Article Per Year (5 Year)
p-Index From 2020 - 2025
0.92
P-Index
This Author published in this journals
All Journal Majalah Kedokteran Bandung Indonesian Journal of Obstetrics & Gynecology Science Andalas obstetrics and gynecology journal
Madjid, Tita Husnitawati
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

Published : 6 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 6 Documents
Search

 1 
Effect of Methotrexate on Anti-Mullerian Hormone Levels, β-hCG and Tumor Size in Women with Low-Risk Gestational Trophoblast Disease Madjid, Tita Husnitawati; Masitoh, Imas; Harsono, Ali Budi; Purwara, Benny Hasan; Rinaldi, Andi; Mose, Johannes Cornelius; Sunardi, Sunardi
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 1 Maret 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i1.610

Abstract

Introduction: This study aimed to evaluate the effect of methotrexate (MTX) chemotherapy on anti-mullerian hormone (AMH) levels, human chorionic gonadotropin (HCG) levels, and tumor size in women with gestational trophoblastic disease (GTD). Method: This study was conducted at Hasan Sadikin General Hospital, Bandung, West Java, from April to October 2020. The AMH level, beta human chorionic gonadotropin (ß-hCG) and tumor size in women with a low risk of GTD prior to and after MTX chemotherapy treatment were measured and compared.Results: Our study found a reduction in mean AMH level to 0.82 ng/ml after the MTX chemotherapy. The mean AMH level after chemotherapy in women with low-risk GTD decreased to 0.82 ng / ml. In addition, ß-hCG level decreased after chemotherapy with MTX. There was a negative relationship between ß-hCG level and tumor size before and after chemotherapy. Higher ß-hCG levels and tumor size before chemotherapy resulted in a further increase in AMH after chemotherapy.Discussion: There was a decrease in AMH and ß-hCG levels after three cycles of MTX chemotherapy in women with low-risk GTD. Tumor size and ß-hCG correlated with post-chemotherapy AMH results.Pengaruh Metotreksat terhadap Kadar Hormon Anti Mullerian, β-hCG dan Ukuran Tumor pada Wanita dengan Penyakit Trofoblas Gestasional Risiko RendahAbstrakPendahuluan: Penelitian ini mengevaluasi efek kemoterapi metotreksat (MTX) terhadap kadar hormon anti-mullerian (AMH), kadar human chorionic gonadotropin (HCG), dan ukuran tumor pada wanita yang didiagnosis penyakit trofoblas gestasional (GTD) risiko rendah.Metode: Penelitian ini dilakukan di Rumah Sakit Umum Pusat Hasan Sadikin, Bandung, Jawa Barat, dari bulan April hingga Oktober 2020. Kadar AMH, beta human chorionic gonadotropin (ß-hCG), dan ukuran tumor pada wanita dengan GTD risiko rendah sebelum dan sesudah pengobatan kemoterapi MTX diukur dan dibandingkan.Hasil: Pada penelitian kami menemukan penurunan kadar AMH rata-rata menjadi 0,82 ng/ml setelah kemoterapi MTX. Rata-rata kadar AMH setelah kemoterapi pada wanita dengan GTD risiko rendah menurun menjadi 0,82 ng/ml. Selain itu, kadar ß-hCG juga menurun setelah kemoterapi dengan MTX. Terdapat hubungan negatif antara kadar ß-hCG dan ukuran tumor sebelum kemoterapi dan AMH setelah kemoterapi. Kadar ß-hCG yang lebih tinggi dan ukuran tumor sebelum kemoterapi menunjukkan peningkatan lebih tinggi pada AMH setelah kemoterapi.Kesimpulan: Terjadi penurunan kadar AMH dan ß-hCG setelah tiga siklus kemoterapi MTX pada wanita dengan GTD risiko rendah. Ukuran tumor dan kadar ß-hCG berkorelasi dengan hasil kadar AMH setelah kemoterapi.Kata kunci: Kemoterapi, Metotreksat, Hormon anti-mullerian, ß-hCG, Tumor trofoblas gestasional
Permasalahan Perujukan Pasien dengan Malposisi yang telah Mencapai Kala II Muhamad, Ayrton Fajar; Madjid, Tita Husnitawati
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 1 Maret 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i1.638

