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Frethernety, Agnes
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Efektivitas Penyembuhan Luka Sediaan Patch Kombinasi Beberapa Spesies Sirih Secara in Vivo Ranti, Dalia; Trinovita, Elsa; Praja, Rian Ka; Frethernety, Agnes; Widayati, Ratna
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.960

Abstract

Luka merupakan permasalahan kesehatan dengan tingkat kejadian yang sering terjadi di Indonesia. Pemberian terapi berbahan herbal dapat menjadi salah satu alternatif dalam penyembuhan luka. Sirih merah (Piper crocatum) dan sirih hijau (Piper betle L.) mempunyai berbagai senyawa metabolit sekunder yang berperan dalam penyembuhan luka sayatan pada kulit. Penelitian ini bertujuan untuk mengetahui efektivitas sediaan patch kombinasi ekstrak daun sirih merah dan daun sirih hijau terhadap penyembuhan luka sayat. Hewan coba dibagi menjadi 5 kelompok perlakuan yaitu kontrol positif (plaster povidone iodine), kontrol negatif patch tanpa ekstrak, dan kelompok dengan ekstrak pada beberapa konsentrasi (7,5%, 15% dan 30%). Beberapa parameter yang dilakukan dengan pengukuran panjang luka, pengamatan waktu penyembuhan luka dan infeksi lokal berdasarkan kriteria Nagaoka. Sediaan patch kombinasi ekstrak daun sirih merah dan daun sirih hijau secara statistik tidak menunjukkan perbedaan bermakna terhadap efektivitas dalam penyembuhan luka yang dinilai berdasarkan kriteria Nagaoka dengan beberapa parameter penilaian luka. Namun, pengamatan secara makroskopis pada kelompok K2 (konsentrasi 15%) menunjukkan terjadinya penyembuhan luka yang lebih baik dibandingkan dengan kelompok plaster povidone iodine. Wounds are a health problem that is a frequent occurrence in Indonesia. Providing herbal therapy can be an alternative for healing wounds. Red betel (Piper crocatum) and green betel (Piper betle L.) have various secondary metabolite compounds that play a role in healing wounds of skin incisions. This study aims to determine the effectiveness of a combination patch preparation of red betel leaf extract and green betel leaf in healing cuts on the skin. The experimental animals were divided into five treatment groups: positive control (povidone-iodine plaster), negative control patch without extract, and groups with extract at several concentrations (7.5%, 15%, and 30%). Several parameters were measured by measuring wound length and observing wound healing time and local infection based on the Nagaoka criteria. The combination patch preparation of red betel leaf extract and green betel leaf extract did not statistically show a significant difference in effectiveness in wound healing as assessed based on the Nagaoka criteria with several wound assessment parameters. However, macroscopic observation in the K2 group (concentration 15%) showed better wound healing compared to the povidone-iodine plaster group.
Uji aktivitas antihiperglikemia ekstrak batang Uncaria gambir (W.Hunter) Roxb. pada tikus diabetes Alexandra, Francisca Diana; Frethernety, Agnes; Amiani, Winney; Aprelea, Reza Nathasya
Jurnal Kedokteran Universitas Palangka Raya Vol 11 No 1 (2023): Jurnal Kedokteran Universitas Palangka Raya
Publisher : Fakultas Kedokteran, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/jkupr.v11i1.8577

Abstract

This study aimed to prove the antihyperglycemic activity of the ethanol extract of bajakah Tampala stem (Uncaria gambir (W.Hunter) Roxb.) in rats induced by streptozotocin. The research was conducted experimentally using a true experiment posttest-only control group design. bajakah Tampala extract was extracted by maceration method using 96% ethanol solvent. The extract was made at 50mg/kgBB, 75mg/KgBB, and 100mg/KgBB in diabetic rats. The decrease in blood glucose levels of the negative control (27.27%) in this treatment was lower than that of glibenclamide (35.12%). The most significant decrease in blood glucose levels was achieved by 100 mg/kg BW, which was 44.85%. The treatment of Bajakah ethanol extract at various dose levels at the end of the observation showed a decrease in blood glucose levels but was not significantly different (p > 0.05). The results of this study did not show a significantly different decrease in blood glucose levels.    
Hubungan kebiasaan makan dan stres terhadap dispepsia mahasiswa kedokteran Universitas Palangka Raya Larasaty, Anggie; Frethernety, Agnes; Mutiasari, Dian
Barigas: Jurnal Riset Mahasiswa Vol. 1 No. 3 (2023): Barigas: Jurnal Riset Mahasiswa
Publisher : Fakultas Kedokteran Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/barigas.v1i3.8073

