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All Journal Indonesian Journal of Obstetrics & Gynecology Science Jurnal Biomedika dan Kesehatan
Nugrahani, Annisa Dewi
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The Analysis of Premature Rupture of Membrane Outcomes: Comparison Between 34-36 Weeks and Term Gestation Yordian, Kendry Savira; Pribadi, Adhi; Syam, Hanom Husni; Nugrahani, Annisa Dewi; Handono, Budi; Susiarno, Hadi; Suardi, Dodi
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 2 Juli 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i2.710

Abstract

Introduction: This study analysed the maternal and neonatal outcomes in premature rupture of membrane at 34-36 weeks of gestation compared to term gestation to provide an overview of the current protocol’s efficacy which is currently widely varied. Method: This was a cross-sectional study using a simple random sampling technique. The subject of this study consisted of a total of 450 pregnant women diagnosed with PPROM at 34-36 weeks and term gestation during the period January 2019-December 2021. P<0.05 was considered statistically significant. Results: That women with premature rupture of membrane (PROM) at term gestation had a higher risk of 1.13 times (OR= 1.13, CI 95%) for neonatal asphyxia, 1.34 times for early neonatal death (OR= 1.34, CI 95%), and 4.03 times for developing clinical chorioamnionitis (OR= 4.03, CI 95%) compared to the 34-36 weeks of gestation group. There was no statistically significant difference between gestational age and the incidence of early neonatal death (P= 0.70). There were no maternal deaths in this study. Conclusion: the management protocol applied for both groups had the same efficacy. The incidence of clinical chorioamnionitis was higher in the term gestation group, which may be associated with risk factors such as COVID-19 and hepatitis B.Analisis Hasil Ketuban Pecah Dini: Perbandingan Antara Usia Kehamilan 34-36 Minggu dan Masa Kehamilan Cukup BulanAbstrakPendahuluan: Penelitian ini menganalisis hasil maternal dan neonatal pada ketuban pecah dini pada usia kehamilan 34 - 36 minggu dibandingkan dengan kehamilan jangka panjang untuk memberikan gambaran tentang kemanjuran protokol saat ini yang sangat bervariasi. Metode: Penelitian ini adalah studi cross-sectional menggunakan teknik simple random sampling. Subjek penelitian ini terdiri atas total 450 wanita hamil yang didiagnosis dengan PROM pada 34 - 36 minggu dan kehamilan jangka panjang selama periode Januari 2019 - Desember 2021. P<0,05 dianggap signifikan secara statistik. Hasil: hasil analisis menunjukan bahwa wanita dengan ketuban pecah dini pada usia kehamilan memiliki risiko lebih tinggi 1,13 kali (OR= 1,13, CI 95%) untuk asfiksia neonatal, 1,34 kali untuk kematian neonatal dini (OR= 1,34, CI 95%), dan 4,03 kali untuk mengembangkan chorioamnionitis klinis (OR= 4,03, CI 95%) dibandingkan dengan kelompok kehamilan 34 - 36 minggu. Tidak ada perbedaan yang signifikan secara statistik antara usia kehamilan dan kejadian kematian neonatal dini (P = 0,70). Tidak ada kematian ibu dalam penelitian ini. Kesimpulan: Protokol manajemen yang diterapkan untuk kedua kelompok memiliki kemanjuran yang sama. Insiden chorioamnionitis klinis lebih tinggi pada kelompok kehamilan, yang mungkin terkait dengan faktor risiko seperti COVID-19 dan hepatitis B.Kata kunci: Ketuban pecah dini, asfiksia, kematian neonatal
The Influence of COVID-19 Severity on Maternal and Perinatal Outcomes: Evidence from a Cohort Study in Indonesia Aziz, Muhammad Alamsyah; Nurdiawan, Windi; Avivi, Safiya Fathina; Wahyudi, Kurnia; Irianti, Setyorini; Fauzi, Ali Amali; Lillah, Alfarisi Syukron; Mariana, Ana; Nugrahani, Annisa Dewi
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 2 July 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i2.883

