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Factors Affecting the Quality of Life Among Pulmonary Tuberculosis Patients at the TB-DOTS Outpatient Clinic of Public Hospital Zahra, Diandra Angelia Az; Sinaga, Bintang Yinke Magdalena
Public Health of Indonesia Vol. 10 No. 1 (2024): January - March
Publisher : YCAB Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/phi.v10i1.774

Abstract

Background: Indonesia is the second country in the world with the highest burden of tuberculosis. Pulmonary tuberculosis is one of the global health issues that can substantially affect quality of life. Objective: To analyze the quality of life and associated factors among pulmonary tuberculosis patients. Methods: A cross-sectional study was conducted at the TB-DOTS outpatient clinic of Prof. Chairuddin Panusunan Lubis Universitas Sumatera Utara Hospital, Medan, Indonesia. The study subject was 100 pulmonary tuberculosis patients aged ≥18 years, newly diagnosed, and undergoing treatment from August to October 2023, selected using consecutive sampling. Primary data were collected through face-to-face interviews using the WHOQOL-BREF questionnaire. Descriptive statistics, the chi-square test, and the logistic regression test were used for data analyses. Results: The chi-square test showed there was a significant relationship between age (p = 0.022), family income (p = 0.005), treatment phase (p < 0.001), and adverse drug reactions (p = 0.040) with overall quality of life. The logistic regression test showed there was a significant relationship between family income (p = 0.007, OR = 3.685, 95% CI = 1.432–9.479) and treatment phase (p < 0.001, OR = 5.643, 95% CI = 2.139–14.888) with the deterioration of overall quality of life. Conclusion: The treatment phase lasting less than 2 months was the factor that most influenced the deterioration of the overall quality of life. Hence, families, healthcare workers, and the government should consider the treatment phase as a focus of interventions to enhance the quality of life of pulmonary tuberculosis patients
Perianal Fistula Due to Tuberculosis Infection: A Case Report Sinaga, Bintang Yinke Magdalena; Siagian, Novi Andriani; Siagian, Parluhutan; Muhar, Adi Muradi
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 6 No. 3 (2024): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v6i3.15613

Abstract

Introduction: Approximately 5% of all cases of tuberculosis are extrapulmonary. A rare extrapulmonary variant of the disease is known as perianal tuberculosis, which accounts for 0.001% of all extrapulmonary tuberculosis cases. Case Report: A 28-year-old male presented with intermittent chronic anal pain and purulent discharge from the anal for 6 months, without respiratory complaints. Chest X-Ray examination shows minimal infiltrate on the right lung apex and broncho vascular pattern partially covered with infiltrate. Fistulotomy has been done three times in this patient within 6 months. Colonoscopy examination shows recti polyp, and the histopathology result from biopsy specimen taken from the last fistulotomy is tuberculosis-specific chronic inflammatory process. The Human Immunodeficiency Virus test is negative. This patient has been treated with anti-tuberculosis treatment for 7 months and 2 months after consuming it the wound on the perianal is healing and the patient’s weight is gaining 10 kgs within 7 months. Conclusion: The diagnosis of perianal tuberculosis is challenging, especially in the absence of pulmonary focus. Tuberculosis should be considered in the differential diagnosis of perianal ulcers and fistulas, mainly in non-healing and recurrent anal lesions, especially in regions where tuberculosis is endemic. Management with anti-tuberculosis treatment can provide complete recovery.
Clinical Spectrum and Factors Associated to Post Covid Syndrome in Healthcare Workers Sinaga, Joshua Princeman; Sinaga, Bintang Yinke Magdalena; Siagian, Parluhutan; Eyanoer, Putri Chairani; Samodra, Yoseph Leonardo
Public Health of Indonesia Vol. 10 No. 4 (2024): October - December
Publisher : YCAB Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/phi.v10i4.844

