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All Journal ACTA VETERINARIA INDONESIANA Journal Of Widya Medika Junior Jurnal Kesehatan Tambusai Buletin Pengabdian Jurnal Widya Medika
Suwasanti, Niluh
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Agriculture, Biological Sciences & Forestry Dentistry Education Engineering Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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THE EFFECT OF ADMINISTERING AFRICAN BITTER LEAF EXTRACT ON SPERMATOGENIC CELLS OF HYPERGLYCEMIC WISTAR RATS Kartana, Kartana; Tahalele, Paul L; Suwasanti, Niluh
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 3, No 3 (2021): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v3i3.3337

Abstract

Introduction: Diabetes is still a world health problem that can cause many complications.Male infertility is one of the diabetic complications. This condition is caused by oxidativestress in diabetic patients. African bitter leaf is believed to contain an antioxidant compoundthat can repair male infertility. Purpose: This study aims to determine the effect of administering African bitter leaf extracton spermatogenic cell count in hyperglycemic Wistar rats. Method: This study use Rattus norvegicus as an animal model, which was administrated withalloxan to induce hyperglycemic. P0 group were given Na CMC 0,1%, Control group were given glibenclamide 0,63/kg bodyweight for 14 days. 100mg/kg bodyweight (P1), 200mg/kg (P2), and 400mg/kg (P3) of African bitter leaf extract were administrated for 14 days. In theend, the animals were sacrificed, and testicle histopathologic sections were made. Results: Significant result (P<0,05) comparing spermatogonium, primary spermatocyte, andspermatid count between groups. Post-hoc test shows the significant result on comparison ofprimary spermatocyte and spermatid count between P0 and P1.Conclusions: There is an effect of bitter leaf extract administration on spermatogenic cellcount in hyperglycemic Wistar rats. The best improvement can be observed in the P1 group,administered with 100mg/kg bodyweight African bitter leaf.
AFRICAN BITTER LEAF EXTRACT EFFECT ON EPITHELIUM THICKNESS OF SEMINIFEROUS TUBULES IN WISTAR RATS WITH DIABETES MELLITUS Lienardi, Aurellia R; Suwasanti, Niluh; Dewi, Dewa AL
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 3, No 4 (2021): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v3i4.3503

Abstract

Introduction: Diabetes mellitus (DM) is a metabolic disease that can cause complications in the form of damage to male reproductive organs, such as decreased sperm motility and cell count, impaired spermatogenesis, and erectile dysfunction. A measurement that can be done to detect male reproductive disorders is to measure the thickness of the seminiferous tubule epithelium. Herbal medicines can be used to support treating diabetes. Studies have claimed that African bitter leaf helps in treating DM and its complications.Purpose: This study aims to determine the effect of African bitter leaf extract on epithelium thickness of seminiferous tubules in rats with DM.Method: True Experimental with Post-Test Only Control Group Design using Rattus norvegicus. Rats were divided into five groups, with six rats in each group. Rats were administered with a single dose of alloxan 150 mg/kg BW/IP. Group K is diabetic rats given glibenclamide 0,63 mg/kg BW. Group P0 are diabetic rats given CMC 0,1% 0,7 ml. Group P1 are diabetic rats given African bitter leaf extract 100 mg/kg BW. Group P2 are diabetic rats given African bitter leaf extract 200 mg/kg BW. Group P3 are diabetic rats given African bitter leaf extract 400 mg/kg BW. Treatments were given with oral gavage for 14 days. Rats were dissected, and their testis was made as histological slides. Results are statistically tested with ANOVA.Results: The average epithelium thickness from group K are 79,61 μm, group P0 are 59,96 μm, group P1 are 71,87 μm, group P2 are 67,31 μm, group P3 are 63,95 μm showed significant result (p=0,000).Conclusions: African bitter leaf extract affects epithelium thickness of seminiferous tubules, with group K, shows the best result, followed by group P1.
Efek Anti Diabetes Buah Pare (Momordica charantia Linn.) Terhadap Kadar Glukosa Darah, Sel Penyusun Pulau Langerhans dan Sel Leydig pada Tikus Putih Hiperglikemia I Dewa Putu Anom Adnyana; Dewa Ketut Meles; . Wurlina; Sunarni Zakaria; Niluh Suwasanti
Acta VETERINARIA Indonesiana Vol. 4 No. 2 (2016): Juli 2016
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (880.818 KB) | DOI: 10.29244/avi.4.2.43-50

