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FAKTOR-FAKTOR YANG BERKORELASI DENGAN KADAR ANTIBODI ANTITETANUS PADA IBU HAMIL Merry, Yussie Ater; Suharti, Netti
Jurnal Ilmu Keperawatan dan Kebidanan Vol 8, No 2 (2017): JURNAL ILMU KEPERAWATAN DAN KEBIDANAN
Publisher : STIKES Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/jikk.v8i2.295

Abstract

Kadar antibodi antitetanus pada ibu hamil dipengaruhi berbagai faktor, yaitu: umur, interval vaksinasi Tetanus toksoid (TT)-1 – TT-2, TT-1, TT-2 – waktu pemeriksaan dan kadar Hb. Penelitian ini bertujuan untuk mengetahui faktor – faktor yang berkorelasi dengan kadar antibodi antitetanus pada ibu hamil. Disain penelitian cross sectional, observasional terhadap 67 ibu hamil di wilayah kerja puskesmas Lubuk Buaya, Nanggalo dan Ambacang Kuranji kota Padang, bulan Juni - Desember 2015, teknik consecutive sampling. Kadar antibodi diukur menggunakan metode Indirect ELISA di Laboratorium Biomedik Universitas Andalas. Uji normalitas data dengan Kolmogorov-Smirnov, Spearman untuk korelasi antara umur, interval: TT-1 – TT-2, TT-1, TT-2 – waktu pemeriksaan, kadar Hb dengan kadar antibodi dan uji Kruskal Walis untuk menilai perbedaan kadar antibodi berdasar interval TT-1 – waktu pemeriksaan serta uji regresi linier untuk menentukan faktor determinan yang berkorelasi dengan kadar antibodi.Hasil penelitian menunjukkan terdapat korelasi negatif yang sangat lemah, tidak signifikan antara umur  dengan kadar antibodi (r=-0,076 p=0,540), terdapat korelasi positif lemah dan signifikan antara: interval TT-1 – TT-2 (r= 0,353, p = 0,003), korelasi positif kuat dan signifikan antara TT-1, TT-2 waktu pemeriksaan (r=0,696 p = 0,000 dan r= 0,729 p= 0,000) dengan kadar antibodi. Terdapat korelasi positif sangat lemah antara kadar Hb dengan kadar antibodi (r=0,200 p=0,104). Kesimpulan penelitian, faktor determinan yang berkorelasi dengan kadar antibodi antitetanus adalah: interval TT-1 – TT-2 dan TT-2 – waktu pemeriksaan
HUBUNGAN JUMLAH KOLONI BAKTERI ASAM LAKTAT AIR SUSU IBU DENGAN PH FESES BAYI PADA IBU BERSALIN NORMAL DAN SECTIO CAESAREA Lubis, Sunarti; Suharti, Netti; Rahmatini
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 6 No. 3 (2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (777.127 KB) | DOI: 10.22487/htj.v6i3.156

Abstract

Air Susu Ibu merupakan bagian penting untuk mendukung pertumbuhan komposisi usus bayi setelah lahir. ASI mengandung banyak bakteri bermanfaat bagi usus bayi. Bakteri ini berperan menghambat pertumbuhan bakteri merugikan dalam tubuh bayi yang dapat menyebabkan berbagai penyakit atau infeksi. Bakteri ini juga mampu menjaga keasaman usus bayi sehingga berperan untuk menghambat pertumbuhan bakteri yang merugikan. Tujuan penelitian ini adalah untuk mengetahui hubungan jumlah koloni bakteri asam laktat ASI dengan pH feses bayi pada ibu bersalin normal dan sectio caesarea. Penelitian ini bersifat observasional dengan rancangan cross sectional terhadap 50 orang ibu yang menyusui dan di wilayah kerja Puskesmas Andalas dan RSIA Restu Ibu Padang. Sampel dipilih secara purposive sampling. Instrumen penelitian yang digunakan adalah Colony Counter dan Indikator Universal. Uji normalitas data menggunakan Shapiro-wilk, uji Spearman dan Pearson untuk menilai hubungan jumlah koloni BAL ASI dengan pH feses bayi. Hasil penelitian menunjukkan bahwa jumlah koloni BAL ASI pada persalinan normal adalah 378 CFU/ML dan pH feses bayi 5,92 sedangkan pada persalinan sectio caesarea adalah 69,20 CFU/ML dan pH feses bayi 6,32. Tidak terdapat hubungan bermakna antara jumlah koloni BAL ASI dengan pH feses bayi pada persalinan normal dengan p=0,740 (r=-0,070) dan tidak terdapat hubungan bermakna antara jumlah koloni BAL ASI dengan pH feses bayi pada sectio caesarea dengan p=0,777 (r=-0,060). Penelitian ini dapat disimpulkan bahwa jumlah koloni BAL ASI dapat mempengaruhi pH feses bayi. Persalinan normal memiliki jumlah koloni BAL ASI lebih tinggi dari pada persalinan SC dan pH feses bayi lebih rendah pada persalinan normal dari pada persalinan SC. Jumlah koloni BAL ASI secara teori berhubungan dengan pH feses bayi tetapi secara statistik tidak terdapat hubungan yang signifikan pada persalinan normal dan SC.
Correlation of Uji Tahap Bersama (National Joint Exam) Results with Multiple Choice Questions (MCQ) Exam Scores in Medical Students Hendra, Gabriel Septian; Yulistini, Yulistini; Suharti, Netti; Firdawati, Firdawati; Usman, Elly; Putri, Biomechy Oktomalio
Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Vol 13, No 4 (2024): December
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpki.93452