Abstract

Dyspepsia is gastrointestinal tract syndrome, common symptom of dyspepsia is heartburn. Eating habits and stress are among risk factors for dyspepsia. This study aims to determine relationship of eating habits and stress to dyspepsia in medical students, Palangka Raya University. This study is observational analytic with cross-sectional design. Sampling using simple random sampling. The results of the study in 100 respondents found 27 people with dyspepsia and 73 people who do not; 56 people with good eating habits and 44 with bad eating habits; 9 people with mild stress, 83 people with moderate stress, and 8 people with severe stress. This study used chi-square and fisher-exact test, the results there is no relationship between eating habits and dyspepsia (p-value 0.778 >α 0.10); there is no relationship between stress and dyspepsia (p-value 1.00 >α 0.10). This shows that there is no relationship between eating habits and stress to dyspepsia.
Literature Review: Pengaruh Pemakaian Air Sumur Dengan Kejadian Karies Gigi Purba, As Gaby Clarita; Jelita, Helena; Sampurna Putra, Ravenalla Abdurrahman Al Hakim; Frethernety, Agnes; Lestarisa, Trilianty
Barigas: Jurnal Riset Mahasiswa Vol. 2 No. 1 (2024): Barigas: Jurnal Riset Mahasiswa
Publisher : Fakultas Kedokteran Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Oral health is the biggest health problem faced by developing countries, namely dental caries. Dental caries is a progressive and cumulative disease of the hard tissues of the teeth and is most prevalent in children aged 5-9 years. Water is the most needed thing in everyday life. Water contains chemical content, one of which is flour content, if abnormal levels can cause dental problems. This study used a systematic review approach with the prism method so that 15 data were found consisting of 10 national journals and 5 international journals. The results of the study found that 11 journals stated a high incidence of caries and 4 journals stated a low incidence of caries based on the DMF-T index and knew the effect of fluorine in well water on the incidence of dental caries.
Oral Klebsiella sp. Involved in Dental Caries: A Case of Individuals Gargling with Peatwater Turnip, Oktaviani Naulita; Frethernety, Agnes; Hanasia; Panjaitan, Desimaria; Damayanti, Elvina; Rovik, Anwar; Malik, Handayani
Jurnal Sumberdaya Hayati Vol. 10 No. 3 (2024): 2024
Publisher : Departemen Biologi, Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jsdh.10.3.122-127

Abstract

Most of the microbes inhabiting the oral cavities are harmless but can cause disturbance and discomfort if the microbial population increases significantly. One of the oral disorders that is often experienced by children, is dental caries. Dental caries is causedby various factors, including eating and brushing habits. The people of Central Kalimantan who live in the watershed use peat water in their daily activities, including for gargling and brushing their teeth. The acidic characteristics of peat water and the high content of organic substances trigger the development of microbes that cause dental caries.This study used dental caries swab samples of patients who rinsed their mouths with peat water. Bacteria were identified molecularly with 16SrRNA markers with primers 63F and 1387R. The similarity of nucleotide sequences was analyzed with BLAST on GeneBank. A phylogenetic tree was built with Maximum Likelihood. Both isolates have a fairly high level of similarity to Klebsiella pneumoniae, namely 91% and 93%. Both isolates are in the same clade, Klebsiella spp., and are close to various commonly found bacteria in the oral cavity, such as Streptococcus mutans and Lactobacillus salivarius.
Perbandingan Tekanan Darah Pada Pasien Hipertensi Obesitas Dan Non Obesitas di Puskesmas Bukit Hindu Palangka Raya Abigail, Keshia; Balyas , Abi Bakring; Frethernety, Agnes
Barigas: Jurnal Riset Mahasiswa Vol. 3 No. 1 (2025): Barigas: Jurnal Riset Mahasiswa
Publisher : Fakultas Kedokteran Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/barigas.v3i1.11727

