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Alexandra, Francisca Diana
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Other

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Uji aktivitas antihiperglikemia ekstrak batang Uncaria gambir (W.Hunter) Roxb. pada tikus diabetes Alexandra, Francisca Diana; Frethernety, Agnes; Amiani, Winney; Aprelea, Reza Nathasya
Jurnal Kedokteran Universitas Palangka Raya Vol 11 No 1 (2023): Jurnal Kedokteran Universitas Palangka Raya
Publisher : Fakultas Kedokteran, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/jkupr.v11i1.8577

Abstract

This study aimed to prove the antihyperglycemic activity of the ethanol extract of bajakah Tampala stem (Uncaria gambir (W.Hunter) Roxb.) in rats induced by streptozotocin. The research was conducted experimentally using a true experiment posttest-only control group design. bajakah Tampala extract was extracted by maceration method using 96% ethanol solvent. The extract was made at 50mg/kgBB, 75mg/KgBB, and 100mg/KgBB in diabetic rats. The decrease in blood glucose levels of the negative control (27.27%) in this treatment was lower than that of glibenclamide (35.12%). The most significant decrease in blood glucose levels was achieved by 100 mg/kg BW, which was 44.85%. The treatment of Bajakah ethanol extract at various dose levels at the end of the observation showed a decrease in blood glucose levels but was not significantly different (p > 0.05). The results of this study did not show a significantly different decrease in blood glucose levels.    
Hubungan gerakan masyarakat hidup sehat (GERMAS) DENGAN kejadian hipertensi pada usia 20-60 tahun di wilayah kerja Puskesmas Pahandut Palangka Raya Rahmadita, Annisa; Alexandra, Francisca Diana; Ratnasari, Arini; Widodo, Tri; Arifin, Syamsul
Barigas: Jurnal Riset Mahasiswa Vol. 1 No. 1 (2023): Barigas: Jurnal Riset Mahasiswa
Publisher : Fakultas Kedokteran Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/barigas.v1i1.7883

Abstract

Hypertension is a serious problem in Indonesia. The purpose of this study was to determine the relationship between Healthy Living Community Movement (GERMAS) and the occurrence of hypertension at the age of 20-60 years in the Pahandut Public Health Center, Palangka Raya. In this research is an analytic observational study with a cross-sectional study design. The sample in this study was 110 respondents who came from the society in the working area of ​​the Pahandut Health Center. The sampling technique used systematic random sampling. The data obtained came from a questionnaire and was tested for chi square using analysis through the SPSS application.  The results in this study showed that the respondents GERMAS behavior was in the less category (60%) and with a history of hypertension (54.5%). The value means that there is a relationship between GERMAS behavior and the occurrence of hypertension (p = 0.003). There is a relationship between GERMAS behavior and the occurrence of hypertension at the age of 20-60 years in the working area of ​​the Pahandut Public Health Center, Palangka Raya City.
In Vitro Anthelmintic Activity of Orthosiphon aristatus (Blume) Miq Leaves Against Haemonchus contortus Augustina, Indria; Jesika, Debora; Elma, Pransiska; Elsa, Trinovita; Alexandra, Francisca Diana; Jabal, Arif Rahman
Jurnal Ilmu Pertanian Indonesia Vol. 29 No. 3 (2024): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18343/jipi.29.3.470