Abstract

Background:Post-COVID Syndrome (PCS) is a newly recognized condition reported by approximately 45% of individuals following COVID-19 infection. This syndrome is estimated to affect the health-related quality of life in 10–30% of affected individuals. Objective:To examine the characteristics of Post-COVID Syndrome among healthcare workers at Adam Malik Hospital. Methods:This study employed a cross-sectional descriptive design. Data were collected using structured questionnaires administered to healthcare workers at Adam Malik Hospital who had contracted COVID-19 between 2020 and 2022. Results:A total of 120 participants were included in the study. The sample was predominantly female (78.3%), with the youngest age group (19–30 years) comprising 37.5% of participants. Most participants had direct exposure to patient care (78.3%) and were confirmed COVID-19 positive in 2021 (42.5%). Notably, 45.0% of participants were unvaccinated, 20.9% had a history of hospitalization, and 78.3% experienced mild COVID-19 infections. Hypertension was identified as the most common comorbidity. Participants were categorized as experiencing Acute PCS (43.9%) or Chronic PCS (56.1%), with both groups exhibiting similar predominant symptoms, including fatigue, persistent cough, memory impairment, and cognitive difficulties. Statistically significant associations were identified between PCS and variables such as sex (p=0.004, OR=0.27), age (p=0.015, OR=4.46), severity of prior COVID-19 infection (p=0.040, OR=1.77), vaccination status (p<0.001, OR=3.82), and the presence of comorbidities (p=0.025, OR=2.53). Conclusion:Post-COVID Syndrome is characterized by multifactorial etiologies and heterogeneous clinical manifestations. Factors such as gender, age, vaccination status, comorbid conditions, and severity of prior infections were significantly associated with PCS outcomes. Gender-related differences, potentially influenced by immune response, hormonal mechanisms, and antibody production, appear to contribute to variations in PCS manifestations. These findings underscore the need for further research to elucidate the epidemiology, clinical presentations, and pathological mechanisms underlying this emerging post-viral condition.  Keywords:Post-COVID Syndrome; healthcare workers; COVID-19; clinical manifestations; post-viral sequelae
Contributing Factors of Anxiety on Healthcare Workers during COVID-19 Pandemic at Referral Hospital of Sumatra Region in Indonesia Simanjuntak, Christine Raphaela Tiarmauli; Sinaga, Bintang Yinke Magdalena; Siagian, Parluhutan; Effendy, Elmeida; Zaluchu, Fotarisman
Public Health of Indonesia Vol. 11 No. S1 (2025): Special Issue
Publisher : YCAB Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/phi.v11iS1.888

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Background:During the Coronavirus Disease 2019 (COVID-19) pandemic, nurses and doctors served as the frontline healthcare workers. Consequently, mental health issues among healthcare workers can develop into significant health problems and impose a substantial social burden, particularly on nurses and doctors working in hospital settings. Objective:To analyze the prevalence and factors influencing anxiety levels among healthcare workers, specifically nurses and doctors, at Adam Malik General Hospital Medan during the COVID-19 pandemic. Methods:This study employed a cross-sectional design with bivariate analysis. Data were collected using the DASS-42 questionnaire, which was distributed to 114 participants comprising nurses and doctors working in both the COVID-19 emergency isolation and ward isolation units. Results:The findings revealed that 29 participants (25.4%) exhibited symptoms of anxiety, with the majority experiencing mild anxiety (13.2%). The nursing profession demonstrated the highest prevalence of anxiety disorders, with 33.3% of nurses reporting symptoms. Being a nurse was significantly associated with higher anxiety levels compared to being a doctor, and working in the emergency isolation room was significantly associated with higher anxiety levels compared to working in the isolation ward or both units (p<0.05). Conclusion:Factors such as gender, marital status, parental status, post-COVID-19 status, family history of COVID-19, vaccination history, and comorbidities did not significantly affect anxiety levels among healthcare workers during the COVID-19 pandemic at Adam Malik General Hospital Medan. However, anxiety was prevalent among healthcare workers, with nurses and those working in the emergency isolation room being particularly affected. Keywords:anxiety; COVID-19; healthcare workers; mental health; Indonesia
Relationship between Transaminase Enzyme Levels and Severity of Dengue Fever Sidabutar, Wita Lestari; Saragih, Restuti Hidayani; Rohmawati, Lili; Sinaga, Bintang Yinke Magdalena
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol. 25 No. 1 (2025): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v25i1.22076

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Since dengue hemorrhagic fever (DHF) can cause liver damage, aminotransferase levels as liver function test may be useful in predicting the severity of dengue hemorrhagic fever. The purpose of this study was to determine the relationship between transaminase enzyme levels and the severity of dengue hemorrhagic fever. This study used analytic observational approach with cross-sectional design. The data used was secondary data, namely medical records of H. Adam Malik Hospital and Hospital of Prof. Dr. Chairuddin P. Lubis University of North Sumatera. From a total of 65 patients included, there were 63.1% (41 patients) with DHF grade 1, 29.2% (19 patients) were DHF grade 2, 6.2% (4 patients) were DHF grade 3 and 1.5% (1 medical record) were DHF grade 4. For aminotransferase level 56.9% (37 records) had elevated SGPT levels and 92.3% (60 records) had elevated SGOT levels, it was found that there was no relationship between increased levels of SGPT and SGOT with the severity of DHF (SGPT p = 0.628 and SGOT p = 1.00). There is no association between the elevations of transaminase enzyme levels and the severity of DHF.
Nutritional Status of Kindergarten Children in Medan Helvetia Subdistrict and the Factors Affecting It Pasaribu, Ira Nurhasanah; Wijaya, Hendri; Sinaga, Bintang Yinke Magdalena; Yunita, Rina
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 2 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i2.18618

