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All Journal Pharmaciana: Jurnal Kefarmasian JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang MEDICINUS
Yusuf, Helmy
Department Of Pharmaceutical Science, Faculty Of Pharmacy, Universitas Airlangga, Surabaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Formulations of liposomal vaccine containing AdhO36 antigen and β-glucan as immunoadjuvant Hidajah Rachmawati; Raditya Weka Nugraheni; Firasti Agung Nugrahening Sumadi; Helmy Yusuf
Pharmaciana Vol 11, No 3 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (725.329 KB) | DOI: 10.12928/pharmaciana.v11i3.19264

Abstract

Humans are the most crucial host of Salmonella Typhi as it has limited ability to reproduce outside the human body. Salmonella Typhi infections caused Typhoid fever which can be prevented with vaccines. This study aims to develop an effective typhoid fever oral vaccine using a liposomal delivery system.  Several studies showed that the immunization of AdhO36 protein from Salmonella Typhi orally provides significant protection in inhibiting the Salmonella Typhi to the mice intestine. β-Glucan is a potent immunostimulant for macrophages activations. Meanwhile, the method used to produce Liposome formulations was using thin-film hydration. The liposomal products had good characteristics based on their particle size. The particle size results met the requirement for optimum intestinal absorption 399.220+28.095 nm Liposome+AdhO36 and 383.360+8.594 nm Liposome+β-glucan. Based on the zeta potential measurement, the electrical charges of the three formulations were positive, meaning that the liposome is cationic because of the DDAB (Dimethyl Dioctadecyl Ammonium Bromide) component. The positive charge will facilitate the internalization of antigen to the immunity cells.
Aphrodisiac Activity of Ethanolic Extracts from the Fruits of Three Pepper Plants from Piperaceae Family Idha Kusumawati; Syailendra Mahatmaputra; Rohman Hadi; Rohmania Rohmania; Subhan Rullyansyah; Helmy Yusuf; Abdul Rahman
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 8 No. 2 (2021): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v8i22021.194-199

Abstract

Background: Pepper plants belong to the Piperaceae family with many pharmacological activities. The fruits of these plants have been widely used traditionally for various therapies, one of which is an aphrodisiac. Objective: The purpose of this study was to determine the aphrodisiac activity of the fruits of three pepper plants, Piper nigrum, Piper retrofractum, and Piper cubeba to prove their traditional use. Methods: The level of piperin, the active compound of plants from the family Piperaceae, was also determined in the ethanolic extract of those three fruits of the pepper plant. The aphrodisiac activity was determined by counting the number of introducing and mounting mice. The acute toxicity test of the extract was carried out according to the OECD-423 guidelines. Results: The ethanolic extract of Piper nigrum fruits had the highest piperin concentration, while the ethanolic extract of Piper retrofractum fruits had the highest aphrodisiac activity, according to the findings. During the entire duration of the acute toxicity study, no signs of toxicity or mortality were discovered.Conclusion: This study proves that all fruits of three species of pepper plants exhibit aphrodisiac activity. Furthermore, this study also shows that not only piperin is responsible for the aphrodisiac effect.
Pengaruh Desain Punch Terhadap Mutu Fisik dan Disolusi Tablet MUPS Metformin HCl Wanda B. Putri; Friesca S. Nurhaidah; Helmy Yusuf; Maria L.A.D. Lestari
MEDICINUS Vol. 36 No. 3 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/af7svb90

Abstract

The compaction of multi-unit pellet system (MUPS) into tablets is a potential alternative for sustained release drugs. Tableting tools (punch and die) affect the compaction process and quality of MUPS tablets. The punch design intends to preserve the desired drug release of compacted pellets. This study aims to investigate the effect of two punch shapes, the flat face radius edge (FFRE) and concave-faced punch (concave), each at two different cup depths, on the physical properties and release profile of metformin HCl MUPS tablets. Drug release parameters, t50 values, showed that the metformin HCl released from MUPS tablets was faster than the uncompacted sustained release pellets. The similarity of the dissolution profile (f2) between MUPS tablets and uncompacted metformin HCl pellets was lower than 50 as the minimum acceptance value. The tablet tensile strength obtained was below the requirements (<1.7 MPa). Tablet disintegration time was approximately less than 2 minutes. In conclusion, drug release profile of the MUPS tablets showed damage of the pellets due to compaction process. Nevertheless, pellets compacted at low compaction pressure using FFRE with a deeper cup depth (size 0.80 mm) showed a slightly better protection compared to other punch shapes and cup depth sizes applied.
Drug and cosmetic safety training for cadres of family welfare program Tristiana Erawati; Dewi Melani Hariyadi; Noorma Rosita; Widji Soeratri; Tutiek Purwanti; Hadi Poerwono; Marcellino Rudyanto; Helmy Yusuf; Djoko Agus Purwanto; I Nyoman Wijaya
Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Vol. 9 No. 2 (2024): May 2024
Publisher : University of Merdeka Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26905/abdimas.v9i2.11161