Abstract

Objective: This study aimed to assess the association between COVID-19 severity and maternal and neonatal outcomes at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.Methods: A retrospective cohort study was conducted among pregnant women with confirmed COVID-19 who delivered between March 1, 2020, and March 31, 2022. Patients were categorized by disease severity (asymptomatic, mild, moderate, severe, or critical). Demographic, clinical, maternal, and neonatal data were collected. Statistical analyses included Fisher’s exact and Kruskal-Wallis tests for bivariate analysis and Poisson regression for multivariate analysis (significance level α = 0.05).Results: Among 199 pregnant women, most were asymptomatic (42.7%) or had mild symptoms (37.2%). Higher COVID-19 severity was significantly associated with increased ICU/semi-ICU admission and oxygen therapy, as well as neonatal complications. After adjustment, moderate to critical cases showed significantly increased risks for ICU/semi-ICU care (p = 0.012, aRR 14.6; 95% CI: 1.8–118.2) and oxygen therapy (p = 0.001, aRR 12.2; 95% CI: 2.7–55.3). Mild cases were not linked to adverse outcomes.Conclusion: Moderate to critical COVID-19 during pregnancy is associated with higher risks of adverse maternal and neonatal outcomes, emphasizing the importance of early detection and close monitoring.Dampak Keparahan COVID- 19 pada Luaran Kehamilan: Studi Kohort di IndonesiaAbstrakTujuan: Penelitian ini bertujuan mengevaluasi hubungan antara tingkat keparahan COVID-19 dan luaran kehamilan serta neonatal di RSUP Dr. Hasan Sadikin, Bandung.Metode: Metode yang digunakan pada penelitian ini adalah kohort retrospektif pada ibu hamil dengan konfirmasi COVID-19 yang melahirkan antara 1 Maret 2020 hingga 31 Maret 2022. Pasien dikelompokkan berdasarkan tingkat keparahan (asimtomatik, ringan, sedang, berat, kritis). Data demografi, klinis, serta luaran ibu dan bayi dikumpulkan. Analisis statistik dilakukan menggunakan SPSS, dengan uji Fisher’s exact dan Kruskal-Wallis untuk bivariat, serta regresi Poisson untuk multivariat (α=5%).Hasil: Hasil penelitian menunjukkan dari 199 ibu hamil yang dianalisis, mayoritas bersifat asimtomatik (42,7%) atau ringan (37,2%). Keparahan penyakit yang lebih tinggi secara signifikan berhubungan dengan peningkatan kebutuhan perawatan ICU/semi-ICU dan terapi oksigen, serta komplikasi neonatal. Setelah penyesuaian, COVID-19 sedang–kritis berkorelasi dengan peningkatan risiko ICU/semi-ICU (p=0,012, aRR 14,6; 95% CI 1,8–118,2) dan terapi oksigen (p=0,001, aRR 12,2; 95% CI 2,7–55,3). Kasus ringan tidak menunjukkan hubungan dengan luaran buruk.Kesimpulan: Keparahan COVID-19 sedang hingga kritis pada kehamilan meningkatkan risiko luaran buruk sehingga diperlukan identifikasi dini dan pemantauan ketat.
Kardiomiopati peripartum vs Kardiomiopati peripartum dengan preeklamsia: dari pendekatan biomolekuler hingga manajemen Fahreza, Lufthi; Winato, Brigad Mahardika; Nugrahani, Annisa Dewi; Arianto, Steven
Jurnal Biomedika dan Kesehatan Vol 7 No 3 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.351-361

