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Indah Sapta Wardani
Fakultas Kedokteran Universitas Mataram, Lombok, Indonesia
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary

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Journal : Jurnal Penelitian Pendidikan IPA (JPPIPA)

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Hidroksi Metil Glutaril Coenzyme-A (HMG CoA) Reduktase Inhibitor and New Onset Diabetes Mellitus: A Review of Correlation and Clinical Implication Wardani, Indah Sapta
Jurnal Penelitian Pendidikan IPA Vol 9 No 9 (2023): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i9.5274

Abstract

Treatment of lipid abnormalities with HMG CoA reductase inhibitor (statin) has been used for diabetic and non diabetic patients. Various studies have describe increased risk of new onset diabetes associated with statin therapy. This review aims to explain potential mechanism that related to diabetogenic effect of statin. This research was created by collecting literature that relevant to the topic. The types of literature used are clinical trials, meta analyzes and systematic reviews between 2013 until 2021. HMG CoA reductase is the target of statin therapy and the acting of this enzyme is inhibited by statin in competitive way. In vivo and in vitro studies reveal that statin reduce synthesis of mevalonate pathway and increase cholesterol transport that influence B cell function and decrease of insulin sensitivity and insulin secretion by multiple mechanism. Recent genetic study suggest that increased risk of type 2 diabetes mellitus pathway explained by gene variant target for LDL cholesterol lowering drugs. Accumulating evidence from several statin studies suggest that pravastatin is the least diabetogenic statin. Simvastatin, atorvastatin and rosurvastatin are more diabetogenic statin. The used of statin in clinical practice should concerned about benefit on cardiovascular while still considering the possible risk of developing type 2 diabetes mellitus. Regular monitoring of patients glycemic control is mandatory
Co-Authors A.A Ayu Niti Wedayani Adam Trojan Alisyahbana Akelba, Shalsa Damai Aliza Raudatin Sahly Aulia Dwi Hendriani Baiq Ramdhani Amelia Negara Bramantyo, Rofi Daffa Muhammad Rizky Decky Aditya Z Devi Rahmadhona Dewi Suryani Dewi Suryani Dhevi, Ni Made Shaithanya Gitanjali Dzulilmi, Dhaifatu Fahmi Akbar Utomo Fauzan, Naufal Revaldy Grandis Cristagalli1, Izza Mufida Herpan Syafii Harahap Hudhori, Syalsa I Dewa Ayu Natih Canis Paloma I Putu Diatmika Ika Nurfiria Tauhida Ilsa Hunaifi Indana Eva Ajmala Isnaeni, Wilya Jayadi, Agung Jurnal Pepadu Karina Khilmi Adzuba Layus Iranna Umayya Lestari, Rizka Vidya Liya Maulidianti M. Andre Darmawan Maudina, Baiq Zaskia Maz Isa Ansyori Arsatt Metta Octora Mitha Yunda Pertiwi Mohammad Rizki Mohammad Rizki Muhammad Gasim Al aydrus Nadia Safira Ni Luh Made Mirah Rahayu Ni Luh Putu Harta Wedari Ni Putu Visty Wedhiani Nurhidayati Padauleng, Novrita Pandu Ishaq Nandana Prameswari, Devi Shanti Prima Belia Fathana Putri, Alifia Sabira Putri, Septy Rianty Salsabilla Dwi Putu Wika Pramesti Iswari Rike Delya Rizqina Rizqi, Amanda Suana Sahly, Aliza Raudatin Salsabila, Ruhaniah Najwa Tri Sastra Pradhini Wahyudi, Reza Rizwandipa Zanetha Mauly Ilawanda