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Sari, Lia Cahya
Sekolah Tinggi Ilmu Kesehatan Wira Medika Bali
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GAMBARAN PEMERIKSAAN ANTIBODI HIV PADA SOPIR TAKSI DI WILAYAH KELURAHAN KUTA KABUPATEN BADUNG Anggraeni Suarsana; A.A. Ngurah Subawa; Lia Cahya Sari
Bali Medika Jurnal Vol 4 No 1 (2017): Jurnal Chemistry Laboratory Vol 4 No 1 July 2017
Publisher : Stikes Wira Medika Bali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36376/bmj.v4i1.54

Abstract

Introduction: AIDS is a collection of certain clinical conditions that are the outcome of infection by HIV. Currently, the problem of HIV / AIDS is a big problem that threatens many countries around the world, one of them is Indonesia. HIV / AIDS is much affected by the productive age population and more affected by men than women. The taxi driver job has a lot of time on the highway. Taxi drivers will be vulnerable to HIV transmission when performing high-risk behaviors against its HIV transmission. This study aims to find out the description of HIV antibody examination on taxi drivers in Kelurahan Kuta Kabupaten Badung. Method: The type of research used is descriptive research. This research was conducted on May 2017. The sampling of the research was done at UPT. Puskesmas Kuta 1 and the examination was conducted at Health Analyst Laboratory of STIKes Wira Medika Bali. The population used in this study are all taxi drivers who are in Kelurahan Kuta Kabupaten Badung and the samples are 33 drivers. The method used in this research is Rapid Test / Immunochromatography method. The data have been analyzed and presented in tabular form. Result: The results of this study were all samples of taxi drivers showed non-reactive results against HIV antibodies. Discussion: This means no HIV antibodies found in taxi drivers serum.
The Impact of Pro-Inflammatory Cytokines on the Clinical Manifestations and Disease Progression of Spondyloarthritis: a Narrative Review Sari, Lia Cahya; Sitanggang, Robestri Natalia; Qudsiyyah, Farida
Humantech : Jurnal Ilmiah Multidisiplin Indonesia Vol. 4 No. 2 (2025): Humantech : Jurnal Ilmiah Multidisiplin Indonesia
Publisher : Program Studi Akuntansi IKOPIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32670/qn0cnp03

Abstract

Spondyloarthritis (SpA) is a group of inflammatory joint and spine diseases with various clinical manifestations. The classification and diagnosis of SpA are determined based on observations of the sacroiliac joints, hip joints, enthesitis, or the presence of human leukocyte antigen B27 (HLA-B*27). The main clinical manifestations of SpA are inflammatory pain, stiffness, and swelling of the joints and spine. Although the pathogenesis of SpA is not fully understood, genetic and environmental factors can lead to inflammation by producing pro-inflammatory cytokines such as TNF-α and the IL-23/IL-17 axis, which cause dysregulation of immune cells and stromal cells. This review aims to find out the impact of pro-inflammatory cytokines on the clinical manifestations and disease progression of Spondyloarthritis. Pro-inflammatory cytokines, such as TNF-α, IL-17, and IL-23 have an important role in the pathogenesis and progression of Spondyloarthritis. IL-17A stimulates the expression of RANKL and inhibits Wnt signaling, thereby suppressing osteoblast activity, promoting osteoclast differentiation and bone resorption in axSpA and PsA. IL-17 also trigger arthritis, spondylitis, and conjunctivitis in ReA. Increased expression of IL-17, IL-23, and TNF-α due to microbiota activity provides immune cell recruitment and mucosal injury, thus maintaining chronic inflammation in IBD. Pro-inflammatory cytokines have an impact on clinical manifestations of spondyloarthritis by stimulating an inflammatory response in the joints, leading to pain, and influencing disease progression by causing bone and joint tissue destruction. They also contribute to the formation of scar tissue around the joints, reducing mobility and causing significant stiffness in the spine
The Relationship Between Compliance and Knowledge of Medical Laboratory Technologists Regarding the Use of Personal Protective Equipment Rio Saputra Dana; A.A.A. Eka Cahyani; Lia Cahya Sari
Jurnal Kesehatan Cendikia Jenius Vol. 3 No. 1 (2025): Desember
Publisher : CV. CENDIKIA JENIUS INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70920/jenius.v3i1.282

