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All Journal Indonesian Journal of Obstetrics & Gynecology Science JURNAL PENDIDIKAN TAMBUSAI Majalah Kedokteran Andalas Andalas obstetrics and gynecology journal Frontiers on Healthcare Research
Djanas, Dovy
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Kehamilan Pada Jejas Luka Sesar: Diagnosis Yang Akurat Dan Keberhasilan Dalam Tatalaksana Secara Konservatif Purnomo, Satrio Budhi; Djanas, Dovy
Andalas Obstetrics And Gynecology Journal Vol 4, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.4.1.114-119.2020

Abstract

Reported case in a woman aged 30 years, with a history of cesarean scar four years ago, diagnosed with gravid two by one gravid 7-8 weeks with gestation on cesarean scar. The patient had a history of accidental trauma two days prior to the complaint of bleeding from the genitals. Several obstetricians have examined but still obtained different results (intrauterine pregnancy and ectopic pregnancy). An accurate diagnosis is critical to the success of the management of a patient with a pregnancy with this life-threatening cesarean scar. With a precise and accurate transvaginal ultrasound examination, the diagnostic criteria with ultrasound on previous surgical scars have been fulfilled in this patient, including an empty uterus, an empty cervical canal image, growth of a gestational pouch in the anterior lower segment of the uterus, and the absence of myometral image between the bladder wall and the gestational pocket. On B-HCG examination, the result was 58,808.70 mlU / mL. Conservative therapy with metrotrexate (MTX) 50 mg / m2 intramuscularly. After giving metrotrexate (MTX) therapy for four times, the results of B-HCG decreased significantly with 21.530, 12 mlU / mL, 2,949.47 mlU / mL, and 593.61 mlU / mL, respectively. After administration of metrotrexate (MTX) therapy, there was a decrease in the size of the gestational bag. Keywords: Ectopic, Pregnancy, Methotrexate, Cesarean Section
Pengaruh Pemberian Antibiotik Profilaksis Sefazolin, Seftriakson dan Antibiotik Seftriakson Sebelum dan Sesudah Operasi Terhadap Infeksi Luka Pasca Operasi Marni, Herti; Djanas, Dovy; Bachtiar, Hafni
Andalas Obstetrics And Gynecology Journal Vol 4, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.4.1.77-86.2020

Abstract

Objective : To determine the effect of giving prophylactic antibiotic ceftriaxone and cefazolin and giving ceftriaxone before and after surgery to the risk of postoperative wound infection in postoperative patients.Method: This study was an experimental study with a post test control group design that looked at the differences in the effect of administration of ceftriaxone, cefazolin, and ceftriaxone before and after surgery on the risk of postoperative wound infection. The population in this study were patients planned for surgery in the Obstetric and Gynelologic Departement of Dr. M. Djamil General Hopital, Padang. The number of samples used by 30 people with a group of 10 people each group. The study began in August until the number of samples was fulfilled. Univariate analysis was used to see the frequency, percentage, mean, and standard deviation. Bivariate analysis using Chi-square test with 95% CI (α <0.05) was used to see differences in the effect of the three antibiotic procedures.Results: There were no cases of postoperative wound infection based on the three procedures used. There was no difference in the effect of prophylactic antibiotics in postoperative infections. Conclusion: There was no difference in the effect of the three procedures for prophylactic antibiotics in postoperative infections.Keywords: Prophylactic Antibiotics, Surgical Wound Infections, Cefazolin, Ceftriaxone, Superficial incisional SSI
The Effect of Oral Albumin Intake on Serum Albumin Levels in Preeclamsia Patients With Hypoalbuminemia in RSUP Dr. M. Djamil Padang Fitriansyah, Irwin; Djanas, Dovy; Bachtiar, Hafni
Andalas Obstetrics And Gynecology Journal Vol. 5 No. 1 (2021)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.5.1.69-81.2021

