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INDONESIA
Indonesia Chimica Acta
Published by Universitas Hasanuddin
ISSN : 2085014X     EISSN : 26556049     DOI : -
Core Subject : Engineering,
Chemical Engineering, Chemistry & Bioengineering
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) is a peer-reviewed research journal that is devoted to the dissemination of new and original knowledge in all branches of chemistry. The result of research and development in the fields of chemistry in both experimental and theory/ computation, chemical-based technological innovations, and chemical applications in industrial fields. The journal publishes original research articles or review articles in organic chemistry, inorganic chemistry, analytical chemistry, physical chemistry, biochemistry, and environmental chemistry.
Arjuna Subject : -
Articles 142 Documents
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Molecular Docking of Chemical Compounds from n-Hexane Extract of Moringa oleifera Seeds with E.coli and S.aureus ATP Synthase Subunit C Fredy Saudale; Apriono Sutiono; Luther Kadang; Early G. Boelan; Origenes B Kapitan
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 13, No 2: December 2020
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v13i2.11536

Abstract

The development of new antibiotics is an urgent need amidst the reported increase in bacterial resistance. The n-hexane extracts of Moringa oleifera seeds have been known to have antibacterial effects against E.coli and S.aureus. However, the mechanism of inhibition and the protein from these bacteria targeted by the chemical compounds from n-hexane extracts of Moringa seeds remains elusive. ATP synthase subunit c (ATPase c) plays an important role in the synthesis and hydrolysis of ATP providing energy for bacterial growth. It is an attractive for the new antibiotic development. This study aims to computationally study the interaction between the chemical compound from n-hexane extract of Moringa seeds and ATPase c from E. coli and S. aureus that may shed the light on their inhibitory potentials using molecular docking method. The compound trans-9-octadecenoic acid shows the highest affinity energy with ATPase c from E. coli (-4.1 kcal/mol). Meanwhile, 9-cis-octadecanoic acid and glycerol-1,3-dioctadecanote show the highest interaction (-4.3 kcal/mol) with ATPase c from S.aureus. Nonetheless, these interaction energies are lower than a positive control Tomatidine on ATPase c E.coli (-6.9 kcal/mol) and S. aureus (-6.2 kcal/mol). Further in vitro assays are needed to validate their potential as novel antibacterial candidates.
Dengue Antiviral Activity of n-Hexane and Acetone Extract of X. testudinaria’s Rhizome from Spermonde Islands, South Sulawesi Nur Awaliah
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 13, No 2: December 2020
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v13i2.11597

Abstract

DHF is a disease that continues to spread in Indonesia and often causes death to sufferers. DHF is caused by the dengue virus which is transmitted by A. aegypty and A. albopictus mosquitoes. Even though there is a vaccine available in Indonesia, its use is still very limited and requires a very large cost, so a solution is needed to find a drug that is effective in inhibiting the dengue virus. The research conducted was related to the assessment of dengue antiviral activity from the sponge extract X. testudinaria originating from the waters of the Spermonde Islands, South Sulawesi. The research stage included the extraction process with the maceration method using alternating n-hexane and acetone solvents, the extract phytochemical test, the extract's toxic activity test against vero cells and the dengue antiviral activity test (DENV2) from the extract. The results of the study obtained evidence that the extract contains steroid and flavonoid compounds. The extract of n-hexane and acetone X. testudinaria had toxic activity against vero cells where the acetone extract with a lower CC50 value of 2.1 μg/mL had stronger toxic properties to cells compared to n-hexane extract with a CC50 value of 21 μg/mL. While the n-hexane extract had very strong inhibitory activity against dengue virus with a low IC50 value of 3.11 μg / mL, and stronger than acetone extract with an IC50 value of 73.1 μg/mL. The SI values ​​of n-hexane and acetone extract respectively showed that the n-hexane extract was more selective with an SI greater than 3, namely 6.75 compared to acetone extract with SI 0.028. This means that the n-hexane extract has more potential to be used as an antiviral drug than the acetone extract
Biosynthesis and Characterization of Silver Nanoparticles Using Cacao (Theobroma cacao L) Skin Extract Irham Pratama Ridwan
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 13, No 2: December 2020
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v13i2.11602

