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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Scientific Journal Jurnal Pengabdian Masyarakat Kesehatan (JURABDIKES) Journal of Public Health Science (JoPHS)
Anggraini, Debie
(ORCID : 0000-0002-6180-7380, Scopus ID : 58198560800) - Universitas Baiturrahmah
Humanities Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Comparison of Platelet-to-High-Density Lipoprotein Cholesterol Ratio between Patients with Ischemic Stroke and Healthy Controls Debie Anggraini; Yuri Haiga; Vina Tri Septiana
Scientific Journal Vol. 5 No. 2 (2026): SCIENA Volume V No 2, March 2026
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v5i2.382

Abstract

Background: Ischemic stroke is a major cerebrovascular disorder involving complex interactions between thrombosis, platelet activation, endothelial dysfunction, and lipid abnormalities. The platelet-to-high-density lipoprotein cholesterol ratio (PHR) is a simple composite index combining platelet count and HDL-C, potentially reflecting the interaction between thrombotic and lipid-related vascular processes. However, evidence directly comparing PHR between patients with ischemic stroke and healthy individuals remains limited. Objective: To compare the platelet-to-high-density lipoprotein cholesterol ratio between patients with ischemic stroke and healthy controls. Methods: This analytical observational study used a case-control design and was conducted at Siti Rahmah Hospital, Padang, Indonesia, using data from 2022–2024. The study included 21 patients with ischemic stroke confirmed by brain computed tomography and 21 healthy controls. Platelet count and HDL-C measurements were obtained from laboratory records. For stroke patients, laboratory measurements obtained on the first day of hospitalization were used. PHR was calculated as platelet count (×10³/µL) divided by HDL-C (mg/dL). Differences between groups were analyzed using the Mann–Whitney U test for non-normally distributed continuous variables. A p value <0.05 was considered statistically significant. Results: The median PHR was significantly higher in patients with ischemic stroke than in healthy controls (5.80 [IQR, 5.27–7.56] vs. 3.61 [IQR, 3.13–5.00], p = 0.001). HDL-C concentrations were significantly lower in the ischemic stroke group (40 [36–51] vs. 59 [45–76] mg/dL, p < 0.001). In contrast, platelet count did not differ significantly between the groups (285 [227–318] vs. 245 [192–289] ×10³/µL, p = 0.119). Conclusion: PHR was significantly higher in patients with ischemic stroke than in healthy controls, with the difference appearing to be driven predominantly by lower HDL-C rather than by a significant difference in platelet count. PHR may represent a simple laboratory index reflecting the interaction between platelet-related and lipid-related processes in ischemic stroke. Further studies with larger and well-matched populations are needed to validate these findings.
Co-Authors Adelin, Prima Afni Mesna Putri Anandia Putriyuni Chandra Adilla Cindy Munawaroh Pratama Putri Desi Aliefia Desi Alifia Dewi, Nadia Purnama Dita Hasni Efriza Elsa Nadhia Amanda Fidiariani Sjaaf Gangga Mahatma Lismawati Maryeti Marwazi Melia Roza Linda Meta Zulyati Oktora Muhamad Ivan Muhamad Ivan Muhammad Fharel Nabila Jihan Zakiyah Nana Liana Nesi Meldi Pratiwi Nidya Naysa Evra Nilas Warlem Nurwiyeni Prima Adelin Prima Adelin Puja Wanandri Salsha Bila Soufni Morawati Soufni Morawati Sri Nani Jelmila Tati Khairina Vina Tri Septiana Vina Tri Septiana Yanti Fitri Yasa Yessi Ekawati Yuri Haiga Yuri Haiga Yuri Haiga Yuri Haiga Zikra Humaira