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Analisis Ketahanan Hidup Pasien Kanker Paru di RSUD Dr. Saiful Anwar Pratiwi, Suryanti Dwi; Setyawan, Ungky Agus; Falyani, Silvy Amalia; Permatasari, Adinda Pramitra; Santosa, Andrew; Febriawati, Juwita; Prasetyo, Kevin Wahyudy; Yokanan
Jurnal Klinik dan Riset Kesehatan Vol 3 No 3 (2024): Edisi Juni
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.03.3.2

Pendahuluan: Kanker paru insidennya sebesar 14% dari semua kanker, dan merupakan penyebab utama kematian akibat keganasan di seluruh dunia. Berbagai studi menunjukkan perbedaan terkait angka ketahanan hidup, serta berbagai faktor yang signifikan terkait dengan angka ketahanan hidup tersebut pada pasien kanker paru. Tujuan: Penelitian ini bertujuan untuk mengetahui profil dan angka tahan hidup (ATH) pasien kanker paru yang mendapatkan kemoterapi di RSUD dr. Saiful Anwar pada tahun 2018-2020. Metode: Studi kohort retrospektif dengan menggunakan data rekam medik pasien terdiagnosis kanker paru pada tahun 2018 – 2020 yang mendapatkan kemoterapi. Analisis data dilakukan menggunakan uji log rank Mantel Cox, serta ketahanan hidup pasien berupa progression free survival (PFS) dan overall survival (OS) ditampilkan dengan kurva Kaplan Meier. Hasil: Pasien kanker paru terbanyak berjenis kelamin laki-laki (73,2%). Adenokarsinoma merupakan jenis sel kanker paru terbanyak (59,8%) dengan mutasi EGFR wild type 20,6%. Karboplatin–Paklitaksel merupakan jenis kemoterapi yang paling sering digunakan (54,6%). Analisis ATH menunjukkan terdapat hubungan signifikan antara usia dengan PFS dan OS (p < 0,05). Kesimpulan: Berbagai faktor seperti jenis kelamin, jenis sel kanker, mutasi EGFR, dan jenis kemoterapi diketahui tidak berkaitan signifikan dengan ATH pasien kanker paru. Hubungan signifikan antara usia dengan ATH menunjukkan potensi faktor usia sebagai prediktor ketahanan hidup pasien kanker paru.

Risk Analysis of Obstructive Sleep Apnea and Mental Disorders with Self-Reporting Questionnaire (SRQ-20) in Hospitalized COVID-19 Patients Falyani, Silvy Amalia; Pratiwi, Suryanti Dwi; Sugiri, Yani Jane Rosihaningsih; Djajalaksana, Susanthy; Listyoko, Aditya Sri
Malang Respiratory Journal Vol. 7 No. 2 (2025): Volume 7 No 2, September 2025 Edition
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2025.007.02.07

Introduction: Obstructive Sleep Apnea (OSA) is closely related to diseases such as hypertension, diabetes, cardiovascular disease, and obesity. Evaluation of sleep disorders and mental health in COVID-19 patients who are hospitalized has not been widely studied. The purpose of this study was to analyze the risk of OSA with STOP-Bang and mental disorders with the Self-Reporting Questionnaire (SRQ-20) in hospitalized COVID-19 patients at RSUD dr. Saiful Anwar Malang. Case: Thirty five respondents with confirmed mild and moderate COVID-19 criteria randomly selected and agreed to give informed consent were given the STOP-Bang and SRQ-20 questionnaires, then the score was associated with the oxygenation ratio through blood gas levels. The research was conducted by cross sectional and statistical test using Chi Square and Mann Whitney test with p<0.05. Thirty five respondents were divided into two groups, 17 people (48%) with mild criteria and 18 people (52%) with severe criteria. The severity of COVID-19 had low effect on the risk of OSA (p=0.581) and mental disorders (p=0.191). The risk of mental disorders through SRQ-20 scoring had low effect on the severity of COVID-19 (p=0.229) and on the oxygenation ratio (p=0.068). Conclusion: The severity of COVID-19 and oxygenation ratio had low effect to the risk of OSA and mental disorders through the STOP-Bang and SRQ-20 scores in hospitalized COVID-19 patients at dr. Saiful Anwar Malang.

