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All Journal Jurnal Respirologi Indonesia Narra J Jurnal Impresi Indonesia Public Health and Safety International Journal (PHASIJ) The Journal of Society Medicine (JSOCMED)
Syarani, Fajrinur
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Relationship between interleukin-6 (IL-6) levels and chest X-ray severity scoring in COVID-19 patients Kardiasyah, Alzi; Syarani, Fajrinur; Bihar, Syamsul; Lubis, Netty D.; Mutiara, Erna; Syahputra, Hafid
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.690

Abstract

The severity of coronavirus disease 2019 (COVID-19) may be measured by interleukin-6 (IL-6) and chest X-rays. Brixia score of the chest radiographs is usually used to monitor COVID-19 patients’ lung problems. The aim of this study was to demonstrate the relationship between IL-6 levels and chest radiographs (Brixia score) that represent COVID-19 severity. A retrospective cohort study was conducted among COVID-19 patients who had a chest X-ray and examination of IL-6 levels at H. Adam Malik General Hospital, Medan, Indonesia. A multinomial logistic regression analysis was conducted to evaluate the association between IL-6 levels and the severity of the chest radiograph. A total of 76 COVID-19 patients were included in the study and 39.5% of them were 60–69 years old, with more than half were female (52.6%). A total of 17.1%, 48.7%, and 34.2% had IL-6 level of <7 pg/mL, 7–50 pg/mL and >50 pg/mL, respectively. There were 39.5%, 36.8% and 23.7% of the patients had mild, moderate and severe chest X-rays based on Brixia score, respectively. Statistics analysis revealed that moderate (OR: 1.77; 95% CI: 1.05–3.32) and severe (OR: 1.33; 95% CI: 1.03–3.35) lung conditions in the chest X-rays were significantly associated with IL-6 levels of 7–50 pg/mL. IL-6 more than 50 pg/mL was associated with severe chest X-ray condition (OR: 1.97; 95% CI: 1.15–3.34). In conclusion, high IL-6 levels significantly reflected COVID-19 severity through chest X-rays in COVID-19 patients.
Correlation of Bronchoscopy Visualization With Cell Type in Lung Cancer Patients at Haji Adam Malik Hospital Medan 2023 Fachrina, Intan; Bihar, Syamsul; Syarani, Fajrinur
Journal of Society Medicine Vol. 3 No. 10 (2024): Oktober
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i10.167

Abstract

Introduction: Lung cancer is defined as a tumor that originates in the lung parenchyma or is located around the bronchi. The two main types are Non Small Cell Lung Carcinoma (NSCLC) and Small Cell Lung Carcinoma (SCLC). When carrying out the procedure, several bronchoscopy visualizations are assessed, such as the bronchial lumen, bronchial mucosa, secretions and bronchial anatomy. Timely bronchoscopic intervention is important for rapid and accurate diagnosis. To determine the relationship between bronchoscopic visualization and carcinoma cell type characteristics from histopathology. Method: This study was conducted with an observational analytic design conducted in a cross-sectional manner, from October 2023 to May 2024. The subjects of this study were taken from the population of lung cancer patients who were hospitalized and outpatient in the hospital, were found to be 67 samples of Non Small Cell Lung Carcinoma (NSCLC). Data included bronchoscopic visualization with lung carcinoma cell type from histopathology, were analyzed univariately and bivariately to assess the relationship between bronchoscopy visualization and lung carcinoma cell type. Results: All patients had Non Small Cell Lung Cancer (100%) are Adenocarcinoma as much as 63% and Squamous Cell Carcinoma as much as 37%. Bronchoscopy visualization shows a central location (62%), partially closed lumen (65%), smooth mucosa (64.5%), mucoid secretion (83.8%), and most often in the right main bronchus (32.2%). Conclusion: There was a significant relationship between bronchoscopy location and type of lung cancer cell (P value 0.001), as well as between mucosa and cell type (P value 0.001).
Hubungan Antara Pola Kuman dengan Mortalitas pada Pasien Pneumonia di IPI RS. HAM Medan Nadia, Agnes; Bihar, Syamsul; Syarani, Fajrinur
Public Health and Safety International Journal Vol. 5 No. 01 (2025): Public Health and Safety International Journal (PHASIJ)
Publisher : YCMM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55642/phasij.v5i01.990