Abstract

Introduction : Albumin main function is maintaining the plasma colloid oncotic pressure. Preeclampsia cause a decrease in serum albumin in the pregnant woman. Low albumin levels increase mortality, longer wound healing and longer hospital stays. The intake of oral albumin is expected to be effective in increasing the level of albumin in the blood.Objective : To determine the effect of freeze dryer method intake compared to liquid snakehead fish extract in patients with preeclampsia and hypoalbuminemia.Material and methods : Using pre and post-test control group design.The total sample was 38 patients with severe preeclampsia with hypoalbuminemia, divided into control and intervention groups. Control was given the intake of liquid snakehead fish extract, in the intervention was given the Freeze dryer method. The research data were analyzed using the Mann Whitney test method and the Wilcoxon test.Results : In the intervention group the mean pretest albumin level was 2.66 ± 0.17 gr / dl and on the 4th day it was 3.13 ± 0.16 gr / dl (p = 0.000). In the control group the mean pretest albumin level was 2.72 ± 0.15 gr / dl and on the 4th day it became 3.06 ± 0.14 gr / dl (p = 0.000). On the 4th day after treatment, the increase in serum albumin levels in the intervention group was 0.47 ± 0.19 gr / dl; whereas in the control group was 0.34 ± 0.10 gr / dl with a value of p = 0.031 (p <0.05).Conclusion : The freeze dryer method (freeze dryer method ) for the Cork Fish Extract resulted in a higher increase in albumin levels than the liquid snakehead fish extract.Keywords: Preeclampsia, Hypoalbuminemia, freeze dryer method of Snakehead Fish Extract
The Relationship Between Magnesium Level in Pregnancy with Gestational Diabetes Mellitus Ambelina, Syntia; Djanas, Dovy; Bachtiar, Hafni
Andalas Obstetrics And Gynecology Journal Vol. 5 No. 1 (2021)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.5.1.102-111.2021

Abstract

Introduction : Magnesium is one of important micronutrients in pregnancy. Pregnant women needs higher magnesium intake than non-pregnant women at similar age. Decreased blood and cellular magnesium level was related to insulin resistance.Objective : To determine relationship between mean magnesium level in pregnant women with incidence of gestational diabetes mellitus.Methods : This was quantitative analytic study using cross sectional comparative design conducted in 8 Primary Health Care in Padang and 5 General Hospital in West Sumatra. This study was done from December 2019 until March 2020. Total sample collected was 36 samples consisted of 18 pregnant mother with gestational diabetes mellitus and 18 control sample with normal pregnancy, both were in gestational age between 24-28 weeks. Statistical analysis was done using independent sample T-test.Results : Mean magnesium level of pregnant mother with gestational diabetes mellitus was 1.85 ± 0.12 mg/dL, while in control sample was 2.10 ± 0.15 mg/dL. Statistical result using independent sample T-test showed significant correlation between mean magnesium level and incidence of gestational diabetes mellitus with p <0.001 (p value <0.05)Conclusion : Magnesium level during pregnancy is related to gestational diabetes mellitus incidence.Keywords: magnesium level, pregnant women, gestational diabetes mellitus
The Correlation of the Average Increase in Blood Magnesium Levels with the Incidence of Preeclampsia After Magnesium Supplementation in Hypomagnesemic Pregnant Women at the Padang City Health Center Utama, Try Genta; Djanas, Dovy
Andalas Obstetrics And Gynecology Journal Vol. 5 No. 2 (2021)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.5.2.186-192.2021

Abstract

Preeclampsia is a hypertensive disorder in pregnancy that occurs in 5-10% of pregnancies and occurs after 20 weeks of gestation and recovers spontaneously after delivery. Several studies have stated that one of the risks of hypertension in pregnancy is related to magnesium homeostasis. Magnesium plays an important role in forming new tissues (maternal and fetal). Pregnant women need a higher intake of magnesium than non-pregnant women of the same age. Magnesium deficiency during pregnancy not only causes problems for the nutrition of pregnant women and fetuses, but also associated with the occurrence of preeclampsia, preterm labor and muscle cramps during pregnancy. This study aims to determine the relationship between the average increase in blood magnesium levels with the incidence of preeclampsia in hypomagnesemic pregnant women.Keywords: preeclampsia, hypertension, blood magnesium levels
Clinical Characteristics, Laboratory, Maternal and Fetal Outcomes in Pregnancy with Covid-19 at RSUP dr. M. Djamil Padang Sriyanti, Roza; Farnas, Heri; Djanas, Dovy
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.569-578.2024

