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All Journal IDJP (Indonesian Journal of Pharmaceutics) FITOFARMAKA: Jurnal Ilmiah Farmasi Majalah Farmasetika Indonesia Natural Research Pharmaceutical Journal (INRPJ) FASKES : Jurnal Farmasi, Kesehatan, dan Sains Current Biomedicine Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Pengabdian Masyarakat Inovatif Jurnal Pengabdian Masyarakat Inovatif Jurnal Bioteknologi & Biosains Indonesia Helium: Journal of Science and Applied Chemistry
Mahyuni, Siti
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Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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THE POTENCY OF PSIDIUM GUAJAVA LEAVES AS A NATURAL DISINFECTANT AND ANTISEPTIC INGREDIENT Mahyuni, Siti; Komala, Oom; Wiendarlina, Ike Yulia; Fatah, Muhammad Fajar Saeful
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 1 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.9216

Abstract

Preventing the spread of nosocomial infection are generally carried out by disinfection process of the tools to be used with chemical disinfectant such as phenol, alcohol, chlorine, iodine or sublimate. Excessive use of chemicals can cause health problems. Guava leaves (Psidium guajava L.) have long been empirically used to treat diarrhea and acne. Scientific data shows that guava leaves have positive activity against several types of pathogenic bacteria due to its tannin content. Guava leaves have the potential to be developed as a disinfectant and antiseptic material. This study aims to determine the disinfection activity of guava leaves on surgical instruments using the total plate count method, skin irritation test using patch test method and quantify the tannin content in young and old guava leaves using spectrophotometry method. The results showed that the tannin content in old and young guava leaves was 68.73 ± 0.067 mg/g (6.873%) and young 61.87 ± 0.046 mg/g (6.187%). At concentrations of 10, 20, 30 and 40% guava leaf extract were able to reduce the total plate count in surgical instrument samples by 6.85; 37; 80.82; and 83.56%. The primary irritation index of 0.05 only occurs at a concentration of 40%, classified as non-irritant. It can be concluded that guava leaves have the potential to be further developed as a natural disinfectant or antiseptic.
Formulasi dan Uji Aktifitas Anti Jerawat Masker Gel Peel Off Ekstrak Daun Teh (Camelia sinensis L.) Dengan Variasi Polivinil Alkohol (PVA) Mahyuni, Siti; Sulistiyono, Fitria Dewi; Almashuri, Almashuri; Fandi Dealfif, Dio
Majalah Farmasetika Vol 10, No 6 (2025)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v10i6.66942

Abstract

Jerawat terjadi karena penyumbatan sebum pada folikel rambut disertai peradangan  akibat infeksi bakteri Propionibacterium acne pada lapisan pilosebaceous. Daun teh (Camelia sinensis L) diketahui mengandung senyawa katekin dan epigallokatekin yang memiliki sifat antibakteri. Ekstrak daun teh dapat dimanfaatkan sebagai sediaan anti jerawat dalam bentuk masker gel peel off. Masker gel harus memiliki formula optimal agar aplikasinya efektif. Tujuan penelitian ini adalah menentukan konsentrasi polivinil alkohol (PVA) terbaik untuk membuat formula masker gel peel off ekstrak daun teh dan menentukan aktivitas antibakteri Propionibacterium acne dari formula tersebut. Ekstraksi daun teh dilakukan dengan metode maserasi menggunakan pelarut etanol 70%. Hasil penelitian menunjukkan bahwa konsentrasi PVA terbaik dalam formulasi sediaan masker gel peel off ekstrak daun teh adalah 6.5%. Formulasi ini memiliki diameter zona hambat 17,41± 0.096 mm, terkategori sedang. Nilai ini mendekati nilai diameter zona hambat kontrol klindamisin 1% sebesar 17.63 ± 0.093 mm. Dari hasil penelitian dapat disimpulkan formula sediaan masker gel peel off ekstrak daun teh berpotensi dikembangkan lebih lanjut sebagai sediaan kosmetik antijerawat.  
The Effect of Ethanol Polarities on Tannin Content of Persea americana Mill Seeds Extract Using Gelatin Precipitation Method Wardatun, Sri; Mahyuni, Siti; Sri Mulyani, Jeni
Helium: Journal of Science and Applied Chemistry Vol. 4 No. 2 (2024): Helium: Journal of Science and Applied Chemistry
Publisher : Study Program of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/helium.v4i2.10

Abstract

Persea americana Mill (avocado) seed waste contains tannin compounds with several benefits and high economic value. Tannin is a natural compound widely used in various industries, including the pharmaceutical industry. The difference in concentration of ethanol causes polarity differences. This research aims to determine the effectiveness of tannin extraction from avocado seed using different concentration polarities of ethanol as a solvent. The dry powder of avocado seed was macerated in ethanol at concentrations of 30, 50, 70, and 96% for 72 hours, respectively. The gelatin precipitation method was applied to determine the tannin content in each extract; absorbance was read using a spectrophotometer UV-Vis, and the Folin Ciocalteu reagent was added to the avocado seed extract before spectrophotometer measurement. The results show that the polarity of ethanol has a significant effect (p<0.05) on the yield extract and tannin level in each extract. The extract yield and tannin content in avocado seed extracted with 30, 50,70 and 96% ethanol were 21.47%, 26.70%, 30.40%, and 47.67%, while the tannin content was 32.27 mg/g, 50.58 mg/g, 60.94 mg/g, and 85.30 mg/g respectively. The highest extract yield and tannin content are found in avocado seed extracted with 96% ethanol, which has lower polarity. It can be concluded that 96% ethanol is the best solvent to extract tannin from avocado seeds.
Co-Authors Almashuri, Almashuri Almasyhuri Almasyhuri Anna Pradiningsih Dewi, Elfrieda Kusuma Fandi Dealfif, Dio Fatah, Muhammad Fajar Saeful Fitria Dewi Sulistiyono Hermawati, Ema Ike Yulia Wiendarlina Novi Fajar Utami Nurul Fadilah, Nurul Oom Komala Putra Setiawan Rahminiwati, Min Rikkit Sausan, Alfy Salma Siti Maisaroh Sri Mulyani, Jeni Sri Wardatun Supardi, Arviani Rahmawati Tri Retno Handayani, Marybet Yulianita Zaldy Rusli