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Potential of Hydrogel Acemannan Aloe Vera (Aloe vera) on Wound Healing After Tooth Extraction In vivo Via Regulation of Inflammatory Response Firdha Muharraran; Gusbakti Rusip; Rosa Paradita Dalimunthe
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 6 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i6.532

Background: Tooth extraction is a surgical procedure that involves hard tissue such as bone and soft tissue. Wounds on soft tissue are then followed by a healing process that occurs through three phases, namely the inflammatory phase, the proliferative phase, and the remodeling phase. Acemannan has the ability to stimulate hematopoiesis and antioxidant effects. Acemannan is able to reduce inflammation through prostaglandin synthesis and increase leukocyte infiltration and play a significant role in the oral wound healing process. Methods: This study is an in vivo experimental study. A total of 30 rats (5 each/group) were divided into groups that received 1%, 2%, 4%, 8%, povidone-iodine, and carbopol acemannan Aloe vera hydrogel. Furthermore, the number of macrophage cells in the tissue after tooth extraction was assessed. Data analysis was carried out with the help of SPSS with ANOVA and post hoc LSD tests. Results: There was a significant difference between the application of acemannan 1% hydrogel and 4% acemannan hydrogel, 8%, povidone-iodine, and carbopol, between the application of acemannan 2% hydrogel 4% acemannan hydrogel, 8%, povidone-iodine and carbopol, applications acemannan hydrogel 8% with carbopol, and between povidone-iodine and carbopol (p≤0.05). Conclusion: Acemannan Aloe vera hydrogel is able to accelerate wound healing after tooth extraction in vivo by suppressing macrophage cell activity.

Potential of Hydrogel Acemannan Aloe Vera (Aloe vera) on Wound Healing After Tooth Extraction In vivo Via Regulation of Inflammatory Response Firdha Muharraran; Gusbakti Rusip; Rosa Paradita Dalimunthe
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 6 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i6.532

Background: Tooth extraction is a surgical procedure that involves hard tissue such as bone and soft tissue. Wounds on soft tissue are then followed by a healing process that occurs through three phases, namely the inflammatory phase, the proliferative phase, and the remodeling phase. Acemannan has the ability to stimulate hematopoiesis and antioxidant effects. Acemannan is able to reduce inflammation through prostaglandin synthesis and increase leukocyte infiltration and play a significant role in the oral wound healing process. Methods: This study is an in vivo experimental study. A total of 30 rats (5 each/group) were divided into groups that received 1%, 2%, 4%, 8%, povidone-iodine, and carbopol acemannan Aloe vera hydrogel. Furthermore, the number of macrophage cells in the tissue after tooth extraction was assessed. Data analysis was carried out with the help of SPSS with ANOVA and post hoc LSD tests. Results: There was a significant difference between the application of acemannan 1% hydrogel and 4% acemannan hydrogel, 8%, povidone-iodine, and carbopol, between the application of acemannan 2% hydrogel 4% acemannan hydrogel, 8%, povidone-iodine and carbopol, applications acemannan hydrogel 8% with carbopol, and between povidone-iodine and carbopol (p≤0.05). Conclusion: Acemannan Aloe vera hydrogel is able to accelerate wound healing after tooth extraction in vivo by suppressing macrophage cell activity.

Pengaruh faktor risiko pekerja pemanen kelapa sawit terhadap terjadinya keluhan musculoskeletal disorders (MSDS) di PT. Perkebunan Nusantara IV unit Kebun Meranti Paham -, Hartono; Simatupang, Mega Riama Sawitri Br; Lina, Juliana; Bukit, Rosmeri br; Muharraran, Firdha
Jurnal Kesmas Prima Indonesia Vol. 7 No. 2 (2023): Edisi Juli
Publisher : Program Studi Sarjana Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jkpi.v7i2.4161

Musculoskeletal Disorders (MSDs) are the most common occupational diseases that occur in the working population. The purpose of this study was to determine the effect of risk factors between age, workload, smoking habits and years of service of oil palm harvesters on the occurrence of musculoskeletal disorders. This study used an analytical survey method using a cross sectional design. The research sample is the entire population studied, namely 50 respondents at PT. Perkebunan Nusantara IV Meranti Paham Plantation Unit. The sampling technique used in this study is a total sampling technique where the number of samples is the same as the population. Data was collected using a Nordic Body Map (NBM) questionnaire. The analysis used was univariate, bivariate (Chi-square test) and multivariate analysis. The results of the bivariate analysis showed that there was a strong relationship between age and complaints of musculoskeletal disorders and the results also showed that there was a strong relationship between years of service and complaints of musculoskeletal disorders. The results of the multivariate analysis of the most dominant variable affecting musculoskeletal complaints were years of service after controlling for the age variable. So it was concluded that there was an influence between age and tenure with complaints of musculoskeletal disorders in oil palm harvesters. The most dominant factor for musculoskeletal complaints is years of service.

