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All Journal ODONTO Dental Journal Dentino: Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Odonto dental journal
Firdaus, I Wayan Arya Krishnawan
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Dentistry Health Professions Medicine & Pharmacology

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EFFECT OF FICUS DELTOIDEA JACK. TO NEUTROPHIL AND MACROPHAGE CELLS IN ORAL WOUND HEALING Apriasari, Maharani Laillyza; Firdaus, I Wayan Arya Krishnawan; Sari Fitri, Rahayu Wida; Ishmah, Hana Nur; Pramitha, Selviana Rizky; Mahamad Apandi, Nurul Inaas
Dentino: Jurnal Kedokteran Gigi Vol 11, No 1 (2026)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v11i1.26130

Abstract

Background: Oral mucosal wounds require effective inflammatory control for optimal healing. However, conventional agents such as povidone-iodine may cause irritation and cytotoxicity, limiting their use. Ficus deltoidea, a medicinal plant from Kalimantan, possesses antimicrobial, antioxidant, and anti-inflammatory properties, making it a promising alternative for oral wound therapy. Objectives: To evaluate the effect of Ficus deltoidea leaf extract gel on neutrophil and macrophage cells in oral mucosal wound healing. Methods: A true experimental posttest-only control group study was conducted on 48 male Wistar rats. Standardized buccal mucosal wounds were treated with Ficus deltoidea J. leaf extract gel (GEDTB) 5%, 10%, 15% or gel base (control). Animals were sacrificed on days 1, 3, and 7, and neutrophil and macrophage counts were assessed histopathologically. Data were analyzed using two-way ANOVA with Bonferroni post hoc. Results: Neutrophil counts decreased significantly over time in all groups, with a faster reduction in extract-treated groups, particularly at 15%. On day 1, the control group had the highest neutrophil count, significantly greater than the 15% group (p<0.05), while by day 7, all treatment groups showed significantly lower neutrophil levels than control. Macrophage counts increased from day 1, peaked on day 3—highest in the 15% group—and declined significantly by day 7. Both treatment and time had significant effects on neutrophil and macrophage counts (p<0.05), with a significant interaction observed for macrophages. Conclusion: Ficus deltoidea J. leaf extract gel effectively modulates inflammatory cell by accelerating neutrophil reduction and enhancing macrophage activity in oral wound healing.Keywords: Anti-inflammatory activity, Ficus deltoidea jack.,Macrophages, Neutrophils, Oral wound healing
Co-Authors Adhiya, Geyanina Melda Apriasari, Maharani Lailyza Arifin, Rahmad Azminida, Dhiya Salma Bambang Setiawan Bayu Indra Sukmana Dewi Nurdiana Dewi Puspitasari Diana Wibowo Fachriani, Fachriani Fuady, Ridwan Ichshalul Ishmah, Hana Nur Mahamad Apandi, Nurul Inaas Maharani Laillyza Apriasari Muhlisin, Mahmud Nur Tsaniya, Gusti Erysa Oktiani, Beta Widya Pramitha, Selviana Rizky Robiyansyah, Hengki Sari Fitri, Rahayu Wida Sari, Tiara Intan Permata Tri Putri, Deby Kania Utami, Juliyatin Putri Wydiamala, Erida Yusrinie Wasiaturrahmah