Abstract

Penelitian ini bertujuan untuk membuktikan ekstrak buah pare (Momordica charantia Linn.) terhadap kadar glukosa darah, sel penyusun pulau Langerhans dan sel Leydig tikus putih (Rattus norvegicus) hiperglikemia. Tikus putih sebanyak 25 ekor dibagi secara acak menjadi 5 kelompok. Induksi aloksan dengan dosis 150 mg/kgbb secara intraperitoneal untuk menimbulkan kerusakan pankreas dilakukan pada 5 kelompok perlakuan. Tiga kelompok perlakuan diterapi dengan berbagai dosis ekstrak buah pare, (P1) 29 mg/1ml/hari, (P2) 50 mg/1ml/hari, dan (P3) 59 mg/1ml/hari, satu kelompok sebagai kontrol negatif (P0) diberi CMC Na 0,5% 1ml/hari, kontrol positif (K+) diberi Glibenclamide® 0,126 mg/1ml/hari. Ekstrak buah pare diberikan selama 21 hari. Kadar glukosa diperiksa setelah 2 jam, 4 jam, 6 jam dan 8 jam pascapemberian dihari pertama. Kadar glukosa selanjutnya diperiksa pada hari ke 7, 14 dan 21. Semua tikus dieuthanasia setelah 21 hari perlakuan, pankreas dan testis diambil untuk dibuat preparat histopatologi. Hasil menunjukkan bahwa ekstrak buah pare (Momordica charantia Linn.) memiliki efek antidiabetik yang dapat menurunkan kadar gula darah, meningkatkan jumlah sel insula Langerhans dan meningkatkan jumlah sel Leydig pada dosis 50 mg/1ml/hari pada hari ke 21 setelah perlakuan.
ANALYSIS OF INCREASED C-REACTIVE PROTEIN LEVELS IN BLOOD SERUM OF RATTUS NORVEGICUS WISTAR STRAIN DUE TO INTAKE OF POLYETHYLENE MICROPLASTICS Julian, Alvin; Suwasanti, Niluh; Sincihu, Yudhiakuari; Novita, Bernadette Dian; Samsudin, Kevin
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 6, No 2 (2024): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v6i2.5511

Abstract

Background: The widespread use of plastic and poor management of plastic waste is an environmental problem and has an impact on human health. The most commonly found microplastic contaminant is polyethylene polymer. Ingested microplastic particles will undergo an endocytosis mechanism and be absorbed into the bloodstream. This then triggers an increase in reactive oxygen species (ROS) which induces oxidative stress and results in an inflammatory response. This study tries to analyze the effect of administering microplastics on increasing blood serum C-reactive protein as a biomarker and marker of the inflammatory response due to microplastics. Method: The experimental analytical research used 42 Rattus Norvegicus Wistar Strain animals, which were divided into 5 experimental groups and 1 control group. Quantitative data measurements/collection were carried out at two times (pre-post-test control group design) and analyzed by non-parametric comparison using the Friedman Test to see the increase in C-Reactive Protein (CRP) levels in the blood serum of Rattus norvegicus Wistar Strain before and after being given intake polyethylene microplastics. Result: In all groups X0-X5, The results of the comparative test using the Friedman test showed a significant value of P = 0.000 (P < 0.05), so it can be concluded that there is a difference in pre and post experimental CRP levels. Discussion: The increase in serum CRP levels from the control group to the X5 treatment group may be due to oxidative stress mechanisms, especially in hepatocyte cells, smooth muscle cells, macrophage cells, endothelial cells, lymphocyte cells and adipocyte cells which induce the production of CRP protein, especially native C-reactive protein (nCRP) and monomeric C-reactive protein (mCRP). The difference in serum CRP levels was significant (P = 0.000), where there was an increase in serum CRP levels post treatment (post experimental) from the lowest mean of 0.05 mg/L (pre experimental) to the highest of 0.98 mg/L on average, indicating that administration of microplastic intake at the dose studied had an impact on increasing serum CRP levels in response to an inflammatory reaction. The limitation of this research is that there are no journals that examine microplastics on serum CRP levels, resulting in a lack of research that can be used as a reference or comparative theory. Conclusion: Administration of Microplastic Polyethylene at the dose studied in the treatment group caused a significant increase in Rattus Norvegicus Wistar Strain Serum CRP levels.
THE INFLUENCE OF WORKING PERIOD ON WORK DUE TO LUNG DISEASES IN PRODUCTION WORKERS OF NATURAL STONE PROCESSING, IN TULUNGAGUNG Dinata, Mulya; Sincihu, Yudhiakuari; Suwasanti, Niluh; Rihadi, Lukas Slamet; Steven, Steven; Darmadi, Epriyanto Tri; Wulansari, Nurlita
JURNAL WIDYA MEDIKA Vol. 10 No. 1 (2024): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v10i1.5343

