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All Journal Jurnal Prima Medika Sains Buletin Kedokteran dan Kesehatan Prima
Tanjung, Fahrul Azmi
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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Mikroenkapsulasi atenolol dengan penyalut hidroksipropil metilselulosa (HPMC) menggunakan metode emulsifikasi penguapan pelarut Neswita, Elfia; Razoki, Razoki; Tanjung, Fahrul Azmi; Novita, Cut Elvira; Sinaga, Ade Putra Fratama; Samin, Buter
Jurnal Prima Medika Sains Vol. 4 No. 1 (2022): Juni
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v4i1.2261

Abstract

Tujuan utama dari penelitian ini adalah memformulasi mikroenkapsulasi atenolol dengan penyalut HPMC menggunakan metode emulsifikasi penguapan pelarut. Dalan metode ini, HPMC dilarutkan dalam pelarut campuran methanol-diklorometana. Sedangkan atenolol dilarutkan ke dalam larutan HPMC. Dalam gelas lain dimasukkan paraffin cair. Hasil penelitian menunjukkan rasio atenolol dan HPMC adalah 1:0,5; 1:1; dan 1:1,5 berturut-turut untuk masing-masing Formula (Formula I, II, III dan IV). Mikroenkapsulasi yang dihasilkan dievaluasi berdasarkan distribusi ukuran partikel dan senyawa aktif yang dilepaskan. Mikrokapsul memiliki distribusi ukuran partikel antara 212-2000 µm. Spektrofotmeter UV dalam metanol yang digunakan untuk mengukur konsentrasi senyawa aktif diperoleh 56,963 ± 17,589; 60,41 ± 1,0045; 60 dan 173 ± 1,0160 % untuk masing-masing Formula (Formula I, II, dan III). Dapat disimpulkan bahwa mikrokapsul dengan perbandingan atenolol dan HPMC 1:1,5 memiliki pelepasan zat aktif yang lebih baik. Kinetika atenolol yang dilepaskan dari mikrokapsul mengikuti persamaan Higuchi.
Factors influencing the occurrence of neck pain complaints in garment convection tailors Siregar, Damayanti; Handoko, Ellya Keriahen; Setiawan, Deni; Sembiring, Sindy Boru; Yumardika, Deza; Renaldi, Muhammad Rizal; Pane, Herlin Novita; Tanjung, Fahrul Azmi; Siahaan, Nelly Christina; Mylano, Tri Adi; Nur, Putri Amriany
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.7445

Abstract

This study aimed to identify the factors influencing neck pain complaints among garment convection tailors in Medan City. A total of 44 tailors from a convection workshop on Jl. Denai were included as the study's population and sample, utilizing a total sampling technique. The research employed a cross-sectional analytical survey design with data analysis using the Chi-Square test. The findings from the bivariate analysis showed a significant association between neck pain complaints and three key factors: years of service (p=0.021), work duration (p=0.044), and work posture (p=0.000). Specifically, a higher percentage of severe neck pain was found in workers with fewer years of service and longer work durations (more than 8 hours a day). The analysis also revealed that age (p=0.717) and lighting (p=0.062) were not statistically significant factors. A subsequent multivariate analysis identified work posture and work duration as independent factors influencing neck pain, with work posture being the most dominant variable (p=0.000). The multivariate analysis for work posture had an odds ratio of 64.346, indicating a strong positive correlation with severe neck pain. However, a contradictory result for work duration in the multivariate analysis suggested a need for re-examination of its coding. The study concludes that workload, work duration, and working posture are the primary factors influencing neck pain complaints in convection tailors, with work posture being the most dominant. These findings highlight the importance of ergonomic interventions, proper posture, and regulated work hours to mitigate occupational health risks in this population.
Factors influencing the occurrence of neck pain complaints in garment convection tailors Siregar, Damayanti; Handoko, Ellya Keriahen; Setiawan, Deni; Sembiring, Sindy Boru; Yumardika, Deza; Renaldi, Muhammad Rizal; Pane, Herlin Novita; Tanjung, Fahrul Azmi; Siahaan, Nelly Christina; Mylano, Tri Adi; Nur, Putri Amriany
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.7445

Abstract

This study aimed to identify the factors influencing neck pain complaints among garment convection tailors in Medan City. A total of 44 tailors from a convection workshop on Jl. Denai were included as the study's population and sample, utilizing a total sampling technique. The research employed a cross-sectional analytical survey design with data analysis using the Chi-Square test. The findings from the bivariate analysis showed a significant association between neck pain complaints and three key factors: years of service (p=0.021), work duration (p=0.044), and work posture (p=0.000). Specifically, a higher percentage of severe neck pain was found in workers with fewer years of service and longer work durations (more than 8 hours a day). The analysis also revealed that age (p=0.717) and lighting (p=0.062) were not statistically significant factors. A subsequent multivariate analysis identified work posture and work duration as independent factors influencing neck pain, with work posture being the most dominant variable (p=0.000). The multivariate analysis for work posture had an odds ratio of 64.346, indicating a strong positive correlation with severe neck pain. However, a contradictory result for work duration in the multivariate analysis suggested a need for re-examination of its coding. The study concludes that workload, work duration, and working posture are the primary factors influencing neck pain complaints in convection tailors, with work posture being the most dominant. These findings highlight the importance of ergonomic interventions, proper posture, and regulated work hours to mitigate occupational health risks in this population.
Co-Authors DENI SETIAWAN Handoko, Ellya Keriahen Mylano, Tri Adi Neswita, Elfia Novita, Cut Elvira Nur, Putri Amriany Pane, Herlin Novita Razoki, Razoki Renaldi, Muhammad Rizal Samin, Buter Sembiring, Sindy Boru Siahaan, Nelly Christina Sinaga, Ade Putra Fratama Siregar, Damayanti Yumardika, Deza