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Background: During childhood, especially from toddlerhood to school age, children experience significant body growth. Therefore, children require an adequate concentration of nutrients per kilogram of body weight. Low nutritional status affects the quality of human resources because it affects intelligence and resistance to disease. The aim of the study was to analyse the factors that contribute to the nutritional status of kindergartens in Medan Helvetia Sub-district. Methods. This study was a quantitative analytic study using a cross sectional approach. The study population was kindergartens in Medan Helvetia Subdistrict with a sample of 100 people. The sampling technique in this study used a stratified random sampling method. Data collection method was questionnaire method using questionnaire and 24-hour food recall and anthropometric measurement using weighing tool and microtoise. Data analysis using chi square and fisher’s exact test. Results. Of 100 children, it was known that 58 was female, 42 children was male, 29 children was < 60 months old, 64 children was 60 to 72 months old, 7 children is > 72 months old. 1 child has poor nutritional status, 29 children was found with malnutrition, 57 had good nutritional status, 9 had an overnutrition status, while 4 children was obese. Bivariate analysis of food intake with a p value = 0.004; family income with a p value = 0.672; maternal insight with a p value = 0.234; infectious diseases with a p value = 0.030; immunization status with a p value = 0.399; maternal education level with a p value = 0.092. Conclusion. Factors that influence the nutritional status of kindergarten children in Medan Helvetia Sub-district are food intake and infectious diseases.
Comparison of Sensitivity and Specificity between Tuberculin Skin Test (TST) and Interferon-Gamma Release Assays (IGRA) for Latent TB Infection (LTBI) in Household Contacts of Drug-Sensitive TB Patients in Medan Sundari, Rina; Sinaga, Bintang Yinke Magdalena; Sormin, Delores Elisabeth; Wahyuni, Arlinda Sari
Jurnal Impresi Indonesia Vol. 4 No. 8 (2025): Jurnal Impresi Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v4i8.6926

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Latent Tuberculosis Infection (LTBI) is a condition characterized by the absence of clinical symptoms of active disease, yet it carries the risk of progressing to active tuberculosis (TB), particularly within the first two years following infection. The diagnosis of LTBI relies on immunological tests, such as the Tuberculin Skin Test (TST) and Interferon-Gamma Release Assays (IGRA), each with its own strengths and limitations. To compare the sensitivity and specificity of TST and IGRA in the diagnosis of LTBI in household contacts of drug-sensitive TB patients in Medan. This study is an analytical observational study with a cross-sectional design involving 105 subjects who were household contacts of drug-sensitive TB patients. All subjects underwent chest X-ray, TST, IGRA, and Xpert MTB/RIF examination when indicated. Data were statistically analyzed using the Chi-Square test. Among 105 participants, 93 did not have pulmonary TB. Of 93 subjects, 24.7% tested positive by TST and 32.3% by IGRA. TST's calculated sensitivity and specificity compared to IGRA were 76.7% and 63.5%, respectively. TST demonstrates lower sensitivity and specificity than IGRA in diagnosing LTBI. However, TST remains a valuable screening tool, particularly in resource-limited settings.
Contact Investigation Among Household Contacts of Drug-Resistant Tuberculosis Patients in Medan Rizky, Handan; Sinaga, Bintang Yinke Magdalena; Siagian, Parluhutan; Ashar, Taufik
Jurnal Impresi Indonesia Vol. 4 No. 8 (2025): Jurnal Impresi Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v4i8.6938