Abstract

Background: Uji Tahap Bersama is a form of formative assessment initiated by the Association of Indonesian Medical Education Institutions (AIPKI) and the Ministry of Education and Culture (Kemendikbud) to maintain the quality of medical student learning in Indonesia. The Faculty of Medicine Universitas Andalas uses the Problem-Based Learning (PBL) method in organizing an educational system with summative assessment in the form of a computer-based Multiple-Choice Questions (MCQ) exam. Formative and summative assessment is a form of assessment that assesses the extent to which students understand the learning material that has been given. This study aims to determine the correlation between summative and formative assessment results in medical students' classes in 2017 and 2018, Faculty of Medicine, Universitas Andalas.Methods: This analytic, cross-sectional research involved 174 medical students from the Faculty of Medicine, Universitas Andalas, representing the 2017 and 2018 classes. The participants completed all pre-clinical phase blocks (except elective blocks) and took Uji Tahap Bersama I and II during their respective periods. Purposive sampling, meeting inclusion and exclusion criteria, determined the sample. The secondary data, which included the results of Uji Tahap Bersama I and II as well as MCQ scores before remedial, were analyzed through regression using the Pearson correlation test. To determine the extent to which MCQ affects the UTB outcomes, the coefficient of determination (r2) is used, which is obtained from the square of the correlation coefficient (r). The findings were interpreted based on Colton's correlation interpretation guidelines. Results: The findings revealed significant correlations in all four analyses conducted. UTB I results correlated significantly with average MCQ scores for the 1st to 4th semesters, while UTB II results correlated substantially with average MCQ block scores for the 1st to 7th semesters across batches. These correlations ranged from moderate to very strong.Conclusion: This study establishes a noteworthy correlation between UTB results and the average MCQ scores among medical students at the Faculty of Medicine, Universitas Andalas. The findings underscore the relevance of UTB as a formative assessment tool in maintaining and gauging the quality of medical education in Indonesia.
Effect of probiotic-fermented milk containing Lactiplantibacillus pentoses strain HBUAS 53657 on serum glutathione peroxidase activity and pancreatic histopathology in hyperglycemic rats Yaswir, Rita; Yerizel, Eti; Suharti, Netti; Ilmiawati, Cimi
Acta Biochimica Indonesiana Vol. 7 No. 2 (2024): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.174

Abstract

Background: Hyperglycemia is characterized by elevated blood glucose levels caused by impaired insulin production or function, leading to oxidative stress. Probiotic-fermented milk containing Lactiplantibacillus pentosus strain HBUAS 53657 (PFM) has antioxidant and antimicrobial properties that may reduce oxidative stress. Objective: This study aimed to investigate the effects of PFM L. pentosus strain HBUAS 53657 on serum glutathione peroxidase (GPx) activity and pancreatic histopathology in hyperglycemic rats. Method: A post-test-only experimental design was conducted using 25 adult male Wistar rats divided into five groups (n = 5 per group): normal control, hyperglycemic control group, and hyperglycemic rats treated with PFM at doses of 1 × 10⁸ CFU/day (P1), 1 × 10⁹ CFU/day (P2), and 1 × 10¹⁰ CFU/day (P3) for 28 days. Serum GPx activity was assessed via spectrophotometry, Langerhans islet area was measured using ImageJ, and islet damage was evaluated using the Ningrum Score. Statistical analysis was performed using One-Way ANOVA and Kruskal-Wallis tests. Results: PFM administration at all doses significantly increased serum GPx activity (p = 0.002), with an optimal dose of 1 × 10⁹ CFU/day (P2). PFM also increased the Langerhans islet area (p = 0.001) and reduced islet damage scores (p < 0.001) in a dose-dependent manner. Conclusion: Probiotic-fermented milk containing Lactiplantibacillus pentosus strain HBUAS 53657 increases serum GPx activity, expands Langerhans islet area, and reduces islet damage in hyperglycemic rats.
Identifikasi Bakteri Escherichia coli dalam Air Minum Galon pada Kantin yang ada di Universitas Andalas Padang Gitawama, Muhammad Rayhan Braja; Suharti, Netti; Harminarti, Nora
Jurnal Kesehatan Andalas Vol. 10 No. 1 (2021): Online March 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i1.1507

