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Journal : Journal of Pharmaceutical and Sciences.

Green synthesis nanoperak menggunakan ekstrak batang dadap serep (Erythrina Subumbrans (Hassk.) Merr) Maharini, Indri; Fitrianingsih, Fitrianingsih; Utami, Diah Tri
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.410

Abstract

Dadap serep stems contain secondary metabolite compounds of flavonoids, saponins, isoflavonoids, alkaloids and lectins which can act as reducing agents in the biosynthesis of nanosilver. This research aims to determine the effect of the concentration of liquid extract of dadap serep stem on the green synthesis silver nanoparticle (AgNPs) process. The aqueous extract of dadap serep stem reacted with one mM AgNO3 in a ratio of volume 1: 1 (FI), 1: 2 (FII), and 2: 1 (FIII). Characterization of AgNPs includes Surface Plasmon resonance (SPR) using UV/Vis spectrophotometer at wavelengths of 300-700 nm, particle size, and zeta potential using a particle size analyzer (PSA). The result showed that the SPR of AgNP values is 429-436 nm. AgNPs FI, II, and III particle sizes were 66.13 nm, 75.76 nm, and 75.96 nm, respectively. The PDI values below 0.5 confirmed that the distribution of nanoparticles was uniform. The most stable nanoparticle is Formula I.
Uji toksisitas buah palem merah (Cyrtostachys renda Blume.) menggunakan metode brine shrimp lethality test (BSLT) method Syamsurizal, Syamsurizal; Utami, Diah Tri; Sutrisno, Sutrisno; Efrini, Emi; Jumardi, Muhammad Ikhsan
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.429

Abstract

The red palm plant (Cyrtostachys renda) is a species of the Areca genus that grows widely in Jambi Province, making it an affordable plant to research for its medicinal properties. The Brine Shrimp Lethality Test (BSLT) is a toxicity test to screen for anticancer bioactive substances, with the test subject being Artemia salina Leach larvae, which are highly sensitive when exposed to toxic substances. The fruit and roots of C. renda were extracted using the maceration method by using a methanol solvent and partitioning using n-hexane, dichloromethane, ethyl acetate, and water. Based on the extract toxicity evaluation results, all extracts were toxic. Meanwhile, C.renda root dichloromethane extract had the highest toxic properties, with an LC50 value of 43.42 ± 0.659 ppm. However, the positive control's toxicity, potassium dichromate, was more toxic, with an LC50 value of 29.93 ± 0.668 ppm. The dichloromethane extract of C. renda roots can potentially be a poisonous agent. Further toxicity tests on cancer cells need to be carried out to be developed as an anticancer agent.
Formulasi body scrub dari kombinasi temu putih (Curcuma zedoaria) dan biji kurma (Phoenix dactylifera) Yuliawati, Yuliawati; Elisma, Elisma; Utami, Diah Tri; Pratiwi, Puspa Dwi
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.456

Abstract

Body scrub is a cosmetic form that removes dead skin cells caused by free radicals from various pollutants and ultraviolet (UV) radiation so skin cells become more accessible to regenerate. White turmeric (Curcuma zedoaria) and date seeds (Phoenix dactylifera) are plants that contain bioactive compounds to maintain and nourish the skin and have antioxidant activity. Besides, date seeds also have the potential as exfoliating agents to facilitate the release of dead skin cells. This study aimed to formulate a body scrub containing ethanol extract of white turmeric rhizome and date seed powder with five types of formulas (K+, K-, F1, F2, F3). This type of research is a true experimental, which includes the formulation and stability test. The stability test was conducted with the Cycling test method in 6 cycles (1 cycle for 2x24 hours) at temperatures of -4oC and 40oC and four months for stability at room temperature. Parameters observed include organolepticity, homogeneity, dispersibility, adhesion, pH, and viscosity. The results showed that this body scrub did not show any change in the organoleptic character, homogeneity, spreadability, adhesion, or pH values that met the requirements of a body scrub preparation. Viscosity met the requirement for stability test for room temperature in four months. This study concludes that the combination of ethanol extract of white turmeric rhizome and date seed powder seeds can be formulated to be a body scrub dosage form.