Analisis Ketahanan Hidup Pasien Kanker Paru di RSUD Dr. Saiful Anwar Pratiwi, Suryanti Dwi; Setyawan, Ungky Agus; Falyani, Silvy Amalia; Permatasari, Adinda Pramitra; Santosa, Andrew; Febriawati, Juwita; Prasetyo, Kevin Wahyudy; Yokanan
Jurnal Klinik dan Riset Kesehatan Vol 3 No 3 (2024): Edisi Juni
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.03.3.2

Background: Comprising 14% of all cancer, lung cancer is the main cause of cancer-related mortality worldwide. Previous studies showed various findings regarding the survival rate of lung cancer, and factors significantly correlated with survival rate in lung cancer patients. Aim: This research aims to identify the profile and survival rate of lung cancer patients receiving chemotherapy in Saiful Anwar General Hospital from 2018 to 2020. Methods: This cohort retrospective study used medical records of patients diagnosed with lung cancer who underwent chemotherapy from 2018 to 2020. Data analysis was done using the Mantel Cox log rank test. Survival data shown as progression free survival (PFS) and overall survival (OS) were shown using Kaplan-Meier curves. Results: Subjects were largely male (73,2%). Adenocarcinoma is the most often type of lung cancer found (59,8%) with wild type EGFR mutation being the most prevalent (20,6%). Carboplatin – Paclitaxel is the most widely used chemotherapy regimen (54,6%). Survival analysis showed a significant correlation between age, OS, and PFS (p < 0,05) Conclusion: Various factors such as gender, cancer cell type, EGFR mutation, and chemotherapy regimen were not found to be related to survival rate in lung cancer patients. A significant correlation between age and survival rate showed potential in utilizing age as a predictor of survival rate in lung cancer patients.

D-Dimer and Brixia Score to Mortality in COVID-19 Patients Falyani, Silvy Amalia; Pratiwi, Suryanti Dwi; Setyawan, Ungky Agus; Erawati, Dini Rachma; Djajalaksana, Susanthy; Listyoko, Aditya Sri
Jurnal Respirasi Vol. 10 No. 2 (2024): May 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.2.2024.99-106

Introduction: Coronavirus disease 2019 (COVID-19) is a highly contagious severe and acute respiratory syndrome caused by the SARS-CoV-2 virus. A variety of factors can increase a patient's risk of death, including coagulopathy characterized by increased D-dimer levels. Brixia scores could be one of the determinants of COVID-19 severity, as assessed by chest radiographs. This study aimed to analyze chest radiographic severity based on the Brixia score at the degree of coagulation based on D-dimer in mortality of COVID-19 patients who were hospitalized. Methods: This cohort retrospective study was conducted at Dr. Saiful Anwar General Hospital, Malang, using an observational cross-sectional design. The study included 300 medical records of COVID-19 patients who passed away while hospitalized. The data were analyzed using the Wilcoxon test, and the results were also tested for Spearman correlation to determine the relationship between variables. Results: Significance results of median D-dimer were found by age and severity of COVID-19 (p-values 0.015 and 0.002), and median Brixia scores by age, gender, severity of COVID-19, and length of treatment (p-values 0.001, 0.001, 0.001, and 0.005). The results were also compared with normal values, which were significant (p = 0.000). Spearman correlation test results between the final D-dimer and the initial Brixia score (p = 0.005). Conclusion: The research results display a retrospective study of the correlation between D-dimer and Brixia score values "‹"‹and outcomes in COVID-19 patients. Higher D-dimer values"‹ "‹and Brixia scores on admission were shown to be associated with mortality.

Primary Pre-Extensively Drug-Resistant (Pre-XDR) Tuberculosis with Meningoencephalitis in Nineteen Years Old Young Woman : A Case Report Sugiri, Yani Jane Rosihaningsih; Tantular, Rezki; Falyani, Silvy Amalia; Maulana, Uray Riki Arif
Malang Respiratory Journal Vol. 6 No. 2 (2024): September 2024
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2024.006.02.02

Introduction. Mycobacterium tuberculosis (MTB) is continually evolving in order to resist treatment. This has resulted in drug-resistant tuberculosis, which has a greater rate of therapy failure and mortality, as well as the necessity for other ways of disease transmission prevention. Pre-extensively drug-resistant tuberculosis (Pre-XDR TB) is caused by MTB strains that are resistant to isoniazid, rifampicin, and any fluoroquinolone medicines. Case Report. A 19-year-old HIV-negative immunocompetent female presented to our emergency department with dyspnea and severe headache. She also complained of a cough, a low-grade temperature, and weight loss. She has no relevant medical history and has never been exposed to tuberculosis. A chest X-ray revealed infiltrates with cavities and fibrosis in both lungs, while a brain CT suggested meningoencephalitis. We performed a sputum drug sensitivity test and discovered that this patient was resistant to rifampin, isoniazid, levofloxacin, and moxifloxacin. She was later diagnosed with Pre-XDR TB and was given a tailored lengthier regimen that included Bedaquiline, Cycloserin, Linezolide, Clofazimine, and Etambutol. Her symptoms improved significantly as a result of this program. Discussion. Primary pre-XDR TB in an immunocompetent patient is uncommon, and our case is even more unusual due to meningoencephalitis involvement. The treatment of pre-XDR TB requires a personalized regimen that is tailored to the patient's clinical status and comorbidities. The possibility of transmission via a positive contact was raised in this patient, prompting us to conduct a more thorough contact inquiry to prevent future spread. Conclusion. In our region, there is a risk of'silent' drug resistant tuberculosis. Early detection and treatment of such patients are critical to preventing uncontrollable pan-resistant TB. Successful management with cautious contact investigation will minimize the mortality rate and spread rate of drug-resistant TB. Keywords. Drug-Resistant Lung Tuberculosis, Drug-Resistant Meningoencephalitis Tuberculosis