Abstract

Medical Laboratory Technologists (MLTs) play an important role in ensuring occupational safety through the use of personal protective equipment (PPE). However, compliance with PPE use in clinical laboratories still faces challenges, even though facilities are available. This study aimed to analyze the relationship between the level of knowledge and compliance of MLTs in using PPE during the pre-analytical phase of clinical laboratories.A quantitative approach with a non-experimental cross-sectional correlational design was employed. The study sample consisted of 33 respondents selected through total sampling, comprising MLTs from three hospitals in Badung Regency, Bali. Data were collected in May–June 2025 using a structured questionnaire that had been tested for validity and reliability (Cronbach’s alpha = 0.933). Data analysis was conducted using descriptive statistics and the Spearman Rank test.The results showed that 96% of respondents had very good knowledge and 96% demonstrated very good compliance with PPE use. The Spearman Rank test revealed a significant positive relationship between knowledge and compliance (p = 0.007; r = 0.458).It can be concluded that higher levels of knowledge among MLTs are associated with greater compliance in PPE use. These findings emphasize the need for continuous education, consistent supervision, and a strong safety culture in clinical laboratories.
Hubungan Lingkungan Dengan Kejadian Malaria Pada Masyarakat Kab Yalimo Papua Pegunungan Selviana Magrid Martha Rumandewai, Ni Ketut Mirayanti, Lia Cahya Sari
Integrative Perspectives of Social and Science Journal Vol. 2 No. 04 September (2025): Integrative Perspectives of Social and Science Journal
Publisher : PT Wahana Global Education

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Abstract

Malaria masih menjadi salah satu masalah kesehatan masyarakat di Indonesia, terutama di wilayah Papua yang menyumbang sebagian besar kasus nasional. Kabupaten Yalimo di Papua Pegunungan merupakan salah satu daerah endemis dengan angka kejadian malaria yang fluktuatif, dipengaruhi oleh kondisi geografis, lingkungan, dan perilaku masyarakat. Penelitian ini bertujuan untuk mengetahui hubungan faktor lingkungan fisik, biologis, dan sosial budaya dengan kejadian malaria pada masyarakat di Kabupaten Yalimo. Penelitian menggunakan pendekatan kualitatif dengan metode deskriptif. Informan penelitian terdiri dari tenaga kesehatan, tokoh masyarakat, dan kepala keluarga yang dipilih secara purposive. Data dikumpulkan melalui wawancara mendalam, observasi lingkungan, serta telaah dokumen dari instansi kesehatan setempat. Analisis data dilakukan dengan model interaktif yang meliputi reduksi, penyajian, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa kondisi rumah yang dekat dengan genangan air dan konstruksi sederhana memungkinkan nyamuk Anopheles masuk dengan mudah, kebiasaan masyarakat berkumpul di luar rumah pada malam hari tanpa perlindungan meningkatkan risiko gigitan, sedangkan keberadaan ternak di sekitar rumah berperan ganda, dapat mengurangi atau justru meningkatkan risiko tergantung pada penempatan kandang. Penelitian ini menyimpulkan bahwa faktor lingkungan fisik, biologis, dan sosial budaya saling berinteraksi dalam memengaruhi kejadian malaria. Penanggulangan malaria di Yalimo membutuhkan pendekatan terpadu yang mencakup perbaikan lingkungan fisik, pengelolaan ternak, serta perubahan perilaku masyarakat melalui edukasi dan intervensi berbasis budaya lokal agar pengendalian malaria lebih efektif dan berkelanjutan.
Pemberdayaan Remaja Dalam Pencegahan Faktor Resiko Stunting Sejak Dini Ni Ketut Ayu Mirayanti; Putra Pradnyantara, I Gusti Agung Ngurah; Ni Luh Nova Dilisca; Wahyu Aditya, Made; Cahya Sari, Lia
Jurnal Pengabdian Masyarakat Permata Indonesia Vol 5 No 2 (2025): Volume 5, Nomor 2, Oktober 2025
Publisher : Permata Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59737/jpmpi.v5i2.356