Abstract

Introduction : The data obtained from various studies about covid-19 conducted in several hospitals in the world are currently considered not sufficient to provide a clinical picture that occurs in pregnancies with Covid-19 infection. The aims to provide an overview of the clinical, laboratory, maternal and fetal outcomes in pregnancy with Covid-19 infection at dr. M. Djamil Padang. Methods: This study used a descriptive design with data collection starting from March 01, 2020 - March 31, 2021 based on medical record data. Carried out in a single center at RSUP dr. M. Djamil Padang in pregnant patients with confirmed Covid-19 by PCR examination. Results: Total 136 pregnant patients confirmed Covid-19 by PCR examination. Most of the symptoms were asymptomatic (47.1%) and without any comorbidities (76.5%). There were 3 patients who experienced critical symptoms (2.2%). Maternal mortality was found at 2.3% and fetal death 4.7%. The values of d-dimer and NLR were found increasing significantly, 2025.35±1392.18 for d-dimer and 6.39±4.43 for NLR. Pregnancy terminations done for 77.9% patients with cesarean section is the most method (83%). There were 4 cases (3.8%) of babies infected with Covid-19 from mothers who had pregnancy terminations. Conclusions: Most cases had asymptomatic clinical symptoms (47.1%). There are 2.3% cases of maternal death and 4.7% cases of fetal death. Most of the pregnancy terminations were performed by cesarean section (88%). On laboratory examination, there was a significant increase in maternal d-dimer (2,025.35±1.392.18) and NLR (6.39±4.43) in pregnancies with Covid-19.
Pola Kuman dan Uji Kepekaan Antibiotik pada Kasus Infeksi Daerah Operasi di Departemen Obstetri & Ginekologi RSUP Dr. M. Djamil Padang Periode 2020-2022 Alfajri, Muhammad Hafizh; Djanas, Dovy; Suharti, Netti; Rasyid, Roslaily; Usman, Elly
Majalah Kedokteran Andalas Vol. 48 No. 4 (2025): MKA October 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v48.i4.p412-425.2025

Abstract

Latar Belakang: Infeksi Daerah Operasi (IDO) adalah infeksi pada lokasi insisi yang muncul dalam 30–90 hari setelah tindakan operasi. Pedoman penggunaan antibiotik di rumah sakit perlu disesuaikan dengan hasil surveilans pola kuman dan uji kepekaan antibiotik. Metode: Penelitian ini menggunakan desain deskriptif potong lintang dengan data sekunder berupa hasil kultur mikrobiologi dan rekam medis pasien IDO di Departemen Obstetri dan Ginekologi RSUP Dr. M. Djamil Padang periode 2020–2022. Dari 28 pasien yang terdata, 18 memenuhi kriteria inklusi. Hasil: Kelompok usia terbanyak yang mengalami IDO adalah wanita usia subur 15–49 tahun (77,8%). Kultur mikrobiologi menunjukkan kuman terbanyak adalah Escherichia coli (27,8%), diikuti Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter cloacae, dan Staphylococcus aureus. Uji kepekaan menunjukkan kuman Gram negatif sebagian besar sensitif terhadap amikasin dan meropenem, sedangkan kuman Gram positif sensitif terhadap gentamisin, klindamisin, tetrasiklin, dan vankomisin. Antibiotik profilaksis yang paling banyak digunakan adalah seftriakson (66,7%). Kesimpulan: Escherichia coli merupakan penyebab utama IDO pada pasien obstetri dan ginekologi di RSUP Dr. M. Djamil Padang. Amikasin dan meropenem efektif untuk kuman Gram negatif, sementara gentamisin, klindamisin, tetrasiklin, dan vankomisin efektif terhadap kuman Gram positif. Seftriakson menjadi antibiotik profilaksis yang paling banyak diresepkan, sehingga perlu evaluasi kesesuaiannya dengan pola kuman lokal.
Letter to the Editor: Strengthening Antimicrobial Resistance Control Practice at Dr. M. Djamil Central General Hospital Padang, Indonesia Djanas, Dovy
Frontiers on Healthcare Research Vol. 3 No. 1 (2026)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v3.n1.p69-71.2026