Abstract

The National Food and Drug Agency has controlled the refill drinking water in drinking water depots and also controlled food at school canteens ranging from elementary, junior high, to high school, but the National Food and Drug Agency never do food quality controlling in canteens at universities. Objectives: To identified the contamination by coliform and E. coli bacteria in drinking water at Andalas University canteen. Methods: This research was descriptive to identify coliform bacteria on  15 drinking water at the Andalas University faculty canteens.  Samples were taken directly using a sterile bottle, while data analysis using Most Probable Number  (MPN)  tables 5-1-1 and the presence of E. coli bacteria colonies from drinking water samples. Results: 9 of 15 water samples were contaminated by coliform bacteria with the highest MPN index of 240/100 ml that was found in 2 samples. From 9 samples containing coliform bacteria, all of them were found to contain E. coli bacteria. Conclusion: Most of the samples were contaminated by coliform and E. coli bacteria. Drinking water served using a kettle was more contaminated than drinking water served using gallons.Keywords: Coliform, Escherichia coli, MPN
Perbandingan Lama Rawatan Pasien Sectio Caesarea Metode ERACS dengan Metode Konvensional di RSIA Restu Ibu Padang Harbaindo, Shavira Quincy; Effendi, Rinal; Linosefa, Linosefa; Suharti, Netti; Rustini, Rini; Antonius, Puja Agung
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 4 (2024): Desember 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i4.989

Abstract

Latar Belakang. Angka sectio caesarea yang mengalami peningkatan dari tahun ke tahun mendorong banyaknya potensi yang timbul untuk mengembangkan pelayanan, salah satunya dari aspek kecepatan pemulihan yang ditawarkan metode ERACS (Enhanced Recovery After Caesarean Surgery). Metode ERACS memiliki beberapa perbedaan dari metode konvensional, dan menurut penelitian terdahulu, metode ERACS menunjukan lebih banyak keunggulan yang dapat menguntungkan pasien, salah satunya dari segi lama rawatan. Objektif. Mengetahui perbandingan lama rawatan pasien sectio caesarea metode ERACS dengan metode konvensional di RSIA Restu Ibu Padang. Metode. Jenis penelitian ini adalah analitik observasional dengan desain kohort. Data diambil secara retrospektif dari rekam medik pasien sectio caesarea di RSIA Restu Ibu periode November-Desember 2021. Sampel berjumlah 67 pasien yang dipilih menggunakan total samplingberdasarkan kriteria inklusi dan eksklusi. Hasil. Frekuensi lama rawatan paling tinggi pada pasien sectio caesarea dengan metode konvensional adalah lebih dari atau sama dengan 3 hari, sedangkan lama rawatan pada metode ERACS menunjukan paling banyak pasien dirawat selama 2 hari. Hasil analisis dengan uji Chi-square pada perbandingan lama rawatan antara metode ERACS dengan metode konvensional di rumah sakit tempat penelitian menunjukan nilai p=0,002. Kesimpulan. Kesimpulan dari penelitian ini adalah terdapat hubungan yang signifikan (p<0,05) dari perbandingan lama rawatan antara metode ERACS dengan metode konvensional di RSIA Restu Ibu Padang.
Hubungan Severitas Gambaran Radiologis Foto Toraks Pasien Covid-19 Dengan Peningkatan Kadar D-Dimer Randa, Ilham; Handayani, Tuti; Suharti, Netti
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 2 (2024): Juni 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i2.1195