Abstract

Stunting is a chronic nutritional problem that affects physical growth, cognitive development, and the productivity of future generations. Prevention efforts need to be carried out upstream, including among adolescents who will become future parents. This community service program aimed to empower adolescents in preventing stunting risk factors through knowledge enhancement, nutrition education, and health screening. The program was implemented at Bali Dewata Health Vocational School in June 2025, involving five lecturers and two students from STIKES Wira Medika Bali. The activities included coordination with the school and primary health center, pretest, health education sessions, health screening (blood pressure measurement and medical history), distribution of educational booklets, and a posttest to evaluate knowledge improvement. A total of 61 students participated in the program. The results showed a significant increase in knowledge about stunting prevention, with the proportion of students in the “good” category rising from 50.8% to 88.5%. Health screening also revealed a small number of students with anemia, a condition that may contribute to future stunting in their offspring. This program highlights the crucial role of adolescents as agents of change in stunting prevention through healthy lifestyles, balanced nutrition, and peer education. With the active involvement of schools, health centers, and students, the program successfully improved adolescent awareness of stunting issues and produced outputs in the form of scientific publication and educational media. Continuous monitoring is planned to ensure program sustainability.
HUBUNGAN KADAR T3, T4, DAN TSH DENGAN DIAGNOSIS KANKER TIROID: THE RELATIONSHIP OF T3, T4, AND TSH LEVELS WITH THYROID CANCER DIAGNOSIS Anggraini, Desty Prastika; Abadi, Moh Fairuz; Sari, Lia Cahya; Prihatiningsih, Diah
Medic Nutricia : Jurnal Ilmu Kesehatan Vol. 14 No. 5 (2025): Medic Nutricia : Jurnal Ilmu Kesehatan
Publisher : Cahaya Ilmu Bangsa Institute

