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Journal : Sanus Medical Journal

Difficulties Differentiating Between Basal Cell Carcinoma and Trichoepithelioma: A Case Report Nurusshofa, Zahra; irena ujianti
Sanus Medical Journal Vol. 2 No. 2 (2021)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v2i2.7371

Abstract

Background. Basal cell carcinoma (BCC) is the most common type of malignant skin tumor with basal cell differentiation. Trichoepithelioma (TE), however, is a rare benign skin tumor with follicular differentiation. Both types of tumor have commonalities in terms of clinical and histopathological features. Some cases, in fact, require ancillary studies to distinguish between the two. Confusing the two tumors may result in different future outcomes for the patient, due to their vastly different prognoses and treatments. This case report outlines two different cases, and discusses how to distinguish between the two types of tumor without the use of an ancillary study.Method. We examined the cases of one patient with basal cell carcinoma and one patient with trichoepithelioma, comparing their clinical manifestations and characteristic histological features.Results. Trichoepithelioma and BCC share several overlapping histopathological features. Trichoepithelioma and BCC share several overlapping histopathological features. The TE in this case report also exhibited a nodular pattern, connection to the epidermis, stromal cleft, and prominent nuclear palisading, which are more commonly found in BCC. However, scanty mitotic activity, the presence of non-atypia cells, and symmetry of the lesion, are favor TE.Conclusion. Differentiation between BCC and TE is only possible using cytomorphological assessment with a high-power field of view.
Hubungan Tingginya Nilai ANC (Absolute Neutrophil Count) dengan Kejadian Apendisitis Akut dan Perforasi di RS Islam Jakarta Pondok Kopi Pada Tahun 2018-2020 Amalia, Amirah; Hasan, Fahad; Wahyuni, Ira; El Anshori, Mohamad Riza; Nurusshofa, Zahra
Sanus Medical Journal Vol. 5 No. 1 (2023)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v5i1.10715

Abstract

Apendisitis adalah kejadian peradangan pada apendiks vermiformis. Penelitian ini melihat hubungan antara tingginya nilai Absolute Neutrophil Count (ANC) dengan kejadian apendisitis akut dan perforasi. Penelitian ini dilakukan menggunakan desain analitik observasional dengan pendekatan cross sectional. Hasil penelitian menyatakan bahwa terdapat hubungan yang signifikan antara tingginya nilai ANC dengan kejadian apendisitis akut dan perforasi dengan nilai p value sebesar 0.000. Juga ditemukan cut off nilai ANC antara apendisitis akut dan perforasi sebesar 9053 sel/µL dengan sensitivitas sebesar 100% dan spesifisitas sebesar 72,6%. Hasil penelitian menyarankan bahwa penghitungan nilai ANC dapat digunakan sebagai pemeriksaan alternatif untuk penegakan diagnosis apendisitis, namun tidak dapat dijadikan sebagai satu-satunya tolak ukur untuk membedakan antara diagnosis apendisitis akut dan perforasi.