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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Prima Medika Sains Buletin Kedokteran dan Kesehatan Prima
Tarigan, Susiani
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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Detection of glibenclamide adulteration in herbal remedies for diabetes mellitus using TLC Budi, Andre; Razoki, Razoki; Harahap, Halimah; Amansyah, Adek; Edlin, Edlin; Tarigan, Susiani
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5287

Abstract

The widespread use of jamu, a traditional Indonesian herbal medicine, has been accompanied by a surge in adulteration with synthetic drugs to enhance efficacy and sales. This study aimed to detect the presence of glibenclamide, a common adulterant, in antidiabetic jamu product using TLC. This study employed three herbal medicine samples marketed for lowering blood glucose levels, with glibenclamide BPFI serving as a reference standard. Thin-layer chromatography, employing a mobile phase consisting of chloroform, cyclohexane, ethanol, and glacial acetic acid (9:9:1:1), was utilized for the analysis. Thin-layer chromatography (TLC) analysis revealed a standard Rf value of 0.4 for glibenclamide, producing a distinct blue-violet spot when visualized with 10% sulfuric acid. The results indicated that the tested herbal medicine samples did not contain the pharmaceutical substance glibenclamide. This conclusion was drawn from the absence of a corresponding Rf value for glibenclamide in the herbal samples when compared to the reference standard.
Perbedaan efektivitas ekstrak kulit apel hijau (Pyrus malus L) 25% dengan larutan xylitol 10% dalam menghambat pertumbuhan bakteri Streptococcus mutans secara in vitro Hutagalung, Mangatas Halomoan Parluhutan; Tarigan, Susiani
Jurnal Prima Medika Sains Vol. 1 No. 1 (2019): Desember
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (325.505 KB)

Abstract

One of the most predominant bacteria that cause dental caries is Streptococcus mutans. Streptococcus mutans is a gram-positive bacterium that can metabolize carbohydrates, especially sucrose and creates acid environment in the oral cavity. Streptococcus mutans has two enzyme systems in the cell walls to form two esktraseluler polysaccharides from sucrose. Streptococcus mutans can be treated with medication. One is the green apple skin extract (Pyrus Malus L) 25% to 10% xylitol solution. Green apple skin contains several phytochemicals including quercetin, catechin and chlorogenic acid and xylitol solution containing xylitol can inhibit Streptococcus mutans In Vitro secra. The purpose of this study to determine whether there are differences in the effectiveness of green apple skin extract (Pyrus Malus L) 25% to 10% xylitol solution in inhibiting the growth of bacteria Streprococcus mutans in vitro. The method used is an experimental laboratory research. This study was conducted using a sample of the bacteria Streptococcus mutans. The results of this study indicate that there are significant not differences in inhibiton zone diameter green apple skin extract of 25% 10,042±0,3797 and xylitol solution of 10%. Based on the test results conducted, it is concluded that green apple skin extract (Pyrus Malus L) 25% not differences of Streptococcus mutans bacteria with 10% xylitol solution 9,8±0,3594.
Penerapan sistem manajemen keselamatan dan kesehatan kerja (SMK3) pada industri pengolahan minyak kelapa sawit Tarigan, Susiani
Jurnal Prima Medika Sains Vol. 3 No. 1 (2021): Juni
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v3i1.1469