Abstract

Pendahuluan: Presentasi sungsang pada kehamilan prematur berhubungan dengan risiko obstetrik yang lebih tinggi dibandingkan dengan presentasi kepala. Pada kehamilan prematur, faktor predisposisi terjadinya letak sungsang adalah KPD, oligohidramnion, usia ibu lanjut, nuliparitas, riwayat operasi seksio sesarea sebelumnya, berat badan lahir janin di bawah persentil 10, dan kelainan kongenital janin. Pada persalinan prematur, presentasi sungsang merupakan keadaan berisiko tinggi. Rujukan yang tidak tepat dapat berujung timbulnya komplikasi maternal dan fetal pada presentasi sungsang prematur.Kasus: Wanita berusia 34 tahun, G4P2A1 parturien 32 - 33 minggu rujukan dari Puskesmas datang ke Rumah Sakit Hasan Sadikin dengan keluhan mules-mules yang semakin sering dan bertambah kuat. Pasien mengetahui kehamilannya letak sungsang sejak usia kehamilan lima bulan saat memeriksakan kandungannya di SpOG. Diskusi: Pada saat pasien rujukan datang ke RSHS, diketahui pembukaan telah lengkap dan hasil pemeriksaan dalam menunjukkan presentasi janin bokong, tidak teraba bagian-bagian kecil janin, tidak teraba tali pusat pada bagian terbawah janin. Pasien didiagnosis dengan G4P2A1 parturien 32-33 minggu kala II presentasi bokong murni, kemudian direncanakan partus pervaginam spontan dengan bracht. Kesimpulan: Perujukan yang tepat dan cepat masih menjadi kendala. Puskesmas sebagai fasilitas primer harus mampu merujuk tepat waktu mencegah komplikasi ibu dan janin pada saat persalinan dan nifas.Problem of Referral of Patients with Malposition who Have Reached Stage IIAbstractIntroduction: Breech presentation in preterm pregnancy is associated with higher obstetric risk compared to head presentation. In preterm pregnancy, the predisposing factors for breech presentation are KPD, oligohydramnios, advanced maternal age, nulliparity, history of previous cesarean section, fetal birth weight below 10th percentile, and fetal congenital abnormalities. In preterm labor, breech presentation is a high-risk condition. Inappropriate referral can lead to maternal and fetal complications in preterm breech presentation.Case: A 34 year old woman, G4P2A1 parturien 32 - 33 weeks referred from Puskesmas came to Hasan Sadikin Hospital with complaints of increasingly frequent and stronger contractions. The patient knew her pregnancy was breech since five months of gestation when she was examined at an Obstetrician and Gynecology Specialist.Discussion: When the referral patient came to RSHS, it was known that the opening was complete and the results of the internal examination showed breech fetal presentation, no palpable small parts of the fetus, no palpable umbilical cord at the bottom of the fetus. The patient was diagnosed with G4P2A1 parturien 32-33 weeks time II pure breech presentation, then planned spontaneous vaginal partus with bracht. Conclusion: Efficient and prompt referral is still an area of concern. Primary health centers as primary facilities must be able to refer on time to prevent maternal and fetal complications during labor and postpartum.Key words: Breech, premature, referral system 
Vitamin D Levels and Incidence of Preterm Labor Aziz, Muhammad Alamsyah; Syahbana, Chandra Garnida; Effendi, Jusuf Sulaeman; Purwara, Benny Hasan; Madjid, Tita Husnitawati; Susiarno, Hadi
Majalah Kedokteran Bandung Vol 56, No 1 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3070

Abstract

One pathophysiology of preterm delivery is maternal or fetal hypothalamus-pituitary-adrenal (HPA) axis activation. The HPA axis can be affected by vitamin D, which increases uterine contractions and affects the body’s immune mechanism against bacterial infections. A lower level of vitamin D in pregnant women is suspected to contribute to the incidence of premature conditions. This study aimed to compare the 25-hydroxy-vitamin D3 concentration in preterm parturient with non-preterm parturient, and the correlation between vitamin D level and the incidence of preterm labor. This comparative analytic study used a cross-sectional approach and involved 46 subjects who were divided into case and control groups. This study was conducted in August–September 2017 at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. The Electro-chemiluminescence Immunoassay (ECLIA) method was used to examine the serum 25-hydroxy-vitamin D3 concentration in case and control groups, demonstrating that 25-hydroxy-vitamin D3 concentration in case group (17.26 ng/mL) was significantly (p<0.0001) lower than in control group (24.30 ng/mL). The correlation coefficient between the 25-hydroxy-vitamin D3 and the incidence of preterm labor was -0.837 (p<0.001).  Thus, there was a correlation between the 25-hydroxy-Vitamin D3 level and the incidence of preterm labor that vitamin D supplementation in pregnant women must be considered.
Overview of Menstrual Patterns in Female Patients Diagnosed with Tuberculosis with a History of Infertility at DOTS Polyclinic Hasan Sadikin Hospital and Community Health Centers in Bandung City Madjid, Tita Husnitawati; Utomo, Suhendro Rahmat; Susilo, Artha Falentin Putri; Ritonga, Mulyanusa Amarullah; Arya, Insi Farisa Desy
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 1 Maret 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i1.725

