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All Journal Jurnal Biologi Tropis The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Maudina, Baiq Zaskia
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology

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Effectiveness of Combination Therapy of Stereotactic Body Radiation Therapy with Lenvatinib in Advanced Hepatocellular Carcinoma Putri, Alifia Sabira; Nuriasti, Rovera; Pambudi, Balqis Prudena Kurnia; Fauzan, Naufal Revaldy; Maudina, Baiq Zaskia; Prawira, Yoga; Larasati, Anak Agung Ayu Regina; Budyono, Catarina
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 2 (2025): VOLUME 26, NUMBER 2, AGUSTUS, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2622025168-175

Abstract

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and has a high mortality rate, especially in advanced stages. Treatment of advanced HCC remains a significant challenge due to limited effective therapeutic options. This study examines the effectiveness of combining Stereotactic Body Radiation Therapy (SBRT) and Lenvatinib in advanced HCC patients. SBRT is a high-precision radiation technique that allows high-dose irradiation of tumor targets with minimal damage to surrounding healthy tissues. At the same time, Lenvatinib is a multikinase inhibitor that inhibits several critical molecular pathways in angiogenesis and tumor cell proliferation. The results showed that the combination of SBRT and Lenvatinib significantly improved overall survival (OS) by reducing the risk of death by 63%, progression-free survival (PFS) reduced the risk of tumor progression by 67%, intrahepatic tumor progression-free survival (IHPFS) showed a decrease of 71%, objective remission rate (ORR) was also higher in the combination group (56.8%), and disease control rate (DCR) of 91.9% which was higher than the use of Lenvatinib alone. However, this combination therapy also carries a higher risk of side effects, including hypertension and diarrhea, which require close monitoring and dose adjustment. This study suggests combining SBRT and Lenvatinib may be a more practical approach to treating advanced HCC. However, the treatment strategy needs to be tailored to the patient's condition to minimize the risk of toxicity.
Aortic Stenosis Review: Pathophysiology, Clinical Symptoms, and Key Diagnostic Signs Maharani, Baiq Syarifaturrayyan; Febriana, Nanggi Qoriatul; Sari, Padmi Kartika; Maudina, Baiq Zaskia; Hakim, Baiq Sheila Oktalia
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10105

Abstract

Aortic stenosis is among the most common valvular heart diseases, particularly in the elderly, and remains a major cause of morbidity and mortality. It is characterized by narrowing of the aortic valve, leading to increased afterload, compensatory left ventricular hypertrophy, and eventual heart failure or sudden death. To summarize updated evidence on the pathophysiology, clinical manifestations, and diagnostic signs of aortic stenosis. A literature review was conducted through systematic searches of PubMed, ScienceDirect, and Google Scholar, prioritizing publications from the last ten years. Articles on anatomy, physiology, pathophysiology, clinical features, diagnostic findings, and disease progression were critically analyzed. Aortic stenosis develops through degenerative calcification, rheumatic autoimmune inflammation, or congenital malformation. Disease progression leads to elevated transvalvular gradient, reduced stroke volume, and left ventricular hypertrophy. Typical symptoms include angina, syncope, and heart failure. Key diagnostic signs are a crescendo–decrescendo systolic ejection murmur radiating to the carotid arteries and the Gallavardin phenomenon. Aortic stenosis is a progressive valvular disease with complex pathophysiological mechanisms. Comprehensive understanding of its biological processes, clinical manifestations, and diagnostic signs is essential to support early detection and timely management. Such efforts may reduce morbidity and mortality while paving the way for innovative therapeutic strategies in the future.
Androgenic Alopecia: A Comprehensive Literature Review of Epidemiology, Pathophysiology, Diagnosis, and Management Maudina, Baiq Zaskia; Wahyudi, Reza Rizwandipa; Dzulilmi, Dhaifatu; Salsabila D.P, Septy Rianty; Prameswari, Devi Shanti; Fauzan, Naufal Revaldy; Saithanya G.D, Ni Made; Bramantyo, Rofi; Putri, Alifia Sabira; Rizqi, Amanda Suana; Salsabila, Ruhaniah Najwa
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10182