Abstract

Haemonchosis is an infection caused by the Haemonchus contortus worm, a blood-sucking gastrointestinal parasite that can also infect humans. Orthosiphon aristatus (Blume) Miq leaves have been shown to have anthelmintic activity due to the presence of saponins, flavonoids, and tannins. This study aimed to determine the anthelmintic activity of ethanol extract of Orthosiphon aristatus (Blume) Miq leaves against H. contortus. The infective H. contortus larvae were divided into six treatment groups: a 0.5% ethanol extract concentration group, a 1% ethanol extract concentration group, a 2% ethanol extract concentration group, a 4% ethanol extract concentration group, a positive control group (+), and a negative control group (-), each with four replicates. The study was conducted in six hours, with observations made at the 1st, 2nd, 4th, and 6th hours. The results showed that the death of the larvae increased with higher ethanol extract concentrations and longer exposure to the ethanol extract of Orthosiphon aristatus (Blume) Miq leaves. The time of death for infective H. contortus larvae given the ethanol extract of Orthosiphon aristatus (Blume) Miq leaves was at the 4th hour, and the effective dose of the ethanol extract as an anthelmintic was at the concentration of 0.5%. Keywords: Anthelmintic, Haemonchus contortus, Orthosiphon aristatus
Hubungan kadar ureum terhadap kejadian mortalitas pasien sirosis di RSUD dr. Doris Sylvanus Palangka Raya Rejeki, Fransiska Caesaria Silvi; Alexandra, Francisca Diana; Palupi, Didin Retno Endah; Handayani, Septi; Turnip, Oktaviani Naulita
Barigas: Jurnal Riset Mahasiswa Vol. 2 No. 3 (2024): Barigas: Jurnal Riset Mahasiswa
Publisher : Fakultas Kedokteran Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/barigas.v2i3.12089

Abstract

The mortality rate of liver cirrhosis is increasing globally, including in Indonesia. Child-Turcotte-Pugh score as a widely used scoring system is difficult to performed in all health facilities in Indonesia. Innovative prognostic screening assessment that is more accessible, and accurate, such as ureum levels, is needed. This research aims to analyze the correlation between ureum levels and mortality of cirrhosis patients. It applied analytic observational study with a cross-sectional design. Data were taken from the patient’s medical records who were hospitalized at RSUD dr. Doris Sylvanus Palangka Raya for the period 2020-2022. Statistical analysis using the Chi-Square test. The p-value = 0.004 (p < 0.05) and OR = 4.54 were obtained, it showed that there was a significant correlation between ureum levels and mortality events in patients with cirrhosis, and patients with high ureum levels were 4.54 times more likely to develop mortality than patients with normal ureum levels.
Comprehensive In Silico Analysis Of Bioactive Compounds From Pyrrosia piloselloides Leaves As Xanthine Oxidase Inhibitors Sinuhaji, Masira Sony Crespo; Havid, Husnul; Ysrafil, Ysrafil; Alexandra, Francisca Diana
Pharmacology and Clinical Pharmacy Research Vol 10, No 2 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i2.60233

Abstract

This study aimed to evaluate the potential of bioactive compounds from Pyrrosia piloselloides leaves as xanthine oxidase (XO) inhibitors through an in silico approach. Methods included molecular docking and molecular dynamics simulations to identify the binding affinity of test compounds to XO. Among 59 screened compounds, 3 compounds (2,6,10,14,18,22-Tetracosahexaene, 6-Hydroxymethaqualone, and β-Sitosterol acetate) exhibited the lowest binding energy in comparison to the control, Allopurinol, with key residue contributions from GLU 802, ARG 880, and THR 1010. Molecular dynamics simulations confirmed the interaction stability, with β-Sitosterol acetate showing the lowest total binding free energy (-46.23 ± 0.66 kcal/mol). ADMET predictions revealed promising pharmacokinetic profiles for these compounds. This study highlights Pyrrosia piloselloides as a promising source of novel XO inhibitors, with further validation required through in vitro and in vivo experiments.
Analisis Hubungan Kadar Merkuri (Hg) dan Derajat Keasaman Saliva Terhadap Indeks DMF-T Pada Penambang Emas Skala Kecil di Desa Ramang Pulang Pisau Frethernety, Agnes; Jelita, Helena; Nugrahini, Shinta; Alexandra, Francisca Diana; Jakung, Benedikta Cemara Raninai
Jurnal Kesehatan Lingkungan Indonesia Vol 24, No 3 (2025): Oktober 2025
Publisher : Master Program of Environmental Health, Faculty of Public Health, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jkli.71923