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Background of the Problem: In 2000, deaths caused by air pollution in the world reached 57,000 people per year and it is estimated that over the next 20 years this figure will increase to close to 14% or 0.7 per year.  According to Calvin, 2020, in Gold Mining, incidents of Silica exposure among workers aged 45-55 years out of 2255 people, it was found that 1592 (71%) people died. From the number above, there were 1296 people (81%) suffering from silicosis and pulmonary Tuberculosis (TB). Chemical dust (Silica) causes lung disorders, which is one of the Occupational Lung Diseases. The above process has a danger to the environment and workers. According to BPJS Employment 2022, the number of cases of KK (working accidents) and PAK (occupational diseases) in 2021 is 234,370 cases.Method of Research:       Population of 100 workers aged 20 – 61 years, Natural Stone Processors located in Tulungagung, East Java, Indonesia. Workers inspection: (1) Interview and physical examination of workers, (2) Supporting examination: Spirometry and Thorax photos, (3) Work Environment Testing consisting of: Work climate, dust, gas (NO2, CO2).Results: Worker habits: smoking as much as 55%, PPE (Personal Protective Equipment) used by the majority of cloth masks 71%, chemical dust (Silica) highest 4.6995 mg/m3, Climate in the workplace (temperature >32°C). These conditions can influence the occurrence of occupational lung disorders. Lung examination of Natural Stone processing workers in Tulungagung showed lung function disorders in 61 people (61%) and thorax photo examination showed abnormalities in 11 people (11%). WorkingPeriod has an influence on Occupational Lung Disease with a significance value of 0.03 (p-value < 0.05), with a confidence level of 95%.Conclussion: Working Period influences Occupational Lung Disease in workers in the production department of the Natural Stone Processing Company, in Tulungagung (1). Other factors that are suspected to influence the health of workers include: Occupational Lung Disease, namely smoking habits, not using the correct PPE, a dusty work environment (chemical substances) and a workplace climate with temperatures above the recommended values (2).Keywords: PAK, KK, APD, Silica, Working Period, Lung Disease due to work
PENGARUH PARTIKEL MIKROPLASTIK DALAM DARAH TERHADAP KADAR OX-LDL RATTUS NORVEGICUS STRAIN WISTAR Florentia, Marion; Sincihu, Yudhiakuari; Suwasanti, Niluh
Jurnal Kesehatan Tambusai Vol. 5 No. 1 (2024): MARET 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i1.24041

Abstract

Mikroplastik merupakan partikel plastik berukuran kurang dari 5 mm. Mikroplastik yang tertelan oleh manusia selanjutnya akan memasuki traktus gastrointestinal dan mengalami penyerapan ke dalam aliran darah. Mikroplastik di dalam darah dan organ akan menyebabkan peningkatan produksi Reactive Oxygen Species (ROS) dan stres oksidatif. Salah satu akibat dari peningkatan produksi ROS pada hepar adalah terjadinya oksidasi dari Low Density Lipoprotein (LDL) menjadi Oxidized Low Density Lipoprotein (Ox-LDL). Penelitian ini merupakan penelitian eksperimental post-test only control group design. Hewan coba yang digunakan dalam penelitian ini adalah Rattus norvegicus Strain Wistar berjenis kelamin jantan sebanyak 30 ekor yang terbagi menjadi 6 kelompok (1 kelompok kontrol dan 5 kelompok eksperimental). Kelompok kontrol hanya diberikan aquabides, kelompok X1 diberikan dosis mikroplastik sebanyak 0,0375 mg/hari, kelompok X2 diberikan 0,075 mg/hari, kelompok X3 diberikan 0,15 mg/hari, kelompok X4 diberikan 0,3 mg/hari, kelompok X5 diberikan 0,6 mg/hari selama 90 hari. Setelah 90 hari, hewan coba diterminasi dan diambil sampel darahnya. Pada penelitian ini dilakukan uji komparasi pada kadar Ox-LDL plasma dengan menggunakan uji Kruskall Wallis dan didapatkan adanya perbedaan yang bermakna dari kadar Ox-LDL plasma antar kelompok dengan nilai P = 0,016. Selanjutnya dilakukan uji korelasi dengan uji Spearman dan didapatkan hubungan yang bermakna antara kadar partikel mikroplastik dalam darah dengan kadar Ox-LDL plasma dengan nilai P = 0,013.
Keberlanjutan UMKM olahan hasil laut di Pesisir Bulak Surabaya guna meningkatkan daya saing di era new normal (Sustainability of MSMEs processed marine products in Bulak Coastal Surabaya to increase competitiveness in the new normal era) Wurlina, W; Racmawati, Kadek; Utama, Suzanita; Mahasri, Gunanti; Mulyati, Sri; Suwasanti, Niluh
Buletin Pengabdian Vol 2, No 2 (2022): Bull. Community. Serv.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/bulpengmas.v2i2.25217