Abstract

Abstrak Latar Belakang: Corona Virus Disease 2019 (COVID-19) adalah penyakit pneumonia yang disebabkan oleh infeksi SARS-CoV-2 yang dapat mengarah kepada badai sitokin yang menginduksi disregulasi koagulasi (ditandai dengan peningkatan kadar D-dimer) sehingga meningkatkan risiko terjadinya trombosis. Pemeriksaan foto toraks memiliki peranan dalam upaya pemeriksaan lini pertama karena penggunaannya yang mudah dan dapat diterapkan untuk memantau kelainan paru pada pasien COVID-19. Objektif: Penelitian ini bertujuan melihat hubungan severitas gambaran radiologis foto toraks pasien COVID-19 dengan peningkatan kadar D-dimer. Metode: Penelitian ini merupakan penelitian analitik dengan pendekatan cross sectional pada data sekunder pasien COVID-19 yang dilakukan pemeriksaan foto toraks dengan menggunakan skor Brixia dan kadar D-dimer di Rumah Sakit Dr. M. Djamil Padang terhadap 30 sampel. Analisis data menggunakan uji korelasi Pearson. Korelasi dinyatakan bermakna jika p<0,05. Hasil: Penelitian ini memperoleh nilai rerata untuk severitas gambaran radiologis foto toraks pasien COVID-19 sebesar 9,8±4,286 dan kadar D-dimer sebesar 1955±1065,041 µg/L. Hasil analisis bivariat menunjukkan hubungan severitas gambaran radiologis foto toraks dengan kadar D-dimer pada pasien COVID-19 (p=0,028) dan nilai korelasi (r) ialah 0,401. Kesimpulan: Kesimpulan yang didapat adalah terdapat hubungan dengan korelasi moderat antara severitas gambaran radiologis foto toraks dengan kadar D-dimer pada pasien COVID-19. Kata kunci: COVID-19, D-dimer, Foto Toraks Abstract Background: Corona Virus Disease 2019 (COVID-19) is a pneumonia caused by infection with SARS-CoV-2 that can lead to a cytokine storm that induces coagulation dysregulation (characterized by elevated D-dimer levels) thereby increasing the risk of thrombosis. X-ray examination has a role in first-line examination efforts because it is easy to use and can be applied to monitor lung abnormalities in COVID-19 patients. Objective: This study aims to see the relationship between the severity of the chest radiography of COVID-19 patients with increased levels of D-dimer. Methods: This study was an analytic study with a cross sectional approach to secondary data for patients with COVID-19 who were examined for chest X-ray with Brixia scores and D-dimer levels. The sample of this study were patients diagnosed with COVID-19 at Dr. M. Djamil Hospital, Padang as many as 30 samples. Data analysis used univariate and bivariate analysis with the Pearson correlation test. Correlation was significant if p<0,05. Results: The study obtained that the mean value for the chest X-ray scores of COVID-19 patients was 9,8±4,286 and the D-dimer level was 1955±1065,041 µg/L. The results showed that there was a significant relationship between chest X-ray scores and D-dimer levels, the p value was 0,028 and the correlation value (r) was 0,401. Conclusion: It is concluded that there is relationship with a moderate correlation between chest X-ray scores and D-dimer levels in patients with COVID-19.
Gambaran Klinis COVID-19 pada Mahasiswa FK Universitas Andalas Berdasarkan Status Vaksinasi COVID-19 Hanif, Rayhendra; Suharti, Netti; Rasyid, Rosfita; Putra, Andani Eka; Russilawati, Russilawati; Izzah, Amirah Zatil
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 4 (2024): Desember 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i4.1256

Abstract

Background: COVID-19 is a disease caused by SARS-CoV-2 that’s highly infectious and has caused a pandemic. Vaccines are one of the most effective measures to control the spread of COVID-19. COVID-19 vaccines work by targeting the viral spike protein which can be varied in each variant of SARS-CoV-2 that threatens vaccines’ performance. This may allow breakthrough infection to occur with varying clinical characteristics. Objectives: This study aims to determine the clinical characteristics of COVID-19 on students at Medical Faculty of Andalas University based on their COVID-19 Vaccination status Methods: This research was observational descriptive. Data were collected using questionnaire with total sampling technique from December 2022 to January 2023 at the Medical Faculty of Andalas University. The questionnaire contained identity of respondent’s history, clinical characteristics of COVID-19 and their COVID-19 vaccination status. Questionnaire data were processed and displayed in frequency distribution tables. Results: The result showed that 100 samples out of 241 populations on this study were mostly women, mean age of 21.2 years old ± 0,7, range of age between 19-23 years old, most were already vaccinated for the third time, most were infected only once, and most infections happened after the second vaccination. The most common symptoms were fever, sore throat and cough. The severity of COVID-19 infections were relatively mild based despite of the vaccination status. No samples were reported of having severe critical illness. Conclusion: The symptoms of COVID-19 were relatively similar regardless of the vaccination status and the severity of COVID-19 infections were relatively mild regardless of the vaccination status on students at Medical Faculty of Andalas University.
Uji Daya Hambat Filtrat Lactobacillus gasseri Terhadap Pertumbuhan Staphylococcus aureus yang Diisolasi dari Genitalia Wanita Husna, Annisa Tamara; Suharti, Netti; Akhyar, Gardenia; Putra, Andani Eka; Muhammad, Syamel; Ilmiawati, Cimi
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 4 (2024): Desember 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i4.1329

