on the Adsorption Capacity of Pb(II) Metal Ions Using Ionic Imprinted Polymer (IIP) Hayu Anggraini, Hayu Anggraini; Sianita, Maria Monica
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 17, No 2: December 2024
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v17i2.37146

Abstract

Lead (II) metal is a heavy metal that has high toxicity and is easily decomposed, causing long-term adverse effects on the environmental and human health. Therefore, it is important to develop a separation method to effectively detect lead (II) metal ions in water so that it can reduce adverse effects on humans, organisms and aquatic biota. Lead ion imprinted polymer (Pb-IIP) was developed to detect Pb(II) metal ions in water. The commonly used polymerization methods are bulk and precipitation polymerization, therefore this study aims to determine the effectiveness of the adsorption ability of Pb(II) metal ions in water using bulk polymerization and precipitation polymerization methods. The IIP was successfully prepared using Pb(NO3)2 as a template, methacrylic acid (MAA) as a functional monomer, ethylenegycoldimethacrylate (EGDMA) as a crosslinker, benzoyl peroxide (BPO) as an initiator and etylenediaminetetraacetic acid (EDTA) as a chelating ligand. Based on the study, the IIP polymerization method using precipitation polymerization produces adsorbents that have good quality, high adsorption capacity and small particles even though both methods are selective for Pb(II) metal ions. The adsorption capacity of precipitation polymerization is (56,23 mg/g) and the adsorption capacity of bulk polymerization is (46,24 mg/g).
An Antioxidant and Toxicity Test as Anticancer of Jewawut Extract (Setaria italica L.) Local Varieties of West Sulawesi Tahar, Musrifah; Wahid, Masyitha; Hakim, Sufyan 
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 17, No 2: December 2024
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v17i2.40506

Abstract

Jewawut (Setaria italica L.) is a local plant that is widely found and consumed by the people of West Sulawesi. This cereal plant has various benefits, one of which is as an anticancer. So this study aims to determine the antioxidant and anticancer potential of methanol extract of Jewawut (Setaria italica L.). This research includes phytochemical test of secondary metabolites, antioxidant activity test with 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and identification of anticancer potential based on toxicity test with Brine Shrimp Lethality Test (BSLT) method. The results showed that the methanol extract of Jewawut (Setaria italica L.) contained secondary metabolite compounds including alkaloids, flavonoids, tannins, saponins, steroids and terpenoids. The extract has very weak antioxidant activity with an IC50 value of 4104.63 ppm and has potential as an anticancer with a toxicity value (LC50) of 41.65 μg/mL which means the toxicity is very strong.
Exploring the Role of HEPES Buffer in the Synthesis and Characterization of Lanthanide-Nucleotide Complexes Santi, Santi; Amirah; Putri Salsabila, Nabila
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 17, No 2: December 2024
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v17i2.41123

Abstract

Lanthanide-nucleotide complexes are of interest due to their unique luminescent properties and have potential applications in a wide range of fields from medical imaging to environmental sensing. Given the sensitive nature of biochemical reactions, the choice of reaction conditions including pH plays a crucial role in determining the synthesis yield. One of the buffering agents that has gained prominence in this synthetic methodology is HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid). This study investigates the role of HEPES buffer in maintaining stable pH conditions, which are critical for the successful formation of lanthanide-nucleotide complexes. Terbium complexes with adenosine triphosphate ligands have been successfully synthesized with a maximum reaction time of 60 minutes. The complex was characterized using a UV-Vis spectrophotometer where the absorption peak at a wavelength of 257.5 nm indicates the occurrence of π-π* electron transitions. There is an absorption band at a wavelength of 349 cm-1 in the TbATP complex using an FT-IR spectrophotometer, this can be associated with the vibration of the Tb-N bond, which confirms the formation of a terbium complex with adenosine triphosphate. A sharp infrared absorption band at a wavelength of 630 cm-1 indicates the presence of vibrations of the O-H bond bound to the terbium ion, namely the formation of a Tb-OH complex bond, indicating that the phosphate group in ATP is involved in the formation of the complex.
Development of a Multi-epitope Vaccine against Mycobacterium tuberculosis DNA Protein B: An Immunoinformatics-Driven Strategy Nur Indra, Asep Iin; Ashari, Fatkhurrohmah; Aprilia, Keisha Nur Gita; Anggraeni, Putri; Silaban, Veronika Desmita; Widiatmoko, Egi Gussuma
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 17, No 2: December 2024
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v17i2.41408

