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All Journal Jurnal Veteriner The Indonesian Biomedical Journal Jurnal Rekonstruksi dan Estetik Folia Medica Indonesiana
Zarasade, Lobredia
Department Of Plastic Reconstructive And Aesthetic Surgery, Faculty Of Medicine, Universitas Airlangga, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health Veterinary

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PALATE FRACTURE PROFILE IN PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY OF DR. SOETOMO GENERAL ACADEMIC HOSPITAL: JANUARY 2012- DECEMBER 2017 N., Priscilla Valentine; Budi, Agus Santoso; Zarasade, Lobredia
Jurnal Rekonstruksi dan Estetik Vol. 4 No. 1 (2019): Jurnal Rekonstruksi dan Estetik, June 2019
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (289.679 KB) | DOI: 10.20473/jre.v4i1.29216

Abstract

Highlights: The demographic data of patients with palate fractures is young adult men aged 19-30 years, the most common of palatal fracture type is parasagittal type, and causes of trauma being traffic accidents. The use of transmolar wiring and plating, occlusion was achieved well. Abstract: Introduction: Palatal fractures are often associated with  maxillofacial fractures and Le Fort fractures. The diagnosis and management of palatal fractures in the midface area is a challenge for a plastic surgeon in restoring function and aesthetics. With the results of this study, it is expected to be a database of maxillofacial fractures treated at SMF Reconstructive Plastic Surgery and Aesthetic Dr. Soetomo General Academic Hospital, Surabaya and gave the ability to make a fast and precise diagnosis for time and technical maxillofacial fractures. Methods: This study uses medical record data for all patients diagnosed with palatal fractures in Dr. Soetomo General Academic Hospital, Surabaya during January 2012 to December 2017. The variables studied were demographic data including sex, age, mechanism of occurrence of accidents, types of fractures, management, complications that occur and length of treatment. Discussion: There were 82 patients with palatal fractures, with traffic accidents being the most common cause of palate fracture (n=61) followed by workplace accidents and households in second place (12 and 9%). Most sufferers were men (68%), women (14%) with the highest age range of men aged 19-30 years who were followed by ages 31-45. The most were parasagittal fractures (56%), then Sagittal (15%), paraalveolar (9%), alveolar (1%), comminutive (1%). no fractures with anterior and posterolateral alveolar types, posterolateral type or transverse type  fractures. Hospitalization period with plating (12 days), transmolar wiring (10.6 days), and conservative (13.8 days). Conclusions: In this study assessed the experience in the reconstruction and aesthetic plastic surgery department of Dr. Soetomo General Academic Hospital regarding palatal fractures and accompanying demographic data. The type of fracture that occurs is also related to the management performed. Incomplete medical records caused problems in this study.
Elevated Serum Transaminase (SGOT/SGPT) and Sepsis in Burn Patients in a Tertiary Hospital, Surabaya, Indonesia Saputro, Iswinarno Doso; Zarasade, Lobredia; Kurniawan, Rifqi
Folia Medica Indonesiana Vol. 58, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: • There is no correlation between the increase of SGOT and sepsis. • Correlation between the increase of SGPT and sepsis was significant founded. Abstract: Burns trigger hypermetabolic stress reactions that cause inflammatory responses. When there is a sustained or increased hypermetabolic reaction, the inflammatory response can be life-threatening, such as sepsis, and significantly impact hepatic metabolic function. After burns, varying degrees of liver injury are usually associated with burn severity. This study determined the correlation between elevated serum transaminases (SGOT/ SGPT) and sepsis in burn patients at a tertiary hospital of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, from January 1, 2018, to December 31, 2020. This was a descriptive-analytic study with a retrospective cohort design. The data in this study included the demography of burn patients, causes of burns, inhalation trauma, burn severity, increased serum transaminase (SGOT/SGPT), mortality, and sepsis. This study found that the correlation between elevated serum transaminases (SGOT/SGPT) and sepsis was determined using the Spearman-Rho Rank statistical test. Burn patients with sepsis in the hospital were dominated by males (65.2%) and mostly aged 26-55 years (69.6%). The flame was found to be the highest cause of burns (80.4%), burn area above 20% (91.3%), the highest level of severity was major burn (91.3%), and no inhalation trauma (54.3%). In this study, there was an increase in SGOT of 69.6% and SGPT of 78.3%, with a mortality rate of 39.1%, with average inpatient days of 24 days. The correlation test between elevated serum transaminase (SGOT) and sepsis showed an insignificant relationship (p = 0.065, p> 0.05) with a correlation coefficient of 0.200. In contrast, the correlation between elevated serum transaminase (SGPT) and sepsis was significant (p=0.006, p<0.05) with a correlation coefficient of 0.296.
Elevated D-dimer is Associated with Anemia, Immune Dysregulation, and Hepatic–Renal Dysfunction in Acute Burn Patients Paramita, Anindya; Hariani, Lynda; Zarasade, Lobredia; Syakdiyah, Noer Halimatus; Dewi, Nurrani Mustika; Sandra, Ferry
The Indonesian Biomedical Journal Vol 18, No 1 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i1.3925