Abstract

In order to increase public understanding and awareness regarding the safety use of drugs and cosmetics, the Community Service Team of the Faculty of Pharmacy, Airlangga University has held community service in Jonggrangan Village, Klaten, Central Java. The community service was carried out on July 31, 2023, with approximately 60 family welfare programs or PKK cadres and health cadres participating through training, presentations, and discussions. The activity began with a pre-test, continued with training, a presentation of the material by three experts, and a discussion, then ended with giving a post-test to the participants. The results of the pre and post-test analysis showed that participants' understanding increased. The results of the analysis of the answers to the 15 questions given showed that the increase in participants' understanding ranged from  2.13-46.02 percent. The impact of these activities on society. The increase in participants' understanding of each topic is not the same depending on the initial understanding. However, the problem is that the level of public understanding after receiving training is still below 50 percent namely on topics about the stages of using cosmetic products and about drug classification. So it is necessary to deepen the material using other strategies (appropriate methods and media).
PENDIDIKAN KOGNITIF DAN AFEKTIF DAGUSIBU UNTUK PENCEGAHAN RESISTENSI ANTIBIOTIK DI SMA SURABAYA Abhimata Paramanandana; Dini Retnowati; Andang Miatmoko; Dewi Isadiartuti; Sugiyartono1; Mohammad Agus Sjamsur Rijal; Dwi Setiawan; Esti Hendradi; Tutiek Purwanti; Noorma Rosita; Dewi Melani Hariyadi; Tristiana Erawati; Ardhani Dwi Lestari1; Helmy Yusuf; Retno Sari
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 1 (2019): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (620.49 KB) | DOI: 10.32734/abdimastalenta.v4i1.2395

Abstract

Antibiotics are not only used for humans, but also often used for cattle and livestock which are then been consumed by humans. This over prescribed and missed used of antibiotic is a major factor in antibiotic resistance. Antibiotic resistance is a condition where bacteria are unable to be treated with antibiotics. In fact, the use of antibiotics is the first response in curing infectious diseases (by bacteria) and preventing infectious diseases spreading. With antibiotic resistance, preventing infectious diseases by bacteria became harder. This community service activity came up with a slogan "Antibiotic Resistence Awareness Movement" was carried out in Surabaya 10 Public High Schools and Surabaya 17 Public High Schools with 60 students per school using several methods, namely: (a) giving lecture material using LCD projectors ) the implementation of poster making competitions, and (c) poster presentations that have been made that are accompanied by question and answer, and (d) evaluation activities in the form of written tests covering pre-test and post-test. Concerning the results of posters results, poster presentations and improving the results of this posttest can be concluded as a result of an increase in understanding and or knowledge of students of SMA 10 and SMA 17 Surabaya
Co-Authors Abdul Rahman Abhimata Paramanandana Alya Nur Amilia Andang Miatmoko Ardhani Dwi Lestari1 Dewi Isadiartuti Dewi Melani Hariyadi Dini Retnowati Djoko Agus Purwanto Dwi Setiawan Esti Hendradi Firasti Agung Nugrahening Sumadi Friesca S. Nurhaidah Hadi Poerwono Hidajah Rachmawati I Nyoman Wijaya Idha Kusumawati Marcellino Rudyanto Maria L.A.D. Lestari Mohammad Agus Sjamsur Rijal Noorma Rosita Raditya Weka Nugraheni Retno Sari Rohman Hadi Rohmania Rohmania Subhan Rullyansyah Sugiyartono1 Syailendra Mahatmaputra Tristiana Erawati Tristiana Erawati Tutiek Purwanti Wanda B. Putri Widji Soeratri