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All Journal The Indonesian Biomedical Journal Journal Of Widya Medika Junior Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Community Development Journal: Jurnal Pengabdian Masyarakat AKSONA International Journal of Public Health Excellence (IJPHE) Journal of Medicine and Health Jurnal Widya Medika
Erwin, Ferdinand
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Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Jurnal Widya Medika

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VITAMIN B SUPPLEMENTATION IN GERIATRIC PATIENTS: A POTENTIAL STRATEGY TO MANAGING HYPERHOMOCYSTEINEMIA IN CEREBROVASCULAR DISEASE Meryana, Meryana,; Sugianto, Paulus; Erwin, Ferdinand; Jaya, David Karunia
JURNAL WIDYA MEDIKA Vol. 10 No. 2 (2024): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v10i2.6024

Abstract

Homocysteine is a non-essential amino acid produced in the biosynthesis pathway between methionine and cysteine. Its levels tend to rise with age due to physiological, lifestyle, and nutritional factors. Elevated homocysteine can induce oxidative stress, inflammation, and endothelial dysfunction, which are critical in the development of cerebrovascular diseases. These mechanisms involve increased free radicals, decreased antioxidant enzyme activity, and enhanced inflammatory responses. Specifically, elevated homocysteine heightens oxidative stress and inflammation by increasing pro-inflammatory cytokines and decreasing anti-inflammatory cytokines, leading to endothelial cell damage and apoptosis. Supplementation with vitamins B6, B9, and B12 has been shown to lower homocysteine levels and reduce the risk of ischemic stroke. However, there is currently no established guideline for the appropriate dosing of these vitamins.
ANALYSIS OF STROKE RISK FACTORS ON THE FREQUENCY OF RECURRENT STROKE EVENTS IN ACUTE ISCHEMIC STROKE PATIENTS Kurniawati, Nita; Supit, Paulus Alexander; Erwin, Ferdinand
JURNAL WIDYA MEDIKA Vol. 10 No. 2 (2024): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v10i2.6033

Abstract

Introduction: Ischemic strokes making up over three quarters of all cases are a major global cause of disability and mortality. Survivors face a 15% risk of recurrence within two years, with recurrent strokes often resulting in more severe neurological damage and increasing the risk of death and long-term disability. Methods: This retrospective cross-sectional study analyzed medical records from Gotong Royong Hospital in Surabaya from January 2023 to June 2024, selecting patients with acute ischemic stroke and a history of prior strokes. The data were descriptively analyzed and further examined using bivariate analysis to identify correlations with recurrent stroke episodes, followed by a multivariate regression analysis. Results: The study recruited 87 participants, predominantly male (64.4%), with an average age of 63.2 years and varying medical histories, including hypertension (79.3%), diabetes mellitus (46%), and dyslipidemia (31%). Bivariate analysis revealed no significant correlations between hyperten
Co-Authors Budipramana, Vicky Sumarki Dyana Sarvasti Ernawati, Titiek Hadi, Wiyono Jaya, David Karunia Kartikasari, Desy Kurniawati, Nita Laksono, Gerardo AK Mayung, Claraiva Meryana, Meryana Meryana, Meryana, Novita, Bernadette Novita, Bernadette Dian Paul L Tahalele Paulus Alexander Supit Paulus Sugianto, Paulus Raymond Desun, Evander Aloysius S.Pd. M Kes I Ketut Sudiana . Samsudin, Kevin Setiawan, Albert Sianty Dewi Supit, Paulus Supit, Paulus A Supit, Vincentius Diamantino Theodora, Imelda Tjahyanto, Teddy Wibowo, Tjipto Wiracakra, I Gusti Lanang Krisna Yohanes, Guntur