Abstract

Latar Belakang: Aktivitas penambangan emas skala kecil di sekitar Sungai Kahayan menyebabkan kontaminasi merkuri yang dapat masuk ke tubuh manusia melalui air atau makanan. Merkuri bersifat toksik dan dapat memengaruhi kondisi saliva, termasuk pH, yang turut berperan dalam proses terbentuknya karies gigi. Studi tentang hubungan langsung kadar merkuri dan keasaman saliva terhadap karies masih terbatas, khususnya pada kelompok penambang emas. Tujuan studi ini menganalisis hubungan kadar merkuri dan derajat keasaman saliva terhadap indeks DMF-T pada penambang emas skala kecil di Desa Ramang, Kecamatan Banama Tingang, Kabupaten Pulang Pisau.Metode: Jenis penelitian ini merupakan studi observasional analitik dengan pendekatan cross-sectional study dengan 30 Jenis penelitian ini adalah observasional analitik dengan desain cross-sectional yang dilakukan pada bulan Mei 2024. Sebanyak 30 responden penambang emas dipilih secara purposive sampling. Variabel kadar merkuri dalam saliva diukur menggunakan Inductively Coupled Plasma Mass Spectrometry (ICP-MS), pH saliva menggunakan pH meter digital, dan indeks DMF-T diperoleh melalui pemeriksaan klinis gigi. Analisis data dilakukan dengan menggunakan uji korelasi Spearman.Hasil: Rerata kadar merkuri dalam saliva adalah 290,6 mg/L, yang tergolong sangat tinggi dibanding ambang batas aman dalam tubuh (20 mg/L). Rerata pH saliva sebesar 4,8 menunjukkan kondisi asam (pH < 5,5), dan indeks DMF-T sebesar 13,4 mengindikasikan tingkat kerusakan gigi yang sangat tinggi (DMF-T≥9,0). Hasil uji Spearman menunjukkan bahwa tidak terdapat hubungan yang signifikan antara kadar merkuri dengan indeks DMF-T (p = 0,704) maupun antara pH saliva dengan indeks DMF-T (p = 0,403).Simpulan: Meskipun kadar merkuri dan pH saliva cukup bervariasi di antara responden, keduanya tidak memiliki hubungan signifikan dengan indeks DMF-T. Keterbatasan penelitian ini tidak memasukan faktor lain seperti pola makan dan kebersihan gigi yang dapat memengaruhi kejadian karies gigi pada penambang emas skala kecil di Desa Ramang, Kabupaten Pulang Pisau. ABSTRACT  Title: Correlation between Mercury (Hg) Levels and Salivary Acidity with DMF-T Index among Small-Scale Gold Miners in Ramang Village, Pulang Pisau RegencyBackground: Small-scale gold mining activities around the Kahayan River have led to mercury contamination, which can enter the human body through water or food. Mercury is toxic and can affect salivary conditions, including pH, which plays a role in the development of dental caries. Studies investigating the direct relationship between mercury levels and salivary acidity in relation to caries are still limited, particularly among gold miners. This study aims to analyze the relationship between mercury levels and salivary pH with the DMF-T index among small-scale gold miners in Ramang Village, Banama Tingang Subdistrict, Pulang Pisau Regency.Methods: This research is an analytical observational study with a cross-sectional design conducted in May 2024. A total of 30 small-scale gold miners were selected through purposive sampling. Mercury levels in saliva were measured using Inductively Coupled Plasma Mass Spectrometry (ICP-MS), salivary pH was assessed using a digital pH meter, and the DMF-T index was obtained through clinical dental examinations. Data analysis was performed using Spearman's correlation test.Results: The average mercury level in saliva was 290.6 µg/L, which is considered very high compared to the safe threshold (20 µg/L). The mean salivary pH was 4.8, indicating an acidic condition (pH < 5.5), and the DMF-T index averaged 13.4, suggesting a very high level of dental caries (DMF-T ≥ 9.0). Spearman’s test showed no significant correlation between mercury levels and the DMF-T index (p = 0.704), nor between salivary pH and the DMF-T index (p = 0.403).Conclusion: Although mercury levels and salivary pH varied among respondents, neither showed a significant relationship with the DMF-T index. This study is limited by not accounting for other influencing factors such as dietary habits and oral hygiene, which may contribute to the occurrence of dental caries among small-scale gold miners in Ramang Village, Pulang Pisau Regency.
Pendampingan Pembuatan Jamu Instan Tanaman sebagai Produk KB Alami pada Ibu Pkk Marwati, Marwati; Khairi, Nur; Alexandra, Francisca Diana; Fadillah, Nurul; Anggyasti, Anggyasti
Yumary: Jurnal Pengabdian kepada Masyarakat Vol. 6 No. 1 (2025): September
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35912/yumary.v6i1.3826