Abstract

Dr. M. Djamil Central General Hospital (RSUP Dr. M. Djamil) Padang has been at the forefront of efforts to combat antimicrobial resistance (AMR) through a comprehensive antimicrobial stewardship program guided by the Antimicrobial Resistance Control Committee (KPRA). The program focuses on three key components: surveillance, research, and education. Notable achievements include significant reductions in inappropriate antibiotic use, enhanced treatment strategies, and improved patient outcomes. A robust surveillance system has tracked both the quantity and quality of antibiotic use, leading to a marked increase in rational antibiotic prescriptions. Additionally, the implementation of antibiotic sensitivity patterns has allowed for more targeted therapies, particularly in treating multidrug-resistant organisms. Multidisciplinary collaboration through the Forum Kajian Kasus Infeksi Terintegrasi (FORKKIT) has further optimized patient care. Ongoing research into advanced diagnostic tools, such as RT-PCR, has advanced AMR control efforts, contributing to more precise treatments. Despite these successes, the continued prevalence of multidrug-resistant infections highlights the need for sustained efforts in surveillance, research, and education. Looking forward, RSUP Dr. M. Djamil Padang aims to reduce the incidence of these infections, improve prophylactic antibiotic administration, and align practices with national and international guidelines. The hospital’s commitment to advancing research and collaboration is vital in the global effort to preserve antibiotic effectiveness for future generations
Precision Chromosomal Surgery before Birth: Allele-Specific CRISPR-Cas9 Editing for Trisomy 21 in Perinatal Medicine Sanjaya, I Nyoman Hariyasa; Andonotopo, Wiku; Bachnas, Muhammad Adrianes; Prabowo, Wisnu; Yuliantara, Eric Edwin; Lukas, Efendi; Dewantiningrum, Julian; Pramono, Mochammad Besari Adi; Wiradnyana, Anak Agung Gede Putra; Mulyana, Ryan Saktika; Kusuma, Anak Agung Ngurah Jaya; Pangkahila, Evert Solomon; Gumilar, Khanisyah Erza; Darmawan, Ernawati; Akbar, Muhammad Ilham Aldika; Yeni, Cut Meurah; Aldiansyah, Dudy; Bernolian, Nuswil; Pribadi, Adhi; Anwar, Anita Deborah; Suryawan, Aloysius; Putra, Ridwan Abdullah; Gondo, Harry Kurniawan; Nugraha, Laksmana Adi Krista; Andanaputra, Waskita Ekamaheswara Kasumba; Dharma, Wibisana Andika Krista; Djanas, Dovy; Stanojevic, Milan
Indonesian Journal of Obstetrics & Gynecology Science Volume 9 Number 1 March 2026
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v9i1.965