Abstract

Upaya penanggulangan risiko bahaya industri harus dikendalikan sebaik mungkin. Keselamatan harus dikelola dalam sistem manajemen yang disebut sistem manajemen keselamatan dan kesehatan kerja (SMK3). Data dari P2K3 sebuah industri pengolahan minyak kelapa sawit di Asahan menunjukkan bahwa pada tahun 2016-2018 menunjukkan kasus terbanyak yang terjadi adalah semburan dari katup uap. Penelitian ini menganalisis penerapan SMK3 dalam pengendalian kecelakaan kerja pada steam valve pada industri pengolahan minyak sawit. Penelitian ini menggunakan rancangan deskriptif dengan desain studi cross-sectional dengan data retrospektif selama 3 tahun (tahun 2016-2018). Sampel diambil dari seluruh jumlah populasi (sampling jenuh) berjumlah 48 orang yang terdiri dari 1 orang manajer, 29 orang pekerja di bagian instalasi katup uap, dan 18 orang pengurus Panitia Pembina Kesehatan dan Keselamatan Kerja (P2K3). Data primer diperoleh dengan observasi lapangan dan wawancara langsung dengan menggunakan kuesioner berdasarkan Permenaker No. 05/Men/969 yang berisi pertanyaan tentang penerapan SMK3. Data sekunder diperoleh dari dokumentasi struktur organisasi, laporan kecelakaan selama 2016-2018, catatan medis tenaga kerja, dan data-data tingkat pendidikan tenaga kerja. Hasil penelitian menunjukkan tidak ada satupun bidang penerapan dalam sistem manajemen keselamatan dan kesehatan kerja (SMK3) yang terlaksana dengan baik sesuai Permenaker No. 05/Men/96. Hal ini disebabkan karena tim P2K3 belum bekerja dengan optimal dalam mencegah kecelakaan kerja khususnya pada katup uap di industri tersebut. Perusahaan perlu membuat suatu program pencegahan kecelakaan kerja pada katup uap meliputi pengendalian secara administratif, penyuluhan, dan pendidikan teknis secara berkala.
Glycemic control, periodontal disease, and tooth mobility in type 2 diabetes Molek, Molek; Tarigan, Susiani; Nuari, Arifah Nur Amaliyah
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.6835

Abstract

Diabetes mellitus, a growing global and national health crisis, is associated with various systemic complications, including often-overlooked oral health deterioration, particularly periodontal disease. While the general bidirectional link between diabetes and periodontal disease is established, research on the direct correlation between glycaemic control (HbA1c) and periodontal status or tooth mobility in specific regional contexts like Indonesia remains inconsistent. This study aimed to analyse this relationship in patients with Type 2 Diabetes Mellitus (T2DM) at Dr. Yuliddin Away Tapaktuan Hospital. An analytical survey with a cross-sectional design was conducted in September-October 2024 at RSUD dr. Yuliddin Away Tapaktuan. A convenience sample of 40 T2DM patients was selected from a population of 63. HbA1c level was the independent variable, while periodontal disease status and tooth mobility degree were the dependent variables. Data were collected via direct oral examination and patient medical records, and subsequently analysed to determine associations. The study cohort (n=40) was predominantly female (72.5%) and over 45 years old (85%). A significant majority (80.0%) exhibited uncontrolled HbA1c levels. Periodontal disease was highly prevalent, with 80.0% of patients having gingivitis. The bivariate analysis revealed a strong and statistically significant relationship between blood glucose control and periodontal disease severity (p < 0.001). Among patients with controlled HbA1c, 87.5% maintained healthy periodontal status, whereas 96.8% of those with uncontrolled HbA1c presented with gingivitis. Conversely, while all controlled HbA1c patients showed no tooth mobility (Degree 0), 21.9% of the uncontrolled group had some degree of mobility (Degree 1 or 2). However, this association between HbA1c control and tooth mobility was not statistically significant (p = 0.910). This study confirms a significant inverse relationship between optimal blood glucose control and the severity of periodontal disease in T2DM patients, particularly regarding gingivitis. Effective glycaemic management is therefore critical for promoting periodontal health. While a trend was observed, the relationship between HbA1c control and tooth mobility did not reach statistical significance, suggesting its multifactorial nature. These findings underscore the importance of integrating comprehensive diabetes management with oral healthcare to prevent and mitigate periodontal complications.
Detection of glibenclamide adulteration in herbal remedies for diabetes mellitus using TLC Budi, Andre; Razoki, Razoki; Harahap, Halimah; Amansyah, Adek; Edlin, Edlin; Tarigan, Susiani
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5287

Abstract

The widespread use of jamu, a traditional Indonesian herbal medicine, has been accompanied by a surge in adulteration with synthetic drugs to enhance efficacy and sales. This study aimed to detect the presence of glibenclamide, a common adulterant, in antidiabetic jamu product using TLC. This study employed three herbal medicine samples marketed for lowering blood glucose levels, with glibenclamide BPFI serving as a reference standard. Thin-layer chromatography, employing a mobile phase consisting of chloroform, cyclohexane, ethanol, and glacial acetic acid (9:9:1:1), was utilized for the analysis. Thin-layer chromatography (TLC) analysis revealed a standard Rf value of 0.4 for glibenclamide, producing a distinct blue-violet spot when visualized with 10% sulfuric acid. The results indicated that the tested herbal medicine samples did not contain the pharmaceutical substance glibenclamide. This conclusion was drawn from the absence of a corresponding Rf value for glibenclamide in the herbal samples when compared to the reference standard.
Glycemic control, periodontal disease, and tooth mobility in type 2 diabetes Molek, Molek; Tarigan, Susiani; Nuari, Arifah Nur Amaliyah
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.6835

