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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Kesmas Prima Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research
Muharraran, Firdha
Department Of Dental Sciences, Faculty Of Dentistry, Universitas Prima Indonesia, Medan, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Potential of Hydrogel Acemannan Aloe Vera (Aloe vera) on Wound Healing After Tooth Extraction In vivo Via Regulation of Inflammatory Response Firdha Muharraran; Gusbakti Rusip; Rosa Paradita Dalimunthe
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 6 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i6.532

Abstract

Background: Tooth extraction is a surgical procedure that involves hard tissue such as bone and soft tissue. Wounds on soft tissue are then followed by a healing process that occurs through three phases, namely the inflammatory phase, the proliferative phase, and the remodeling phase. Acemannan has the ability to stimulate hematopoiesis and antioxidant effects. Acemannan is able to reduce inflammation through prostaglandin synthesis and increase leukocyte infiltration and play a significant role in the oral wound healing process. Methods: This study is an in vivo experimental study. A total of 30 rats (5 each/group) were divided into groups that received 1%, 2%, 4%, 8%, povidone-iodine, and carbopol acemannan Aloe vera hydrogel. Furthermore, the number of macrophage cells in the tissue after tooth extraction was assessed. Data analysis was carried out with the help of SPSS with ANOVA and post hoc LSD tests. Results: There was a significant difference between the application of acemannan 1% hydrogel and 4% acemannan hydrogel, 8%, povidone-iodine, and carbopol, between the application of acemannan 2% hydrogel 4% acemannan hydrogel, 8%, povidone-iodine and carbopol, applications acemannan hydrogel 8% with carbopol, and between povidone-iodine and carbopol (p≤0.05). Conclusion: Acemannan Aloe vera hydrogel is able to accelerate wound healing after tooth extraction in vivo by suppressing macrophage cell activity.
Potential of Hydrogel Acemannan Aloe Vera (Aloe vera) on Wound Healing After Tooth Extraction In vivo Via Regulation of Inflammatory Response Firdha Muharraran; Gusbakti Rusip; Rosa Paradita Dalimunthe
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 6 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i6.532

Abstract

Background: Tooth extraction is a surgical procedure that involves hard tissue such as bone and soft tissue. Wounds on soft tissue are then followed by a healing process that occurs through three phases, namely the inflammatory phase, the proliferative phase, and the remodeling phase. Acemannan has the ability to stimulate hematopoiesis and antioxidant effects. Acemannan is able to reduce inflammation through prostaglandin synthesis and increase leukocyte infiltration and play a significant role in the oral wound healing process. Methods: This study is an in vivo experimental study. A total of 30 rats (5 each/group) were divided into groups that received 1%, 2%, 4%, 8%, povidone-iodine, and carbopol acemannan Aloe vera hydrogel. Furthermore, the number of macrophage cells in the tissue after tooth extraction was assessed. Data analysis was carried out with the help of SPSS with ANOVA and post hoc LSD tests. Results: There was a significant difference between the application of acemannan 1% hydrogel and 4% acemannan hydrogel, 8%, povidone-iodine, and carbopol, between the application of acemannan 2% hydrogel 4% acemannan hydrogel, 8%, povidone-iodine and carbopol, applications acemannan hydrogel 8% with carbopol, and between povidone-iodine and carbopol (p≤0.05). Conclusion: Acemannan Aloe vera hydrogel is able to accelerate wound healing after tooth extraction in vivo by suppressing macrophage cell activity.
Pengaruh faktor risiko pekerja pemanen kelapa sawit terhadap terjadinya keluhan musculoskeletal disorders (MSDS) di PT. Perkebunan Nusantara IV unit Kebun Meranti Paham -, Hartono; Simatupang, Mega Riama Sawitri Br; Lina, Juliana; Bukit, Rosmeri br; Muharraran, Firdha
Jurnal Kesmas Prima Indonesia Vol. 7 No. 2 (2023): Edisi Juli
Publisher : Program Studi Sarjana Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jkpi.v7i2.4161