Abstract

Purpose: The purpose of community service is to increase the knowledge of the PKK cadre women on the types of medicinal plants that are efficacious as natural birth control, increase their knowledge of traditional medicine processing that is efficacious as natural family planning, and increase their knowledge of reproductive health and types of family planning. Methodology: This study was conducted at the Moreira Farm in the Al Anshar East Timor Islamic Boarding School area. Hydroponics innovation has been applied by increasing the quantity and quality of hydroponics through technological tools and innovations to streamline and increase the yield of hydroponic plants to achieve higher quality than before. Results: The service method applied is the method of applying innovations by providing counselling assistance and practicing making instant herbal medicine Natural contraception of traditional medicine to increase understanding to cadres of PKK mothers in the development of natural materials. Conclusion: The conclusion of this activity is the increased knowledge of PKK women cadres and the community about the utilization of traditional medicine as instant herbal medicine for natural contraception to reduce the birth rate. Limitation: The knowledge of the PKK cadre and the community on the use of traditional medicine for natural family planning is still lacking. Contribution: This service is useful in the traditional medicine industry and the development of natural materials as products.
Hubungan Penggunaan Air Gambut dengan Keluhan Kulit yang Terjadi pada Masyarakat Desa Handil Sohor, Indonesia Nawan, Nawan; Wulandari, Intan Wahyu; Alexandra, Francisca Diana; Handayani, Septi
Jurnal Biomedika dan Kesehatan Vol 6 No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.170-177

Abstract

Background The use of peat water as a water source, especially in areas with large peatlands, such as in central Kalimantan, is still common. Handil Sohor is one of the villages in Central Kalimantan Province where the community still uses peat water for daily needs. Peat water, which does not fulfill the health requirement, is used for daily needs such as bathing and washing; therefore it can cause health complaints on the skin. Purpose of this study was to determine the correlation between peat water and skin disease complaints that happened in society. Methods The research type used is an analytical descriptive method with a cross-sectional design. The samples used in this research are 116 people taken with the purposive sampling technique and peat water samples. This research is conducted in June - October 2022. Results This research results showed that in a society with a contact duration of more than 60 minutes/day experienced skin disease complaints are 32 respondents in a society with a frequency of using peat water more than three times/day who experienced skin disease complaints are 41 respondents. The statistical test results through the chi-square test obtained the results for the contact duration variable with scores (p-value = 0,007) and (OR = 2,857). Conclusions Contact duration and frequency of use of peat water correlate with skin disease complaints.
Aktivitas Antioksidan Ekstrak Etanol Bajakah Kalalawit (Uncaria gambir (W.Hunter) Roxb) Menggunakan Metode DPPH: Antioxidant Activity of Ethanol Extract of Bajakah Kalalawit (Uncaria gambir (W.Hunter) Roxb) Using DPPH Method Halisa, Nida; Frethernety, Agnes; Permatasari, Silvani; Alexandra, Francisca Diana; Ysrafil, Ysrafil
Jurnal Surya Medika (JSM) Vol. 10 No. 2 (2024): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v10i2.6151

