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Kualitas hidup pasien osteoarthritis di Rumah Sakit Royal Prima Knelissen, Aldy Nicbrian; Yani, Herlina; Samin, Buter; Suwarmo, Suwarmo; Rajagukguk, Horas; Lubis, Elvi Sahara; Wilsen, Wilsen
Buletin Kedokteran & Kesehatan Prima Vol. 2 No. 1 (2023): Maret
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v2i1.3378

Osteoarthritis dapat menyebabkan nyeri dan disabilitas yang mengakibatkan keterbatasan dalam aktivitas sehari-hari dan keterbatasan interaksi sosial. Kualitas hidup saat ini merupakan sebuah konsep penting yang dijadikan sebagai salah satu kriteria untuk mengevaluasi intervensi pelayanan kesehatan. Tujuan dari penelitian ini untuk mengetahui hubungan status kesehatan berdasarkan WOMAC dengan kualitas hidup berdasarkan SF-36 questionnaire pada pasien osteoarthritis di Rumah Sakit Royal Prima. Studi ini merupakan penelitian kuantitatif dengan design cross sectional yang melibatkan sampel sebanyak 20 pasien osteoarthritis. Pengambilan sampel dengan consecutive sampling. Pengumpulan data menggunakan kuesioner Western Ontario and McMaster Universities Arthritis Index (WOMAC) dan kuesioner Short Form-36 (SF-36). Analisis data menggunakan uji Chi Square. Hasil uji menunjukkan hubungan signifikan antara status kesehatan dengan kualitas hidup pasien osteoarthritis (0,001).

Mikroenkapsulasi atenolol dengan penyalut hidroksipropil metilselulosa (HPMC) menggunakan metode emulsifikasi penguapan pelarut Neswita, Elfia; Razoki, Razoki; Tanjung, Fahrul Azmi; Novita, Cut Elvira; Sinaga, Ade Putra Fratama; Samin, Buter
Jurnal Prima Medika Sains Vol. 4 No. 1 (2022): Juni
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v4i1.2261

Tujuan utama dari penelitian ini adalah memformulasi mikroenkapsulasi atenolol dengan penyalut HPMC menggunakan metode emulsifikasi penguapan pelarut. Dalan metode ini, HPMC dilarutkan dalam pelarut campuran methanol-diklorometana. Sedangkan atenolol dilarutkan ke dalam larutan HPMC. Dalam gelas lain dimasukkan paraffin cair. Hasil penelitian menunjukkan rasio atenolol dan HPMC adalah 1:0,5; 1:1; dan 1:1,5 berturut-turut untuk masing-masing Formula (Formula I, II, III dan IV). Mikroenkapsulasi yang dihasilkan dievaluasi berdasarkan distribusi ukuran partikel dan senyawa aktif yang dilepaskan. Mikrokapsul memiliki distribusi ukuran partikel antara 212-2000 µm. Spektrofotmeter UV dalam metanol yang digunakan untuk mengukur konsentrasi senyawa aktif diperoleh 56,963 ± 17,589; 60,41 ± 1,0045; 60 dan 173 ± 1,0160 % untuk masing-masing Formula (Formula I, II, dan III). Dapat disimpulkan bahwa mikrokapsul dengan perbandingan atenolol dan HPMC 1:1,5 memiliki pelepasan zat aktif yang lebih baik. Kinetika atenolol yang dilepaskan dari mikrokapsul mengikuti persamaan Higuchi.

The Effect of Giving Aloe Vera Gel on Collagen Growth in Wistar Rats (Rattus Norvegicus) with Exposure to Ultra Violet-B Light Fitria , Inola; Djamin, Djamin; Samin, Buter
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 4 (2023): November 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i4.310

Exposure to UV rays can cause photochemical damage to the DNA of cells in the body, triggering cancer formation, especially skin cancer in humans. The skin may lose elasticity. Research is needed to ensure that currently, we are still looking for plants or foods that contain collagen, which can prevent wrinkles. This research is an original experiment carried out in a laboratory. Two types of variables play a role in this research: independent variables and dependent variables. In this experiment, aloe vera gel was used as an independent variable as a substitute for UVB light exposure. Collagen development, measured in mouse skin, is the dependent variable here. This study found that the standard control group had no collagen growth and was stable. This was because the typical control treatment was not exposed to UVB rays; hence, collagen formation was stable. The group administered 15% aloe vera extract gel had a more substantial effect on rat skin tissue collagen development after UVB light exposure than the 5% and 10% groups. This is because a higher dose of aloe vera extract includes more chemical components that promote mouse skin collagen formation.