Abstract

Synthesis of silver nanoparticles has been successfully carried out using extracts of cocoa pod (Theobroma cacao L). Silver nanoparticles were synthesized using the green synthesis method. Biosynthesis was carried out by mixing 1 mM 40 ml AgNO3 solution with 0.5 ml of cocoa pod husk extract, stirring for 1 minute, after a few minutes the solution will change color from yellowish to dark colored, the color change that occurs shows the ion reduction process so that silver nanoparticles are formed. When silver nanoparticles are formed, the UV-Vis absorption spectrum is at a wavelength between 400-500 nm. Characterization and stability using a UV-Vis spectrophotometer with a time variation of 4 hours, 24 hours, 3 days and 7 days of reduction time. With increasing time the resulting long wave gets higher and bigger the size of the aggregation. Sample (1) shows 446, 446, 446, 447.5 nm, obtained a maximum wavelength of 447.5 nm, repeated repetition is labeled sample (2) shows 447, 446.5, 450, 449.5 nm with a maximum wavelength of 495 , 5 nm seen from the wavelength value tends to be stable so there is no need to add a stabilizing agent. The absorbance value increases with time, the greater the absorbance value, the more nanoparticles formed
A Synthesis and Characterization of Gold Nanoparticles Using The Bioreductor Bay Leaf (Syzygium polyanthum) Muhammad Fathir Hasyim
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 13, No 2: December 2020
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v13i2.11798

Abstract

Bay leaf extract has been used successfully in the synthesis of gold nanoparticles. This is indicated by the color change from the gold solution which is yellow to burgundy after the addition of the bay leaf extract and the resulting wavelength is in the range of 500 - 550 nm which indicates that gold nanoparticles have been formed. The growth and stability of the resulting gold nanoparticles were observed using UV-Vis Spectroscopy. Particle Size Analyzer (PSA), Scanning Electron Microscope (SEM), X-Ray Spectrometer Diffractometer (XRD) and Fourir Transform InfraRed (FTIR) were used to characterize Nanoparticles are produced before they are made into blood sugar nanosensors. The maximum wavelength was obtained at a wave of 533 nm using a UV-Vis spectrophotometer. The particle size was determined using PSA with average particle a size distribution of 15.49 nm.
The Comparison of Three Different Methods on Extraction of Cigarette Butt as Natural Insecticide Syadza Firdausiah; Firdaus; Hamdayanty; Taufik Hidayat; Muhammad Alfliadhi
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 13, No 2: December 2020
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v13i2.11812

Abstract

Background: Cigarette butt could be used as an insecticide due to the present of alkaloid compounds in high yield, especially nicotine and eugenol. To maximize the extraction process of cigarette butt, the study related to the effect of extraction method to the effectivity of extraction process should be performed. Objective: The main purpose of this study was to identify the effect of extraction methods on the total yield and the nicotine and eugenol content of the extract of cigarette butt. Methods: In this study, maceration (CB-1), soxletation (CB-2), and microwave-assisted extraction (MAE) (CB-3) methods were conducted and compared the yield and the nicotine and eugenol content of the extracts by LC-MS. Results: The results showed that the extract CB-3 has the highest yield (26,77%), which compared to CB-1 and CB-2, which are 11.72% and 14.56%, respectively. Furthermore, the nicotine content of all extracts are 54.15%, 36.43%, and 48.51% for extract CB-1, CB-2, and CB-3, respectively, while eugenol content of CB-1, CB-2, and CB-3 are 5.09%, 6.35%, and 8.41%, respectively. Conclusion: Based on the results, it can be concluded that MAE method was more effective to extract the cigarette butt compared to maceration and soxletation method. This method was also reduced the time consuming and the volume of the solvent used in the extraction process which follow green chemistry rule. Thus, MAE method is potential to be used in extraction process of cigarette butt in order to produce a biopesticide.
Synthesis and Inhibitory Activity Evaluation of N-butyl-3(4-hydroxyphenyl)acrylamide Against Receptor Tyrosine Kinases (R.T.K.s) hmuddin, amiruddin
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 14, No 1: June 2021
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v14i1.12111

Abstract

Cinnamic acid amide derivatives play an essential role as anticancer agents because of their excellent inhibitory activity against tyrosine kinases. Tyrosine kinases are enzymes that are directly involved in the development of cancer cells. Therefore, to develop a new class of inhibitors, the amide derivative of cinnamic acid has been synthesized from p-coumaric acid to give N-butyl-3-(4-hydroxyphenyl)acrylamide (5). The synthesis stages include acetylation, chlorination, amidation, and deacetylation. The products were characterized by T.L.C. test, melting point determination, FT-IR, 13C-NMR, and 1H-NMR spectroscopy. The inhibitory activity of compound 5 was evaluated against the eight receptor tyrosine kinases (R.T.K.s) using the bioluminescent A.D.P. detection method. The results showed that compound 5 was obtained as a white crystalline solid with a melting point a 140-142°C and 95.45% yield. Of the eight R.T.K.s used, compound 5 only showed feeble inhibitory activity against the three R.T.K.s, namely c-MER, FLT1, and F.M.S., with inhibition percentages are lower than erlotinib. Thus, compound 5 has no potential as a tyrosine kinase enzyme inhibitor.
Antioxidant Activity from synthesis product of Hydoxycinamic Acid Derivative.: Antioxidant Activity from synthesis product of Hydoxycinamic Acid Derivative. Novia, Ni Kadek Ayu
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 14, No 1: June 2021
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v14i1.12271