Abstract

Antioksidan dalam mendetoksifikasi radikal bebas akan ikut teroksidasi sehingga untuk mencukupi kebutuhan tubuh diperlukan antioksidan eksogen. Antioksidan eksogen dapat diperoleh dari tanaman herbal salah satunya Bajakah Kalalawit. Bajakah Kalalawit (Uncaria gambir (W.Hunter) Roxb.) adalah salah satu jenis bajakah yang terdapat di Kelurahan Marang, Kalimantan Tengah yang berpotensi sebagai antioksidan. Penelitian ini bertujuan untuk menganalisis aktivitas antioksidan dan kekuatan antioksidan Bajakah Kalalawit (Uncaria gambir (W. Hunter) Roxb.). Batang Bajakah Kalalawit diekstrak dengan metode maserasi 3x24 jam menggunakan pelarut etanol 96%. Setelah didapatkan ekstrak kental kemudian dianalisis kandungan senyawa metabolit sekunder dengan uji fitokimia. Uji aktivitas antioksidan dibuat dengan konsentrasi ekstrak 20ppm, 40ppm, 60ppm, 80ppm, dan 100ppm dengan metode DPPH (2,2-diphenyl-1-picrylhydrazyl). Hasil penelitian menunjukkan senyawa yang terdapat dalam ekstrak etanol Bajakah Kalalawit (Uncaria gambir (W.Hunter) Roxb) adalah terpenoid, flavonoid, fenolik, steroid, saponin, alkaloid, dan tanin. Ekstrak etanol Bajakah Kalalawit memiliki aktivitas antioksidan yang sangat kuat dengan nilai IC50 8,69ppm.
Potensi Antiglikasi Ekstrak Etanol Batang Bajakah Kalawait (Uncaria gambir (W. Hunter) Roxb.) dengan Reaksi Glikasi Secara In Vitro: Antiglycation Potensial of Ethanol Extract from the Stem of Bajakah Kalawait (Uncaria gambir (W. Hunter) Roxb.) Using In Vitro Glycation Reaction Method Berliani, Victoria; Frethernety, Agnes; Permatasari, Silvani; Alexandra, Francisca Diana; Widayati, Ratna
Jurnal Surya Medika (JSM) Vol. 10 No. 2 (2024): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v10i2.6190

Abstract

Hiperglikemia kronis menyebabkan terjadinya peningkatan reaksi glikasi  glukosa dengan protein. Produk akhir glikasi yaitu AGEs (Advanced Glycation End Products) berperan dalam komplikasi diabetes. Hasil skrining fitokimia yang telah dilakukan sebelumnya menunjukkan bahwa batang Bajakah Kalalawit (Uncaria gambir (W.Hunter) Roxb.) mengandung flavonoid, terpenoid, tanin, alkaloid yang diduga berpotensi sebagai antiglikasi. Penelitian ini bertujuan untuk mengetahui potensi antiglikasi ekstrak etanol batang Bajakah Kalalawit (Uncaria gambir (W.Hunter) Roxb.). Metode: Jenis penelitian adalah true eksperimental. Model reaksi glikasi menggunakan BSA dan glukosa sebagai kelompok kontrol. Ekstrak etanol 96% batang Bajakah Kalalawit (Uncaria gambir (W.Hunter) Roxb.) dibuat menjadi larutan konsentrasi 100, 200, 400, 600, 800 dan 1000ppm dan ditambahkan ke model reaksi glikasi, selanjutnya diukur absorbansi menggunakan spektrofotometer, dan dihitung nilai potensi antiglikasi. Hasil rerata potensi antiglikasi ekstrak Bajakah Kalalawit berdasarkan ANOVA berbeda signifikan (p<0.05) untuk setiap kenaikan konsentrasi ,yaitu konsentrasi 100, 200, 400, 600, 800 dan 1000ppm memiliki potensi 42,131%, 47,541%, 57,541%, 67,377%, 70,328%, 80,656% dengan nilai IC50 253,043ppm. Kesimpulan: Ekstrak etanol batang Bajakah Kalalawit (Uncaria gambir (W.Hunter) Roxb.) memiliki potensi antiglikasi dengan konsentrasi efektif 100ppm.
Co-Authors Amiani, Winney Anggyasti, Anggyasti Annisa Rahmadita Aprelea, Reza Nathasya Arif Rahman Jabal Arini Ratnasari Augustina, Indria Berliani, Victoria Elma, Pransiska Elsa Trinovita Frethernety, Agnes Halisa, Nida Handayani, Septi Havid, Husnul Jakung, Benedikta Cemara Raninai Jelita, Helena Jesika, Debora Khairi, Nur Marwati - Nawan, Nawan Nugrahini, Shinta Nurul fadillah, Nurul Palupi, Didin Retno Endah Permatasari, Silvani Rejeki, Fransiska Caesaria Silvi Sinuhaji, Masira Sony Crespo Syamsul Arifin Tri Widodo Turnip, Oktaviani Naulita Widayati, Ratna Wulandari, Intan Wahyu Ysrafil, Ysrafil