Abstract

Musculoskeletal Disorders (MSDs) are the most common occupational diseases that occur in the working population. The purpose of this study was to determine the effect of risk factors between age, workload, smoking habits and years of service of oil palm harvesters on the occurrence of musculoskeletal disorders. This study used an analytical survey method using a cross sectional design. The research sample is the entire population studied, namely 50 respondents at PT. Perkebunan Nusantara IV Meranti Paham Plantation Unit. The sampling technique used in this study is a total sampling technique where the number of samples is the same as the population. Data was collected using a Nordic Body Map (NBM) questionnaire. The analysis used was univariate, bivariate (Chi-square test) and multivariate analysis. The results of the bivariate analysis showed that there was a strong relationship between age and complaints of musculoskeletal disorders and the results also showed that there was a strong relationship between years of service and complaints of musculoskeletal disorders. The results of the multivariate analysis of the most dominant variable affecting musculoskeletal complaints were years of service after controlling for the age variable. So it was concluded that there was an influence between age and tenure with complaints of musculoskeletal disorders in oil palm harvesters. The most dominant factor for musculoskeletal complaints is years of service.
Phytochemical Screening and In Vitro Antibacterial Activity of Swietenia mahagoni Leaf Extract against Streptococcus mutans: A Promising Natural Approach for Caries Prevention Muharraran, Firdha; Florenly; Ivan Melka
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1269

Abstract

Background: Dental caries, primarily caused by Streptococcus mutans, is a prevalent oral health issue. The rise of antibiotic resistance and side effects of synthetic antimicrobials have fueled the search for plant-derived alternatives. Swietenia mahagoni (mahogany) leaves, traditionally used for medicinal purposes, exhibit potential antibacterial properties. This study investigated the phytochemical composition and in vitro antibacterial activity of S. mahagoni leaf extracts against S. mutans. Methods: S. mahagoni leaves were collected, processed, and extracted using ethanol. Phytochemical screening identified alkaloids, tannins, flavonoids, and saponins. Antibacterial activity was assessed through the agar well diffusion method against S. mutans, using various extract concentrations (25%, 50%, 75%) and chlorhexidine as a positive control. Inhibition zone diameters were measured to determine antibacterial efficacy. Results: Phytochemical analysis confirmed the presence of alkaloids, tannins, flavonoids, and saponins in the S. mahagoni leaf extract. The extract demonstrated significant antibacterial activity against S. mutans at all concentrations. The highest concentration (75%) showed the largest inhibition zone (18.07 ± 0.37 mm), significantly larger than those of lower concentrations and the positive control (chlorhexidine, 13.87 ± 0.21 mm). Conclusion: S. mahagoni leaf extract exhibits substantial antibacterial activity against S. mutans, likely due to its diverse phytochemical content. These findings suggest its potential as a natural anti-caries agent. Further research is needed to explore its use in developing novel oral health products.
Phytochemical Screening and In Vitro Antibacterial Activity of Swietenia mahagoni Leaf Extract against Streptococcus mutans: A Promising Natural Approach for Caries Prevention Muharraran, Firdha; Florenly; Ivan Melka
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1269

Abstract

Background: Dental caries, primarily caused by Streptococcus mutans, is a prevalent oral health issue. The rise of antibiotic resistance and side effects of synthetic antimicrobials have fueled the search for plant-derived alternatives. Swietenia mahagoni (mahogany) leaves, traditionally used for medicinal purposes, exhibit potential antibacterial properties. This study investigated the phytochemical composition and in vitro antibacterial activity of S. mahagoni leaf extracts against S. mutans. Methods: S. mahagoni leaves were collected, processed, and extracted using ethanol. Phytochemical screening identified alkaloids, tannins, flavonoids, and saponins. Antibacterial activity was assessed through the agar well diffusion method against S. mutans, using various extract concentrations (25%, 50%, 75%) and chlorhexidine as a positive control. Inhibition zone diameters were measured to determine antibacterial efficacy. Results: Phytochemical analysis confirmed the presence of alkaloids, tannins, flavonoids, and saponins in the S. mahagoni leaf extract. The extract demonstrated significant antibacterial activity against S. mutans at all concentrations. The highest concentration (75%) showed the largest inhibition zone (18.07 ± 0.37 mm), significantly larger than those of lower concentrations and the positive control (chlorhexidine, 13.87 ± 0.21 mm). Conclusion: S. mahagoni leaf extract exhibits substantial antibacterial activity against S. mutans, likely due to its diverse phytochemical content. These findings suggest its potential as a natural anti-caries agent. Further research is needed to explore its use in developing novel oral health products.
Co-Authors Bukit, Rosmeri Br Florenly Gusbakti Rusip Hartono Ivan Melka Lina, Juliana Rosa Paradita Dalimunthe Simatupang, Mega Riama Sawitri Br