Phytochemical Screening and In Vitro Antibacterial Activity of Swietenia mahagoni Leaf Extract against Streptococcus mutans: A Promising Natural Approach for Caries Prevention Muharraran, Firdha; Florenly; Ivan Melka
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1269

Background: Dental caries, primarily caused by Streptococcus mutans, is a prevalent oral health issue. The rise of antibiotic resistance and side effects of synthetic antimicrobials have fueled the search for plant-derived alternatives. Swietenia mahagoni (mahogany) leaves, traditionally used for medicinal purposes, exhibit potential antibacterial properties. This study investigated the phytochemical composition and in vitro antibacterial activity of S. mahagoni leaf extracts against S. mutans. Methods: S. mahagoni leaves were collected, processed, and extracted using ethanol. Phytochemical screening identified alkaloids, tannins, flavonoids, and saponins. Antibacterial activity was assessed through the agar well diffusion method against S. mutans, using various extract concentrations (25%, 50%, 75%) and chlorhexidine as a positive control. Inhibition zone diameters were measured to determine antibacterial efficacy. Results: Phytochemical analysis confirmed the presence of alkaloids, tannins, flavonoids, and saponins in the S. mahagoni leaf extract. The extract demonstrated significant antibacterial activity against S. mutans at all concentrations. The highest concentration (75%) showed the largest inhibition zone (18.07 ± 0.37 mm), significantly larger than those of lower concentrations and the positive control (chlorhexidine, 13.87 ± 0.21 mm). Conclusion: S. mahagoni leaf extract exhibits substantial antibacterial activity against S. mutans, likely due to its diverse phytochemical content. These findings suggest its potential as a natural anti-caries agent. Further research is needed to explore its use in developing novel oral health products.

Phytochemical Screening and In Vitro Antibacterial Activity of Swietenia mahagoni Leaf Extract against Streptococcus mutans: A Promising Natural Approach for Caries Prevention Muharraran, Firdha; Florenly; Ivan Melka
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1269

Background: Dental caries, primarily caused by Streptococcus mutans, is a prevalent oral health issue. The rise of antibiotic resistance and side effects of synthetic antimicrobials have fueled the search for plant-derived alternatives. Swietenia mahagoni (mahogany) leaves, traditionally used for medicinal purposes, exhibit potential antibacterial properties. This study investigated the phytochemical composition and in vitro antibacterial activity of S. mahagoni leaf extracts against S. mutans. Methods: S. mahagoni leaves were collected, processed, and extracted using ethanol. Phytochemical screening identified alkaloids, tannins, flavonoids, and saponins. Antibacterial activity was assessed through the agar well diffusion method against S. mutans, using various extract concentrations (25%, 50%, 75%) and chlorhexidine as a positive control. Inhibition zone diameters were measured to determine antibacterial efficacy. Results: Phytochemical analysis confirmed the presence of alkaloids, tannins, flavonoids, and saponins in the S. mahagoni leaf extract. The extract demonstrated significant antibacterial activity against S. mutans at all concentrations. The highest concentration (75%) showed the largest inhibition zone (18.07 ± 0.37 mm), significantly larger than those of lower concentrations and the positive control (chlorhexidine, 13.87 ± 0.21 mm). Conclusion: S. mahagoni leaf extract exhibits substantial antibacterial activity against S. mutans, likely due to its diverse phytochemical content. These findings suggest its potential as a natural anti-caries agent. Further research is needed to explore its use in developing novel oral health products.

Effectiveness of Mango Mistletoe on Lung Superoxide Dismutase in Hypertensive Rats Exposed to DOCA-Salt Darma, Surya; Angie, Evelyn; Lubis, Yuliani Mardiati; Muharraran, Firdha
Poltekita : Jurnal Ilmu Kesehatan Vol. 17 No. 4 (2024): February
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v17i4.3676

Vascular disease, caused by oxidative stress and endothelial cell inflammation during hypertension's development, produces substantial mortality and morbidity. Mango mistletoe was tested for its effect on pulmonary superoxide dismutase (SOD) in hypertensive rats exposed to DOCA-salt in a preventative model. This study involves experimental quantitative research. SPSS was used for one-way ANOVA and post-hoc LSD testing. The population used was male Wistar rats (Rattus norvegicus). The samples used were 25 male Wistar rats divided into five treatment groups because of the Shapiro-Wilk test for normality analysis. The treatment group included a negative control group, a positive control group, and a group given different doses of mango mistletoe methanol extract: P1 at 75 mg/kgBW, P2 and P3 at 150 mg/kgBW, and P3 at 250 mg/kgBW. The study indicated that 250 mg/kg BW mango mistletoe extract increased SOD levels in DOCA-Garam-exposed Wistar white rats (Rattus norvegicus). Enhanced superoxide dismutase, malondialdehyde (MDA), ureum, creatinine, and renal histology see this. The normality of study data in the complete group assessing SOD, MDA, ureum, and creatinine levels showed a significance value larger than 0.05. The significance probability and one-way ANOVA test values are more than 0.05. The study found that mango mistletoe extract contains saponins, tannins, flavonoids, and triterpenoids that increase SOD levels and repair kidney cells damaged by hypertension in Wistar white rats. The study examined how mango mistletoe extract affects mouse hypertension. However, its conclusions should not be applied to humans. Clinical trials are needed to determine mango mistletoe extract's safety and efficacy for humans.