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Abstract

Karsinoma tiroid sering kali bersifat euthyroid (kadar hormon normal), namun beberapa literatur terbaru menunjukkan adanya disregulasi hormon pada keganasan, sehingga hubungan spesifik antara profil hormon tiroid dengan diagnosis histopatologis masih menjadi perdebatan. Penelitian ini bertujuan untuk menganalisis korelasi kadar serum T3, T4, dan TSH dengan diagnosis karsinoma tiroid di Rumah Sakit Pusat Pertamina. Studi observasional analitik dengan desain potong lintang (cross-sectional) ini dilakukan pada data rekam medis pasien nodul tiroid periode 2020–2024, di mana 54 sampel dipilih melalui teknik simple random sampling dengan diagnosis histopatologi sebagai baku emas. Hasil analisis statistik menunjukkan proporsi karsinoma tiroid sebesar 46,3% dan mengungkapkan hubungan yang sangat signifikan antara kadar T4 dengan kejadian karsinoma tiroid (p=0,001). Menariknya, 100% pasien dengan peningkatan kadar T4 terdiagnosis mengalami keganasan, berbeda dengan kadar T3 (p=0,054) dan TSH (p=0,093) yang tidak menunjukkan signifikansi statistik meskipun terdapat tren klinis penurunan T3 pada kasus kanker. Dapat disimpulkan bahwa peningkatan kadar T4 merupakan indikator potensial untuk memprediksi keganasan pada nodul tiroid di populasi ini, sehingga disarankan sebagai panel rutin dalam stratifikasi risiko pra-operasi. Kata kunci: Hormon T3, Hormon T4, Hormon TSH, Kanker Tiroid Abstract Thyroid carcinoma typically presents as euthyroid; however, recent evidence suggests potential hormonal dysregulation in malignancy, leaving the specific association between thyroid hormone profiles and histopathological diagnosis controversial. This study aimed to analyze the correlation between serum T3, T4, and TSH levels with the diagnosis of thyroid carcinoma at Pertamina Central Hospital. An observational analytic study with a cross-sectional design was conducted using medical records from 2020 to 2024, selecting 54 samples via simple random sampling with histopathology as the gold standard. The results indicated a 46.3% prevalence of carcinoma and revealed a highly significant association between T4 levels and malignancy (p=0.001). Notably, 100% of patients with elevated T4 were diagnosed with cancer, whereas T3 (p=0.054) and TSH (p=0.093) levels showed no statistically significant association, despite a clinical trend of lower T3 in the cancer group. In conclusion, elevated serum T4 levels serve as a potential predictor for malignancy in this population and are recommended for preoperative risk stratification. Keywords: T3 hormone, T4 hormone, TSH hormone, Thyroid cancer
KORELASI PEMERIKSAAN IGE TOTAL DENGAN PERSENTASE EOSINOFIL PADA PASIEN TERDIAGNOSA HIPERSENSITIVITAS TIPE 1 : CORRELATION TOTAL IGE LEVELS AND EOSINOPHIL PERCENTAGE IN PATIENTS DIAGNOSED WITH TYPE 1 HYPERSENSITIVITY Fahri, Muhamad; Prihatiningsih, Diah; Sari, Lia Cahya
Medic Nutricia : Jurnal Ilmu Kesehatan Vol. 14 No. 5 (2025): Medic Nutricia : Jurnal Ilmu Kesehatan
Publisher : Cahaya Ilmu Bangsa Institute

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Abstract

Hipersensitivitas tipe 1 merupakan reaksi imunologis kompleks yang umumnya ditandai oleh peningkatan kadar Imunoglobulin E (IgE) dan aktivasi eosinofil, namun literatur yang ada menunjukkan inkonsistensi mengenai hubungan linier antara kedua parameter biologis tersebut. Penelitian ini bertujuan untuk mengevaluasi korelasi antara kadar IgE total dengan persentase eosinofil pada populasi pasien yang terdiagnosis hipersensitivitas tipe 1, guna memahami pola respons imun yang terjadi. Studi ini menggunakan desain observasional analitik dengan pendekatan cross-sectional, yang melibatkan 114 pasien yang memenuhi kriteria diagnosis klinis di lokasi penelitian. Berdasarkan hasil analisis statistik menggunakan uji Chi-Square, penelitian ini menemukan bahwa tidak terdapat korelasi yang signifikan antara kadar IgE total dengan persentase eosinofil (p = 0,241). Temuan ini mengindikasikan bahwa meskipun IgE dan eosinofil sama-sama berperan sentral dalam patogenesis alergi, keduanya mungkin merepresentasikan jalur aktivasi imun atau fase peradangan yang berbeda, di mana peningkatan kadar IgE tidak serta-merta disertai dengan eosinofilia perifer. Oleh karena itu, faktor lain seperti variasi individual, aktivasi sel mast, atau mediator inflamasi lainnya perlu dipertimbangkan, dan penegakan diagnosis sebaiknya tidak bergantung pada parameter tunggal melainkan melalui pendekatan multiparameter yang komprehensif. Kata Kunci: Eosinofil, hipersensitivitas tipe 1, IgE total Abstract Type 1 hypersensitivity is a complex immune reaction typically characterized by elevated levels of Immunoglobulin E (IgE) and eosinophil activation; however, existing literature presents inconsistent findings regarding the linear relationship between these two biological markers. This study aimed to evaluate the correlation between total IgE levels and eosinophil percentage in patients diagnosed with type 1 hypersensitivity to elucidate the underlying immune response patterns. Employing an analytical observational design with a cross-sectional approach, this study involved 114 patients who met the specific diagnostic criteria at the study site. Statistical analysis using the Chi-Square test revealed no significant correlation between total IgE levels and eosinophil percentage (p = 0.241). These findings indicate that although both IgE and eosinophils play central roles in allergic pathogenesis, they may represent distinct immune activation pathways or different inflammatory phases, where elevated IgE levels are not necessarily accompanied by peripheral eosinophilia. Consequently, other factors such as individual variability, mast cell activation, or alternative inflammatory mediators should be considered, suggesting that clinical diagnosis requires a comprehensive multiparameter approach rather than reliance on a single biomarker. Keywords: Eosinophils, Total IgE, Type 1 Hypersensitivity
PENGUATAN LITERASI KESEHATAN REMAJA TENTANG BAHAYA KONSUMSI ALKOHOL MELALUI PENDEKATAN INTERAKTIF, TEKNIK PENGELOLAAN DAN PEMERIKSAAN ALKOHOL URINE, SERTA EDUKASI REKAM MEDIS BERBASIS APLIKASI Ni Luh Nova Dilisca Dwi Putri; Ni Ketut Ayu Mirayanti; Made Wahyu Aditya; Agung Ngurah Putra Pradnyantara; Lia Cahya Sari
JURNAL PENGABDIAN MANDIRI Vol. 5 No. 1 (2026): Januari 2026
Publisher : Bajang Institute