Abstract

Prevalence of hypertension in obese people is much greater and the relative risk of suffering from hypertension in obese people is 5 times higher than in people of normal weight. Hypertension sufferers at the Puskesmas Bukit Hindu in mid-2023 experienced an increase from previous year, which amounted to 107 to 189 cases.  The aim of the study was to measure blood pressure in obese and non-obese hypertensive patients at the Bukit Hindu Health Center. This is a type of analytical descriptive research with a cross sectional approach using quantitative descriptive methods. Population in this study were all hypertension sufferers at Puskesmas Bukit Hindu in January – June 2023 who were selected using the Purposive Sampling technique with a total sample of 85 people. Data collection from the Puskesmas Bukit Hindu Medical Record Register Book. The results of bivariate analysis showed that there was a significant difference in systolic and MAP, but there was no significant difference in diastolic between obese and non-obese hypertensive patients. The conclusion of this study is that there is a significant difference between systolic blood pressure and Mean Arterial Pressure (MAP) in obese and non-obese hypertensive patients, but there is no significant difference between diastolic blood pressure in obese and non-obese hypertensive patients at the Bukit Hindu Health Center.
Analisis Hubungan Kadar Merkuri (Hg) dan Derajat Keasaman Saliva Terhadap Indeks DMF-T Pada Penambang Emas Skala Kecil di Desa Ramang Pulang Pisau Frethernety, Agnes; Jelita, Helena; Nugrahini, Shinta; Alexandra, Francisca Diana; Jakung, Benedikta Cemara Raninai
Jurnal Kesehatan Lingkungan Indonesia Vol 24, No 3 (2025): Oktober 2025
Publisher : Master Program of Environmental Health, Faculty of Public Health, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jkli.71923

Abstract

Latar Belakang: Aktivitas penambangan emas skala kecil di sekitar Sungai Kahayan menyebabkan kontaminasi merkuri yang dapat masuk ke tubuh manusia melalui air atau makanan. Merkuri bersifat toksik dan dapat memengaruhi kondisi saliva, termasuk pH, yang turut berperan dalam proses terbentuknya karies gigi. Studi tentang hubungan langsung kadar merkuri dan keasaman saliva terhadap karies masih terbatas, khususnya pada kelompok penambang emas. Tujuan studi ini menganalisis hubungan kadar merkuri dan derajat keasaman saliva terhadap indeks DMF-T pada penambang emas skala kecil di Desa Ramang, Kecamatan Banama Tingang, Kabupaten Pulang Pisau.Metode: Jenis penelitian ini merupakan studi observasional analitik dengan pendekatan cross-sectional study dengan 30 Jenis penelitian ini adalah observasional analitik dengan desain cross-sectional yang dilakukan pada bulan Mei 2024. Sebanyak 30 responden penambang emas dipilih secara purposive sampling. Variabel kadar merkuri dalam saliva diukur menggunakan Inductively Coupled Plasma Mass Spectrometry (ICP-MS), pH saliva menggunakan pH meter digital, dan indeks DMF-T diperoleh melalui pemeriksaan klinis gigi. Analisis data dilakukan dengan menggunakan uji korelasi Spearman.Hasil: Rerata kadar merkuri dalam saliva adalah 290,6 mg/L, yang tergolong sangat tinggi dibanding ambang batas aman dalam tubuh (20 mg/L). Rerata pH saliva sebesar 4,8 menunjukkan kondisi asam (pH < 5,5), dan indeks DMF-T sebesar 13,4 mengindikasikan tingkat kerusakan gigi yang sangat tinggi (DMF-T≥9,0). Hasil uji Spearman menunjukkan bahwa tidak terdapat hubungan yang signifikan antara kadar merkuri dengan indeks DMF-T (p = 0,704) maupun antara pH saliva dengan indeks DMF-T (p = 0,403).Simpulan: Meskipun kadar merkuri dan pH saliva cukup bervariasi di antara responden, keduanya tidak memiliki hubungan signifikan dengan indeks DMF-T. Keterbatasan penelitian ini tidak memasukan faktor lain seperti pola makan dan kebersihan gigi yang dapat memengaruhi kejadian karies gigi pada penambang emas skala kecil di Desa Ramang, Kabupaten Pulang Pisau. ABSTRACT  Title: Correlation between Mercury (Hg) Levels and Salivary Acidity with DMF-T Index among Small-Scale Gold Miners in Ramang Village, Pulang Pisau RegencyBackground: Small-scale gold mining activities around the Kahayan River have led to mercury contamination, which can enter the human body through water or food. Mercury is toxic and can affect salivary conditions, including pH, which plays a role in the development of dental caries. Studies investigating the direct relationship between mercury levels and salivary acidity in relation to caries are still limited, particularly among gold miners. This study aims to analyze the relationship between mercury levels and salivary pH with the DMF-T index among small-scale gold miners in Ramang Village, Banama Tingang Subdistrict, Pulang Pisau Regency.Methods: This research is an analytical observational study with a cross-sectional design conducted in May 2024. A total of 30 small-scale gold miners were selected through purposive sampling. Mercury levels in saliva were measured using Inductively Coupled Plasma Mass Spectrometry (ICP-MS), salivary pH was assessed using a digital pH meter, and the DMF-T index was obtained through clinical dental examinations. Data analysis was performed using Spearman's correlation test.Results: The average mercury level in saliva was 290.6 µg/L, which is considered very high compared to the safe threshold (20 µg/L). The mean salivary pH was 4.8, indicating an acidic condition (pH < 5.5), and the DMF-T index averaged 13.4, suggesting a very high level of dental caries (DMF-T ≥ 9.0). Spearman’s test showed no significant correlation between mercury levels and the DMF-T index (p = 0.704), nor between salivary pH and the DMF-T index (p = 0.403).Conclusion: Although mercury levels and salivary pH varied among respondents, neither showed a significant relationship with the DMF-T index. This study is limited by not accounting for other influencing factors such as dietary habits and oral hygiene, which may contribute to the occurrence of dental caries among small-scale gold miners in Ramang Village, Pulang Pisau Regency.
Overview of The Rationality of Medication Use In Covid-19 Patients at The Inpatition Installation of The Bhayangkara Hospital, Palangka Raya Prillyanisa , Pasca; Alexandra, Francsisca Diana; Hanasia; Frethernety, Agnes; Turnip, Oktaviani Naulita
Barigas: Jurnal Riset Mahasiswa Vol. 3 No. 2 (2025): Barigas: Jurnal Riset Mahasiswa
Publisher : Fakultas Kedokteran Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/barigas.v3i2.11910