Rosella Flower Decreases the CML Serum and Liver Inflammation of Rats Given Baked-Food Diet Falyani, Silvy Amalia; Soeharto, Setyawati; Widjajanto, Edi; Ratna, Ardhiyanti Puspita; Batmomolin, Pia Bataif
The Journal of Experimental Life Science Vol. 6 No. 2 (2016)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jels.2016.006.02.03

Advanced Glycation Endproducts (AGEs) or so-called glycotoxin can be triggered by heated food in which the Maillard reaction occurs. One type of glycotoxins is CML. Accumulated N-Carboxymethyl-Lysine (CML) can cause inflammation of organs, e.g. liver. Rosella flowers contain anthocyanin compound that has anti-glycation and antioxidant effects. This study aimed to determine the effect of ethanol extract of Rosella on CML serum level, IL-6 level, and NF-ƙB activation in the liver of mice fed with baked food. This study used post-test design using 25 Wistar rats aged 3-4 months old that were divided into 5 groups, namely negative control group, positive control group, treatment groups given Rosella extract dose of 200mg.kgBW-1, 300mg.kgBW-1, and 400mg.kgBW-1. Baked feed was given for 12 weeks, and Rosella ethanol extract was administered in the 9th to 12th week. The examination on CML serum and IL-6 of the liver was using ELISA method. Immunofluorescent staining was used to determine NF-ƙB activation in the liver using a confocal microscope. CML serum is proven to increase significantly (p = 0.000). The effective dose of Rosella flower extract to prevent CML Serum increase is 200 mg.kgBW-1, whereas a dose of 400 mg.kgBW-1 can decrease IL-6 level and NF-ƙB activation. Ethanol extract of Rosella flower decrease the levels of N-carboxymethyl-lysine serum, IL-6, and NF-ƙB activation in the liver of rats given baked-food diet. Keywords: Advanced Glycation Endproducts (AGEs), Interleukin-6, N-Carboxymethyl-lysine, Rosella.

Rosella Flower Extract Prevent Increasing of Interleukin-6 and Amyloid-β Levels in Brain Tissue of Heated Diet-Treated Rats Ratna, Ardhiyanti Puspita; Soeharto, Setyawati; widjajanto, Edi; Falyani, Silvy Amalia; Batmomolin, Pia Bataif
The Journal of Experimental Life Science Vol. 8 No. 2 (2018)
Publisher : Graduate School, Universitas Brawijaya

Heated food is a source of formation of various types of Advanced Glycation Endproducts (AGEs). One of which is N-carboxymethyl-lysine (CML) that is often used as a sign of the formation of AGEs in the diet. The accumulation of AGEs in the brain can trigger neurodegenerative conditions. It also accelerates the accumulation of Amyloid β and proinflammatory cytokines which exacerbate neurodegeneration. Hibiscus sabdariffa L or rosella known to have antiglycation, antioxidant, and anti-inflammatory effects. This study aims to prove the effect of food heating to the increasing levels of CML serum and evaluate the effects of daily intake of Rosella extract IL-6 levels and Amyloid β in the Wistar rats' brain given a diet high of AGEs. This experimental study with post test only control group design was conducted using 25 white male rats Wistar strain (Rattus novergicus) which were divided into 5 groups namely positive control, negative control, the treatment group with rosella dose 200mg.kgBW-1, 300mg.kgBW-1, and 400mg.kgBW-1. The high diets of AGEs are given for 12 weeks, and it was added to the rosella extract with various doses on the 9th to 12th weeks. The examination of CML serum level, interleukin 6 brain level, and Amyloid β of the brain was carried by ELISA. This study found differences between CML serum level of rats which fed a standard diet and the one that was given a heated diet (p= 0.0001). It also found that rosella flower extract can prevent the increasing levels of interleukin 6 and Amyloid β in the brain tissue of rats which were given a heated diet, and both effective doses were on 200mg.kgBW-1. Keywords: Advanced Glycation End products, Amyloid β, Interleukin 6, N-carboxymethyl-lysine, Rosella.

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