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All Journal Jurnal Penelitian dan Pengkajian Ilmiah Jurnal Sains, Teknologi dan Kesehatan
Miftah Irramah
Universitas Andalas
Humanities Computer Science & IT Economics, Econometrics & Finance Engineering Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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HUBUNGAN KADAR UREUM DAN KREATININ SERUM DENGAN FUNGSI KOGNITIF PENDERITA PENYAKIT GINJAL KRONIK Adzra Fadhila Iswan; Restu Susanti; Dian Pertiwi; Lydia Susanti; Almurdi Almurdi; Miftah Irramah
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 3 No. 2 (2026): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Juni 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v3i2.2596

Abstract

Chronic Kidney Disease (CKD) may lead to various complications, including cognitive impairment. The causative factor is the toxic substances accumulation in the body, including serum ureum and creatinine. This study aimed to determine the relationship between serum ureum and creatinine levels with cognitive function in CKD patients. Samples were taken using a consecutive sampling technique on 46 CKD patients who were hemodialyzed at RSUP Dr. M. Djamil Padang. Cognitive function was assessed using the Montreal Cognitive Assessment Indonesian version (MoCA-Ina). Serum ureum and creatinine were measured with a spectrophotometer. Data were analyzed using the Chi-Square test. Results showed that CKD patients with cognitive impairment were more likely to be older than 50 years old (54.2%) and male (58.3%), had at least a high school education and above (70.8%), were accompanied by hypertension (75%), and without diabetes mellitus (91.7%). The median serum ureum and creatinine levels in patients with cognitive impairment were 124 mg/dL and 10.05 mg/dL. The relationship between serum ureum and creatinine levels with cognitive function had a 0.039 and 0.768 p-value. There is no relationship between the characteristics of the sample, including age, gender, education level, hypertension, and diabetes mellitus with cognitive function in CKD patients. There is a significant relationship between serum ureum levels and cognitive function, but a non-significant relationship between serum creatinine with the cognitive function of CKD patients.
The Difference in Endothelial Nitric Oxide Synthase Levels in STEMI Patients With Comorbid Diabetes Mellitus And Those Without Comorbid Diabetes Mellitus at RSUP. Dr. M. Djamil Padang Muhammad Bhagus Andina Putra; Eka Fithra Elfi; Rauza Sukma Rita; Mefri Yanni; Miftah Irramah
CENDEKIA : Jurnal Penelitian dan Pengkajian Ilmiah Vol. 3 No. 6 (2026): CENDEKIA : Jurnal Penelitian Dan Pengkajian Ilmiah, Juni 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/cendekia.v3i6.2695

Abstract

Background: Cardiovascular disease is a leading cause of global mortality, with Indonesia ranking third in the highest cardiovascular deaths. Acute myocardial infarction, divided into STEMI and NSTEMI, is part of the acute coronary syndrome due to total occlusion of coronary arteries requiring immediate revascularization. Diabetes Mellitus reduces endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) production, leading to endothelial dysfunction and an increased risk of vascular disease. DM-related endothelial dysfunction affects vascular relaxation and the formation of atherosclerotic plaques as well as thrombi in ST-elevation myocardial infarction (STEMI). Methods: This research was an analytical observational study with a cross-sectional approach, using normality tests and the Mann-Whitney U Test. The research sample was collected using consecutive sampling techniques and obtained from the medical records of 72 confirmed STEMI patients, with and without comorbid Diabetes Mellitus. Results: The research results indicated that the majority of patients were in the age range of 60-69 years (52.7%), male (86.1%), with a Body Mass Index (BMI) of 23-24.9 (45.8%), comorbid hypertension (52.7%), and a history of smoking (72.3%). The mean eNOS level in the control group was Median eNOS 38,839 U/mL with maximum level 584,762 U/ml and minimum 17,024 U/ml. Median eNOS level in the test group was 36,077 U/mL with the maximum level 679,754 U/ml and minimum 1,836 U/ml. Conclusions: There was no significant difference in eNOS levels between the two groups (Sig (2-Tailed) > 0.05).
Pengaruh Pemberian Ekstrak Buah Pohon Andalas (Morus Macroura Miq.) terhadap Gambaran Histopatologi Miokardium pada Tikus Model Aterosklerosis Intan Putri Syamtoni; Henny Mulyani; Rita Hamdani; Noza Hilbertina; Miftah Irramah; Endrinaldi Endrinaldi
CENDEKIA : Jurnal Penelitian dan Pengkajian Ilmiah Vol. 3 No. 6 (2026): CENDEKIA : Jurnal Penelitian Dan Pengkajian Ilmiah, Juni 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/cendekia.v3i6.2698