Abstract

Vaccination is a primary strategy in the prevention of tuberculosis (TB), a serious infectious disease caused by Mycobacterium tuberculosis. This study aims to design a novel multiepitope vaccine using the DNA B protein from M. tuberculosis through immunoinformatics and molecular dynamics approaches. The design process begins with the identification of potential epitopes from the DNA B protein using various bioinformatics tools to predict both B and T cell epitopes based on their immunogenic properties. After epitope identification, the selected epitopes are combined into a multiepitope vaccine construct to enhance a broad and specific immune response. The three-dimensional structural model of the vaccine construct is predicted and validated using molecular modeling techniques. Molecular dynamics simulations are performed to evaluate the stability and interactions between the multiepitope vaccine and the immune system, providing insights into the expected immune response. Simulation analysis indicates that the vaccine construct is stable and capable of eliciting a strong immune response. In silico testing was conducted to predict the vaccine's affinity for Major Histocompatibility Complex (MHC) receptors and its ability to induce T and B cell immune responses. The results of this analysis demonstrate that the designed multiepitope vaccine has high potential to trigger an effective immune response against Mycobacterium tuberculosis. This study provides a solid foundation for further development and evaluation of the vaccine in in vivo studies to determine its clinical safety and efficacy
Determination of Total Flavonoid Content, Antioxidant and Antibacterial Activities of Yellow Root (Fibraurea tinctoria L.) Yansyah, Rudi
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Vol. 18 No. 1 (2025): Volume 18, No 1: June 2025
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v18i1.37088

Abstract

Abstract. Yellow root (F. tinctoria) is one of endemic plants from Kalimantan and commonly used by local society as a traditional medicine. Alkaloids are the main chemical constituent and has been reported widely. Unfortunately, other secondary metabolites such as flavonoids and terpenoids are scarce. Total flavonoid contents was determined by a spectrophotometric method, DPPH method was conducted for antioxidant activity, and antibacterial activity against Staphylococcus aureus and Escherichia coli was measured by the well diffusion method. The result showed that methanol fraction has the highest total flavonoid content with 52.23 ± 0.00781 mg QE/g extract. Methanol extract, fractions of methanol and ethyl acetate exhibited weak antioxidant activity with IC50 values of 472.5; 390.6; and 369.3 mg/L, respectively. The antibacterial activity of the three samples against Staphylococcus aureus at a concentration of 50 µg/µL showed a weak-medium category.
Pharmaceutic Production of Microcrystalline Cellulose (MCC) as Tablet Excipient from Sugarcane Bagasse Putri, Elisa
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Vol. 18 No. 1 (2025): Volume 18, No 1: June 2025
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v18i1.42631

Abstract

Waste from sugarcane ice milling in Langsa is abundant without processing, so it is necessary to think about its more useful utilization without causing environmental pollution. Sugarcane bagasse is one of the samples that is rich in cellulose, so it has the potential to be developed into cellulose microcrystals that can be used as a filling material in tablet making. The preparation of bagasse MCC was carried out in 2 (two) stages, namely the α-cellulose isolation stage (including delignification, swelling, and bleaching processes), and the second stage is the hydrolysis of α-cellulose using 2.5 N HCl solvent to obtain bagasse MCC. From the results of this study, the sugarcane bagasse MCC produced has physical characteristics in the form of hablur, white in color, odorless, and tasteless, has a moisture content of 3.78%, with a pH of 7, a permanganate content of 2.54% and a size of 33.843 μm. So it can be concluded that the sugarcane bagasse MCC produced has met the tablet excipient requirements as required by the Handbook of Pharmaceutical Excipients.
The Toxicity and Cytotoxicity Test of Anticancer Peptides Isolated from Symbiotic Bacteria Asmi, Nur; Ahmad, Ahyar; Natsir, Hasnah; Karim, Harningsih; Muhakim, Ali; Khairunnur, Siti
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Vol. 18 No. 1 (2025): Volume 18, No 1: June 2025
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v18i1.43925

Abstract

The purpose of this research was to evaluate the toxicity and cytotoxicity of the fragment peptide from symbiotic bacteria in the lung cancer LK-2 cell line, compared normal M5S cell line. Protein hydrolyzates were separated using Molecular Weight Cut Off (MWCO) to isolate peptide fragments. Fragments were categorized as ≤ 5 kDa, > 5-10 kDa, and > 10 kDa to evaluate their toxicity through the Brine Shrimp Lethality Test (BSLT) method and to study cytotoxicity effects and proliferation in LK-2 lung cancer cells against normal M5S cells. MTT assay was used to analyze the percentage of living cells and cell growth. The Selectivity Index (SI) equation was applied to determine selectivity. Findings indicated that the peptide fragment ≤ 5 kDa had the highest toxicity, with an LC50 of 8.15 µg/ml. The number of LK-2 cells that died increased when exposed to peptide fragments of sizes ≤ 5 kDa, > 5-10 kDa, and > 10 kDa over 16 hours. Moreover, cell growth in LK-2 cells decreased after 16 hours, while there was no significant decline (P < 0.05) in M5S cells compared to the controls. The peptide fragments with molecular weights ≤ 5 kDa and > 5-10 kDa demonstrated the highest selectivity, resulting in an SI value of 3. These results suggest that the selected peptide fragments may serve effectively as anticancer agents. This study highlights the potential of peptides from symbiotic bacteria as possible treatments for cancer, particularly lung cancer.

Page 14 of 15 | Total Record : 142

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