Abstract

Peripartum cardiomyopathy (PPCM) is a potentially life-threatening pregnancy-related condition that typically occurs during the peripartum period. It is characterized by impaired function of the left ventricle and heart failure. Preeclampsia is recognized as a risk factor for PPCM and can coexist with this condition. However, there is limited available data that explains the variations in treatment approaches between cases of peripartum cardiomyopathy with and without preeclampsia. Hence, the objective of this study is to examine the distinctions between PPCM and PPCM accompanied by preeclampsia, encompassing their molecular, pathogenic, and pathophysiological aspects, as well as their treatment and management strategies. These factors could potentially play a role in influencing the treatment of patients diagnosed with peripartum cardiomyopathy. A thorough review of existing literature was conducted between June and August 2023. Articles were retrieved from medical databases including PubMed, EBSCOhost, Medline, SAGE, JSTOR, and ScienceDirect, utilizing keywords such as "Peripartum Cardiomyopathy," "PPCM," "Preeclampsia," "Biomolecular," and "Treatment." This study encompassed original articles written in either English or Indonesian, focusing on a ten-year time frame. Articles categorized as literature reviews, systematic reviews, and/or meta-analyses were excluded from consideration in this study. The Results of this review, In instances of PPCM accompanied by preeclampsia, the secretion of sFlt1 from the placenta is notably elevated compared to cases of PPCM alone. PPCM and PPCM with preeclampsia exhibit distinct pathogenic and pathophysiological characteristics. Patients with concentric left ventricular remodeling (PPCM with preeclampsia) may not derive the same degree of benefit from angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, or beta-blockers as those with eccentric left ventricular remodeling (PPCM without preeclampsia). The Conclusion of this review, PPCM and PPCM with preeclampsia are differentiated by underlying biomolecular factors, pathogenesis, and pathophysiology. Furthermore, they respond differently to treatment and have different approaches to management.
Placenta Senescence and the Genesis of Preeclampsia: Is There Any Potential Role? – A Review Nugraha, Azka Ardian; Nugrahani, Annisa Dewi; Adriansyah, Putri Nadhira Adinda; Shodiq, Ja’far; Santoso, Dhanny Primantara Johari
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 3 November 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i3.706

Abstract

Introduction: Preeclampsia is a hypertensive disorder of pregnancy and is responsible for around 800 maternal deaths. The etiologies of preeclampsia remain unidentified, although the premature senescence of the placenta is a possible cause. To date, various markers such as oxidative stress and mitochondrial dysfunction have been identified to be related to placental aging.Method: This study uses a narrative review approach; the search engines used are Scopus, PubMed, and Cochrane. The keyword combinations are placenta senescence AND aging AND preeclampsia, while excluding the results that are correspondence or not written in English.Results: The senescence of the placenta has a role in the pathophysiology of preeclampsia. The epigenetic alterations marked by the changes in the trophoblast’s telomere length as the result of the damage done by ROS to the mitochondria marked by various biomarkers can lead to accelerated cell death.Conclusion: Preeclampsia is due to premature placental aging and apoptosis, resulting in widespread blood vessel lining dysfunction.Penuaan Plasenta dan Asal Mula Preeklampsia: Adakah Peran Potensial? – Sebuah TinjauanAbstrakPendahuluan: Preeklampsia adalah gangguan hipertensi pada kehamilan yang menyebabkan sekitar 800 kematian ibu. Penyebab preeklampsia masih belum diketahui, namun penuaan dini plasenta merupakan salah satu penyebabnya. Sampai saat ini, berbagai markah seperti stress oksidatif dan disfungsi mitokondria telah teridentifikasi berhubungan dengan penuaan plasenta.Metode: Penelitian ini menggunakan pendekatan tinjauan naratif dan mesin pencari yang digunakan adalah Scopus, PubMed, dan Cochrane. Kombinasi kata kunci yang digunakan adalah penuaan plasenta DAN penuaan DAN preeklampsia dan mengecualikan hasil yang bersifat korespondensi atau tidak ditulis dalam bahasa Inggris.Hasil: Penuaan plasenta memiliki peran dalam patofisiologi preeklampsia. ROS merusak mitokondria dengan mengubah panjang telomer trofoblas. Perubahan tersebut dapat menyebabkan percepatan kematian sel yang bisa ditandai dengan berbagai biomarkerKesimpulan: Preeklampsia disebabkan oleh penuaan plasenta dini dan apoptosis yang mengakibatkan disfungsi lapisan pembuluh darah yang meluas.Kata kunci: Perubahan Epigenetik, Stres Oksidatif, Penuaan Plasenta, Preeklampsia
Co-Authors Adhi Pribadi Adriansyah, Putri Nadhira Adinda Ana Mariana, Ana Arianto, Steven Avivi, Safiya Fathina Aziz, Muhammad Alamsyah Budi Handono Dodi Suardi Fahreza, Lufthi Fauzi, Ali Amali Hanom Husni Syam Kurnia Wahyudi, Kurnia Lillah, Alfarisi Syukron Nugraha, Azka Ardian Santoso, Dhanny Primantara Johari Setyorini Irianti Shodiq, Ja’far Susiarno, Hadi Winato, Brigad Mahardika Windi Nurdiawan Yordian, Kendry Savira