Abstract

Androgenetic alopecia (AGA) is the most common form of hair loss in men and women, caused by a complex interaction of genetic and hormonal factors, particularly dihydrotestosterone (DHT). This condition is characterized by the miniaturization of hair follicles and changes in hair growth patterns, which affect the physical and psychological aspects of the sufferers. This article is prepared through a literature review from various recent scientific sources discussing the definition, etiology, epidemiology, pathophysiology, clinical manifestations, diagnosis, management, complications, and prognosis of AGA. Androgenetic alopecia (AGA) is triggered by genetic predisposition, follicle sensitivity to dihydrotestosterone (DHT), and supporting factors such as malnutrition, aging, and vascular disorders. The pattern of baldness differs in men and women, assessed using the Hamilton–Norwood or Ludwig scale. Diagnosis is established through history taking, physical examination, and supportive tests. Management includes topical and systemic therapy, supplements, hair transplantation, and low-level laser therapy (LLLT). AGA is also associated with the risk of actinic keratosis, cardiovascular disease, metabolic disorders, and polycystic ovary syndrome (PCOS) in women. AGA is a progressive chronic condition with multifactorial etiology. Early and appropriate management can slow progression and improve the quality of life of patients. Therapy is individualized, tailored to the degree of severity, gender, and patient response to treatment.
Literature review: Maturity Onset Diabetes of the Young (MODY) Bramantyo, Rofi; Fauzan, Naufal Revaldy; Wahyudi, Reza Rizwandipa; Dzulilmi, Dhaifatu; Putri, Septy Rianty Salsabilla Dwi; Prameswari, Devi Shanti; Dhevi, Ni Made Shaithanya Gitanjali; Putri, Alifia Sabira; Maudina, Baiq Zaskia; Rizqi, Amanda Suana; Salsabila, Ruhaniah Najwa; Wardani, Indah Sapta
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.8362

Abstract

Maturity Onset Diabetes of the Young (MODY) is a group of monogenic genetic disorders that cause diabetes with an autosomal dominant inheritance pattern, generally appearing before the age of 25. MODY is caused by gene mutations affecting pancreatic beta cell function, with 14 genetic subtypes identified. Diagnosis is often delayed or incorrect, as symptoms resemble type 1 or type 2 diabetes. The diagnosis of MODY is diagnosed through family history, clinical examination, and genetic analysis. MODY treatment is tailored to the genetic subtype, including lifestyle changes, sulfonylureas, and insulin, is tailored to the genetic subtype. Prognosis and risk of complications vary depending on the subtype, with MODY 2 (GCK) having the best prognosis. Prevention includes genetic testing for individuals with a family history of MODY, as well as lifestyle modifications to reduce the risk of complications. Patient education is important to ensure optimal management and prevention of long-term complications. This journal aims to learn more about the following definitions, to prognosis and education of MODY.
Co-Authors Bramantyo, Rofi Catarina Budyono, Catarina Dhevi, Ni Made Shaithanya Gitanjali Dzulilmi, Dhaifatu Fauzan, Naufal Revaldy Febriana, Nanggi Qoriatul Hakim, Baiq Sheila Oktalia Indah Sapta Wardani Larasati, Anak Agung Ayu Regina Maharani, Baiq Syarifaturrayyan Nuriasti, Rovera Pambudi, Balqis Prudena Kurnia Prameswari, Devi Shanti Prawira, Yoga Putri, Alifia Sabira Putri, Septy Rianty Salsabilla Dwi Rizqi, Amanda Suana Saithanya G.D, Ni Made Salsabila D.P, Septy Rianty Salsabila, Ruhaniah Najwa Sari, Padmi Kartika Wahyudi, Reza Rizwandipa