Abstract

Bhayangkara Palangka Raya Hospital is one of the government's referral hospitals for treating COVID-19 patients. COVID-19 patients need good service and treatment because there is no appropriate drug formulary for treating COVID-19 at Bhayangkara Hospital. Currently, the standard for COVID-19 treatment is based on the third edition of the COVID-19 management guidebook. This research aims to understand the rationale for using COVID-19 drugs in patients treated at the Bhayangkara Palangka Raya Hospital Outpatient Installation.The type of research used is descriptive qualitative. This research uses the method Total Sampling. The samples in this study were patients who received COVID-19 drug therapy and were hospitalized at Bhayangkara Palangka Raya Hospital who met the inclusion criteria for the July-August 2021 period. There are 6 indicators of rationality for drug use, namely correct indication, correct drug, correct dose, correct duration and method. administration, and be aware of side effects. In this study, a sample of 41 patients was taken. Based on the results of research evaluating the rationality of using COVID-19 drugs in the Bhayangkara Hospital Palangka RayaInpatient Installation for the period July-August 2021 based on the COVID-19 management guidebook, 3rd edition of 2020, in terms of 6 indicators of rationality, it was concluded that the analysis results were correct indications (100% ), the right drug (100%), the right patient (100%), the right dose (100%), the right duration and method of administration (100%), and being aware of side effects (100%) are completely rational. Judging from the 6 indicators of rationality including the right indication, the right drug, the right patient, the right dose, the right duration and method of administration, being alert to side effects is declared completely rational
Aktivitas Antioksidan Ekstrak Etanol Bajakah Kalalawit (Uncaria gambir (W.Hunter) Roxb) Menggunakan Metode DPPH: Antioxidant Activity of Ethanol Extract of Bajakah Kalalawit (Uncaria gambir (W.Hunter) Roxb) Using DPPH Method Halisa, Nida; Frethernety, Agnes; Permatasari, Silvani; Alexandra, Francisca Diana; Ysrafil, Ysrafil
Jurnal Surya Medika (JSM) Vol. 10 No. 2 (2024): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v10i2.6151