Abstract

Pneumonia is one of the leading causes of morbidity and mortality, partIPIlarly in hospital settings. Identifying bacterial patterns and antibiotic resistance is essential to determine appropriate therapy and reduce mortality rates. This study aimed to examine the association between bacterial patterns, antibiotic resistance, and mortality in pneumonia patients. A retrospective design was used by analyzing medical record data of pneumonia patients treated in 2022. A total of 66 patients who met the inclusion criteria were included in the analysis. Data included sputum culture results, antibiotic resistance profiles, and patient mortality status. The results showed that the most commonly found bacteria were Klebsiella pneumoniae (31.8%), followed by Acinetobacter baumannii (25.8%) and Pseudomonas aeruginosa (16.7%). The highest resistance rates were observed for meropenem (31.8%) and levofloxacin (28.8%). Statistical analysis revealed a significant association between antibiotic resistance and patient mortality (p = 0.017). However, no significant association was found between the type of causative bacteria and mortality (p = 0.414). These findings indicate that antibiotic resistance plays a major role in clinical outcomes of pneumonia patients. Therefore, regular monitoring of bacterial and resistance patterns and the implementation of rational antibiotic use policies are essential to reduce pneumonia-related mortality in hospitals.
Association Between Glycated Hemoglobin (HBA1C) Levels and The Incidence of Pulmonary Drug-Resistant Tuberculosis Among Patients With Type 2 Diabetes Mellitus Harahap, Kartini; Syarani, Fajrinur; Sinaga, Bintang Yinke Magdalena; Eyanoer, Putri Chairani
Jurnal Impresi Indonesia Vol. 4 No. 8 (2025): Indonesian Impression Journal (JII)
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v4i8.6939

Abstract

Patients with type 2 diabetes mellitus (T2DM) are at increased risk of developing multidrug-resistant tuberculosis (MDR-TB). In Indonesia, data regarding the characteristics and risk factors for MDR-TB among diabetic populations remain limited. Managing MDR-TB in individuals with T2DM is complicated by potential drug interactions and challenges associated with poor glycemic control. This study aimed to assess the association between glycated hemoglobin (HbA1c) levels and the risk of developing MDR-TB among T2DM patients at Adam Malik General Hospital, Medan. A case-control analytical study was conducted using secondary data from medical records. A total of 120 participants were, including 60 MDR-TB cases and 60 drug-sensitive tuberculosis controls. Variables analyzed included age, sex, education, employment status, body mass index, smoking status, and HbA1c levels. Statistical analyses involved chi-square tests and multivariate logistic regression. Multivariate analysis identified smoking as the strongest risk factor for MDR-TB, followed by poor glycemic control, indicated by elevated HbA1c levels. Smoking substantially increases the risk of MDR-TB among patients with T2DM, with smokers being twelve times more likely to develop MDR-TB. These findings emphasize the need to integrate smoking cessation initiatives into MDR-TB prevention and management strategies targeting diabetic populations.
Factors that Affected the Mortality Rate of Chronic Obstructive Pulmonary Disease Patients with Respiratory Failure Nahrisyah, Putri; Syarani, Fajrinur; Tarigan, Amira P; Ashar, Taufik
Jurnal Respirologi Indonesia Vol 45 No 1 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i1.805

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a significant health issue with high morbidity and mortality rates. However, risk factors for COPD, particularly in cases with type II respiratory failure, are not fully understood. This study analyzes factors influencing the mortality rate of COPD patients with type II respiratory failure. Methods: This observational study used a cross-sectional design, analyzing medical records of COPD patients with type II respiratory failure treated at H. Adam Malik General Hospital, Medan, from November 2021 to September 2022. A total of 42 patients met the inclusion criteria. Data analysis included descriptive statistics and inferential tests using the Chi-Square test and multiple logistic regression to identify the most dominant factors. Results: Among the 42 patients, the mortality rate was 50%. Variables such as gender, age, number of comorbidities, smoking habits, and history of exacerbations were not significantly associated with mortality. Patients who did not regularly use inhalers had a 19-fold higher mortality risk than those who did (P=0.004; OR=19.79; 95% CI=2.67-146.99). Length of stay was inversely associated with mortality, with each additional day reducing the risk by 0.77 times (P=0.011; OR=0.77; 95% CI=0.63-0.94). Conclusion: Routine inhaler use and length of stay are significant factors influencing the mortality rate in COPD patients with type II respiratory failure.
Co-Authors Bihar, Syamsul Erna Mutiara Fachrina, Intan Hafid Syahputra Kardiasyah, Alzi Kartini harahap Lubis, Netty D. Nadia, Agnes Nahrisyah, Putri Putri Chairani Eyanoer, Putri Chairani Sinaga, Bintang Yinke Magdalena Tarigan, Amira Permatasari Taufik Ashar