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All Journal The Indonesian Biomedical Journal Jurnal Rekonstruksi dan Estetik Asian Journal of Health Research Folia Medica Indonesiana
Zarasade, Lobredia
Department Of Plastic Reconstructive And Aesthetic Surgery, Faculty Of Medicine, Universitas Airlangga, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Elevated Serum Transaminase (SGOT/SGPT) and Sepsis in Burn Patients in a Tertiary Hospital, Surabaya, Indonesia Saputro, Iswinarno Doso; Zarasade, Lobredia; Kurniawan, Rifqi
Folia Medica Indonesiana Vol. 58, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: • There is no correlation between the increase of SGOT and sepsis. • Correlation between the increase of SGPT and sepsis was significant founded. Abstract: Burns trigger hypermetabolic stress reactions that cause inflammatory responses. When there is a sustained or increased hypermetabolic reaction, the inflammatory response can be life-threatening, such as sepsis, and significantly impact hepatic metabolic function. After burns, varying degrees of liver injury are usually associated with burn severity. This study determined the correlation between elevated serum transaminases (SGOT/ SGPT) and sepsis in burn patients at a tertiary hospital of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, from January 1, 2018, to December 31, 2020. This was a descriptive-analytic study with a retrospective cohort design. The data in this study included the demography of burn patients, causes of burns, inhalation trauma, burn severity, increased serum transaminase (SGOT/SGPT), mortality, and sepsis. This study found that the correlation between elevated serum transaminases (SGOT/SGPT) and sepsis was determined using the Spearman-Rho Rank statistical test. Burn patients with sepsis in the hospital were dominated by males (65.2%) and mostly aged 26-55 years (69.6%). The flame was found to be the highest cause of burns (80.4%), burn area above 20% (91.3%), the highest level of severity was major burn (91.3%), and no inhalation trauma (54.3%). In this study, there was an increase in SGOT of 69.6% and SGPT of 78.3%, with a mortality rate of 39.1%, with average inpatient days of 24 days. The correlation test between elevated serum transaminase (SGOT) and sepsis showed an insignificant relationship (p = 0.065, p> 0.05) with a correlation coefficient of 0.200. In contrast, the correlation between elevated serum transaminase (SGPT) and sepsis was significant (p=0.006, p<0.05) with a correlation coefficient of 0.296.
Elevated D-dimer is Associated with Anemia, Immune Dysregulation, and Hepatic–Renal Dysfunction in Acute Burn Patients Paramita, Anindya; Hariani, Lynda; Zarasade, Lobredia; Syakdiyah, Noer Halimatus; Dewi, Nurrani Mustika; Sandra, Ferry
The Indonesian Biomedical Journal Vol 18, No 1 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i1.3925

Abstract

BACKGROUND: Burn injury induced increased risk of venous thromboembolism (VTE) due to hypercoagulability, immobilization, and endothelial injury. Despite this risk, VTE in burn patients often remains clinically undetected. Although D-dimer is widely used as a VTE marker, its utility in burn patients is inconsistent, particularly in the early post-burn period. Therefore, this study was conducted to evaluate the correlation between D-dimer levels and factors related to VTE, including hematologic, coagulation, immunologic, organ function parameters, and burn characteristics.METHODS: An analytical observational study was conducted involving adult patients with acute burn injuries enrolled in Dr. Soetomo General Hospital from March to June 2025. Demographic, anthropometric, burn characteristic, and existing comorbid were documented from subjects’ medical records. Blood samples from subjects were collected immediately via venipuncture. D-dimer was analyzed with Enzyme-Linked Fluorescent Assay (ELFA) method, hematology and coagulation profiles were also assessed using hematology analyzer and automated coagulation system, respectively. Meanwhile, hepatic and renal function were analyzed with chemistry analyzers.RESULTS: Most burn subjects (18 of 20) demonstrated elevated D-dimer levels. Higher D-dimer levels were associated with increased leukocyte counts and upward trend of RDW-CV and RDW-SD. Further analysis among the subjects with elevated D-dimer level showed significant negative correlations were observed between D-dimer levels and anemia-related parameters, including hemoglobin, erythrocyte count, and hematocrit (all p<0.05). Elevated D-dimer was also associated with immune dysregulation, reflected by increased basophil percentages and decreased immunoglobulin (Ig) levels. Additionally, D-dimer levels showed significant positive correlations with aspartate aminotransferase (AST), alanine aminotransferase (ALT), and blood urea nitrogen (BUN), suggesting a link between hypercoagulability and kidney as well as renal dysfunction following burn injury.CONCLUSION: Leukocyte count, RDW-CV, and RDW-SD are higher in burn patient with elevated D-dimer levels, suggesting that high D-dimer might be correlated with VTE. Elevated D-dimer in burn patients correlates with several VTE risks including anemia, immune dysregulation, and hepatic–renal dysfunction, indicating early coagulation activation and systemic injury following burn injury. KEYWORDS: burn injury, D-dimer, hypercoagulability, VTE, anemia, immune dysregulation, organ dysregulation
Cleft Surgery at Ship Hospital in Remote Island: Reflections and Experiences Fakhriah Safirah; Mohammed Avicenna; Jeremy Nicolas Sibarani; Kezia Eveline; Alki Andana; Lobredia Zarasade; Agus Harianto
Asian Journal of Health Research Vol. 5 No. 1 (2026): Volume 5 No 1 (April) 2026
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v5i1.316

Abstract

Introduction: Cleft lip with or without cleft palate requires timely surgical management to optimize feeding, speech development, and facial growth. In archipelagic regions, geographic isolation and limited healthcare infrastructure may delay access to specialized cleft care. Hospital ship–based outreach programs have emerged as an alternative strategy to deliver surgical services to underserved island communities. This report presents a descriptive case series of cleft lip repairs performed during a hospital ship mission in remote islands of South Sulawesi, Indonesia. Case Presentation: Two patients with untreated cleft lip deformities were identified during surgical screening conducted as part of a hospital ship outreach mission. Both presented in adolescence or adulthood after prolonged delays in accessing definitive treatment. Cleft lip repair using a modified Millard rotation–advancement technique was performed under general anesthesia. Early postoperative outcomes were assessed based on surgical complications and scar evaluation. Postoperative follow-up was limited to 7 days. Conclusion: Hospital ship–based cleft lip repair may represent a feasible approach to delivering surgical care in remote island settings. However, evidence remains limited to early postoperative outcomes, and further studies with larger cohorts and standardized long-term follow-up are needed to evaluate functional and aesthetic results.
Co-Authors Agus Harianto Agus Santoso Budi, Agus Santoso Alki Andana Arif Tri Prasetyo Diah Mira Indramaya Fakhriah Safirah Ferry Sandra Hamiseno, Gifta Marshanda Qanitah Hariani, Lynda Hutagalung, Magda Rosalina I Nyoman Esha Pradnyana Indri Lakhsmi Putri, Indri Lakhsmi Iswinarno Doso Saputro Jeremy Nicolas Sibarani Kezia Eveline Kurniawan, Rifqi Lupitasari, Ciptomurti M Sjaifuddin Noer Mohammed Avicenna Muharram, Arif Rahmat N., Priscilla Valentine Nata’atmadja, Beta Subakti Ningrum, Laras Puspita Noer Halimatus Syakdiyah Nurrani Mustika Dewi, Nurrani Mustika Paramita, Anindya Putri, Nadia Tamara Revita Widya Prasanti Rifqi Kurniawan Sintaningrum, Elisabeth Prajanti Wulandari, Pratidina