Abstract

Hydroxycinamic acid derivatives have potential as antioxidants. The synthesis of hydroxycinamic acid derivatives from p-coumaric acid with hexylamine yielded 4-(3-hexylamine-3-oxopropenyl) phenyl acetate compounds. Synthesis is carried out through the acetylation, chlorination, and amidation reaction stages. Amidation products were characterized by TLC test, melting point determination, FT-IR spectroscopy. The antioxidant activity was tested using 1,1-diphenyl picrylhydrazyl (DPPH). The results showed that the compound obtained was a white crystalline solid (yield 15.59%, melting point 104 - 106 °C). Compound 4 only shows very weak antioxidant activity with an IC50 value of 11453.03 μg / mL%. Thus compound 4 has no potential as an antioxidant.
Esterification Reaction of Glycerol to The Derivatives Catalyzed by Amberlyst 36 Aisyah, Aisyah; Rezeki, Rezeki; Firnanelty, Firnanelty; Abubakar, A. Nur Fitriani; Zahra, Ummi; Patunrengi, Iswadi Ibrahim; Nur, Arfiani
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 14, No 1: June 2021
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v14i1.12837

Abstract

Several studies reported the use of acid catalysts of esterification of glycerol to acetin derivatives and amberlysts are no exception. However, among these strong sulfuric acid catalysts, amberlyst 36 is still rarely used and hence challenging to investigate. This study aimed to determine the yield and the selectivity of the esterification reaction of glycerol into acetine derivatives using a 5% of solid catalyst amberlyst 36 at a temperature of 90°C in a reflux system. The conversion value resulting from the reaction was 80.74%, with a selectivity value of 6.8% for triacetin. FTIR and GC-MS data support the monoacetin and triacetin structures. The findings indicate that the simple method and easily obtained catalyst can produce a high yield of acetin derivatives. This method is still possibly optimized to perform maximum yield with high selectivity.
Beta-carotent and Antioxidant Activity of Starfruit Extract Powder (Avverhoa blimbi L) Taufiq, Nuramaniyah; Mus, Rosdiana; Palimbong, Deske
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 14, No 1: June 2021
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v14i1.13214

Abstract

Wuluh starfruit is as a tropical plant that has sour taste but it has high nutritional value. One of wuluh starfruiut antioxidant contents is β-carotene. This research aimed to know β-carotene and test of antioxidant activity on Wuluh starfruit. Method of reseach was observational conducted at Chemistry Laboratory of Ujung Pandang Polytechnic with poject of quantitative test using spectrophotometry UV-Vis. The length of wave (nm) was 480 with 0,066 ABS (Absorban) value to analyze β-carotene level and antioxidant test (IC50) with wave length (nm) of 517. Concentration varian used were 0,1 %, 0,2 %, 04 % dan 0,8 % using spectrophotometry UV-Vis with DPPH solution reagent (1,1-dhipenyl-2-picryhirdazyl). This research indicated that quantitative test using spectrophotometry UV-Vis was obtained 24,99555 ppm β-carotene level and the result of antioxidant test (IC50) to reduce 50 % free radicals in DPPH solution required a dry powder sample contentration of 0,6 %.
Chemical Assessment of Crop Producing Soil: A Study in Tangail Sadar, Bangladesh Muliadi, Muliadi; Afrin, Rezuana; Gazi, Sydur Rahman; Md. Hossain Khan, Abu Abdulla Al-Mamun; Mamun, Shamim Al
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 14, No 1: June 2021
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v14i1.13654

Abstract

Soil is a heterogeneous body and varies in characteristics. Different soils have different requirements for fertilizers, liming, and irrigation and tillage practices depending on the physical and chemical characteristics of soils. The study was conducted to investigate the soil chemical properties of four agricultural areas (Sakrail, Santosh, Porabari and Charabari) of Tangail Sadar, Bangladesh. The values of pH, EC, TOC, total N, K, Ca, Mg and Zn ranged 6.40- 7.85, 0 dsm-1, 0.61- 1.47%, 0.05- 0.131%, 0.11- 0.18 meq/100g, 7.46- 11.26 meq/100g, 2.57- 2.78 meq/100g and 0.78- 1.30 µg/g, respectively. The highest pH level was found in Charabari area indicating almost neutral condition. The highest TOC, total N, Ca and Mg were found in Sakrail area indicating nutrient rich soil in this area. The value of K was highest in Santosh and Charabari areas and Zn level was highest in Santosh area. Significant positive correlations were found between TOC and total N in Santosh area, total N and TOC in Porabari area, Ca and TOC in Charabari area and significant negative correlations were found between Zn and Ca in Porabari area, pH and TOC, pH and Ca and pH and total N in Charabari area. Most of the nutrients were found higher in Santosh and Sakrail areas. So the crop production levels of Porabari and Charabari areas may be hampered due to lack of the essential nutrients.

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