Abstract

Objective: Trisomy 21 remains the most common live-born aneuploidy and a major contributor to perinatal morbidity. Although prenatal screening, particularly non-invasive prenatal testing (NIPT), has advanced substantially, clinical management offers no corrective options. Emerging allele-specific genome-editing approaches propose targeted removal or silencing of the extra chromosome 21. This review summarizes current evidence and evaluates the translational relevance of these technologies in perinatal medicine.Methods: A narrative review was conducted following PRISMA-aligned procedures. A structured search of PubMed, Scopus, and Web of Science (January 2000–July 2025) identified 1,242 records. After duplicate removal, title/abstract screening, and full-text assessment based on predefined inclusion criteria, 54 studies met eligibility requirements. Data were synthesized across four domains: mechanistic strategies, developmental applicability, translational feasibility, and ethical–regulatory considerations.Results: Allele-specific CRISPR-Cas9 studies demonstrated selective cleavage of the supernumerary chromosome 21 in cellular models, with partial restoration of near-euploid transcriptional patterns. Additional approaches—XIST-mediated silencing and centromere destabilization—provided alternative mechanisms with varying stability and specificity. Evidence remains limited to in vitro systems, with no validated embryo or fetal applications. Key challenges include mosaicism, delivery barriers, individualized SNP targeting, and ethical governance.Conclusions: Allele-specific chromosome editing represents a promising but still experimental direction for future perinatal therapeutics. Current findings justify continued multidisciplinary investigation while emphasizing cautious interpretation and rigorous ethical oversight prior to any clinical translation. Abstrak Tujuan: Trisomi 21 tetap menjadi aneuploidi yang paling sering ditemukan pada kelahiran hidup dan merupakan kontributor utama terhadap morbiditas perinatal. Meskipun skrining prenatal—khususnya non-invasive prenatal testing (NIPT)—telah mengalami kemajuan yang signifikan, penatalaksanaan klinis hingga kini belum menawarkan opsi korektif. Pendekatan pengeditan genom spesifik alel yang mulai berkembang mengusulkan penghilangan atau penghambatan terarah terhadap salinan ekstra kromosom 21. Tinjauan ini merangkum bukti terkini serta mengevaluasi relevansi translasional teknologi tersebut dalam kedokteran perinatal.Metode: Tinjauan naratif dilakukan dengan mengikuti prosedur yang selaras dengan PRISMA. Pencarian terstruktur terhadap PubMed, Scopus, dan Web of Science (Januari 2000–Juli 2025) mengidentifikasi 1.242 rekaman. Setelah penghapusan duplikasi, penyaringan judul/abstrak, dan penilaian teks lengkap berdasarkan kriteria inklusi yang telah ditentukan, sebanyak 54 studi memenuhi persyaratan kelayakan. Data disintesis ke dalam empat domain: strategi mekanistik, aplikabilitas perkembangan, kelayakan translasional, serta pertimbangan etika dan regulasi.Hasil: Studi CRISPR-Cas9 spesifik alel menunjukkan pemotongan selektif terhadap kromosom 21 supernumerari pada model seluler, dengan pemulihan parsial pola transkripsi menuju profil ekspresi gen yang menyerupai kondisi euploid. Pendekatan lain—seperti penghambatan berbasis XIST dan destabilisasi sentromer—menyediakan mekanisme alternatif dengan tingkat kestabilan dan spesifisitas yang bervariasi. Bukti saat ini terbatas pada sistem in vitro, tanpa aplikasi yang tervalidasi pada embrio maupun janin. Tantangan utama meliputi mosaikisme, hambatan pengantaran, kebutuhan penargetan SNP individual, serta tata kelola etis.Kesimpulan: Pengeditan kromosom spesifik alel merupakan arah yang menjanjikan, namun masih bersifat eksperimental bagi terapi perinatal di masa mendatang. Temuan saat ini mendukung keberlanjutan penelitian multidisipliner, sekaligus menekankan perlunya interpretasi yang hati-hati dan pengawasan etika yang ketat sebelum penerapannya dalam praktik klinis.Kata Kunci: Bedah genom janin; CRISPR-Cas9; Penyuntingan gen perinatal; Terapi kromosom; Trisomi 21
Co-Authors Adhi Pribadi Aldiansyah, Dudy Aldika Akbar, Muhammad Ilham Alfajri, Muhammad Hafizh Aloysius Suryawan Andanaputra, Waskita Ekamaheswara Kasumba Andani Eka Putra Andonotopo, Wiku Anita Deborah Anwar Ariwibowo, Bayu Pramudyo Bachnas, Muhammad Adrianes Cut Meurah Yeni Darmawan, Ernawati Dharma, Wibisana Andika Krista Efendi Lukas Efri, Gunawan Eric Edwin Yuliantara Evert Solomon Pangkahila Farnas, Heri Fauzan . Ferry, Ferdinal Fitriansyah, Irwin Hafni Bachtiar Harry Kurniawan Gondo I Nyoman Hariyasa Sanjaya Julian Dewantiningrum Khanisyah Erza Gumilar Kusuma, Anak Agung Ngurah Jaya Marni, Herti Mayuliani, Mayuliani Mila Permata Sari Netti Suharti, Netti Nugraha, Laksmana Adi Krista Nuswil Bernolian Pramono, Mochammad Besari Adi Purnomo, Satrio Budhi Putra, Ridwan Abdullah Roslaily Rasyid Ryan Saktika Mulyana Setia, Dyhan Purna Sriyanti, Roza Stanojevic, Milan Suhandri, Wiwin Sulin, Djusar Syaputra, Gunawan Efri Syntia Ambelina Utama, Try Genta Wiradnyana, Anak Agung Gede Putra WISNU PRABOWO Wulandari, Wira Dhika Tri