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All Journal Heart Science Journal JSMARTech : Journal of Smart Bioprospecting and Technology
Hose, Victor Alvianoes Guterez
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience

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Phylogenetic Study of Several Parasitic Plant Species Based on The atp-1 Gene Sequence Pratama, Ardo Cahya; Karuniasari, Nadaa; Rahmadini, Agnia Fadillah; Ezra, Achmad; Hose, Victor Alvianoes Guterez; Turhadi, Turhadi; Suyanto, Eko; Fatchiyah, Fatchiyah
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 5 No. 2 (2024): JSMARTech Volume 5, No. 2, 2024
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2024.005.02.57

Abstract

The distinction between parasitic and non-parasitic plants can be determined by analyzing the atp-1 gene, which plays a vital role in respiration and is known for its high mutation rate. This study analyzed the kinship of parasitic plant subclass species through the construction of a phylogenetic tree based on atp-1 gene sequences. The atp-1 gene sequences of parasitic and non-parasitic plants with a total of 29 species were obtained from NCBI. The sequences were then aligned with ClustalW and analyzed for mutation patterns. Sequences that have been aligned, phylogenetic trees were made with MEGA11 software with the Maximum Likelihood method and analyzed using the iTOL website. The sequences were analyzed for similarity and kinship with Matrix Coefficient and Haplotype Construction. The atp-1 gene proved that parasitic plants (hemiparasites) are furthermore related to non-parasitic plants compared to holoparasite parasitic plants. Besides that, the kinship of parasitic plants can be analyzed by several methods, namely matrix coefficient to measure similarity, DnaSP to analyzing haplotype, and haplotype network to find out detailed information on mutations that occur. Matrix coefficients can also be used to measure specific similarities between species. It was found that the same subclass had high similarities, for example the species Santalum album and Heisteria parvifolia with a genetic distance value of 0.00574. Meanwhile, different subclasses have low similarity, such as Cassytha filiformis and Ombrophytum with a genetic distance value of 0.07871. This study shows that the atp-1 gene is effective in analyzing the kinship between parasitic and non-parasitic plants. Hemiparasites are genetically closer to non-parasitic plants than holoparasites, with higher genetic similarity within the same subclass.
Molecular mechanisms of vascular calcification in diabetes mellitus: insights from human aortic smooth muscle cells, a systematic review Weningtyas, Anditri; Rohman, Mohammad Saifur; Chomsy, Indah Nur; Hose, Victor Alvianoes Guterez; Riza, Mochamad Faishal; Purbaningroom, Dian Laila; Rudijanto, Achmad; Nugrahenny, Dian
Heart Science Journal Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Pa
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.01.2

Abstract

Background: Vascular calcification is a significant contributor to cardiovascular complications in diabetes mellitus (DM), particularly affecting the prognosis of patients.   Objectives: To conduct a comprehensive analysis of the molecular mechanisms underlying vascular calcification in DM, with a focus on insights from human aortic smooth muscle cells (HASMCs). Methods: The search was conducted following the PRISMA guidelines, utilizing databases such as MEDLINE/PubMed, Science Direct, and Google Scholar. The search focused on articles published within the last 5 years that discussed the molecular mechanisms of vascular calcification in DM, specifically in HASMCs. Results: Five selected reviews were found in a total of 637 articles. DM significantly accelerates vascular calcification in HASMCs through the upregulation of osteogenic markers and activation of the Wnt/β-catenin signaling pathway. Other identified mechanisms include inflammation, ferroptosis, and endothelial dysfunction, contributing to the complex interplay of factors that drive vascular calcification in diabetic patients. Conclusion: It is concluded that DM significantly accelerates vascular calcification in enhanced expression of osteogenic markers and activation of the Wnt/β-catenin signaling pathway in human aortic smooth muscle cells. Patients with diabetes are more likely to have cardiovascular issues as a result of this pathological process.
Regulatory RNAs and coronary artery calcification: A systematic review of clinical associations and biological insights Tsuraya, Alfi; Raras, Tri Yudani Mardining; Lestari, Bayu; Ramadhani, Risa; Hose, Victor Alvianoes Guterez; Rohman, Mohammad Saifur; Waranugraha, Yoga; Fajar, Jonny Karunia
Heart Science Journal Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.02.7

Abstract

BACKGROUND: Regulatory RNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), have emerged as key regulators of vascular remodelling and coronary heart disease. However, their specific roles in coronary artery calcification (CAC) remain fragmented across diverse clinical studies. OBJECTIVES: This review aims to systematically synthesize human observational evidence on differentially expressed regulatory RNAs associated with CAC and their underlying molecular mechanisms. METHODS: We included clinical observational studies (case-control, cross-sectional, or cohort designs) that compared regulatory RNA expression in patients with and without CAC. We searched PubMed, BioMed Central, Wiley, ScienceDirect, and Cochrane between January 2010 and June 2025. Risk of bias was assessed using the JBI Critical Appraisal Checklist for Observational Studies. Data were synthesized narratively with stratification by RNA type, direction of expression, and biological mechanism. RESULTS: A total of 10 eligible studies were included. Several regulatory RNAs demonstrated potential as biomarkers or modulators of CAC. However, the diversity of regulatory RNAs highlights the complex and multifactorial nature of CAC, while also revealing opportunities for future investigation. CONCLUSION: Notably, circSmad4 demonstrated a favourable trend with a high AUC and a reasonably balanced mix of sensitivity and specificity, despite with relatively larger sample sizes.
Co-Authors Achmad Rudijanto Anditri Weningtyas Chomsy, Indah Nur Dian Nugrahenny Eko Suyanto Ezra, Achmad Fajar, Jonny Karunia fatchiyah . Karuniasari, Nadaa Lestari, Bayu Mohammad Saifur Rohman Pratama, Ardo Cahya Purbaningroom, Dian Laila Rahmadini, Agnia Fadillah Ramadhani, Risa Riza, Mochamad Faishal Tri Yudani MR Tsuraya, Alfi Turhadi Turhadi Yoga Waranugraha