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All Journal The Journal of Experimental Life Sciences (JELS) Heart Science Journal
Chomsy, Indah Nur
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Molecular mechanisms of vascular calcification in diabetes mellitus: insights from human aortic smooth muscle cells, a systematic review Weningtyas, Anditri; Rohman, Mohammad Saifur; Chomsy, Indah Nur; Hose, Victor Alvianoes Guterez; Riza, Mochamad Faishal; Purbaningroom, Dian Laila; Rudijanto, Achmad; Nugrahenny, Dian
Heart Science Journal Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Pa
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.01.2

Abstract

Background: Vascular calcification is a significant contributor to cardiovascular complications in diabetes mellitus (DM), particularly affecting the prognosis of patients.   Objectives: To conduct a comprehensive analysis of the molecular mechanisms underlying vascular calcification in DM, with a focus on insights from human aortic smooth muscle cells (HASMCs). Methods: The search was conducted following the PRISMA guidelines, utilizing databases such as MEDLINE/PubMed, Science Direct, and Google Scholar. The search focused on articles published within the last 5 years that discussed the molecular mechanisms of vascular calcification in DM, specifically in HASMCs. Results: Five selected reviews were found in a total of 637 articles. DM significantly accelerates vascular calcification in HASMCs through the upregulation of osteogenic markers and activation of the Wnt/β-catenin signaling pathway. Other identified mechanisms include inflammation, ferroptosis, and endothelial dysfunction, contributing to the complex interplay of factors that drive vascular calcification in diabetic patients. Conclusion: It is concluded that DM significantly accelerates vascular calcification in enhanced expression of osteogenic markers and activation of the Wnt/β-catenin signaling pathway in human aortic smooth muscle cells. Patients with diabetes are more likely to have cardiovascular issues as a result of this pathological process.
Phylogenetic Patterns of Genus Megophrys (Anura: Megophryidae) from Java and Sumatra Kurniawan, Nia; Affandi, Aminuddin; Wardani, Erintha Eka; Chomsy, Indah Nur; Firdaus, Anggun Sausan; Kurnianto, Agung Sih
The Journal of Experimental Life Science Vol. 7 No. 2 (2017)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1128.003 KB) | DOI: 10.21776/ub.jels.2017.007.02.03

Abstract

The emergence of Java and Sumatra islands at the end of Miocene, has impact to the diversity of fauna that living in the islands. Amphibia, as one of a genetic information series, can be used as a good phylogenetic comparison. Genus Megophrys (Anura: Megophryidae), is a member of amphibians that live isolated at an altitude of 1000 ASL (Above Sea Level) or more. The purpose of this research is to analyze the phylogenetic patterns of genus Megophrys in Java and Sumatra based on the analysis of 16s rRNA gene. We also analyzed the zoogeography to understand the history of relationship and the establishment of these islands. We took samples on 12 localities: 10 areas of Sumatra and 2 areas of Java. We used Qiamp Blood and Tissue Kit to extract the DNA from tissues. Qualitative analysis of DNA was done by running electrophoresis on 1% agarose gel. Qualitative analysis of DNA was done by running electrophoresis on 1% agarose gel. Results show that Clade A has 2 subclasses: I and II. Subclade I consists of Sumatran specimens, whereas subclade II consists of Javanese specimens. Subclaude I and II have paraphyletic connections. Clade B classified as politomy clade consists of Megophrys sp. from West Pasaman, Megophrys sp. from West Sumatra and Megophrys sp. from Pasawaran, Lampung. The result shows that Megophrys sp. of subclade I (clade A) and clade B, belongs to the same group, both of them were originated from Sumatra. Megophrys sp. subclade I (clade A) originated from Tanggamus (Lampung) and West Lampung (Lampung) separated with 2 species of Megophrys sp. of clade B originated from Pasawaran (Lampung).Keywords: 16s rRNA, Java, Megohprys, Sumatra, zoogeography
Co-Authors Achmad Rudijanto Agung Sih Kurnianto Aminuddin Affandi Anditri Weningtyas Dian Nugrahenny Firdaus, Anggun Sausan Hose, Victor Alvianoes Guterez Mohammad Saifur Rohman Nia Kurniawan Purbaningroom, Dian Laila Riza, Mochamad Faishal Wardani, Erintha Eka