Abstract

Introduction: Female genital tuberculosis (FGTB) is one of the leading causes of infertility in countries with high cases of tuberculosis. However, there is a lack of data showing the menstrual patterns of FGTB patients in Indonesia. This study was conducted to describe the menstrual patterns of female patients diagnosed with TB and who have a history of infertility at the Directly Observed Treatment Short Course Polyclinic of Hasan Sadikin Hospital and community health centers in Bandung City.Method: This is a descriptive observational study using primary data. The subjects were outpatient TB patients with a history of infertility in the Directly Observed Treatment Short Course polyclinic of Hasan Sadikin Hospital and community health centers in Bandung City from 2018 to 2022. Data collection was conducted through questionnaire-based interviews.Results: Out of 950 TB patients of childbearing age recorded in medical records, 41 patients matched the specified criteria. The menstrual disorders experienced by patients included polymenorrhagia, oligomenorrhea, amenorrhea, prolonged menstrual cycles, irregular cycles, hypomenorrhea, heavy menstrual bleeding, and intermenstrual bleeding.Conclusion: The most common menstrual disorders in TB patients with a history of infertility were irregular cycles (36.6%), hypomenorrhea (31.7%), and oligomenorrhea (19.5%).Gambaran Pola Menstruasi pada Pasien Perempuan dengan Diagnosis Tuberkulosis dan Riwayat Infertilitas di Poli DOTS RSHS dan Puskesmas Kota BandungAbstrakPendahuluan: Female genital tuberculosis merupakan salah satu penyebab utama infertilitas pada negara dengan kasus tuberkulosis yang tinggi. Sebagai salah satu dari gejalanya, belum ada data yang menunjukkan pola menstruasi dari pasien female genital tuberculosis di Indonesia. Penelitian ini bertujuan untuk mengetahui gambaran pola menstruasi pada pasien wanita dengan diagnosis tubekulosis dan memiliki riwayat infertilitas di Poliklinik Directly Observed Treatment Short Course Rumah Sakit Hasan Sadikin dan Puskesmas Kota Bandung.Metode: Penelitian deskriptif dengan menggunakan data primer. Subjek penelitian adalah pasien tuberkulosis wanita dengan riwayat infertilitas yang dirawat jalan di poliklinik Directly Observed Treatment Short Course Rumah Sakit Hasan Sadikin dan 4 Puskesmas di Kota Bandung dari tahun 2018 - 2022. Subjek diperoleh melalui wawancara berbasis kuesioner.Hasil: Dari 950 pasien tuberkulosis wanita usia subur yang terdata di rekam medis, didapatkan 41 data pasien yang sesuai dengan kriteria yang ditentukan. Gangguan menstruasi yang dialami pasien dapat berupa polimenore, oligomenore, amenore, siklus menstruasi yang memanjang, siklus yang irreguler, hipomenore, heavy menstrual bleeding, dan perdarahan intermenstrual.Kesimpulan: Gangguan menstruasi yang paling sering terjadi pada pasien TB dengan riwayat infertilitas adalah siklus yang irreguler (36.6%), hipomenore (31.7%), dan oligomenore (19.5%).Kata Kunci: Infertilitas, Kota Bandung, Pasien TB wanita, Pola Menstruasi.
Maternal and Neonatal Outcomes in Pregnancies with Systemic Lupus Erythematosus (SLE) from 2021 to 2023 at Hasan Sadikin Hospital, Bandung Putra, Ahmad Rialita; Madjid, Tita Husnitawati; Irianti, Setyirini
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 2 July 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i2.896