TINJAUAN ARTIKEL: PEMASANGAN DENTAL IMPAN SETELAH ELEVASI LANTAI SINUS DENGAN TEKNIK OSTEOTOMI Halim, Susanna; Muharraran, Firdha; Aulia, Dinda Rizky; Kartika, Disya Citta; Selvina, Weni
KNOWLEDGE: Jurnal Inovasi Hasil Penelitian dan Pengembangan Vol. 5 No. 1 (2025)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia (P4I)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/knowledge.v5i1.4784

Dental implant is considered the optimal rehabilitation option for tooth loss, a prevalent issue in Indonesia that can impair oral function. However, it presents technical challenges, particularly in the posterior maxilla where bone volume is limited. This study constitutes a literature review conducted using Google Scholar and Science Direct databases, spanning the years 2000–2024, with the keywords "dental implant", "osteotome technique", "sinus floor elevation", and "case report". The selection process prioritized relevance, scientific rigor, and contribution to the field of study. Two case reports indicate the effectiveness of the osteotome technique in augmenting bone volume and facilitating implant placement in the posterior maxilla. This technique is minimally invasive and expedites the rehabilitation process. Sinus floor elevation using the osteotome technique offers a simpler alternative to conventional procedures, associated with a lower risk of complications. Nevertheless, this technique necessitates operator proficiency and is suitable primarily for cases of mild to moderate bone defects. In conclusion, dental implant placement utilizing the osteotome technique following sinus floor elevation demonstrates efficacy for the rehabilitation of posterior maxillary teeth, contingent upon the consideration of anatomical, aesthetic, economic, and patient preference factors. ABSTRAKKehilangan gigi menjadi masalah umum di Indonesia dan dapat mengganggu fungsi oral. Dental implant merupakan pilihan rehabilitasi terbaik, meskipun memiliki tantangan teknis, khususnya di area posterior maksila dengan volume tulang terbatas. Studi ini merupakan tinjauan literatur menggunakan Google Scholar dan Science Direct pada tahun 2000–2024 dengan kata kunci "dental implant", "osteotome technique", "sinus floor elevation", dan "case report". Seleksi dilakukan berdasarkan relevansi, kualitas ilmiah, dan kontribusi terhadap bidang studi. Dua laporan kasus menunjukkan bahwa teknik osteotomi efektif untuk meningkatkan volume tulang dan memfasilitasi pemasangan implan pada posterior maksila. Teknik ini minimal invasif dan mempercepat proses rehabilitasi. Elevasi sinus dengan osteotomi menjadi alternatif prosedur yang lebih sederhana dibandingkan teknik konvensional, dengan risiko komplikasi yang lebih rendah. Namun, teknik ini memerlukan keterampilan operator dan hanya cocok untuk kasus defek ringan hingga sedang. Dental implant dengan teknik osteotomi setelah elevasi lantai sinus terbukti efektif untuk rehabilitasi gigi posterior maksila, dengan mempertimbangkan faktor anatomi, estetika, ekonomi, dan preferensi pasien.

Pengaruh faktor risiko pekerja pemanen kelapa sawit terhadap terjadinya keluhan musculoskeletal disorders (MSDS) di PT. Perkebunan Nusantara IV unit Kebun Meranti Paham -, Hartono; Simatupang, Mega Riama Sawitri Br; Lina, Juliana; Bukit, Rosmeri br; Muharraran, Firdha
Jurnal Kesmas Prima Indonesia Vol. 7 No. 2 (2023): Edisi Juli
Publisher : Program Studi Sarjana Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jkpi.v7i2.4161

Musculoskeletal Disorders (MSDs) are the most common occupational diseases that occur in the working population. The purpose of this study was to determine the effect of risk factors between age, workload, smoking habits and years of service of oil palm harvesters on the occurrence of musculoskeletal disorders. This study used an analytical survey method using a cross sectional design. The research sample is the entire population studied, namely 50 respondents at PT. Perkebunan Nusantara IV Meranti Paham Plantation Unit. The sampling technique used in this study is a total sampling technique where the number of samples is the same as the population. Data was collected using a Nordic Body Map (NBM) questionnaire. The analysis used was univariate, bivariate (Chi-square test) and multivariate analysis. The results of the bivariate analysis showed that there was a strong relationship between age and complaints of musculoskeletal disorders and the results also showed that there was a strong relationship between years of service and complaints of musculoskeletal disorders. The results of the multivariate analysis of the most dominant variable affecting musculoskeletal complaints were years of service after controlling for the age variable. So it was concluded that there was an influence between age and tenure with complaints of musculoskeletal disorders in oil palm harvesters. The most dominant factor for musculoskeletal complaints is years of service.

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