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All Journal Journal of Dentistry Indonesia ODONTO Dental Journal Dentino: Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Odonto dental journal
Firdaus, I Wayan Arya Krishnawan
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Dentistry Health Professions Medicine & Pharmacology

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EFFECT OF FICUS DELTOIDEA JACK. TO NEUTROPHIL AND MACROPHAGE CELLS IN ORAL WOUND HEALING Apriasari, Maharani Laillyza; Firdaus, I Wayan Arya Krishnawan; Sari Fitri, Rahayu Wida; Ishmah, Hana Nur; Pramitha, Selviana Rizky; Mahamad Apandi, Nurul Inaas
Dentino: Jurnal Kedokteran Gigi Vol 11, No 1 (2026)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v11i1.26130

Abstract

Background: Oral mucosal wounds require effective inflammatory control for optimal healing. However, conventional agents such as povidone-iodine may cause irritation and cytotoxicity, limiting their use. Ficus deltoidea, a medicinal plant from Kalimantan, possesses antimicrobial, antioxidant, and anti-inflammatory properties, making it a promising alternative for oral wound therapy. Objectives: To evaluate the effect of Ficus deltoidea leaf extract gel on neutrophil and macrophage cells in oral mucosal wound healing. Methods: A true experimental posttest-only control group study was conducted on 48 male Wistar rats. Standardized buccal mucosal wounds were treated with Ficus deltoidea J. leaf extract gel (GEDTB) 5%, 10%, 15% or gel base (control). Animals were sacrificed on days 1, 3, and 7, and neutrophil and macrophage counts were assessed histopathologically. Data were analyzed using two-way ANOVA with Bonferroni post hoc. Results: Neutrophil counts decreased significantly over time in all groups, with a faster reduction in extract-treated groups, particularly at 15%. On day 1, the control group had the highest neutrophil count, significantly greater than the 15% group (p<0.05), while by day 7, all treatment groups showed significantly lower neutrophil levels than control. Macrophage counts increased from day 1, peaked on day 3—highest in the 15% group—and declined significantly by day 7. Both treatment and time had significant effects on neutrophil and macrophage counts (p<0.05), with a significant interaction observed for macrophages. Conclusion: Ficus deltoidea J. leaf extract gel effectively modulates inflammatory cell by accelerating neutrophil reduction and enhancing macrophage activity in oral wound healing.Keywords: Anti-inflammatory activity, Ficus deltoidea jack.,Macrophages, Neutrophils, Oral wound healing
In Silico Model of Musa acuminata Stem as an Anticancer on Oral Squamous Cell Carcinoma against EGFR Rachmayani, Nevrila Dewi; Carabelly, Amy Nindia; Firdaus, I Wayan Arya Krishnawan; Apriasari, Maharani Laillyza; Utami, Juliyatin Putri
Journal of Dentistry Indonesia Vol. 33, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Oral squamous cell carcinoma (OSCC) is characterized by overexpression of the epidermal growth factor receptor (EGFR). Citral, eucalyptol, and caffeic acid phenethyl ester (CAPE), which are derived from Musa acuminata, have shown anticancer activity. This study evaluated the potential of citral, eucalyptol, and CAPE from Musa acuminata as anticancer agents for OSCC by targeting EGFR using an in silico approach. Methods: Potential biological activity was predicted using Prediction of Activity Spectra for Substances (PASS) Online. Molecular docking was conducted with AutoDock Vina, and BIOVIA Discovery Studio was used to analyze binding affinity, interaction types, and bond distances between the compounds and active-site residues of EGFR. Results: CAPE showed the strongest binding affinity (-8.6 kcal/mol), whereas citral and eucalyptol each showed a binding affinity of -5.4 kcal/mol. CAPE formed a conventional hydrogen bond with CYS775 at 2.65 Å and hydrophobic interactions with PHE856, LEU777, and MET766, through π-alkyl and π-π T-shaped interactions. These interaction distances were within the effective range of <3.5 Å, indicating a stable ligand-protein complex. Conclusions: These in silico findings suggest that CAPE derived from Musa acuminata is a promising anticancer candidate for OSCC through its interaction with EGFR.
Co-Authors Adhiya, Geyanina Melda Amy Nindia Carabelly Apriasari, Maharani Lailyza Arifin, Rahmad Azminida, Dhiya Salma Bambang Setiawan Bayu Indra Sukmana Dewi Nurdiana Dewi Puspitasari Diana Wibowo Fachriani, Fachriani Fuady, Ridwan Ichshalul Ishmah, Hana Nur Mahamad Apandi, Nurul Inaas Maharani Laillyza Apriasari Muhlisin, Mahmud Nur Tsaniya, Gusti Erysa Oktiani, Beta Widya Pramitha, Selviana Rizky Rachmayani, Nevrila Dewi Robiyansyah, Hengki Sari Fitri, Rahayu Wida Sari, Tiara Intan Permata Tri Putri, Deby Kania Utami, Juliyatin Putri Wydiamala, Erida Yusrinie Wasiaturrahmah