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Hamidu, La
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Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology

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Determination of Total Phenolic Content of The Stem Bark Extract of Nyirih (Xylocarpus granatum J. Koeing) Using UV - Vis Spectrophotometry Method Aswar Aswar; Abd. Malik; La Hamidu; Ahmad Najib
Jurnal Fitofarmaka Indonesia Vol 8, No 3 (2021): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v8i3.728

Abstract

Nyirih is a plant from the Meliaceae family with the Latin name Xylocarpus granatum J.Koeing, this nyirih spreads in tropical waters and does not cluster in certain areas. This study aims to determine the total phenolic content of the stem bark extract of nyirih (Xylocarpus granatum J.Koeing) using the UV-Vis spectrophotometric method. The stem bark extract of nyirih (Xylocarpus granatum J. Koeing) was obtained with maceration method using 96% ethanol solvent. Determination of total phenolic content based on the Folin-Ciocalteau method, where the addition of 7% sodium carbonate provides an alkaline atmosphere that will produce phenolic ions. Furthermore, it will reduce Follin to form a blue complex. At a maximum wavelength of 755 nm, the results showed that the average total phenolic content of the stem bark extract of nyirih (Xylocarpus granatum J. Koeing) was 6.163 mg GAE / g extract.
UJI TOKSISITAS EKSTRAK ETANOL TERPURIFIKASI BIJI MAHONI (Switenia mahagoni) Virsa Handayani; Ahmad Najib; Rezki Amriati Syarif; Abdullah Mahmud; La Hamidu; Aktsar Roskiana Ahmad
Jurnal Fitofarmaka Indonesia Vol 6, No 2 (2019): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (613.207 KB) | DOI: 10.33096/jffi.v6i2.511

Abstract

Mahoni is a medical plant which have the potential as drug. The aims of this research were to analysis phytochemical content and to test the toxicity of ethanol extract of seed from Mahoni. The Phytochemicals that analyzed were total phenolic, total flavonoid and condensed tannin. Toxicity test was assessed using BSLT method. Extraction was done by maseration method using ethanol as the solvent. In BSLT method, the shrimp larvae were placed in a series of test solution of varied concentration. The value of LC50 were obtained based on calculation of shrimp larvae lethality percentage using probit analysis. LC50 values of ethanol extract were 0,95 ppm.
Potensi Ekstrak Buah Buni (Antidesma bunius (L) Spreng) Sebagai Inhibitor Enzim α-Glukosidase La Hamidu; Partomuan Simanjuntak; Rizna Triana Dewi
Jurnal Fitofarmaka Indonesia Vol 7, No 1 (2020): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (338.969 KB) | DOI: 10.33096/jffi.v7i1.598

Abstract

Diabetes mellitus is still a global health problem that continues to increase rapidly and become one of the major metabolic diseases throughout the world. This study aims to determine the potential of Buni fruit as an α-glucosidase inhibitor. α-glucosidase inhibition test is carried out on a blank solution (test solution without sample/standard), acarbose solution as a comparison standard and samples are carried out in accordance with the optimization conditions obtained. The rendemen percent of green and red buni fruit extract yields are 6.35% and 3.09%, respectively. The results of the identification of secondary metabolites using TLC showed that green and red buni fruit extract contains flavonoid, phenolic and alkaloid compounds. The results of the α-glucosidase enzyme inhibition test showed that the red buni fruit extract had the highest activity compared to green buni fruit extract with an IC50 value of 85.27 ppm. 
Postprandial Bioassay and Radical Scavenging on n-Hexane Fraction of Cordia myxa L. Leaf Virsa Handayani; Aktsar Roskiana Ahmad; Nur Rezky Khairun Nisaa; La Hamidu; Ahmad Najib
Jurnal Fitofarmaka Indonesia Vol 9, No 3 (2022): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v9i3.917

