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All Journal Majalah Obstetri dan Ginekologi Molecular and Cellular Biomedical Sciences (MCBS) Majalah Kedokteran Nusantara The Journal Of Medical School Sumatera Medical Journal Jurnal Syntax Fusion : Jurnal Nasional Indonesia Narra J
Ardiansyah, Edy
Fakultas Kedokteran USU
Biochemistry, Genetics & Molecular Biology Dentistry Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Journal : Narra J

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Role of estradiol and C-reactive protein levels on genitourinary syndrome in menopausal women Siregar, Muhammad FG.; Terauchi, Masakazu; Tobing, Immanuel DL.; Lubis, Roni B.; Azmeila, Selly; Pasaribu, Hotma P.; Prabudi, Oky; Ardiansyah, Edy; Effendi, Iman H.
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.626

Abstract

Menopause leads to decreased estradiol levels affecting tissue health and causing local inflammation in the genital organs and urinary tract. The rise of blood C-reactive protein (CRP) levels in menopausal women may indicate systemic inflammation associated with estradiol decline. The aim of this study was to determine the relationship between serum estradiol and CRP levels on genitourinary syndrome in menopausal women. A cross-sectional study was conducted among menopausal women who had not experienced menstruation for at least 12 consecutive months at Prof. dr. Chairuddin P. Lubis Hospital, Medan, Indonesia, in 2023. Estradiol and CRP levels were measured using enzyme-linked immunosorbent assay (ELISA) and the presence of genitourinary syndrome was assessed using the Menopause-Specific Quality of Life (MENQOL) questionnaire. The mean levels of estradiol and CRP were compared to menopausal women with and without genitourinary syndrome with the Mann-Whitney test. To assess the correlation between estradiol and CRP levels, and between their levels with the presence of genitourinary symptoms, the Spearman correlation test was used. The genitourinary syndrome was reported in 25% of the total included menopausal women. Our data indicated that the mean estradiol levels were not significantly different between menopausal women with and without genitourinary syndrome (9.13±2.47 pg/mL vs 18.96±31.23 pg/mL, p=0.881). The mean serum CRP level of menopausal women with genitourinary syndrome (9.72±6.30 mg/L) was higher than that of women without the syndrome (2.09±1.26 mg/L) with p<0.001. In addition, serum CRP level, not estradiol, was correlated with the symptom score of genitourinary syndrome. This study highlights that to identify and manage genitourinary syndrome, monitoring of CRP levels is essential in menopausal women.
Role of serum estradiol and C-telopeptide on musculoskeletal pain in menopausal women Siregar, Muhammad FG.; Terauchi, Masakazu; Lumbantobing, Jonathan T.; Pasaribu, Hotma P.; Prabudi, Muhammad O.; Ardiansyah, Edy; Effendi, Iman H.; Tobing, Immanuel DL.; Azmeila, Selly; Nabila, Nabila
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.747

Abstract

Musculoskeletal pain is one of the common symptoms of menopause syndrome throughout the world. Estradiol is the most potent and abundant derivative of estrogen and is associated with musculoskeletal pain, stiffness, and depressed mood during the menopausal transition. C-telopeptide is a molecule released during osteoclastic bone resorption and degradation of type I collagen, which is reported to have higher levels in individuals with musculoskeletal pain. An observational analytical study with a cross-sectional design was used in this research. Estradiol and C-telopeptide levels were measured in this study using enzyme-linked immunosorbent assay (ELISA). Musculoskeletal pain was assessed using the Nordic Musculoskeletal Questionnaire (NMQ) and the Menopause Quality of Life Questionnaire (MENQOL). Musculoskeletal pain was determined if the participant answered “yes” on questions number 12, 14 and 25 on the MENQOL. Data analysis was performed using the independent Student t-test for normally distributed data and the Mann-Whitney test for non-normally distributed data. A correlation test was performed using the Pearson correlation test for normally distributed data and the Spearman correlation test for non-normally distributed data. The results showed a non-significant relationship between estradiol and C-telopeptide levels with musculoskeletal pain assessed using the NMQ or MENQOL questionnaires. The correlation test also showed no correlation between estradiol and C-telopeptide levels in women with and without musculoskeletal pain.
Co-Authors Azmeila, Selly Benjamin Sihite Chandran Frinaldo Saragih Djaganata, Servin Pandu Dwi Putri, Savira Effendi, Iman H. Fadjrir Fadjrir Iman Helmi Effendi Iman Helmi Effendi Kaban, Yostoto B Khairani Sukatendel Lubis, Roni B. Lumbantobing, Jonathan T. Makmur Sitepu, Makmur Mohamad Fauzie Sahil Muhammad Rizki Yaznil Nabila, Nabila Nasution, Muhammad Siddik Paramita, Deryne Anggia Pasaribu, Hotma P. Prabudi, Muhammad O. Prabudi, Oky Ramadani, Sumi Riza Rivany Rizki Yaznil Sarirah, Munauwarus Sarma Nursani Lumbanraja Sihite, Herbert Siregar, Hendry Salim Siregar, Henry Salim Siregar, Muhammad FG. Syafardi, D. Irsat Tala, M. Rhiza Z Terauchi, Masakazu Tobing, Immanuel DL. Yulfi, Hemma