Abstract

Objective: To describe maternal and neonatal outcomes in pregnant women with SLE at Dr. Hasan Sadikin General Hospital, Bandung.Methods: This descriptive study reviewed secondary data of pregnant women with SLE at RSHS from January 2021 to December 2023.Results. A total of 41 pregnant women with SLE and 82 without SLE were included. SLE patients were younger (29.44±5.03 years) than non-SLE (33.76±7.31 years). Most SLE patients had normal (63.4%) or overweight (36.6%) nutritional status. Skin rash was the most common symptom (78%). Hypertension (14.6% vs 73.2%) and fetal death (4.9% vs 17.1%) were lower in the SLE group. Live birth rate was higher (95.1% vs 89.0%), but low birth weight incidence was higher (65.9% vs 53.7%) in SLE.Conclusion: Pregnant women with SLE tend to be younger and overweight. Hypertension and fetal death were lower, but low birth weight and growth restriction were more frequent in SLE pregnancies, despite quality ANC. The cause of fetal growth restriction in SLE remains unclear.Luaran Ibu dan Bayi pada kehamilan dengan Lupus Eritematosus Sistemik (LES) pada tahun 2021 - 2023 di Rumah Sakit Hasan Sadikin BandungAbstrakTujuan: Penelitian ini bertujuan untuk mendeskripsikan luaran maternal dan neonatus pada wanita hamil dengan LES di RSUP Dr. Hasan Sadikin Bandung.Metode: Penelitian ini menggunakan metode deskriptif untuk meninjau data sekunder ibu hamil dengan LES di RSHS dari Januari 2021 hingga Desember 2023.Hasil. Sebanyak 41 wanita hamil dengan LES dan 82 tanpa LES diikutsertakan. Pasien LES lebih muda (29,44±5,03 tahun) dibanding non-LES (33,76±7,31 tahun). Mayoritas pasien LES berstatus gizi normal (63,4%) atau overweight (36,6%). Ruam kulit paling umum (78%). Hipertensi (14,6% vs 73,2%) dan kematian janin (4,9% vs 17,1%) lebih rendah pada LES. Kelahiran hidup lebih tinggi (95,1% vs 89,0%), tapi berat lahir rendah lebih tinggi (65,9% vs 53,7%) pada LES.Kesimpulan: Wanita hamil dengan LES cenderung lebih muda dan overweight. Komplikasi hipertensi dan kematian janin lebih rendah, tetapi berat lahir rendah dan hambatan pertumbuhan janin lebih sering pada LES, meski mendapat ANC berkualitas. Penyebab hambatan pertumbuhan janin pada LES belum diketahui.Kata kunci: Kehamilan; Komplikasi; Luaran maternal; Luaran neonatus; Lupus Eritematosus Sistemik
KORELASI EKSPRESI IMMUNOSITOKIMIA VASCULAR ENDOTHELIAL GROWTH FACTOR A (VEGF A) DENGAN PROTEIN GENE PRODUCT 9,5 (PGP 9,5) DARAH HAID PADA PATOFISIOLOGI ENDOMETRIOSIS Hendry, Dedy; Madjid, Tita Husnitawati; Anwar, Ruswana; Rachmawati, Anita
Andalas Obstetrics And Gynecology Journal Vol. 1 No. 1 (2017)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.1.1.38-46.2017

Abstract

There are changes of eutopic endometrium molecular fenotipe in endometriosis such as changes in gene expression, steroid hormone response, increase of inflammation marker and cellular adhesion molecule, decrease of apoptotic index and decidualization capacity, increase of oxidative stress marker, increase activity of angiogenesis and neurogenesis. This study was conducted to analyze the differences in the expression of angiogenic factors (VEGF A) and neurogenesis factors (PGP 9.5) eutopic endometrium of menstrual bleeding among patients with endometriosis and non endometriosis and then the correlation of the two factors. This study is a cross sectional that examines the relationship between the incidence of endometriosis with risk factors such as VEGF expression and PGP 9.5 in menstrual blood. There were significant differences in the expression of VEGF A eutopic endometrium menstrual blood between endometriosis and non endometriosis group (p=0.002). There are significant differences expression of VEGF A and PGP 9.5 eutopic endometrial of menstrual blood between endometriosis and non endometriosis groups. There is a positive correlation between the expression of VEGF A with PGP 9.5 eutopic endometrial of menstrual blood on endometriosis patients.Keywords: eutopic endometrium, menstrual blood, VEGF A expression, PGP 9.5 expression, immunocytochemistry
Co-Authors Andi Rinaldi Aziz, Muhammad Alamsyah Benny Hasan Purwara Harsono, Ali Budi Hendry, Dedy Insi Farisa Desy Arya Irianti, Setyirini Jusuf Sulaeman Effendi Masitoh, Imas Mose, Johannes Cornelius Muhamad, Ayrton Fajar Putra, Ahmad Rialita Rachmawati, Anita Ritonga, Mulyanusa Amarullah Ruswana Anwar Sunardi Sunardi Susiarno, Hadi Susilo, Artha Falentin Putri Syahbana, Chandra Garnida Utomo, Suhendro Rahmat