Abstract

BACKGROUND: Burn injury induced increased risk of venous thromboembolism (VTE) due to hypercoagulability, immobilization, and endothelial injury. Despite this risk, VTE in burn patients often remains clinically undetected. Although D-dimer is widely used as a VTE marker, its utility in burn patients is inconsistent, particularly in the early post-burn period. Therefore, this study was conducted to evaluate the correlation between D-dimer levels and factors related to VTE, including hematologic, coagulation, immunologic, organ function parameters, and burn characteristics.METHODS: An analytical observational study was conducted involving adult patients with acute burn injuries enrolled in Dr. Soetomo General Hospital from March to June 2025. Demographic, anthropometric, burn characteristic, and existing comorbid were documented from subjects’ medical records. Blood samples from subjects were collected immediately via venipuncture. D-dimer was analyzed with Enzyme-Linked Fluorescent Assay (ELFA) method, hematology and coagulation profiles were also assessed using hematology analyzer and automated coagulation system, respectively. Meanwhile, hepatic and renal function were analyzed with chemistry analyzers.RESULTS: Most burn subjects (18 of 20) demonstrated elevated D-dimer levels. Higher D-dimer levels were associated with increased leukocyte counts and upward trend of RDW-CV and RDW-SD. Further analysis among the subjects with elevated D-dimer level showed significant negative correlations were observed between D-dimer levels and anemia-related parameters, including hemoglobin, erythrocyte count, and hematocrit (all p<0.05). Elevated D-dimer was also associated with immune dysregulation, reflected by increased basophil percentages and decreased immunoglobulin (Ig) levels. Additionally, D-dimer levels showed significant positive correlations with aspartate aminotransferase (AST), alanine aminotransferase (ALT), and blood urea nitrogen (BUN), suggesting a link between hypercoagulability and kidney as well as renal dysfunction following burn injury.CONCLUSION: Leukocyte count, RDW-CV, and RDW-SD are higher in burn patient with elevated D-dimer levels, suggesting that high D-dimer might be correlated with VTE. Elevated D-dimer in burn patients correlates with several VTE risks including anemia, immune dysregulation, and hepatic–renal dysfunction, indicating early coagulation activation and systemic injury following burn injury. KEYWORDS: burn injury, D-dimer, hypercoagulability, VTE, anemia, immune dysregulation, organ dysregulation
Co-Authors Agus Santoso Budi, Agus Santoso Diah Mira Indramaya Ferry Sandra Hamiseno, Gifta Marshanda Qanitah Hariani, Lynda Hutagalung, Magda Rosalina I Nyoman Esha Pradnyana Indri Lakhsmi Putri, Indri Lakhsmi Iswinarno Doso Saputro Kurniawan, Rifqi Lupitasari, Ciptomurti M Sjaifuddin Noer Muharram, Arif Rahmat N., Priscilla Valentine Nata’atmadja, Beta Subakti Ningrum, Laras Puspita Noer Halimatus Syakdiyah Nurrani Mustika Dewi, Nurrani Mustika Paramita, Anindya Prasetyo, Arif Tri Putri, Nadia Tamara Revita Widya Prasanti Rifqi Kurniawan Sintaningrum, Elisabeth Prajanti Wulandari, Pratidina