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Comparison of the effectiveness of the antibiotics Fosfomycin and levofloxacin in acute cystitis: a systematic review and meta-analysis Fauzi Farhat, Muhammad; Mirsya Warli, Syah; Dharma Kadar, Dhirajaya; Febrian Prapiska, Fauriski
Jurnal KESANS : Kesehatan dan Sains Vol 1 No 5 (2022): KESANS : International Journal of Health and Science
Publisher : Rifa'Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/kesans.v1i5.47

Abstract

Urinary tract infection or UTI is an infection caused by microorganisms that grow in the human urinary tract. Cystitis is a urinary tract infection (UTI) in the bladder (Li & Lesli, 2018). According to the National Kidney and Urological Diseases Information Clearinghouse or NKUDIC, urinary tract infections are the second most common infectious disease after respiratory tract infections, and 8.3 million cases are reported annually. Urinary tract infections can affect patients ranging from new-borns to the elderly. The main treatment for urinary tract infections is treatment using antibiotics according to the 2015 Guidelines on Urological Infections of the European Association of Urology (EAU). Fosfomycin is the main therapy for the treatment of cystitis while levofloxacin is an alternative therapy. Fosfomycin is the main therapy for cystitis, but the drug that is commonly found on the market is levofloxacin.  Purpose. This study aims to compare the effectiveness of the antibiotic Fosfomycin with levofloxacin in acute cystitis. method. This meta-analysis research uses various literature sourced from Cochrane, PubMed, Google Scholar, and ScienceDirect. A literature search using the keywords “Fosfomycin” and “levofloxacin” and “cystitis” and “acute”. This research uses the Review Manager 5.4 application. Results. Fosfomycin is more effective against E. coli bacteria, but levofloxacin is more effective against Fosfomycin on S. saprophyticus bacteria. E. coli bacteria are more resistant to levofloxacin than Fosfomycin, but Fosfomycin is more resistant to S. saprophyticus bacteria than levofloxaci.
Risk Factors Influencing the Occurrence of Urinary Tract Infections in Inpatients Ardiana, Ardiana; Warli, Syah Mirsya; Ritarwan, Kiking; Kusumawati, R. Lia; Harahap, Juliandi
Indonesian Journal of Global Health Research Vol 6 No 6 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i6.4016

Abstract

A urinary tract infection is an infection of the urinary tract both upper and or lower, where the number of bacteria is greater than 10⁵ bacterial colonies per unit per ml in a urine specimen. Several studies have shown that there are risk factors that can cause urinary tract infections such as age, gender, long lying down, and other predisposing factors. Objective: To identify the factors that influence the occurrence of urinary tract infections in H. Adam Malik Hospital Medan. Method: This study was designed cross-sectional approach. 59 patients were applied in this study using consecutive sampling. Data were collected using a questionnaire and analyzed using chi-square and Fisher. Results: the results showed that there was no relationship (p>0.05) among age (p=0.869; OR=0.9), gender (p=0.812; OR=1.1), predisposing factors with diabetes mellitus (p=0.146), human immunodeficiency virus (p=0,286), kidney disease (p=0,386), autoimmune (p=0,641) and there were significant relationship (p< 0.05) among prolonged lying down (p=0.04; OR=3,1) were the most significant factor related to urinary tract infection without urinary catheter. Conclusions: the results showed that there was no relationship among age, gender, or predisposing factors such as diabetes mellitus, human immunodeficiency virus, kidney disease, or autoimmune disease with the incidence of urinary tract infection. Long lying down is a relationship with urinary tract infection.
EFFECTIVENESS OF TRANEXAMIC ACID IN TRANSURETHRAL RESECTION OF THE PROSTATE (TURP) PROCEDURE ON BENIGN PROSTATE HYPERPLASIA (BPH): A SYSTEMATIC REVIEW AND META-ANALYSIS Manalu, Yustika Veronica; Warli, Syah Mirsya; Kadar, Dhirajaya Dharma; Amelia, Sri
Indonesian Journal of Urology Vol 29 No 3 (2022)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v29i3.759

Abstract

Objective: This study aims to determine the effectiveness of tranexamic acid in the TURP procedure in BPH patients. Material & Methods: This meta-analysis research was performed online literature from Pubmed, Google Scholar, Cochrane, and Science Direct with a data collection period from July 2020 to October 2020. The journals used are journals regarding all studies on the effectiveness of tranexamic acid in the TURP procedure on BPH with criteria inclusion were BPH patients receiving TURP-invasive therapy and receiving tranexamic acid before or after surgery vs. no intervention or placebo. The results assessed were in terms of the amount of bleeding, volume of irrigation fluid, duration of operation, and weight of the resected prostate tissue. The statistical analysis was performed in Review Manager v.5.4. Results: We found 6 studies that fitted into our criteria with 436 patients were identified. We found a significant difference of decreasing blood loss between tranexamic acid and control that tranexamic acid was more effective than control (MD -125.39, 95% CI: -247.21 - 3.36, P = 0.04). There was no significant difference of the amount of Hb (MD 0.06, 95%, CI: -0.17 – 0.28, P = 0.63). There was also no significant differences of volume irrigation fluid (MD 0.79, 95%, CI: -1.18 – 2.76, P=0.43), duration of operation (MD 14.55, 95%, CI: -32.56 – 3.47, P = 0.11) and weight of resected prostate tissue (MD 0.77, 95% CI: -1.06 – 2.6, P=0.77). Conclusion: Tranexamic acid is effective in decreasing blood loss in the TURP procedure.