Kualitas hidup pasien osteoarthritis di Rumah Sakit Royal Prima Knelissen, Aldy Nicbrian; Yani, Herlina; Samin, Buter; Suwarmo, Suwarmo; Rajagukguk, Horas; Lubis, Elvi Sahara; Wilsen, Wilsen
Buletin Kedokteran & Kesehatan Prima Vol. 2 No. 1 (2023): Maret
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v2i1.3378

Osteoarthritis dapat menyebabkan nyeri dan disabilitas yang mengakibatkan keterbatasan dalam aktivitas sehari-hari dan keterbatasan interaksi sosial. Kualitas hidup saat ini merupakan sebuah konsep penting yang dijadikan sebagai salah satu kriteria untuk mengevaluasi intervensi pelayanan kesehatan. Tujuan dari penelitian ini untuk mengetahui hubungan status kesehatan berdasarkan WOMAC dengan kualitas hidup berdasarkan SF-36 questionnaire pada pasien osteoarthritis di Rumah Sakit Royal Prima. Studi ini merupakan penelitian kuantitatif dengan design cross sectional yang melibatkan sampel sebanyak 20 pasien osteoarthritis. Pengambilan sampel dengan consecutive sampling. Pengumpulan data menggunakan kuesioner Western Ontario and McMaster Universities Arthritis Index (WOMAC) dan kuesioner Short Form-36 (SF-36). Analisis data menggunakan uji Chi Square. Hasil uji menunjukkan hubungan signifikan antara status kesehatan dengan kualitas hidup pasien osteoarthritis (0,001).

The Effect Of Topical Robusta Coffee Extract (Coffea Robusta) In Accelerating The Healing Process Of Cuts In The Backs Of White Wistar Rats (Rattus Norvegicus) Aditya Wardhana; Xavier Ongko, Nicolas; Samin, Buter; Diana Putri, Lenni
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

The purpose of this study was to test the research hypothesis, namely whether topical administration of coffee extract affects the acceleration of the healing process of cuts on the backs of rats. Based on the results of the research that has been done, it can be concluded that the administration of the Robusta coffee extract (Coffea Robusta) can accelerate the healing of cuts in white Wistar rats, which is characterized by an average difference in the percentage of the recovery. However, after the T-test, the results obtained for H0 were rejected, meaning there was no significant difference between the control group, which was only given 0.9% NaCl and the treatment group, which was given Robusta coffee extract. Topical can accelerate wound healing. The results of this study are expected to be suggestions and references for other researchers who wish to study the use of Robusta coffee extract in understanding the healing process of cuts.

The impact of using Binahong (Anredera Cardifolia) leaf extract on male wistar white rats fed a high-fat diet's liver function and liver histopathology Kusumawardhany, Fitria Marizka; Hanjaya, Hanjaya; Samin, Buter
Science Midwifery Vol 12 No 2 (2024): June: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v12i2.1528

Worldwide, Nonalcoholic Fatty Liver Disease (NAFLD) is the leading cause of chronic liver disease. Nutritional excess causes adipose depot enlargement and ectopic fat buildup, causing NAFLD. The Binahong plant (Anredera cordifolia) contains saponins, alkaloids, polyphenols, flavonoids, and mono polysaccharides like L-arabinose, D-galactose, L-rhamnose, and D-glucose, which have been shown to help NAFLD. The study examined the liver function and histopathology of male white Wistar rats fed high-fat diets after Binahong leaf extract was administered. Research approach/sample/population: Quantitative research employing lab or experiment formats. We sampled 24 white Wistar rats (Rattus norvegicus). A high-fat diet was the precondition, Binahong leaf extract was the independent variable, and liver function and histological characteristics improved. The research approach begins with test animal acclimation, Binahong leaf extract extraction, phytochemical screening, treatment protocols, examination, and Histopathology preparations. Research data was processed with SPSS. The normality test shows a 2-tailed significance of 0.678 > 0.05, indicating regularly distributed data. SGOT 0.10 and SGPT 0.20 liver function analyses demonstrated homogeneity p values > 0.05. The research found that Binahong leaf extract (Anrederacordifolia Ten. Steenis) has 400mg/BW antioxidants and can restore liver function in high-fat livers.

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