Abstract

Latar Belakang: Lactobacillus gasseri merupakan salah satu jenis bakteri terbanyak ditemukan pada vagina wanita yang dapat menghasilkan bakteriosin sebagai senyawa antibakteri. Bakteriosin dijadikan alternatif melawan bakteri yang resisten terhadap antibiotik, salah satunya Staphylococcus aureus. Selain itu, Staphylococcus aureus merupakan salah satu penyebab vaginitis aerobik yang diteliti dapat membahayakan kehamilan hingga persalinan. Objektif: Tujuan penelitian ini adalah mengetahui kadar hambat minimal (KHM) dan kadar bunuh minimal (KBM) sebagai indikator untuk melihat kemampuan filtrat bakteriosin Lactobacillus gasseri dalam menghambat pertumbuhan Staphylococcus aureus. Metode: Penelitian ini dilakukan pada bulan Mei-November 2023 di Laboratorium Mikrobiologi Fakultas Kedokteran Universitas Andalas dan Laboratorium Pusat Diagnostik dan Riset Penyakit Infeksi Fakultas Kedokteran Unand. Sampel penelitian ini adalah Staphylococcus aureus yang diperoleh dari swab vagina yang dikultur di Laboratorium Mikrobiologi Fakultas Kedokteran Universitas Andalas. Penelitian dilakukan dengan teknik dilusi dan Real Time PCR dengan desain penelitian rancangan acak lengkap. Hasil: Nilai KHM dari filtrat bakteriosin Lactobacillus gasseri terhadap Staphylococcus aureus diperoleh pada konsentrasi >20% dan <40%, sedangkan nilai kadar bunuh minimal (KBM) diperoleh pada konsentrasi 40%. Kesimpulan: Filtrat bakteriosin Lactobacillus gasseri memiliki efek bakteriostatik dan bakterisidal terhadap pertumbuhan Staphylococcus aureus yang dipengaruhi oleh konsentrasi dari filtrat bakteriosin Lactobacillus gasseri.
PERBANDINGAN FAKTOR RISIKO DAN MANIFESTASI KLINIS HPV 16 DENGAN HPV 18 PADA PENDERITA KARSINOMA SERVIKS Anavelda, Aura Putri; Putra, Andani Eka; Defrin, Defrin; Suharti, Netti; Antonius, Puja Agung; Elmatris, Elmatris
SINERGI : Jurnal Riset Ilmiah Vol. 2 No. 4 (2025): SINERGI : Jurnal Riset Ilmiah, April 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v2i4.1114

Abstract

Background: High-risk Human Papillomavirus (hrHPV) infection causes 99.7% of cervical carcinoma cases. Among the thirteen types of hrHPV, types 16 and 18 have a strong correlation with- cervical carcinoma. HPV 16 infection makes the immune system in the cervix hyporesponsive compared to HPV 18 infection. Objective: This study aims to compare the risk factors and clinical manifestations of HPV 16 with HPV 18 in cervical carcinoma patients. Method: This is an analytic study with a retrospective cohort approach using secondary data from the research of Dr. dr. Andani Eka Putra, M.Sc and dr. Syandrez Prima Putra which has been collected into a research master table. The sampling technique was non-probability sampling with convenience sampling on 38 respondents whose specimens were stored at the Central Laboratory of Diagnostics and Research on Infectious Diseases, Faculty of Medicine, Andalas University. Data analysis was carried out using Fisher's Exact test. Results: The results of statistical tests on the comparison of marriageable age between patients with HPV 16 and HPV 18 types showed a value of p = 0.038 (p <0.05). In this study, women who are > 45 years old, married early (<20 years), have a low level of education, work as housewives, and have a multiparity history are at high risk of cervical carcinoma. Patients with HPV 16 and 18 had risk factors and clinical manifestations were not much different (p>0.05). Conclusion: There is no significant comparison of the risk factors and clinical manifestations of HPV 16 with HPV 18 in patients with cervical carcinoma.