Abstract

Household contacts of Drug-Resistant Tuberculosis patients potential to develop latent tuberculosis infection (LTBI) or active tuberculosis (TB) infection. This research aims to determine the prevalence of LTBI and Pulmonary TB and the characteristic of household contact with Drug-Resistant Tuberculosis (DR-TB) patients. This is a descriptive analytical study using a cross-sectional approach in people aged > 18 years who have household contact with DR-TB patients whom confirmed by sputum GeneXpert and treated at Adam Malik Hospital Medan. The research subjects then underwent examinations including symptom anamnesis, chest X-ray, sputum GeneXpert, and IGRA blood test From 105 people who had household contact with DR-TB patients, the most common cases found were LTBI cases (55%), followed by uninfected cases (40%). Meanwhile, the only cases of Pulmonary TB found were Drug-Sensitive Pulmonary TB were 6 cases (5%) which are bacteriologically confirmed drug-Sensitive TB was 4 cases and clinically confirmed drug-sensitive TB was 2 cases. Majority of patients were in 18-30 year old group (30.5%), female (70%), high school graduates (61%), housewives (41%), normoweight (80%), no smoking habit (78%), no consuming alcohol (97%), and no comorbid diseases (87.5%). Based on contact duration, 70 people (67%) were found with > 5 hours and 35 patients (33%) with < 5 hours. In addition, the majority of samples (70%) did not sleep in the same room with MDR-TB patients.  LTBI cases were the most common cases found among household contact with DR-TB patients.
Association Between Glycated Hemoglobin (HBA1C) Levels and The Incidence of Pulmonary Drug-Resistant Tuberculosis Among Patients With Type 2 Diabetes Mellitus Harahap, Kartini; Syarani, Fajrinur; Sinaga, Bintang Yinke Magdalena; Eyanoer, Putri Chairani
Jurnal Impresi Indonesia Vol. 4 No. 8 (2025): Jurnal Impresi Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v4i8.6939

Abstract

Patients with type 2 diabetes mellitus (T2DM) are at increased risk of developing multidrug-resistant tuberculosis (MDR-TB). In Indonesia, data regarding the characteristics and risk factors for MDR-TB among diabetic populations remain limited. Managing MDR-TB in individuals with T2DM is complicated by potential drug interactions and challenges associated with poor glycemic control. This study aimed to assess the association between glycated hemoglobin (HbA1c) levels and the risk of developing MDR-TB among T2DM patients at Adam Malik General Hospital, Medan. A case-control analytical study was conducted using secondary data from medical records. A total of 120 participants were, including 60 MDR-TB cases and 60 drug-sensitive tuberculosis controls. Variables analyzed included age, sex, education, employment status, body mass index, smoking status, and HbA1c levels. Statistical analyses involved chi-square tests and multivariate logistic regression. Multivariate analysis identified smoking as the strongest risk factor for MDR-TB, followed by poor glycemic control, indicated by elevated HbA1c levels. Smoking substantially increases the risk of MDR-TB among patients with T2DM, with smokers being twelve times more likely to develop MDR-TB. These findings emphasize the need to integrate smoking cessation initiatives into MDR-TB prevention and management strategies targeting diabetic populations.
Age and Diabetes Mellitus Associated with Hematological Disorders and Peripheral Neuropathy in MDR-TB Patients Treated with the BPaL/M Regimen Tako, Frida Welhelmina; Sinaga, Bintang Yinke Magdalena; Harahap, Juliandi; Daulay, Rini Savitri; Siregar, Jelita; Samodra, Yoseph Leonardo
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.241-249

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Introduction: Tuberculosis (TB) is a disease with a significant treatment burden. Current multidrug-resistant (MDR)-TB therapy uses the bedaquiline, pretomanid, linezolid, and moxifloxacin (BPaL/M) combination. This combination is effective with a short treatment duration. Linezolid is one of the components of the BPaL/M regimen. However, despite its effectiveness, it has side effects that impact treatment management and success. This study aimed to find the association between characteristics and comorbidities with the incidence of linezolid side effects in patients with MDR-TB treated with the BPaL/M regimen. Methods: This was a retrospective analytic study of MDR-TB patients receiving BPaL/M combination. Data were collected from medical records and analyzed using Fisher's exact test to analyze the association between patient characteristics and comorbidities with the incidence of linezolid side effects, namely hematological disorders, peripheral neuropathy, and visual disturbances. Results: There was no significant association between overall patient characteristics and the incidence of linezolid adverse events. However, the results of bivariate analysis showed a significant association in age >50 years old with the incidence of hematological disorders, as well as in patients who have diabetes mellitus (DM) with the incidence of peripheral neuropathy as a side effect of linezolid. Conclusion: Monitoring of MDR-TB patients aged >50 years old and those with DM to minimize the incidence of side effects during treatment is essential. This effort is expected to support the success of the national TB control and treatment program.