Abstract

The Regional Leading Product Development Program (RLPDP) activities are carried out to sustain the existence of Micro, Small, and Medium Enterprises (MSMEs) processed marine products in increasing marketing in the new normal of the Covid-19 Pandemic period. This makes the implementation team assist the strategies used by MSMEs and the effectiveness of these strategies. In this activity, the factors influencing MSMEs sustainability were product innovation, packaging, and marketing. The method used was education, training, and mentoring for the innovation of processed seafood using packaging according to its function and marketing. The result of RLPDP was MSMEs have implemented innovations in processed marine products with packaging accompanied by the length of use, labeling, business permits, and halal accompanied by slogans. Marketing of seafood products processing was carried out through the Surabaya UKM center, namely the Siola MSMEs Center, the SIB (Bulak Fish Center) MSMEs, Merr MSMEs, hotels, and participation in exhibition activities organized by the Surabaya City Government and East Java Province. Furthermore, to expand marketing reach, socialization has been carried out through social media such as WhatsApp, Facebook, Instagram, and e-mail, as well as the marketplaces such as Tokopedia, Bukalapak, and Blibli.
Pemulihan dan pengembangan ekonomi kreatif olahan hasil laut di Pesisir Bulak Surabaya pada era new normal untuk menunjang pertumbuhan ekonomi (Recovery and development of creative economy processed sea products in coastal Bulak Surabaya in new normal era for supporting economic growth) Wurlina, W; Racmawati, Kadek; Utama, Suzanita; Mahasri, Gunanti; Suwasanti, Niluh; Putri, Desak Ketut Sekar Cempaka
Buletin Pengabdian Vol 1, No 1 (2021): Bull. Community. Serv.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/bulpengmas.v1i1.20241

Abstract

The Regional Prominence Product Development Program (RPPDP) aims to determine the impact of thecoronavirus disease2019(COVID-19)pandemic on Micro, Small, and Medium Enterprises (MSMEs) based on the creative economy of seafood culinary in Bulak, Surabaya. This program was conducted to find out the solution that can be taken by government to recover and develop the creative economy of seafood culinary entrepreneur due to the COVID-19 pandemic impacts. Data were collected by interview/questionnaire, literature review, and implementation of recovery of the the creative economy of seafood culinary. The period of this study was from March (the beginning of the COVID-19 pandemic in Indonesia) to the middle of December 2020. The results of RPPDP showed that there were two elements influenced the seafood culinary entrepreneur due to the COVID-19 pandemic, namely Human Resources and innovation processing and marketing products. The government can take steps to overcome these problems, such as providing business capital assistance, giving discounts on electricity bills, deferring loan payments, assisting MSMEs who closed their businesses as result of the pandemic to transform or start new businesses. In conclusion, innovation of seafood culinary during the pandemic should be in accordance with the market demand, innovating traditional souvenirs to be work from home snacks, and online marketing using non-cash payment.
Co-Authors Dewi, Dewa AL Dinata, Mulya Epriyanto Tri Darmadi Florentia, Marion Gunanti Mahasri I Dewa Putu Anom Adnyana Julian, Alvin Kartana, Kartana Lienardi, Aurellia R Meles, Dewa Ketut Novita, Bernadette Dian Paul L Tahalele Putri, Desak Ketut Sekar Cempaka Racmawati, Kadek Rihadi, Lukas Slamet Samsudin, Kevin Sincihu, Yudhiakuari Sri Mulyati Steven Steven Sunarni Zakaria Suzanita Utama Wulansari, Nurlita Wurlina, W