Abstract

Atherosclerosis is an inflammation that occurs in blood vessels, especially arteries, it could be developed by an accumulation of lipids in the body, which is atherosclerosis causes this to become a major factor of cardiovascular disease. The fruit of the andalas contains flavonoid, morasin C and M for anti-inflammatory. The purpose of this experimental is to see the effect of extract andalas fruits to histologial changes in myocardium of rats with aterosclerosis model. This research was an experimental study with a randomized post test only control group design with using 29 mice which have been divided into 5 groups, there is negative control group (K-), positive control group (K+), treatment group 1 (P1), treatment group 2 ( P2), and treatment group 3 (P3). The results measurement of the weight rat's heart after analysis used the One Way ANOVA test were p = 0.000, that’s mean there was a significant difference of weight rat's heart in each other groups. Measuring the thickness of myocardial cell size used the One Way Anova test, the resulted is p = 0.632, that’s mean there was no relationship between the groups. Measuring the blood vessel thickness were used by One Way ANOVA analysis, the resulted is p = 0.301, that’s mean there was no significant difference in arterial blood vessel thickness in all groups. The conclusion of this study is there was changes in rat heart weight in all groups, there was no significant change in the histopathological size of the myocardium in all groups, lipofuscin was found in 1 sample, necrosis wasn’t found, sicatric tissue wasn’t found, and there was no significant change in the histopathological picture of arterial thickness in this experience.
KARAKTERISTIK PEROKOK DI KALANGAN CIVITAS AKADEMIKA FAKULTAS HUKUM UNIVERSITAS ANDALAS Muhammad Raihan; Fenty Anggrainy; Yuniar Lestari; Miftah Irramah; Yessy Susanty Sabri; Zurayya Fadila
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 3 No. 2 (2026): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Juni 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v3i2.1957

Abstract

The number of smokers increases every year. It becomes the focus of the Indonesian government’s attention. Through the healthy campus program, the Indonesian Ministry of Health designated Andalas University as one of the pilot campuses, but there are still smokers on campus. Itsn’t just students who smoke, but lecturers and education staff as well. To determine the characteristics of smokers among the academic civility in Faculty of Law, Andalas University. The method used is descriptive observational with quota sampling technique. The sample consisted of 323 students, 18 lecturers, and 5 staff. Data were collected by questionnaire and analyzed with computerized program. The research results showed that 28.9% of the academic civility at Faculty of Law, Andalas University were smokers. The typical average age is 22 years, dominated by men, in general they also have families who smoke. The highest age for starting smoking is 16 years or older. Smokers are dominated by light smokers. The most commonly consumed type of cigarettes is white cigarettes, but 9.5% also use e-cigarettes. The driving force behind smoking behavior usually the social environment. The level of knowledge of academic civility is sufficient category. The conclusion obtained is that there are still smokers among the academic community, so preventive efforts should be made to reduce the number of smokers on campus.
Co-Authors Adzra Fadhila Iswan Almurdi Almurdi Dian Pertiwi Eka Fithra Elfi Endrinaldi Fenty Anggrainy Henny Mulyani Intan Putri Syamtoni Lydia Susanti Mefri Yanni Muhammad Bhagus Andina Putra Muhammad Raihan Noza Hilbertina Rauza Sukma Rita Restu Susanti Rita Hamdani Yessy Susanty Sabri Yuniar Lestari Zurayya Fadila