Abstract

Cordia myxa L. is empirically used as an antidiabetic medication. The aim of this study is to determine the in-vivo effect of Cordia myxa L. n-hexane fraction on reducing blood sugar levels and their relationship with the anti-free-radical activity assay using DPPH (1,1-diphenyl-2-Picrylhydrazyl). The n-hexane fraction of Cordia myxa L. was used as a sample in the post-prandial assay which was analyzed using the ANOVA statistical test followed by Post-Hoc test. The results showed that there were significant in the extract using a 500 mg dose. In the anti-free-radical test using DPPH (1,1-diphenyl-2-Picrylhydrazyl) at maximum wavelength of 516 nm, 16.49 µg /mL IC50 value was obtained. For comparison, Quercetin with IC50 0.13 µg/mL was used. This shows that the sample has strong anti-free radical inhibitory potential ranged from 10 µg/mL to 50 µg/mL. The data from the calculation showed that there is a correlation between its effect of lowering high blood sugar level and anti-free radical activity
Uji Oligosakarida Ekstrak Tepung Buah Semu Jambu Mete (Anacardium occidentale L.) Terhadap Pertumbuhan Baketri Lactobacillus casei Sebagai Altenatif Prebiotik Rasydy, La Ode Akbar; Elsa, Restia; Nuraini, Nuraini; Hamidu, La
Jurnal Fitofarmaka Indonesia Vol 11, No 2 (2024): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i2.1223

Abstract

Cashew pseudo-fruit (Anacardium occidentale L.) is rich in carbohydrates. Carbohydrates can be chemically hydrolyzed into simple monomers such as oligosaccharides. This study aims to ensure the effectiveness of cashew pseudo-fruit flour oligosaccharide extract as an alternative to prebiotics that are able to stimulate the growth of lactic acid bacteria such as Lactobacillus casei. The test was carried out on the growth of Lactobacillus casei bacteria using a 4% concentration cashew pseudo-fruit flour oligosaccharide solution with a dilution of 10-10 using the pour plate method and incubated at a temperature of 37°C for 48 hours to determine the ALT value. The results of the prebiotic parameter test showed the growth of the number of eligible bacterial colonies, namely 25-250 colonies found in dilution 10-4 - 10-8 with an ALT result of 7.3 x 10-6 so it can be concluded that The oligosaccharides extracted from the cashew pseudo-fruit have met the characteristics and criteria as an alternative prebiotic.
Daun Cempaka Kuning (Michelia champaca Linn) sebagai Kandidat Penghambat Enzim α-glukosidase secara In Silico Amalia, Riyanti; Meiliana, Made Laksmi; Hamidu, La
Jurnal Fitofarmaka Indonesia Vol 11, No 1 (2024): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i1.1183

Abstract

Diabetes Mellitus (DM) is a chronic disease that occurs worldwide and continues to increase rapidly. The purpose of this study was to determine the activity and mechanism of action of the antioxidant compounds in cempaka kuning leaves as an antidiabetic using the in silico method. This study used 8 antioxidant compounds from cempaka kuning leaves, namely octadecadienoic acid, butanoic acid, oleic acid, camphorsulfonic acid, pimaric acid, phenol, andrographolide, and benzoic acid. The α-glucosidase enzymes used in this study were obtained from the Protein Data Bank website with the PDB ID codes 3A4A and 2QMJ. Ligand-macromolecule docking using AutoDockTools (ADT) and AutoDock Vina programs. The results showed that the antioxidant compounds in cempaka kuning leaves that had the lowest ΔGbind values were pimaric acid (-8.9 kcal/mol) and andrographolide (-8.6 kcal/mol) in PDB ID 3A4A. The docking results used PDB ID 2QMJ, the compound with the smallest ΔGbind was andrographolide (-7.4 kcal/mol). The results of visualization of the interaction of the ligand with the macromolecular amino acid residue PDB ID 3A4A showed that the residues Arg315, Arg442, and Tyr158 were found in the compound with the smallest ΔGbind. In the PDB ID 2QMJ macromolecule, Asp542 residue was found in all compounds with the smallest ΔGbind. Based on these results, the compounds pimaric acid and andrographolide have potential as antidiabetic drugs compared to other compounds with a mechanism of action of inhibiting the α-glucosidase enzyme.
Co-Authors Abdullah Mahmud Ahmad Najib Ahmad, Aktsar Roskiana Amalia, Riyanti Aswar Aswar Elsa, Restia Meiliana, Made Laksmi Nur Rezky Khairun Nisaa Nuraini Nuraini Partomuan Simanjuntak Rasydy, La Ode Akbar Rezki Amriati Syarif Rizna Triana Dewi Virsa Handayani