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Abstract

Konsumsi minuman beralkohol di kalangan remaja merupakan permasalahan kesehatan masyarakat berpotensi menimbulkan dampak kesehatan dan sosial. Rendahnya pengetahuan mengenai bahaya konsumsi alkohol serta minimnya pemahaman tentang deteksi alkohol dan pencatatan hasil pemeriksaan kesehatan menjadi faktor pemdorong perlunya upaya edukatif yang terstruktur. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan pengetahuan dan kewaspadaan remaja terhadap bahaya konsumsi alkohol, memperkenalkan tata cara pengelolaan spesimen urine untuk pemeriksaan kandungan alkohol, serta meningkatkan pemahaman tentang pencatatan rekam medis elektronik di lingkungan sekolah. Kegiatan dilaksanakan pada siswa kelas X melalui penyampaian materi, diskusi, simulasi, serta evaluasi. Hasil kegiatan menunjukkan seluruh peserta menyatakan pentingnya penyuluhan bahaya alkohol. Evaluasi post-test menunjukkan peningkatan tingkat pengetahuan siswa tentang bahaya konsumsi alkohol dengan kategori baik sebesar 91%. Pemahaman siswa mengenai pengelolaan spesimen urine dan pemeriksaan alkohol secara kualitatif berada pada kategori baik sebesar 87%. Peningkatan pengetahuan juga terjadi pada aspek pencatatan rekam medis elektronik dengan kategori baik sebesar 90%. Kegiatan ini terbukti efektif dalam meningkatkan pengetahuan, wawasan, dan pemahaman remaja mengenai bahaya alkohol, deteksi alkohol melalui urine, serta pentingnya pencatatan kesehatan yang baik. Pengabdian masyarakat ini diharapkan dapat menjadi langkah preventif dalam upaya peningkatan kualitas kesehatan masyarakat melalui pemberdayaan remaja sebagai agen perubahan di lingkungan sekolah dan Masyarakat.
Co-Authors A.A.A. Eka Cahyani Abadi, Moh Fairuz Anak Agung Ngurah Subawa Anggraeni Suarsana Anggraini, Desty Prastika Diah Prihatiningsih Fahri, Muhamad I Gusti Agung Ngurah Putra Pradnyantara Made Wahyu Aditya Arta Ni Ketut Ayu Mirayanti Ni Luh Nova Dilisca Putri, Ni Luh Nova Dilisca Dwi Qudsiyyah, Farida Rio Saputra Dana Sitanggang, Robestri Natalia