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All Journal Indonesian Journal of Global Health research Indonesian Journal of Global Health Research
Ayodhia Pitaloka Pasaribu
Universitas Sumatera Utara
Education Health Professions Languange, Linguistic, Communication & Media Nursing Public Health

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Accuracy of Hemoglobin Measurement using the SD Biosensor Standard G6PD Analyzer as Point-of-Care in Pediatric Populations in Malaria-Endemic Regions Kevin Effendi; Rosmayanti Syafriani Siregar; Hendri Wijaya; Olga Rasiyanti Siregar; Arlinda Sari Wahyuni; Ayodhia Pitaloka Pasaribu
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6918

Abstract

Background: Malaria remains a significant public health concern, particularly in endemic regions, is frequently associated with anemia in children. Accurate hemoglobin measurement is crucial for diagnosing anemia, especially in resource-limited settings. This study compares the accuracy of SD Biosensor Standard G6PD Analyzer with Hemocue HB301 System for hemoglobin measurement among children in malaria-endemic areas. Objective: To determine the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (LR+), negative likelihood ratio (LR-), pretest odds, post-test odds, and overall accuracy of the SD Biosensor Standard G6PD Analyzer compared to the Hemocue HB301 System. Method: This cross-sectional diagnostic study involved 325 children aged 6-18 years in Kualuh Leidong District. Secondary data were obtained from a previous study conducted in August 2024, using a total sampling technique. Result: The mean hemoglobin level measured by SD Biosensor Standard G6PD Analyzer (14,22±2,21 mg/dL) was higher than that measured by Hemocue HB301 System (13,45±1,63 mg/dL), with significant difference (p=0,001). The prevalence of anemia detected by SD Biosensor and Hemocue was 12,3% and 11,4%, respectively. The SD Biosensor Standard G6PD Analyzer demonstrated a sensitivity of 70,27%, specificity of 95,14%, PPV of 65%, NPV of 96,14% and an overall accuracy of 92,31%. Conclusion: The SD Biosensor Standard G6PD Analyzer exhibited relatively low sensitivity but high specificity compared to Hemocue HB301 System in measuring hemoglobin levels among children in malaria-endemic areas. Further research is needed to compare both devices against the gold-standard automated hematology analyzer and to identify the factors influencing measurement accuracy. Keywords: Anemia, Hemocue HB301 System, Hemoglobin, Malaria, SD Biosensor Standard G6PD Analyzer
Diagnostic Value of Platelet Index as An Early Marker in Suspected Neonatal Sepsis in The Neonatology Unit Ferawati Ferawati; Pertin Sianturi; Yazid Dimyati; Arlinda Sari Wahyuni; Ayodhia Pitaloka Pasaribu; Bugis Mardina Lubis
Indonesian Journal of Global Health Research Vol. 8 No. 1 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i1.605

Abstract

Sepsis neonatorum is a serious blood infection in newborns, mainly affecting premature or low birth weight infants. Early detection is tough, but new research suggests platelet indices could help diagnose it faster. The objective of this study is to analyze the diagnostic value of platelet indices (platelet count, MPV, and PDW) as early markers in suspected neonatal sepsis compared with the gold standard (blood culture). This was an observational analytical study with a retrospective cohort design conducted at the Adam Malik Hospital. A total of 115 suspected neonatal sepsis samples were enrolled. Data collection included demographic characteristics, platelet count, mean platelet volume (MPV), and platelet distribution width (PDW). The data were obtained from secondary sources in medical records and entered into the SPSS software for analysis. Statistical analysis was performed using receiver operator curve (ROC) to assess the diagnostic value of platelet indices (platelet, MPV, and PDW). The study involved 115 newborns suspected of neonatal sepsis, with 46.1% male and 53.9% female. Most were delivered via cesarean section and diagnosed with early onset sepsis. Common clinical signs included respiratory distress and distension. Key risk factors included prolonged rupture of membranes and low birth weight. Blood culture revealed Klebsiella pneumonia as the most common pathogen. Platelet indices showed varied sensitivity and specificity as predictors of sepsis. Diagnostic tests had low sensitivity but varied specificity for detecting sepsis with platelet count, MPV, and PDW.
Accuracy of Procalcitonin, C-Reactive Protein, and Mean Platelet Volume as Infection Markers in Neonatal Sepsis Hardiyanti Fitri; Beby Syofiani Hasibuan; Badai Buana Nasution; Arlinda Sari Wahyuni; Ayodhia Pitaloka Pasaribu; Syamsidah Lubis
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1405

Abstract

Neonatal sepsis remains a significant cause of morbidity and mortality, yet diagnosis is limited by nonspecific symptoms and delayed blood culture results. This study evaluated the diagnostic accuracy of procalcitonin (PCT), C-reactive protein (CRP), and mean platelet volume (MPV) as early biomarkers of neonatal sepsis. A retrospective cohort study was conducted in the Neonatology Unit of H. Adam Malik General Hospital, Medan, from January to December 2024. The sampling technique used is consecutive sampling. Of 346 neonates screened, 121 met the inclusion criteria and had concurrent PCT, CRP, MPV, and blood culture results. Clinical and laboratory data were extracted from electronic medical records. Diagnostic performance was assessed using sensitivity, specificity, predictive values, likelihood ratios, and ROC analysis. Among 121 neonates, 31.4% had positive blood cultures. MPV showed no significant difference between culture-positive and culture-negative groups (p = 0.104) and demonstrated limited discriminatory value (AUC 0.592). CRP was significantly associated with culture results (p = 0.037), showing high specificity (94.7%) but low sensitivity (30.0%) at ≥1 mg/L (AUC 0.624). PCT demonstrated the strongest performance, with significantly higher levels in culture-positive neonates (p = 0.022), sensitivity of 64.5%, specificity of 69.0%, and an AUC of 0.672. Diagnostic accuracy was 66.7% for PCT, 85.1% for CRP, and 55.4% for MPV. PCT provided the most balanced diagnostic utility for neonatal sepsis, while CRP served as a highly specific rule-in marker. MPV showed limited usefulness. Although these biomarkers contribute to early assessment, they are insufficient as standalone diagnostic tools and should be integrated with clinical evaluation and microbiological testing.
Co-Authors Arlinda Sari Wahyuni Badai Buana Nasution Beby Syofiani Hasibuan Bugis Mardina Lubis Ferawati Ferawati Hardiyanti Fitri Hendri Wijaya Kevin Effendi Olga Rasiyanti Siregar Pertin Sianturi Rosmayanti Syafriani Siregar Syamsidah Lubis Yazid Dimyati