Abstract

Antioksidan dalam mendetoksifikasi radikal bebas akan ikut teroksidasi sehingga untuk mencukupi kebutuhan tubuh diperlukan antioksidan eksogen. Antioksidan eksogen dapat diperoleh dari tanaman herbal salah satunya Bajakah Kalalawit. Bajakah Kalalawit (Uncaria gambir (W.Hunter) Roxb.) adalah salah satu jenis bajakah yang terdapat di Kelurahan Marang, Kalimantan Tengah yang berpotensi sebagai antioksidan. Penelitian ini bertujuan untuk menganalisis aktivitas antioksidan dan kekuatan antioksidan Bajakah Kalalawit (Uncaria gambir (W. Hunter) Roxb.). Batang Bajakah Kalalawit diekstrak dengan metode maserasi 3x24 jam menggunakan pelarut etanol 96%. Setelah didapatkan ekstrak kental kemudian dianalisis kandungan senyawa metabolit sekunder dengan uji fitokimia. Uji aktivitas antioksidan dibuat dengan konsentrasi ekstrak 20ppm, 40ppm, 60ppm, 80ppm, dan 100ppm dengan metode DPPH (2,2-diphenyl-1-picrylhydrazyl). Hasil penelitian menunjukkan senyawa yang terdapat dalam ekstrak etanol Bajakah Kalalawit (Uncaria gambir (W.Hunter) Roxb) adalah terpenoid, flavonoid, fenolik, steroid, saponin, alkaloid, dan tanin. Ekstrak etanol Bajakah Kalalawit memiliki aktivitas antioksidan yang sangat kuat dengan nilai IC50 8,69ppm.
Potensi Antiglikasi Ekstrak Etanol Batang Bajakah Kalawait (Uncaria gambir (W. Hunter) Roxb.) dengan Reaksi Glikasi Secara In Vitro: Antiglycation Potensial of Ethanol Extract from the Stem of Bajakah Kalawait (Uncaria gambir (W. Hunter) Roxb.) Using In Vitro Glycation Reaction Method Berliani, Victoria; Frethernety, Agnes; Permatasari, Silvani; Alexandra, Francisca Diana; Widayati, Ratna
Jurnal Surya Medika (JSM) Vol. 10 No. 2 (2024): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v10i2.6190

Abstract

Hiperglikemia kronis menyebabkan terjadinya peningkatan reaksi glikasi  glukosa dengan protein. Produk akhir glikasi yaitu AGEs (Advanced Glycation End Products) berperan dalam komplikasi diabetes. Hasil skrining fitokimia yang telah dilakukan sebelumnya menunjukkan bahwa batang Bajakah Kalalawit (Uncaria gambir (W.Hunter) Roxb.) mengandung flavonoid, terpenoid, tanin, alkaloid yang diduga berpotensi sebagai antiglikasi. Penelitian ini bertujuan untuk mengetahui potensi antiglikasi ekstrak etanol batang Bajakah Kalalawit (Uncaria gambir (W.Hunter) Roxb.). Metode: Jenis penelitian adalah true eksperimental. Model reaksi glikasi menggunakan BSA dan glukosa sebagai kelompok kontrol. Ekstrak etanol 96% batang Bajakah Kalalawit (Uncaria gambir (W.Hunter) Roxb.) dibuat menjadi larutan konsentrasi 100, 200, 400, 600, 800 dan 1000ppm dan ditambahkan ke model reaksi glikasi, selanjutnya diukur absorbansi menggunakan spektrofotometer, dan dihitung nilai potensi antiglikasi. Hasil rerata potensi antiglikasi ekstrak Bajakah Kalalawit berdasarkan ANOVA berbeda signifikan (p<0.05) untuk setiap kenaikan konsentrasi ,yaitu konsentrasi 100, 200, 400, 600, 800 dan 1000ppm memiliki potensi 42,131%, 47,541%, 57,541%, 67,377%, 70,328%, 80,656% dengan nilai IC50 253,043ppm. Kesimpulan: Ekstrak etanol batang Bajakah Kalalawit (Uncaria gambir (W.Hunter) Roxb.) memiliki potensi antiglikasi dengan konsentrasi efektif 100ppm.
Co-Authors Abigail, Keshia Alexandra, Francisca Diana Alexandra, Francsisca Diana Alexandraa, Francisca Diana Amiani, Winney Aprelea, Reza Nathasya Balyas , Abi Bakring Berliani, Victoria Desimaria Panjaitan Dian Mutiasari, Dian Elsa Trinovita Elvariani, Ni Wayan Dessy Risma Elvina Damayanti Faradila, Faradila Fitri, Nurul Aulia Furtuna, Dewi Klarita Halisa, Nida Hanasia Handayani, Septi Jakung, Benedikta Cemara Raninai Jayanti, Ira Jelita, Helena Larasaty, Anggie Leman, Yanti Lestarisa, Trilianty Malik, Handayani Mallewa, Nurul Ilmi Marianti A Manggau Massi, Muh. Nassrum Nugrahini, Shinta Patricia, Tisha Permatasari, Silvani Prillyanisa , Pasca Purba, As Gaby Clarita Ranti, Dalia Rian Ka Praja Rovik, Anwar Sampurna Putra, Ravenalla Abdurrahman Al Hakim Sri Yuliani, Ni Nyoman Turnip, Oktaviani Naulita Widayati, Ratna Ysrafil, Ysrafil