Abstract

Diabetes mellitus, a growing global and national health crisis, is associated with various systemic complications, including often-overlooked oral health deterioration, particularly periodontal disease. While the general bidirectional link between diabetes and periodontal disease is established, research on the direct correlation between glycaemic control (HbA1c) and periodontal status or tooth mobility in specific regional contexts like Indonesia remains inconsistent. This study aimed to analyse this relationship in patients with Type 2 Diabetes Mellitus (T2DM) at Dr. Yuliddin Away Tapaktuan Hospital. An analytical survey with a cross-sectional design was conducted in September-October 2024 at RSUD dr. Yuliddin Away Tapaktuan. A convenience sample of 40 T2DM patients was selected from a population of 63. HbA1c level was the independent variable, while periodontal disease status and tooth mobility degree were the dependent variables. Data were collected via direct oral examination and patient medical records, and subsequently analysed to determine associations. The study cohort (n=40) was predominantly female (72.5%) and over 45 years old (85%). A significant majority (80.0%) exhibited uncontrolled HbA1c levels. Periodontal disease was highly prevalent, with 80.0% of patients having gingivitis. The bivariate analysis revealed a strong and statistically significant relationship between blood glucose control and periodontal disease severity (p < 0.001). Among patients with controlled HbA1c, 87.5% maintained healthy periodontal status, whereas 96.8% of those with uncontrolled HbA1c presented with gingivitis. Conversely, while all controlled HbA1c patients showed no tooth mobility (Degree 0), 21.9% of the uncontrolled group had some degree of mobility (Degree 1 or 2). However, this association between HbA1c control and tooth mobility was not statistically significant (p = 0.910). This study confirms a significant inverse relationship between optimal blood glucose control and the severity of periodontal disease in T2DM patients, particularly regarding gingivitis. Effective glycaemic management is therefore critical for promoting periodontal health. While a trend was observed, the relationship between HbA1c control and tooth mobility did not reach statistical significance, suggesting its multifactorial nature. These findings underscore the importance of integrating comprehensive diabetes management with oral healthcare to prevent and mitigate periodontal complications.
Bahasa Inggris Muharraran, Firdha; Tarigan, Susiani; Delfira, Rizqina
Jurnal Penelitian Pendidikan IPA Vol 9 No SpecialIssue (2023): UNRAM journals and research based on science education, science applic
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9iSpecialIssue.6396

Abstract

Lactobacillus acidophilus one of the bacteria that causes caries among other Lactobacillus species. Mint leaves (Mentha piperita L.) contain active compounds as antibacterials. The aim of this research was to determine the effectiveness of mint leaf extract (Mentha piperita L.) mouthspray in concentrations of 5%, 10%, 25%, 50% against Lactobacillus acidophilus. Type of this research is true experimental with post test only control group design. The sample is pure culture of Lactobacillus acidophilus and 24 students Dentist Study Program, Prima Indonesia University. Antibacterial testing used the disc diffusion method and the solution was made with pure extract and distilled water. Organoleptic data was collected by questionnaire then analyzed using the Kruskal-Wallis and Mann-Whitney. The results is showed the majority of panelists stated did not like the color, aroma and taste of the mouthspray of mint leaf extract (Mentha piperita L.). In the antibacterial test, the inhibition zone was obtained with concentrations of 10%, 25%, 50% and positive control was 3.70 ± 4.273 mm; 8.88±1,250 mm; 11.33 ± 0.126 mm; 11.34 ± 0.126 mm, while the 5% and negative control had no obstacles. This research shows that mouthspray solution has a safe formula as an oral preparation and has antibacterial activity
Co-Authors Adek Amansyah Budi, Andre Delfira, Rizqina Edlin, Edlin Harahap, Halimah Hutagalung, Mangatas Halomoan Parluhutan Molek, Molek Muharraran, Firdha Nuari, Arifah Nur Amaliyah Razoki, Razoki